The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
GluR1 Links Structural and Functional Plasticity at Excitatory Synapses
Open accessAbstract
Long-term potentiation (LTP), a cellular model of learning and memory, produces both an enhancement of synaptic function and an increase in the size of the associated dendritic spine. Synaptic insertion of AMPA receptors is known to play an important role in mediating the increase in synaptic strength during LTP, whereas the role of AMPA receptor trafficking in structural changes remains unexplored. Here, we examine how the cell maintains the correlation between spine size and synapse strength during LTP. We found that cells exploit an elegant solution by linking both processes to a single molecule: the AMPA-type glutamate receptor subunit 1 (GluR1). Synaptic insertion of GluR1 is required to permit a stable increase in spine size, both in hippocampal slice cultures and in vivo. Synaptic insertion of GluR1 is not sufficient to drive structural plasticity. Although crucial to the expression of LTP, the ion channel function of GluR1 is not required for the LTP-driven spine size enhancement. Remarkably, a recombinant cytosolic C-terminal fragment (C-tail) of GluR1 is driven to the postsynaptic density after an LTP stimulus, and the synaptic incorporation of this isolated GluR1 C-tail is sufficient to permit spine enlargement even when postsynaptic exocytosis of endogenous GluR1 is blocked. We conclude that during plasticity, synaptic insertion of GluR1 has two functions: the established role of increasing synaptic strength via its ligand-gated ion channel, and a novel role through the structurally stabilizing effect of its C terminus that permits an increase in spine size.
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AMPA Receptor Trafficking and Synaptic Plasticity
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Self-citationStructural basis of long-term potentiation in single dendritic spines
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Self-citationRecognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
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PSD-95 Involvement in Maturation of Excitatory Synapses
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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
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Receptor trafficking and synaptic plasticity
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Cited by
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993
Self-citationActin in action: the interplay between the actin cytoskeleton and synaptic efficacy.
Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831
Making memories last: the synaptic tagging and capture hypothesis
Redondo, R. L., & Morris, R. G. M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2963 · Cited by 792
Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634
Self-citationSubunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
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Metadata
- Authors
- Kopec, C. D., Real, E., Kessels, H. W., & Malinow, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-12-12
- Volume
- 27
- Issue
- 50
- Pages
- 13706-13718
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2084108505
- Cited by
- 220
- References
- 23
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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