Cited by 352Schizophrenia research and treatmentEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Open access

Huang, Hsien-Sung, Matevossian, Anouch, Whittle, Catheryne, Kim, Se Young, Schumacher, Armin, Baker, Stephen P., Akbarian, Schahram·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.3272-07.2007PMC PMC6673022

Open this paper in CoChat — free account

Abstract

Alterations in GABAergic mRNA expression play a key role for prefrontal dysfunction in schizophrenia and other neurodevelopmental disease. Here, we show that histone H3-lysine 4 methylation, a chromatin mark associated with the transcriptional process, progressively increased at GAD1 and other GABAergic gene promoters ( GAD2 , NPY , SST ) in human prefrontal cortex (PFC) from prenatal to peripubertal ages and throughout adulthood. Alterations in schizophrenia included decreased GAD1 expression and H3K4-trimethylation, predominantly in females and in conjunction with a risk haplotype at the 5′ end of GAD1 . Heterozygosity for a truncated, lacZ knock-in allele of mixed-lineage leukemia 1 ( Mll1 ), a histone methyltransferase expressed in GABAergic and other cortical neurons, resulted in decreased H3K4 methylation at GABAergic gene promoters. In contrast, Gad1 H3K4 (tri)methylation and Mll1 occupancy was increased in cerebral cortex of mice after treatment with the atypical antipsychotic, clozapine. These effects were not mimicked by haloperidol or genetic ablation of dopamine D 2 and D 3 receptors, suggesting that blockade of D 2 -like signaling is not sufficient for clozapine-induced histone methylation. Therefore, chromatin remodeling mechanisms at GABAergic gene promoters, including MLL1-mediated histone methylation, operate throughout an extended period of normal human PFC development and play a role in the neurobiology of schizophrenia.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.3272-07.2007

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×
“Next, we monitored levels of H3K4me3, and of H3-mono-methyl-lysine 4 (H3K4me1) [a related modification that partially overlaps with H3K4me3 in genome-wide screens (Heintzman et al., 2007)] around GAD1 TSS during the course of PFC development.”
Method
Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
Bernstein, B., Kamal, M., Lindblad‐Toh, K., Bekiranov, S., Bailey, D. K., Huebert, D. J., McMahon, S., Karlsson, E. K., Kulbokas, E. J., Gingeras, T., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.001 · Cited by 1,567
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400
MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters
Milne, T. A., Briggs, S. D., Brock, H. W., Martin, M. E., Gibbs, D. Y., Allis, C. D., & Hess, J. L. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00741-4 · Cited by 1,071
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002
Self-citation
Altered Hox expression and segmental identity in Mll-mutant mice
Yu, B., Hess, J. L., Horning, S. E., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Nature · doi:10.1038/378505a0 · Cited by 872
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes
Schneider, R., Bannister, A. J., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2003) · Nature Cell Biology · doi:10.1038/ncb1076 · Cited by 807
Histone lysine methylation: a signature for chromatin function
Sims, R. J., Nishioka, K., & Reinberg, D. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.09.007 · Cited by 708
The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches.
Lieberman, J., Perkins, D., Belger, A., Chakos, M., Jarskog, F., Boteva, K., & Gilmore, J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01303-8 · Cited by 608

Show all 44 references

Sorted by citations

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) · Nature Neuroscience · doi:10.1038/nn.3922 · Cited by 755
GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia
González‐Burgos, G., & Lewis, D. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn070 · Cited by 592
Histone Methylation Regulates Memory Formation
Gupta, S., Kim, S. Y., Artis, S., Molfese, D. L., Schumacher, A., Sweatt, J. D., Paylor, R. E., & Lubin, F. D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3732-09.2010 · Cited by 585
Self-citation
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
Abel, T. G., & Zukin, R. S. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.002 · Cited by 504
Epigenetic basis of mental illness
Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342
Self-citation
Expression of GABA Signaling Molecules KCC2, NKCC1, and GAD1 in Cortical Development and Schizophrenia
Hyde, T. M., Lipska, B. K., Ali, T., Mathew, S., Law, A. J., Metitiri, O. E., Straub, R. E., Ye, T., Colantuoni, C., Herman, M. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1234-11.2011 · Cited by 325
The role of histone modifications: from neurodevelopment to neurodiseases
Park, J., Lee, K., Kim, K., & Yi, S.-J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01078-9 · Cited by 333
Epigenetic principles and mechanisms underlying nervous system functions in health and disease
Mehler, M. F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.10.001 · Cited by 300
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation
Dong, E., Nelson, M., Grayson, D. R., Costa, E., & Guidotti, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805493105 · Cited by 284
A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex
Mellios, N., Huang, H.-S., Grigorenko, A., Rogaev, E., & Akbarian, S. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn201 · Cited by 274
Self-citation
The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders
Grayson, D. R., & Guidotti, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.125 · Cited by 280
Molecular Determinants of Dysregulated GABAergic Gene Expression in the Prefrontal Cortex of Subjects with Schizophrenia
Mellios, N., Huang, H.-S., Baker, S. P., Galdzicka, M., Ginns, E., & Akbarian, S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.019 · Cited by 266
Self-citation
Alterations of cortical GABA neurons and network oscillations in schizophrenia
Gonzalez-Burgos, G., Hashimoto, T., & Lewis, D. A. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0124-8 · Cited by 260
GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
González‐Burgos, G., Fish, K. N., & Lewis, D. A. (2011) · Neural Plasticity · doi:10.1155/2011/723184 · Cited by 250
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
Cheung, I., Shulha, H. P., Jiang, Y., Matevossian, A., Wang, J., Weng, Z., & Akbarian, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001702107 · Cited by 235
Self-citation
An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229
Epigenetic GABAergic targets in schizophrenia and bipolar disorder
Guidotti, A., Auta, J., Chen, Y., Davis, J. M., Dong, E., Gavin, D. P., Grayson, D. R., Matrisciano, F., Pinna, G., Satta, R., et al. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.021 · Cited by 221
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
Ramazi, S., Allahverdi, A., & Zahiri, J. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00099-2 · Cited by 226
Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects
Hurd, Y. L., Manzoni, O. J., Pletnikov, M. V., Lee, F. S., Bhattacharyya, S., & Melis, M. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1165-19.2019 · Cited by 218
Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia
Lewis, D. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.003 · Cited by 217
Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene
Takata, A., Xu, B., Ionita-Laza, I., Roos, J. L., Gogos, J. A., & Karayiorgou, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.043 · Cited by 204
Epigenetic Regulation in Human Brain—Focus on Histone Lysine Methylation
Akbarian, S., & Huang, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.015 · Cited by 216
Self-citation
Epigenetics in the Nervous System: Figure 1.
Jiang, Y., Langley, B. C., Lubin, F. D., Renthal, W. R., Wood, M. A., Yasui, D. H., Kumar, A., Nestler, E. J., Akbarian, S., & Beckel-Mitchener, A. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3797-08.2008 · Cited by 216
Self-citation
Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions
Fukuchi, M., Nii, T., Ishimaru, N., Minamino, A., Hara, D., Takasaki, I., Tabuchi, A., & Tsuda, M. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.05.002 · Cited by 207
Epigenetic Signatures of Autism: Trimethylated H3K4 Landscapes in Prefrontal Neurons
Shulha, H. P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.151 · Cited by 196
Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability
Richetto, J., & Meyer, U. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.03.008 · Cited by 189
Isolation of neuronal chromatin from brain tissue
Jiang, Y., Matevossian, A., Huang, H.-S., Straubhaar, J., & Akbarian, S. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-42 · Cited by 193
Self-citation
Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings
Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0601-3 · Cited by 168
Epigenetic mechanisms in schizophrenia
Roth, T. L., Lubin, F. D., Sodhi, M., & Kleinman, J. E. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.009 · Cited by 176
The regulation of glutamic acid decarboxylases in GABA neurotransmission in the brain
Lee, S. E., Lee, Y., & Lee, G. H. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01196-z · Cited by 176
Regulation of histone H3K4 methylation in brain development and disease
Shen, E., Shulha, H. P., Weng, Z., & Akbarian, S. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0514 · Cited by 167
Self-citation
Epigenetic dysregulation in cognitive disorders
Gräff, J., & Mansuy, I. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06787.x · Cited by 167
Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory
Jakovcevski, M., Ruan, H., Shen, E., Dincer, A., Javidfar, B., Ma, Q., Peter, C. J., Cheung, I. K., Mitchell, A., Jiang, Y., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3004-14.2015 · Cited by 161
Self-citation
GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia
Xu, M., & Wong, A. H. C. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.172 · Cited by 168
Deficits in Transcriptional Regulators of Cortical Parvalbumin Neurons in Schizophrenia
Volk, D. W., Matsubara, T., Li, S., Sengupta, E. J., Georgiev, D. D., Minabe, Y., Sampson, A. R., Hashimoto, T., & Lewis, D. A. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12030305 · Cited by 161
Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects
Glausier, J. R., Fish, K. N., & Lewis, D. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.152 · Cited by 147
The Reelin and GAD67 Promoters Are Activated by Epigenetic Drugs That Facilitate the Disruption of Local Repressor Complexes
Kundaković, M., Chen, Y., Guidotti, A., & Grayson, D. R. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051763 · Cited by 149
Altered Cortical Expression of GABA-Related Genes in Schizophrenia: Illness Progression vs Developmental Disturbance
Hoftman, G. D., Volk, D. W., Bazmi, H. H., Li, S., Sampson, A. R., & Lewis, D. A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt178 · Cited by 148
Neuroprogression in schizophrenia: Pathways underpinning clinical staging and therapeutic corollaries
Davis, J., Moylan, S., Harvey, B. H., Maes, M. H. J., & Berk, M. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414533012 · Cited by 145
Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain
Ratnu, V. S., Emami, M. R., & Bredy, T. W. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23886 · Cited by 144
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders
Delgado‐Morales, R., Agís‐Balboa, R. C., Esteller, M., & Berdasco, M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0365-z · Cited by 147
Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons
Miller, M. L., Chadwick, B., Dickstein, D. L., Purushothaman, I., Egervari, G., Rahman, T., Tessereau, C., Hof, P. R., Roussos, P., Shen, L., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0243-x · Cited by 134
Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes
Perišić, T., Zimmermann, N., Kirmeier, T., Asmus, M., Tuorto, F., Uhr, M., Holsboer, F., Rein, T., & Zschocke, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.188 · Cited by 135
Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics
Lally, J., Gaughran, F., Timms, P. W., & Curran, S. R. (2016) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s115741 · Cited by 133
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling
Guidotti, A., Dong, E., Kundakovic, M., Satta, R., Grayson, D. R., & Costa, E. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.010 · Cited by 130
Histone modifications, DNA methylation, and Schizophrenia
Gavin, D. P., & Sharma, R. P. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.010 · Cited by 121
Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B
Jiang, Y., Jakovcevski, M., Bharadwaj, R., Connor, C., Schroeder, F. A., Lin, C. L., Straubhaar, J., Martin, G., & Akbarian, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1314-10.2010 · Cited by 118
Self-citation
Epigenetics-beyond the genome in alcoholism.
Starkman, B. G., Sakharkar, A. J., & Pandey, S. C. (2012) · Europe PMC (PubMed Central) · Cited by 118
Epigenetic approaches to psychiatric disorders
Ptak, C., & Petronis, A. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.1/cptak · Cited by 120
Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia
Hoftman, G. D., Datta, D., & Lewis, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.022 · Cited by 113
Balancing histone methylation activities in psychiatric disorders
Peter, C. J., & Akbarian, S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.003 · Cited by 111
Self-citation
Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers
Khavari, B., & Cairns, M. J. (2020) · Cells · doi:10.3390/cells9081837 · Cited by 115
Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis
Gavin, D. P., Sharma, R. P., Chase, K. A., Matrisciano, F., Dong, E., & Guidotti, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.221 · Cited by 108
Epigenetics of major psychosis: progress, problems and perspectives
Labrie, V., Pai, S., & Petronis, A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.04.002 · Cited by 103
Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid–Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder
Ruzicka, W. B., Subburaju, S., & Benes, F. M. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.49 · Cited by 101
Genetics of Eating Disorders
Bulik, C. M., Blake, L. E., & Austin, J. (2019) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.10.007 · Cited by 129
Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome
Connor, C., Dincer, A., Straubhaar, J., Galler, J. R., Houston, I. B., & Akbarian, S. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.037 · Cited by 100
Self-citation
Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders
Scuto, M. C., Rampulla, F., Reali, G. M., Spanò, S. M., Salinaro, A. T., & Calabrese, V. (2024) · Antioxidants · doi:10.3390/antiox13040484 · Cited by 103
Epigenetic impacts of endocrine disruptors in the brain
Walker, D. M., & Gore, A. C. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.09.002 · Cited by 94
NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms
Snyder, M. A., & Gao, W. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.03.010 · Cited by 97
White matter neuron alterations in schizophrenia and related disorders
Connor, C., Crawford, B. C., & Akbarian, S. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.07.236 · Cited by 95
Self-citation
Epigenetic Determinants of Healthy and Diseased Brain Aging and Cognition
Akbarian, S., Beeri, M. S., & Haroutunian, V. H. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1459 · Cited by 96
Self-citation
Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons
Marinova, Z., Leng, Y., Leeds, P. R., & Chuang, D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.022 · Cited by 93
Epigenetic Impacts on Neurodevelopment: Pathophysiological Mechanisms and Genetic Modes of Action
Zahir, F., & Brown, C. J. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318213565e · Cited by 93
Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268
Kimoto, S., Bazmi, H. H., & Lewis, D. A. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010004 · Cited by 91
Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice
Shen, E., Ahern, T. H., Cheung, I. K., Straubhaar, J., Dincer, A., Houston, I. B., Vries, G. J. D., Akbarian, S., & Forger, N. G. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.006 · Cited by 94
Self-citation
DNA methylation in schizophrenia: progress and challenges of epigenetic studies
Nishioka, M., Bundo, M., Kasai, K., & Iwamoto, K. (2012) · Genome Medicine · doi:10.1186/gm397 · Cited by 94
Current status and future prospects for epigenetic psychopharmacology
Boks, M. P., de Jong, N. M., Kas, M. J. H., Vinkers, C. H., Fernandes, C., Kahn, R. S., Mill, J., & Ophoff, R. A. (2012) · Epigenetics · doi:10.4161/epi.7.1.18688 · Cited by 89
Methamphetamine-Associated Memory Is Regulated by a Writer and an Eraser of Permissive Histone Methylation
Aguilar‐Valles, A., Vaissière, T., Griggs, E. M., Mikaelsson, M. A., Takács, I. F., Young, E. J., Rumbaugh, G., & Miller, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.014 · Cited by 92
Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia
Jiang, Z., Cowell, R. M., & Nakazawa, K. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00116 · Cited by 91
Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia
Kano, S., Colantuoni, C., Han, F., Zhou, Z., Yuan, Q., Wilson, A., Takayanagi, Y., Lee, Y., Rapoport, J. L., Eaton, W. W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.120 · Cited by 85
Translational potential of olfactory mucosa for the study of neuropsychiatric illness
Borgmann‐Winter, K. E., Willard, S. L., Sinclair, D., Mirza, N. A., Turetsky, B. I., Berretta, S., & Hahn, C.-G. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.141 · Cited by 89
Delays in GABAergic interneuron development and behavioral inhibition after prenatal stress
Lussier, S. J., & Stevens, H. E. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22376 · Cited by 89
Epigenetic mechanisms in schizophrenia
Akbarian, S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/sakbarian · Cited by 89
Self-citation
Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities
Nagahama, K., Sakoori, K., Watanabe, T., Kishi, Y., Kawaji, K., Koebis, M., Nakao, K., Gotoh, Y., Aiba, A., Uesaka, N., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108126 · Cited by 89
Cognitive Dysfunction and Prefrontal Cortical Circuit Alterations in Schizophrenia: Developmental Trajectories
Dienel, S. J., Schoonover, K. E., & Lewis, D. A. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.03.002 · Cited by 87
DNA methylation changes in schizophrenia and bipolar disorder
Connor, C., & Akbarian, S. (2008) · Epigenetics · doi:10.4161/epi.3.2.5938 · Cited by 84
Self-citation
Broad domains of histone H3 lysine 4 trimethylation in transcriptional regulation and disease
Park, S., Kim, G. W., Kwon, S. H., & Lee, J. (2020) · FEBS Journal · doi:10.1111/febs.15219 · Cited by 88
Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders
Guidotti, A., Grayson, D. R., & Caruncho, H. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00089 · Cited by 84
Environmental regulation of the neural epigenome
Caldji, C., Hellstrom, I. C., Zhang, T.-Y., Diorio, J., & Meaney, M. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.032 · Cited by 82
Sex Differences in Brain Epigenetics
Menger, Y., Bettscheider, M., Murgatroyd, C., & Spengler, D. (2010) · Epigenomics · doi:10.2217/epi.10.60 · Cited by 82
Spatial genome organization and cognition
Rajarajan, P., Espeso‐Gil, S., Brennand, K., & Akbarian, S. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.124 · Cited by 83
Self-citation
HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia‐like animals
Večeřa, J., Bártová, E., Krejčí, J., Legartová, S., Komůrková, D., Kučerová, J., Štark, T., Dražanová, E., Kašpárek, T., Šulcová, A., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25914 · Cited by 80
Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits
Carlyle, B. C., Duque, A., Kitchen, R. R., Bordner, K. A., Coman, D., Doolittle, E., Papademetris, X., Hyder, F., Taylor, J. R., & Simen, A. A. (2012) · Development and Psychopathology · doi:10.1017/s095457941200079x · Cited by 80
Epigenetic Mechanisms
Lubin, F. D., Gupta, S., Parrish, R. R., Grissom, N. M., & Davis, R. L. (2011) · The Neuroscientist · doi:10.1177/1073858411386967 · Cited by 99
Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs
Dong, E., Tueting, P. A., Matrisciano, F., Grayson, D. R., & Guidotti, A. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.191 · Cited by 83
Sensitive Periods in Epigenetics: Bringing us Closer to Complex Behavioral Phenotypes
Nagy, C., & Turecki, G. (2012) · Epigenomics · doi:10.2217/epi.12.37 · Cited by 81
Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains
Bai, G., Cheung, I., Shulha, H. P., Coelho, J. E., Li, P., Dong, X., Jakovcevski, M., Wang, Y., Grigorenko, A., Jiang, Y., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu561 · Cited by 77
Self-citation
An Update on the Epigenetics of Psychotic Diseases and Autism
Abdolmaleky, H. M., Zhou, J., & Thiagalingam, S. (2015) · Epigenomics · doi:10.2217/epi.14.85 · Cited by 79
Epigenetics in the Human Brain
Houston, I. B., Peter, C. J., Mitchell, A., Straubhaar, J., Rogaev, E. I., & Akbarian, S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.78 · Cited by 75
Self-citation
Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia
Mellios, N., Galdzicka, M. M., Ginns, E. I., Baker, S. P., Rogaev, E. I., Xu, J., & Akbarian, S. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq091 · Cited by 78
Self-citation
Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post‐mortem brain of patients with schizophrenia and Psychotic bipolar disorder
Abdolmaleky, H. M., Pajouhanfar‎, S., Faghankhani, M., Joghataei, M. T., Mostafavi, A., & Thiagalingam, S. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32361 · Cited by 73
Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT
Marenco, S., Farmer, A. S., van der Veen, J. W. C., Geramita, M. A., Stern, A., Barnett, A. S., Kolachana, B. S., Radulescu, E., Zhang, F., Callicott, J. H., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.35 · Cited by 71
Coordinated Cell Type–Specific Epigenetic Remodeling in Prefrontal Cortex Begins before Birth and Continues into Early Adulthood
Shulha, H. P., Cheung, I. K., Guo, Y., Akbarian, S., & Weng, Z. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003433 · Cited by 73
Self-citation
Histone lysine methylation: critical regulator of memory and behavior
Jarome, T. J., & Lubin, F. D. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0008 · Cited by 74
Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain
Dincer, A., Gavin, D. P., Xu, K., Zhang, B., Dudley, J. T., Schadt, E. E., & Akbarian, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.169 · Cited by 65
Self-citation
Understanding epigenetics of schizophrenia in the backdrop of its antipsychotic drug therapy
Swathy, B., & Banerjee, M. (2017) · Epigenomics · doi:10.2217/epi-2016-0106 · Cited by 69
Activation of Group II Metabotropic Glutamate Receptors Promotes DNA Demethylation in the Mouse Brain
Matrisciano, F., Dong, E., Gavin, D. P., Nicoletti, F., & Guidotti, A. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.070896 · Cited by 68
Genetics of Schizophrenia
van de Leemput, J., Hess, J., Glatt, S. J., & Tsuang, M. T. (2016) · Advances in genetics · doi:10.1016/bs.adgen.2016.08.001 · Cited by 71

Authors: Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S.
Affiliations: University of Massachusetts Chan Medical School (US)
Baylor College of Medicine (US)
Corresponding author: Akbarian, Schahram
ORCID: Huang, Hsien-Sung
Kim, Se Young
Baker, Stephen P.
Akbarian, Schahram
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-10-17
Volume: 27
Issue: 42
Pages: 11254-11262
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3272-07.2007
PMC: PMC6673022
OpenAlex: W2124607109
Cited by: 352
References: 44
Citations by year: 2026: 3 · 2025: 8 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 15 · 2020: 13 · 2019: 12 · 2018: 15 · 2017: 10 · 2016: 27 · 2015: 24 · 2014: 31 · 2013: 27 · 2012: 25
FWCI: 14.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institute of Mental Health
National Institute of Child Health and Human Development
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: schizophrenia, prefrontal cortex, MLL1, histone H3 lysine 4 methylation, GABAergic neurons, GAD1, promoter, chromatin remodeling, clozapine, dopamine D2/D3 receptors, sex differences, brain development
MeSH terms: Adult, Animals, Cells, Cultured, Child, Female, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Histones, Humans, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Promoter Regions, Genetic, Histone-Lysine N-Methyltransferase, Schizophrenia, Prefrontal Cortex, DNA Methylation, Mice, Rats, Myeloid-Lymphoid Leukemia Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks