Cited by 270Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Balanced Excitation and Inhibition Determine Spike Timing during Frequency Adaptation

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Higley, Michael J., Contreras, Diego·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.3506-05.2006PMC PMC6674406

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Abstract

In layer 4 (L4) of the rat barrel cortex, a single whisker deflection evokes a stereotyped sequence of excitation followed by inhibition, hypothesized to result in a narrow temporal window for spike output. However, awake rats sweep their whiskers across objects, activating the cortex at frequencies known to induce short-term depression at both excitatory and inhibitory synapses within L4. Although periodic whisker deflection causes a frequency-dependent reduction of the cortical response magnitude, whether this adaptation involves changes in the relative balance of excitation and inhibition and how these changes might impact the proposed narrow window of spike timing in L4 is unknown. Here, we demonstrate for the first time that spike output in L4 is determined precisely by the dynamic interaction of excitatory and inhibitory conductances. Furthermore, we show that periodic whisker deflection results in balanced adaptation of the magnitude and timing of excitatory and inhibitory input to L4 neurons. This balanced adaptation mediates a reduction in spike output while preserving the narrow time window of spike generation, suggesting that L4 circuits are calibrated to maintain relative levels of excitation and inhibition across varying magnitudes of input.

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Authors: Higley, M. J., & Contreras, D.
Affiliations: University of Pennsylvania (US)
Corresponding author: Contreras, Diego
ORCID: Higley, Michael J.
Contreras, Diego
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-01-11
Volume: 26
Issue: 2
Pages: 448-457
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3506-05.2006
PMC: PMC6674406
OpenAlex: W2040663063
Cited by: 270
References: 65
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 15 · 2019: 16 · 2018: 10 · 2017: 16 · 2016: 21 · 2015: 17 · 2014: 19 · 2013: 13 · 2012: 19
FWCI: 9.23
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: excitation-inhibition balance, spike timing, frequency adaptation, short-term depression, layer 4, barrel cortex, whisker deflection
MeSH terms: Action Potentials, Adaptation, Physiological, Animals, Male, Synaptic Transmission, Neurons, Reaction Time, Somatosensory Cortex, Touch, Vibrissae, Rats, Sprague-Dawley, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Rats

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Balanced Excitation and Inhibition Determine Spike Timing during Frequency Adaptation

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