Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×

Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse

Bernstein, B., Kamal, M., Lindblad‐Toh, K., Bekiranov, S., Bailey, D. K., Huebert, D. J., McMahon, S., Karlsson, E. K., Kulbokas, E. J., Gingeras, T., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.001 · Cited by 1,567

Epigenetic regulation in psychiatric disorders

Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400

MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

Milne, T. A., Briggs, S. D., Brock, H. W., Martin, M. E., Gibbs, D. Y., Allis, C. D., & Hess, J. L. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00741-4 · Cited by 1,071

Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002

Altered Hox expression and segmental identity in Mll-mutant mice

Yu, B., Hess, J. L., Horning, S. E., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Nature · doi:10.1038/378505a0 · Cited by 872

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Schneider, R., Bannister, A. J., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2003) · Nature Cell Biology · doi:10.1038/ncb1076 · Cited by 807

Histone lysine methylation: a signature for chromatin function

Sims, R. J., Nishioka, K., & Reinberg, D. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.09.007 · Cited by 708

The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches.

Lieberman, J., Perkins, D., Belger, A., Chakos, M., Jarskog, F., Boteva, K., & Gilmore, J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01303-8 · Cited by 608

Chromatin-Based Treatments for Affective Disorders – Insight or Utopia

Covington, H. E., & Berton, O. (2010) · Modern trends in psychiatry · doi:10.1159/000319526 · Cited by 1

Molecular mechanisms of D-cycloserine in a fear extinction posttraumatic stress disorder (PTSD) animal model

Malan‐Müller, S. (2014) · SUNScholar (Stellenbosch University) · Cited by 1

Web similarity in sets of search terms using database queries

Cohen, A. R., & Vitanyi, P. M. B. (2015) · Centrum Wiskunde & Informatica (CWI), the national research institute for mathematics and computer science in the Netherlands · Cited by 1

Pathway-based polygenic risk scores for schizophrenia and associations with clinical and neuroimaging phenotypes in UK BiobankPreprint

Barbu, M., Thng, G., Adams, M., Marwick, K., Grant, S. G. N., McIntosh, A., Lawrie, S., & Whalley, H. (2022) · medRxiv · doi:10.1101/2022.07.12.22277553 · Cited by 1

Verhaltens- und Neurogenetik

Graw, J. (2015) · Springer eBooks · doi:10.1007/978-3-662-44817-5_14

The Mind and its Nucleosomes – Chromatin (dys)Regulation in Major Psychiatric Disease

Bharadwaj, R. A., Peter, C. J., & Akbarian, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00007-0

Epigenetic involvement in psychiatric disorders and psychiatric drugs

de Jong, N. M. (2010) · Utrecht University Repository (Utrecht University)

Quantification of GAD67 protein levels in axonal boutons from distinct subtypes of GABA neurons: Redefining circuit level alterations in the prefrontal cortex of schizophrenia

Rocco, B. R. (2015) · D-Scholarship@Pitt (University of Pittsburgh)

Stress Effects on the Brain

Reul, J. M. H. M., Collins, A., & Gutièrrez‐Mecinas, M. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch5

The neurobiology of chromatin-associated mechanisms in the context of psychosisand mood spectrum disorders

Akbarian, S. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777271.036

Differentially Expressed MicroRNAs Act As Inhibitors of BDNF in Prefrontal Cortex - Implications for Schizophrenia: A Dissertation

Mellios, N. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/pz41-4991

Epigenetic control of GLT-1 gene activity and its modulation by psychoactive drugs in comparison to genome-wide drug effects

Perišić, T. (2012) · doi:10.5282/edoc.14393

Chromatin Remodeling in Transgenic Mouse Brain: Implications for the Neurobiology of Depression: A Dissertation

Jiang, Y. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/a1cy-7882

Dr. Perrone-Bizzozero and W. Michael Bullock Reply

Perrone‐Bizzozero, N. I., & Bullock, W. M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09010011r

The role of psychotherapy in the age of medication : a theoretical analysis of biological and psychodynamic perspectives on the etiology and treatment of schizophrenia

Hutchinson, T. L. (2008) · Smith ScholarWorks (Smith College)

Psikiyatrik Hastal›klar›n Gelifliminde Epigenetik Mekanizmalar

Erol, D., Elyas, Z., & Ünal, S. (2010)

Psychiatric disorders and epigenetics.

Koçak, E. E., & Ertuğrul, A. (2012) · PubMed · Cited by 5

A role for astroctye-related genes in suicide

Ernst, C. (2009)

Review Article GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia

González‐Burgos, G., Fish, K. N., & Lewis, D. A. (2011)

Clinical research Epigenetic mechanisms in schizophrenia

Akbarian, S. (2014)

Epigenetics of Psychiatric Diseases

Weaver, I. C. G., & Petronis, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.00097-0

Mechanizmy epigenetyczne w chorobach psychicznych i zaburzeniach funkcji poznawczych

Dmitrzak‐Węglarz, M., & Hauser, J. (2009) · Via Medica Journals · Cited by 3

The Impact of Epigenetics in Schizophrenia Research

Gebicke‐Haerter, P. J. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622499-00028

Study design considerations in epigenetic studies of neuropsychiatric disease

Haghighi, F. G., Zaman, S., & Xin, Y. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777271.034

Epigenetic mechanisms in central nervous system disorders

Gupta, S., Parrish, R., & Lubin, F. D. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511980053.019

Epigenetic Animal Models of GABAergic Deficit in Mental Disorders

Tueting, P. A., Costa, E., & Guidotti, A. (2011) · Neuromethods · doi:10.1007/978-1-61779-157-4_11

The HLA Complex Group 9 Gene Modification Study in Major Psychosis

Pal, M. (2015) · TSpace (University of Toronto)

Screening of a Histone Methyltransferase Inhibitor in Animal Models of Psychiatric Illness

Kosowan, J. (2014) · TSpace (University of Toronto)

Using whole genome sequencing to identify risk alleles for susceptibility to schizophrenia

Davis, G. (2017) · doi:10.7282/t3tt4v31

Die Rolle von Histonmethylierungen in der Entwicklung des zentralen Nervensystems und bei Neuralrohrdefekten

Villarreal, A., Franz, H., & Vogel, T. (2018) · e-Neuroforum · doi:10.1515/nf-2018-0001

Targeting histone modifications in psychotic disorders

Peedicayil, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816422-8.00012-x

Faculty Opinions recommendation of The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes.

Benes, F. M., & Subburaju, S. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1161630.623192

Frontal Cortex

Williams, M. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-68308-5_4

Roles of epigenetics in the neural stem cell and neuron

Yamamoto, N., Uesaka, M., Imamura, T., & Nakashima, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00023-4

Epigenomic Imaging of Neuropsychiatric Diseases

Bahari‐Javan, S. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4280

WNK1/HSN2 Regulates Neural Development via GSK3βPreprint

Shimizu, M., & Shibuyà, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1383513/v1

WHAT IS EPIGENETIC CHANGE AND WHAT DO WE KNOW ABOUT ITS IMPACT ON MOLECULAR PATHOLOGIC MECHANISMS OF THE DISEASES?

Bozkurt, K. K., Tan, A., Ertunç, O., Öztürk, R. G., Çakır, Y., Yılmaz, Z. S., & ÜNLÜ, Ş. (2022) · SDÜ Tıp Fakültesi Dergisi · doi:10.17343/sdutfd.1090522

Altered epigenetic mechanisms related to GABA synthesis identified in schizophrenic brains

(2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0674

Epigenetics and aetiology of mental illness

Campanile, G., Fanelli, G., Fabbri, C., Serretti, A., & Mendlewicz, J. (2022) · doi:10.1093/med/9780198861478.003.0005

FN1, Collagen, MMP-2, and Lumican Associated with ECM Organization with Multiple Signaling Pathways Dysfunction in Schizophrenia Pathogenesis by Network Biology ApproachesPreprint

Bhuiyan, P., Khan, M. A., Sun, Z., & Qian, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2070137/v1

Inhibition of lysine-specific demethylase 1 enzyme activity by TAK-418 as a novel therapy for autism

Matsuda, S., & Kimura, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824421-0.00017-5

A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampusPreprint

Kambali, M., Li, Y., Unichenko, P., Pliego, J. A. F., Yadav, R., Liu, J., McGuinness, P. S., Cobb, J. G., Wang, M., Nagarajan, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.29.542745

Effect of Organic Nutrient Management on Quality Parameters and Yield of Fodder Cowpea Varieties

Puramanagari, B., Hemalatha, S., Tirumala Reddy, S., Leelavathy, G. P., & Chandrika, V. (2023) · International Journal of Environment and Climate Change · doi:10.9734/ijecc/2023/v13i123721

Association between epigenetic mark 5-hydroxymethylcytosine and brain pathophysiology

Kang, A. K., Dhawan, U., & Mallick, B. N. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149755

Inflammation Alters Histone Methylation in the Central Nervous System: Implications for Neuropsychiatric Disease: A Dissertation

Connor, C. (2011) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/9s7h-s649

Psikiyatrik Hastalıkların Gelişiminde Epigenetik Mekanizmalar

Erol, D., Elyas, Z., & Ünal, S. (2010) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.1080/10177833.2010.11790643

Epigenetic Therapies in Neurological Diseases

Huang, H., Philpot, B. D., & Jiang, Y. (2013) · Epigenetics and human health · doi:10.1007/978-3-642-36827-1_8

Histone demethylase PHF2 drives olanzapine-induced dyslipidemia via epigenomic rewiring of hepatic lipogenic genes.

Zhang, L., Zhao, X., Chen, M., Pan, Z., Hu, C.-H., & Liu, X.-M. (2026) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111843

Omics biomarkers of antipsychotic efficacy and safety: focus on lurasidone

Gareeva, A. E., Borodina, L., Mikhailova, E. G., Gindullina, P. A., Valinurov, R. G., & Тимербулатов, И. Ф. (2026) · Pharmacogenetics and Pharmacogenomics · doi:10.37489/2588-0527-0013

Epigenetics processes involved in schizophrenia and antipsychotic treatment

MALIK, K., Davies, S. J. C., RAVINDRAN, N., & LUCA, V. D. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19043-8.00024-4

BindingDB Entry 50018104: Annual review of lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors in 2021.

BindingDB (2024) · UC San Diego · doi:10.7270/q25b06p2

BindingDB Entry 50019655: Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.

BindingDB (2024) · UC San Diego · doi:10.7270/q2320187

Methylation and schizophrenia

Flight, M. H. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2282 · Cited by 8

GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia

Huang, H., & Akbarian, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000809 · Cited by 223

Epigenetic Determinants of Altered Gene Expression in Schizophrenia: a Dissertation

Huang, H. (2008) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/h312-hs12

Brain metabolic patterns correlate with symptom onset in preclinical HD

(2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0675

Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy

Abdolmaleky, H. M., & Thiagalingam, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00011-5 · Cited by 8