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Synaptic AMPA receptor plasticity and behavior

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Kessels, Helmut W., Malinow, Roberto·2009·Neuron
DOI 10.1016/j.neuron.2009.01.015PMC PMC3917551
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Abstract

The ability to change behavior likely depends on the selective strengthening and weakening of brain synapses. The cellular models of synaptic plasticity, long-term potentiation (LTP) and depression (LTD) of synaptic strength, can be expressed by the synaptic insertion or removal of AMPA receptors (AMPARs), respectively. We here present an overview of studies that have used animal models to show that such AMPAR trafficking underlies several experience-driven phenomena-from neuronal circuit formation to the modification of behavior. We argue that monitoring and manipulating synaptic AMPAR trafficking represents an attractive means to study cognitive function and dysfunction in animal models.

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  • The post-synaptic density contains 'slots' that might be occupied by AMPARs supplied by lateral diffusion from the peri-synaptic region.

    “A prominent model of synaptic strength posits that the post-synaptic density (PSD), a dense network of synaptic scaffolding, adhesion and cytoskeletal proteins, contains ‘slots’ that might be occupied by AMPARs supplied by lateral diffusion from the peri-synaptic region (Opazo et al., 2012, Huganir and Nicoll, 2013, Kessels and Malinow, 2009).”

    From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Kessels and Malinow, 2009

    In “Synaptic Strengthening by AMPAR Trafficking” (page unavailable), the paper describes a synaptic AMPAR ‘slot’ formed by interacting proteins. “Synaptic Trafficking in the Absence of Plasticity” describes receptor exchange from extrasynaptic to synaptic sites. Neither passage specifies lateral diffusion from the perisynaptic region into PSD slots, so that mechanism is not supported by this source. (LLM, conf=0.84)

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Authors
Kessels, H. W., & Malinow, R.
Affiliations
University of California San Diego (US)
Corresponding author
  • Kessels, Helmut W.
  • Malinow, Roberto
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2009-02
Volume
61
Issue
3
Pages
340-350
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2009.01.015
PMC
PMC3917551
OpenAlex
W2059117412
Cited by
993
References
21
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FWCI
8.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (AG032132, R01AG032132)
  • National Institute of Mental Health (R01MH049159, R37MH049159, MH049159)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
AMPA receptors, synaptic plasticity, long-term potentiation, long-term depression, receptor trafficking, behavior modification, cognitive impairment, animal models of behavior
MeSH terms
Animals, Behavior, Brain, Cognition, Humans, Learning, Synaptic Transmission, Neuronal Plasticity, Synapses, Receptors, AMPA, Protein Transport

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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