The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters
Open accessAbstract
Alterations in GABAergic mRNA expression play a key role for prefrontal dysfunction in schizophrenia and other neurodevelopmental disease. Here, we show that histone H3-lysine 4 methylation, a chromatin mark associated with the transcriptional process, progressively increased at GAD1 and other GABAergic gene promoters ( GAD2 , NPY , SST ) in human prefrontal cortex (PFC) from prenatal to peripubertal ages and throughout adulthood. Alterations in schizophrenia included decreased GAD1 expression and H3K4-trimethylation, predominantly in females and in conjunction with a risk haplotype at the 5′ end of GAD1 . Heterozygosity for a truncated, lacZ knock-in allele of mixed-lineage leukemia 1 ( Mll1 ), a histone methyltransferase expressed in GABAergic and other cortical neurons, resulted in decreased H3K4 methylation at GABAergic gene promoters. In contrast, Gad1 H3K4 (tri)methylation and Mll1 occupancy was increased in cerebral cortex of mice after treatment with the atypical antipsychotic, clozapine. These effects were not mimicked by haloperidol or genetic ablation of dopamine D 2 and D 3 receptors, suggesting that blockade of D 2 -like signaling is not sufficient for clozapine-induced histone methylation. Therefore, chromatin remodeling mechanisms at GABAergic gene promoters, including MLL1-mediated histone methylation, operate throughout an extended period of normal human PFC development and play a role in the neurobiology of schizophrenia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Given the role of this process in establishing active promoters38, it appears likely that the dysregulation of histone methylation may have downstream effects with the potential to disrupt neurodevelopment and coordinated gene expression, as animal studies have demonstrated39.”
From Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways (2015) · cites this paper as [39]
Citations
Cites
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×
“Next, we monitored levels of H3K4me3, and of H3-mono-methyl-lysine 4 (H3K4me1) [a related modification that partially overlaps with H3K4me3 in genome-wide screens (Heintzman et al., 2007)] around GAD1 TSS during the course of PFC development.”
MethodGenomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
Bernstein, B., Kamal, M., Lindblad‐Toh, K., Bekiranov, S., Bailey, D. K., Huebert, D. J., McMahon, S., Karlsson, E. K., Kulbokas, E. J., Gingeras, T., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.001 · Cited by 1,567
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400
MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters
Milne, T. A., Briggs, S. D., Brock, H. W., Martin, M. E., Gibbs, D. Y., Allis, C. D., & Hess, J. L. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00741-4 · Cited by 1,071
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002
Self-citationAltered Hox expression and segmental identity in Mll-mutant mice
Yu, B., Hess, J. L., Horning, S. E., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Nature · doi:10.1038/378505a0 · Cited by 872
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes
Schneider, R., Bannister, A. J., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2003) · Nature Cell Biology · doi:10.1038/ncb1076 · Cited by 807
Histone lysine methylation: a signature for chromatin function
Sims, R. J., Nishioka, K., & Reinberg, D. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.09.007 · Cited by 708
Lieberman, J., Perkins, D., Belger, A., Chakos, M., Jarskog, F., Boteva, K., & Gilmore, J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01303-8 · Cited by 608
Cited by
Sorted by citations
Items 201–300 of 352
Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia
Cariaga-Martínez, A. E., & Alelú‐Paz, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040790 · Cited by 15
Schizophrenia and gut-flora related epigenetic factors
Zhuo, C., Yao, Y., Xu, Y. J., Liu, C., Chen, M., Ji, F., Li, J., Tian, H., Jiang, D., Lin, C., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.005 · Cited by 15
Kikuchi, M., Nakazawa, T., Kinoshita, M., Yamamori, H., Yasuda, Y., Fujimoto, M., Hashimoto, R., & Numata, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.734606 · Cited by 15
Ramya, V., Shyam, K. P., Angelmary, A., & Kadalmani, B. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159429 · Cited by 14
Kimijima, H., Miyagawa, K., Kurokawa, K., Mochida-Saito, A., Takahashi, K., Takeda, H., & Tsuji, M. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136340 · Cited by 14
Familial hematological malignancies: ASXL1 gene investigation
Hamadou, W. S., Abed, R. E., Besbes, S., Bourdon, V., Fabre, A. J., Youssef, Y. B., Laatiri, M. A., Eisinger, F., Mari, V., Gesta, P., et al. (2015) · Clinical & Translational Oncology · doi:10.1007/s12094-015-1379-7 · Cited by 14
Huang, H., Cheung, I. K., & Akbarian, S. (2010) · Autism Research · doi:10.1002/aur.141 · Cited by 12
Self-citationNwasike, C., Ewert, S., Jovanovic, S., Haider, S. M., & Mujtaba, S. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13017 · Cited by 13
The epigenomics of schizophrenia, in the mouse
Javidfar, B., Park, R., Kassim, B. S., Bicks, L. K., & Akbarian, S. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32566 · Cited by 14
Self-citationBhuiyan, P., Sun, Z., Khan, M. A., Hossain, M. A., Rahman, M. H., & Qian, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25191 · Cited by 14
Kambali, M., Li, Y., Unichenko, P., Pliego, J. A. F., Yadav, R., Liu, J., McGuinness, P. S., Cobb, J. G., Wang, M., Nagarajan, R., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02711-5 · Cited by 14
Veazey, K. J. (2013) · Alcohol research · doi:10.35946/arcr.v35.1.09 · Cited by 13
Gillespie, A. L., Walker, E., Hannon, E. J., McQueen, G., Sendt, K.-V., Avila, A., Lally, J., Okhuijsen‐Pfeifer, C., van der Horst, M. Z., Hasan, A., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03102-8 · Cited by 13
Abdolmaleky, H. M., Glatt, S. J., & Tsuang, M. T. (2011) · Springer eBooks · doi:10.1007/978-1-84882-644-1_11 · Cited by 12
Kitazawa, M., Ohnuma, T., Takebayashi, Y., Shibata, N., Baba, H., Ohi, K., Yasuda, Y., Nakamura, Y., Aleksić, B., Yoshimi, A., et al. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32049 · Cited by 11
Gangisetty, O., & Murugan, S. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_1 · Cited by 12
Sex differences in Gadd45b expression and methylation in the developing rodent amygdala
Kigar, S. L., Chang, L., Hayne, M. R., Karls, N. T., & Auger, A. P. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.031 · Cited by 12
Repetitive Elements and Epigenetic Marks in Behavior and Psychiatric Disease
Darby, M. M., & Sabunciyan, S. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800222-3.00009-7 · Cited by 11
Maćkowiak, M., Guzik, R., Dudys, D., Bator, E., & Wędzony, K. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71469-5 · Cited by 11
Ricq, E. L., Hooker, J. M., & Haggarty, S. J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12426 · Cited by 12
Génétique et épigénétique de la schizophrénie et des psychoses
Chaumette, B., Kébir, O., & Krebs, M. (2017) · Biologie Aujourd hui · doi:10.1051/jbio/2017015 · Cited by 14
WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway
Shimizu, M., & Shibuyà, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-20271-y · Cited by 11
Epigenetic regulation of human-specific gene expression in the prefrontal cortex
Sun, W., Xie, G., Jiang, X., Khaitovich, P., Han, D., & Liu, X. (2023) · BMC Biology · doi:10.1186/s12915-023-01612-3 · Cited by 12
Abbs, B., Achalia, R. M., Adelufosi, A. O., Aktener, A. Y., Beveridge, N. J., Bhakta, S. G., Blackman, R. K., Bora, E., Byun, M. S., Cabanis, M., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.07.024 · Cited by 8
Yokotsuka, S., Nakamura, M., Tomiyasu, Y., Nagai, M., Kato, Y., Tomiyasu, A., Umehara, H., Hayashi, T., Sasaki, N., Ueno, S., et al. (2021) · Journal of Human Genetics · doi:10.1038/s10038-020-00889-4 · Cited by 9
Chromatin-bound RNA and the neurobiology of psychiatric disease
Tushir, J. S., & Akbarian, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.051 · Cited by 10
Self-citationEpigenetic studies of schizophrenia: current status and future directions
Migdalska‐Richards, A., & Mill, J. S. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.12.003 · Cited by 9
[S-adenosyl L-methionine in CNS diseases].
Krzystanek, M., Pałasz, A., Krzystanek, E., Krupka-Matuszczyk, I., Wiaderkiewicz, R., & Skowronek, R. (2011) · PubMed · Cited by 9
Ho, M., Zhang, C., Moon, I., Biernacka, J. M., Coombes, B. J., Ngo, Q., Skillon, C., Skime, M. K., Oesterle, T., Croarkin, P. E., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101798 · Cited by 8
Martínez-Peula, O., Morentín, B., Callado, L. F., Meana, J. J., Rivero, G., & Ramos‐Miguel, A. (2024) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230054 · Cited by 8
Herrero, F., Heeb, C., Meier, M. G., Lin, H.-Y., Mueller, F. S., Schalbetter, S. M., Gruchot, J., Weber‐Stadlbauer, U., Notter, T., Perron, H., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02955-9 · Cited by 9
Histone Modifications in Neurological Disorders
Smith, B. J., & Carregari, V. C. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-05460-0_7 · Cited by 9
Epigenetic Effects of Currently Used Psychotropic Drugs
Boks, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00023-1 · Cited by 8
Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy
Abdolmaleky, H. M., & Thiagalingam, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00011-5 · Cited by 8
Flight, M. H. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2282 · Cited by 8
Restoring GABAergic Signaling and Neuronal Synchrony in Schizophrenia
Akbarian, S. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081225 · Cited by 8
Self-citationDunn, J. T., Guidotti, A., & Grayson, D. R. (2024) · eNeuro · doi:10.1523/eneuro.0186-23.2024 · Cited by 7
Girella, A., Bartolomeo, M. D., Dainese, E., Buzzelli, V., Trezza, V., & D’Addario, C. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04117-9 · Cited by 6
Histone Modifications in the Nervous System and Neuropsychiatric Disorders
Bridi, M. S., & Abel, T. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00002-1 · Cited by 8
Manley, W., Moreau, M., Azaro, M. A., Siecinski, S. K., Davis, G., Buyske, S. G., Vieland, V. J., Bassett, A. S., & Brzustowicz, L. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194233 · Cited by 7
Lysine methylation regulates nervous system diseases
Wang, Z., & Liu, H. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.04.004 · Cited by 7
Brenaut, E., Godin, O., Leboyer, M., Tamouza, R., Assan, F., Pignon, B., & Sbidian, É. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.01.005 · Cited by 7
Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder
Zelena, D. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3345-3_10 · Cited by 7
Epigenetic Mechanisms in the Pathophysiology of Psychotic Disorders
Ruzicka, W. B. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000048 · Cited by 7
The Potential Role of Epigenetics in Aquaculture
Wang, H., & Shen, Z. (2023) · Wiley eBooks · doi:10.1002/9781119821946.ch1 · Cited by 7
Roles of Epigenetics in the Neural Stem Cell and Neuron
Yamamoto, N., Uesaka, M., Imamura, T., & Nakashima, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00004-8 · Cited by 6
Barbu, M. C., Viejo-Romero, M., Thng, G., Adams, M. J., Marwick, K. F. M., Grant, S. G. N., McIntosh, A. M., Lawrie, S. M., & Whalley, H. C. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.03.004 · Cited by 8
Banerjee, M. (2021) · Pharmacogenomics (London) · doi:10.2217/pgs-2021-0140 · Cited by 4
Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia
Huang, T., Lin, C.-C., Chen, R., & Lee, C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.06.010 · Cited by 6
Harlap, S., Perrin, M. C., Deutsch, L., Kleinhaus, K., Fennig, S., Nahon, D., Teitelbaum, A., Friedlander, Y., & Malaspina, D. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.022 · Cited by 6
The Promise of Epigenetic Editing for Treating Brain Disorders
González-Molina, L. A., Dolga, A. M., Rots, M. G., & Sarno, F. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_4 · Cited by 5
Psychiatric disorders and epigenetics.
Koçak, E. E., & Ertuğrul, A. (2012) · PubMed · Cited by 5
Epigenetic analysis of human postmortem brain tissue
Islam, S. A., Lussier, A. A., & Kobor, M. S. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00017-7 · Cited by 6
Chen, S., Tang, D., Deng, L., & Xu, S. (2024) · iScience · doi:10.1016/j.isci.2024.109560 · Cited by 5
Epigenetic Mechanisms in Memory Formation
Reul, J. M. H. M., Collins, A., & Gutièrrez‐Mecinas, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_14 · Cited by 5
Rosenstock, T. R. (2014) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.886877 · Cited by 5
Approaching the Molecular Pathology of Suicide
Akbarian, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.013 · Cited by 5
Self-citationEpigenetic Regulation of Glutamic Acid Decarboxylase 67 in a Hippocampal Circuit
Subburaju, S., Coleman, A. J., Cunningham, M. G., Ruzicka, W. B., & Benes, F. M. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw307 · Cited by 5
Use of the epigenetic toolbox to contextualize common variants associated with schizophrenia risk
Rajarajan, P., & Akbarian, S. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/sakbarian · Cited by 5
Self-citationPang, B., Wang, J., Zhang, W., Gao, Y., Zhang, J., Su, Y., & Kou, C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.07.060 · Cited by 5
Pharmacoepigenetics of Antipsychotic Drugs
Swathy, B., Polakkattil, B. K., & Banerjee, M. (2019) · Pharmacoepigenetics · doi:10.1016/b978-0-12-813939-4.00025-5 · Cited by 3
Baharnoori, M., Bartholomeusz, C., Boucher, A. A., Buchy, L., Chaddock, C., Chiliza, B., Föcking, M., Fornito, A., Gallego, J. A., Hori, H., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.09.008 · Cited by 6
Pathogenic histone modifications in schizophrenia are targets for therapy
Abdolmaleky, H. M., & Thiagalingam, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00006-4 · Cited by 4
Epigenetics of Psychopathology
Smith, A. K., Parets, S. E., & Kim, A. W. (2014) · Springer eBooks · doi:10.1007/978-1-4614-9509-3_10 · Cited by 4
Epigenetic Control in Schizophrenia
D’Addario, C., & Bartolomeo, M. D. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_5 · Cited by 3
DNA Methylation in Psychiatric Diseases
Neidhart, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420194-1.00017-8 · Cited by 3
Huang, T., Hsieh, M.-T., & Lin, C.-C. (2019) · Taiwanese Journal of Psychiatry · doi:10.4103/tpsy.tpsy_18_19 · Cited by 3
Epigenetic Dysregulation in the Schizophrenic Brain
Halene, T. B., Peter, C. J., & Akbarian, S. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0007-0 · Cited by 3
Self-citationMastication and Prefrontal Cortex
Narita, N. (2008) · Nihon Soshaku Gakkai zasshi · doi:10.14858/soshaku1991.18.12 · Cited by 3
Epigenetic biomarkers in neuropsychiatric disorders
Lin, C.-C., & Huang, T. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00003-4 · Cited by 4
Histone and DNA Methylome in Neurodegenerative, Neuropsychiatric and Neurodevelopmental Disorders
Rani, H., & Mahadevan, V. (2019) · RNA technologies · doi:10.1007/978-3-030-14792-1_4 · Cited by 3
Pharmacogenomics and antipsychotics: efficacy and adverse drug reactions
Tsermpini, E. E., Terzi, T., Plesničar, B. K., & Dolžan, V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819602-1.00010-3 · Cited by 3
Known and Unexplored Post-Translational Modification Pathways in Schizophrenia
Smith, B. J., & Carregari, V. C. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-97182-3_6 · Cited by 3
Peedicayil, J. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09010011 · Cited by 3
Matsuda, S., Hattori, Y., & Kimura, H. (2024) · Advances in pharmacology · doi:10.1016/bs.apha.2024.10.017 · Cited by 2
Southey, B. R., Sunderland, G. R., Gomez, A. N., Bhamidi, S., & Rodriguez‐Zas, S. L. (2025) · Gene · doi:10.1016/j.gene.2025.149215 · Cited by 2
Marballi, K. K., Ponomarev, I., Mayfield, R. D., & Harris, R. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00017-1 · Cited by 2
Babkina, A. S., Khadzhiyeva, M. B., Ostrova, I. V., Рыжков, И. А., & Golubev, A. M. (2021) · Russian Open Medical Journal · doi:10.15275/rusomj.2021.0306 · Cited by 2
Ghanbari, M., Khosroshahi, N. S., Alamdar, M., Abdi, A., Aghazadeh, A., Feizi, M. A. H., & Haghi, M. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230607124803 · Cited by 2
Establishment of Tissue-Specific Epigenetic States During Development
Sandovici, I. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8078-5_2 · Cited by 2
Astroglia and Severe Mental Illness: A Role for Glutamate Microdomains
McCullumsmith, R. E., Shan, D., Yates, S. D., & Roberts, R. C. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0974-2_16 · Cited by 2
Biochemical methods for the analysis of DNA-protein interactions
Zhang, J., Pan, Z., Fei, L. I. N., Ma, X., & Liu, H. (2009) · Hereditas (Beijing) · doi:10.3724/sp.j.1005.2009.00325 · Cited by 2
Epigenetic Approaches to Define the Molecular and Genetic Risk Architectures of Schizophrenia
Kundaković, M., Peter, C. J., Roussos, P., & Akbarian, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801829-3.00013-6 · Cited by 2
Self-citationEpigenetics of Psychiatric Disorders
Kundaković, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00019-3 · Cited by 3
Meaney, M. J., Akbarian, S., Nestler, E. J., & Sweatt, J. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00014-8 · Cited by 2
Self-citationOdoemelam, E. C. (2009) · Brunel University Research Archive (BURA) (Brunel University London) · Cited by 2
Gene regulatory networks controlling neuronal development
Lambert, J. T., Haigh, J. L., & Nord, A. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00027-8 · Cited by 1
Petibon, Y., Takano, A., Schwarz, A. J., Yardibi, O., Sandiego, C. M., Barret, O., Constantinescu, C. C., Tauscher, J. T., & Mcquade, P. S. (2025) · EJNMMI Research · doi:10.1186/s13550-025-01350-3 · Cited by 1
Posttranslational Histone Modifications and the Neurobiology of Psychosis
Akbarian, S., Cheung, I. K., Connor, C., Jakovcevski, M., & Jiang, Y. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_1 · Cited by 1
Self-citationHistone methylations in the developing central nervous system and in neural tube defects
Villarreal, A., Franz, H., & Vogel, T. (2018) · e-Neuroforum · doi:10.1515/nf-2018-a001 · Cited by 1
Liu, W., Fang, Y., Shi, Y., Cheng, Y., Sun, C., & Cui, D. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109918 · Cited by 1
Epigenetic effects of currently used psychotropic drugs
Peedicayil, J., & Santhosh, S. (2021) · Epigenetics in Psychiatry · doi:10.1016/b978-0-12-823577-5.00005-2
Epigenetics and Brain Plasticity: Back to Function
Morelli, G., Valle, F. D., & Orlando, V. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-24930-3_11 · Cited by 1
Pei, J.-C., Chang, C.-Y., Liu, Y., Chen, C., Liu, C.-Y., Hsieh, M. H., Liu, C., & Lai, W. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf070 · Cited by 1
Epigenetics in Child Psychiatry
Elia, J., Kingsley, R. S., Yost, O., Bongiorno, C., Bernacki, C. G., Ambrosini, A. P., Okuyama, M., & Hakonarson, H. H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00020-6 · Cited by 1
Epigenetics and It's Detailed Mechanisms in Life Phenomena: A Review
Watanabe, K.-I. (2016) · Nihon Ika Daigaku Igakkai Zasshi · doi:10.1272/manms.12.118
Chromatin modification and remodeling in schizophrenia
Duan, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813796-3.00014-6 · Cited by 1
Web Similarity in Sets of Search Terms Using Database Queries
Cohen, A. R., & Vitanyi, P. M. B. (2020) · SN Computer Science · doi:10.1007/s42979-020-00148-5 · Cited by 1
RNAi for livestock improvement
Shah, U. N., Gnanasekaran, S., Mondal, S., Reddy, I. J., Nandi, S., Gupta, P. S., & Das, D. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820595-2.00007-2 · Cited by 1
Cannabis effects on the adolescent brain
Murlanova, K., Hasegawa, Y., Kamiya, A., & Pletnikov, M. V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823490-7.00007-1 · Cited by 2
Metadata
- Authors
- Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Baylor College of Medicine (US)
- Corresponding author
- Akbarian, Schahram
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-10-17
- Volume
- 27
- Issue
- 42
- Pages
- 11254-11262
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673022
- OpenAlex
- W2124607109
- Cited by
- 352
- References
- 44
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 15 · 2020: 13 · 2019: 12 · 2018: 15 · 2017: 10 · 2016: 27 · 2015: 24 · 2014: 31 · 2013: 27 · 2012: 25
- FWCI
- 14.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institute of Mental Health
- National Institute of Child Health and Human Development
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- schizophrenia, prefrontal cortex, MLL1, histone H3 lysine 4 methylation, GABAergic neurons, GAD1, promoter, chromatin remodeling, clozapine, dopamine D2/D3 receptors, sex differences, brain development
- MeSH terms
- Adult, Animals, Cells, Cultured, Child, Female, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Histones, Humans, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Promoter Regions, Genetic, Histone-Lysine N-Methyltransferase, Schizophrenia, Prefrontal Cortex, DNA Methylation, Mice, Rats, Myeloid-Lymphoid Leukemia Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
