Making memories last: the synaptic tagging and capture hypothesis
Abstract
The synaptic tagging and capture hypothesis of protein synthesis-dependent long-term potentiation asserts that the induction of synaptic potentiation creates only the potential for a lasting change in synaptic efficacy, but not the commitment to such a change. Other neural activity, before or after induction, can also determine whether persistent change occurs. Recent findings, leading us to revise the original hypothesis, indicate that the induction of a local, synapse-specific 'tagged' state and the expression of long-term potentiation are dissociable. Additional observations suggest that there are major differences in the mechanisms of functional and structural plasticity. These advances call for a revised theory that incorporates the specific molecular and structural processes involved. Addressing the physiological relevance of previous in vitro findings, new behavioural studies have experimentally translated the hypothesis to learning and the consolidation of newly formed memories.
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Selective interference with the structural changes that accompany LTD does not affect the increase in synaptic strength, at least not in early stages, up to 1-2 hr following induction.
“Moreover, selective interference with the structural changes that accompany LTD do not seem to affect the increase in synaptic strength, at least not in early stages, up to 1 -2 hr following induction (Fig. 4) (Wang et al. 2007;Redondo and Morris 2011).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Redondo and Morris 2011
Synaptic consolidation leads to remodeling of synapses and spines of neurons contributing to a memory representation, eventually producing enduring changes in efficacy of participating synapses.
“Synaptic consolidation leads to the remodeling of the synapses and spines of the neurons contributing to a memory representation, eventually producing enduring changes in the efficacy of the participating synapses (e.g., Refs. 555,616,977).”
From About Sleep's Role in Memory (2013) · cites this paper as [977]
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- Authors
- Redondo, R. L., & Morris, R. G. M.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Morris, Richard G. M.
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-12-20
- Volume
- 12
- Issue
- 1
- Pages
- 17-30
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2014295524
- Cited by
- 792
- References
- 16
- Citations by year
- 2026: 38 · 2025: 46 · 2024: 90 · 2023: 45 · 2022: 56 · 2021: 58 · 2020: 58 · 2019: 51 · 2018: 42 · 2017: 51 · 2016: 59 · 2015: 37 · 2014: 54 · 2013: 47 · 2012: 35
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- memory persistence, long-term potentiation, protein synthesis-dependent memory, synaptic plasticity, memory consolidation, functional plasticity, structural plasticity
- MeSH terms
- Animals, Humans, Memory, Nerve Net, Neuronal Plasticity, Synapses, Memory, Long-Term
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