The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2AReceptor Heteromers
Open accessAbstract
The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) and A 2A receptors (A 2A Rs) allows adenosine to exert a fine-tuning modulation of glutamatergic neurotransmission. By means of coimmunoprecipitation, bioluminescence and time-resolved fluorescence resonance energy transfer techniques, we showed the existence of A 1 R–A 2A R heteromers in the cell surface of cotransfected cells. Immunogold detection and coimmunoprecipitation experiments indicated that A 1 R and A 2A R are colocalized in the same striatal glutamatergic nerve terminals. Radioligand-binding experiments in cotransfected cells and rat striatum showed that a main biochemical characteristic of the A 1 R–A 2A R heteromer is the ability of A 2A R activation to reduce the affinity of the A 1 R for agonists. This provides a switch mechanism by which low and high concentrations of adenosine inhibit and stimulate, respectively, glutamate release. Furthermore, it is also shown that A 1 R–A 2A R heteromers constitute a unique target for caffeine and that chronic caffeine treatment leads to modifications in the function of the A 1 R–A 2A R heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.
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Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · cited 3×
“A1R–A2AR intramembrane interaction and caffeine tolerance An unresolved issue about caffeine is the strong tolerance for many of its behavioral and biochemical effects that develop after chronic treatment (Holtzman and Finn, 1988; Jacobson et al., 1996; Fredholm et al., 1999).”
BackgroundCaffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens
Solinas, M., Ferré, S., You, Z.-B., Karcz-Kubicha, M., Popoli, P., & Goldberg, S. R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06321.2002 · Cited by 338
Karcz-Kubicha, M., Antoniou, K., Terasmaa, A., Quarta, D., Solinas, M., Justinova, Z., Pezzola, A., Reggio, R., Müller, C. E., Fuxe, K., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300167 · Cited by 189
Self-citationCaffeine alters plasma adenosine levels
Conlay, L. A., Conant, J. A., deBros, F., & Wurtman, R. (1997) · Nature · doi:10.1038/38160 · Cited by 133
Cited by
A Review of Caffeine’s Effects on Cognitive, Physical and Occupational Performance
McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.001 · Cited by 840
Pharmacology of Adenosine Receptors: The State of the Art
Borea, P. A., Gessi, S., Merighi, S., Vincenzi, F., & Varani, K. (2018) · Physiological Reviews · doi:10.1152/physrev.00049.2017 · Cited by 783
Degorce, F. (2009) · Current Chemical Genomics · doi:10.2174/1875397300903010022 · Cited by 501
An Update on the Mechanisms of the Psychostimulant Effects of Caffeine
Ferré, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05196.x · Cited by 440
Self-citationAdenosine receptors and brain diseases: neuroprotection and neurodegeneration
Gomes, C. V., Kaster, M. P., Tomé, A. R., Agostinho, P. M., & Cunha, R. A. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.12.001 · Cited by 419
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Metadata
- Authors
- Ciruela, F., Casadó, V., Rodrigues, R. J., Luján, R., Burgueño, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J., Cortés, A., Canela, E. I., López-Giménez, J. F., Milligan, G., Lluis, C., Cunha, R. A., Ferré, S., & Franco, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-02-15
- Volume
- 26
- Issue
- 7
- Pages
- 2080-2087
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2106307937
- Cited by
- 590
- References
- 5
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ciruela, F., Casadó, V., Rodrigues, R. J., Luján, R., Burgueño, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J., Cortés, A., Canela, E. I., López-Giménez, J. F., Milligan, G., Lluis, C., Cunha, R. A., Ferré, S., & Franco, R. (2006). Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2AReceptor Heteromers. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3574-05.2006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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