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BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain

Thibault, K., Lin, W. K., Rancillac, A., Fan, M., Snollaerts, T., Sordoillet, V., Hamon, M., Smith, G. M., Lenkei, Z., & Pezet, S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0860-14.2014 · Cited by 83 · see citing works

In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery

Vry, J. D., Martínez‐Martínez, P., Losen, M. H., Temel, Y., Steckler, T., Steinbusch, H. W. M., Baets, M. H. D., & Prickaerts, J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.001 · Cited by 73 · see citing works

Pharmacology of Morphine in Obese Patients

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Androgen-Dependent Regulation of Brain-Derived Neurotrophic Factor and Tyrosine Kinase B in the Sexually Dimorphic Spinal Nucleus of the Bulbocavernosus

Ottem, E. N., Beck, L. A., Jordan, C. L., & Breedlove, S. M. (2007) · Endocrinology · doi:10.1210/en.2007-0308 · Cited by 65 · see citing works

NMDA receptor-mediated activation of medullary pro-nociceptive neurons is required for secondary thermal hyperalgesia

Xu, M., Kim, C. J., Neubert, M. J., & Heinricher, M. M. (2006) · Pain · doi:10.1016/j.pain.2006.08.020 · Cited by 64 · see citing works

Hypofunction of Glutamatergic Neurotransmission in the Periaqueductal Gray Contributes to Nerve-Injury-Induced Neuropathic Pain

Ho, Y., Cheng, J., & Chiou, L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5583-12.2013 · Cited by 61 · see citing works

Undesired effects of a combinatorial treatment for spinal cord injury – transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus

Bretzner, F., Liu, J., Currie, E., Roskams, A. J., & Tetzlaff, W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06462.x · Cited by 60 · see citing works

Neuroplasticity of Supraspinal Structures Associated with Pathological Pain

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Brain-Derived Neurotrophic Factor–Mediated Downregulation of Brainstem K+–Cl– Cotransporter and Cell-Type–Specific GABA Impairment for Activation of Descending Pain Facilitation

Zhang, Z., Wang, X., Wang, W., Lu, Y.-G., & Pan, Z. Z. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.086496 · Cited by 56 · see citing works

Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla

LaGraize, S. C., Guo, W., Yang, K., Wei, F., Ren, K., & Dubner, R. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.040 · Cited by 56 · see citing works

Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities

Singh, L., Kaur, A., Bhatti, M. S., & Bhatti, R. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02805-5 · Cited by 55 · see citing works

RNA interference in hippocampus demonstrates opposing roles for CREB and PP1α in contextual and temporal long‐term memory

Peters, M., Bletsch, M., Catapano, R., Zhang, X., Tully, T., & Bourtchouladze, R. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00474.x · Cited by 56 · see citing works

Impact of sex on pain and opioid analgesia: a review

Fullerton, E. F., Doyle, H. H., & Murphy, A. Z. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.08.001 · Cited by 55 · see citing works

Small interfering RNA-mediated knockdown of NF-κBp65 attenuates neuropathic pain following peripheral nerve injury in rats

Sun, T., Luo, J., Jia, M., Li, H., Li, K., & Fu, Z. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.017 · Cited by 54 · see citing works

Adaptations in responsiveness of brainstem pain-modulating neurons in acute compared with chronic inflammation

Cleary, D. R., & Heinricher, M. M. (2013) · Pain · doi:10.1016/j.pain.2013.02.019 · Cited by 53 · see citing works

A Role of Periaqueductal Grey NR2B-Containing NMDA Receptor in Mediating Persistent Inflammatory Pain

Hu, J. R., Wang, Z., Guo, Y., Zhang, X.-N., Xu, Z., Liu, S., Guo, G.-J., Yang, Q., Zhang, F.-X., Sun, X., et al. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-71 · Cited by 53 · see citing works

May BDNF Be Implicated in the Exercise-Mediated Regulation of Inflammation? Critical Review and Synthesis of Evidence

Papathanassoglou, E. D. E., Miltiadous, P., & Karanikola, M. N. K. (2014) · Biological Research For Nursing · doi:10.1177/1099800414555411 · Cited by 53 · see citing works

NK-1 Receptors Modulate the Excitability of on Cells in the Rostral Ventromedial Medulla

Budai, D., Khasabov, S. G., Mantyh, P. W., & Simone, D. A. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00450.2006 · Cited by 51 · see citing works

Increasing Intensity of TENS Prevents Analgesic Tolerance in Rats

Sato, K., Sanada, L. S., Rakel, B. A., & Sluka, K. A. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.06.004 · Cited by 50 · see citing works

Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc

Gruber, H. E., Ingram, J. A., Hoelscher, G. L., Zinchenko, N., Norton, H. J., & Hanley, E. N. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2456 · Cited by 49 · see citing works

Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: a mini review

Nugraha, B., Karst, M., Engeli, S., & Gutenbrunner, C. M. (2011) · Rheumatology International · doi:10.1007/s00296-011-2348-2 · Cited by 48 · see citing works

Brainstem Pain-Modulation Circuitry and Its Plasticity in Neuropathic Pain: Insights From Human Brain Imaging Investigations

Mills, E. P., Keay, K. A., & Henderson, L. A. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.705345 · Cited by 47 · see citing works

Epigenetics: A Promising Paradigm for Better Understanding and Managing Pain

Seo, S., Grzenda, A. L., Lomberk, G. A., Ou, X., Cruciani, R. A., & Urrutia, R. A. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.01.772 · Cited by 47 · see citing works

Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons

Tarsa, L., Bałkowiec-Iskra, E., Kratochvil, F. J., Jenkins, V. K., McLean, A., Brown, A. L., Smith, J. A., Baumgartner, J. C., & Bałkowiec, A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.002 · Cited by 47 · see citing works

Novel candidate genes identified in the brain during nociception in common carp (Cyprinus carpio) and rainbow trout (Oncorhynchus mykiss)

Reilly, S. C., Quinn, J. P., Cossins, A. R., & Sneddon, L. U. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.075 · Cited by 46 · see citing works

Transcranial direct current stimulation combined with exercise modulates the inflammatory profile and hyperalgesic response in rats subjected to a neuropathic pain model: Long-term effects

Lopes, B. C., Medeiros, L. F., de Souza, V. S., Cioato, S. G., Medeiros, H. R., Regner, G. G., de Oliveira, C. L., Fregni, F., Caumo, W., & Torres, I. L. D. S. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.02.025 · Cited by 44 · see citing works

Electroacupuncture Attenuates Cancer-Induced Bone Pain via NF-κB/CXCL12 Signaling in Midbrain Periaqueductal Gray

Xu, M., Fei, Y., He, Q., Fu, J., Zhu, J., Tao, J., Ni, C., Xu, C., Zhou, Q., Yao, M., et al. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00224 · Cited by 43 · see citing works

Descending Control Mechanisms

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Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis

Zhu, C.-J., Xu, Y., Duan, Y., Li, W., Zhang, L., Huang, Y., Zhao, W., Wang, Y., Li, J., Feng, T., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21504 · Cited by 43 · see citing works

Effect of omega-3 polyunsaturated fatty acid treatment over mechanical allodynia and depressive-like behavior associated with experimental diabetes

Redivo, D. D. B., Schreiber, A. K., Adami, E. R., Ribeiro, D. E., Joca, S. R. L., Zanoveli, J. M., & da Cunha, J. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.058 · Cited by 41 · see citing works

RNA interference in pain research

Röhl, T., & Kurreck, J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04082.x · Cited by 39 · see citing works

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin

Fukuda, Y., Berry, T. L., Nelson, M., Hunter, C. L., Fukuhara, K., Imai, H., Ito, S., Granholm-Bentley, A.-C., Kaplan, A. P., & Mutoh, T. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.06.013 · Cited by 39 · see citing works

Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors

Brink, T. S., Pacharinsak, C., Khasabov, S. G., Beitz, A. J., & Simone, D. A. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00678.2011 · Cited by 39 · see citing works

BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended

Smith, P. A. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.02.020 · Cited by 38 · see citing works

Brain-derived neurotrophic factor (BDNF) in the rostral anterior cingulate cortex (rACC) contributes to neuropathic spontaneous pain-related aversion via NR2B receptors

Zhang, L., Wang, G., Ma, J., Liu, C., Liu, X., Zhan, Y., & Zhang, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.016 · Cited by 37 · see citing works

Cyclotraxin-B, a New TrkB Antagonist, and Glial Blockade by Propentofylline, Equally Prevent and Reverse Cold Allodynia Induced by BDNF or Partial Infraorbital Nerve Constriction in Mice

Constandil, L., Goich, M., Hernández, A., Bourgeais, L., Cazorla, M., Hamon, M., Villanueva, L., & Pélissier, T. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.03.008 · Cited by 38 · see citing works

Persistent Inflammation-induced Up-regulation of Brain-derived Neurotrophic Factor (BDNF) Promotes Synaptic Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor GluA1 Subunits in Descending Pain Modulatory Circuits

Tao, W., Chen, Q., Zhou, W., Wang, Y., Wang, L., & Zhang, Z. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.580381 · Cited by 36 · see citing works

Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray

Yin, J.-B., Wu, H., Dong, Y., Zhang, T., Wang, J., Zhang, Y., Wei, Y., Lu, Y.-C., Wu, S., Wang, W., et al. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00137 · Cited by 36 · see citing works

Morphine-responsive neurons that regulate mechanical antinociception

Fatt, M. P., Zhang, M.-D., Kupari, J., Altınkök, M., Yang, Y., Hu, Y., Svenningsson, P., & Ernfors, P. (2024) · Science · doi:10.1126/science.ado6593 · Cited by 35 · see citing works

Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia

Marques-Lopes, J., Pinto, M. T., Pinho, D., Morato, M., Patinha, D., Albino‐Teixeira, A., & Tavares, I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.044 · Cited by 35 · see citing works

Brain-Derived Neurotrophic Factor Enhances the Excitability of Small-Diameter Trigeminal Ganglion Neurons Projecting to the Trigeminal Nucleus Interpolaris/Caudalis Transition Zone following Masseter Muscle Inflammation

Takeda, M., Takahashi, M., Kitagawa, J., Kanazawa, T., Nasu, M., & Matsumoto, S. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-49 · Cited by 35 · see citing works

BDNF Signaling and Pain Modulation

Mazzitelli, M., Kiritoshi, T., Presto, P., Hurtado, Z., Antenucci, N., Ji, G., & Neugebauer, V. (2025) · Cells · doi:10.3390/cells14070476 · Cited by 36 · see citing works

The role of HCN channels within the periaqueductal gray in neuropathic pain

Du, L., Wang, S., Cui, J. G., He, W., & Ruan, H. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.035 · Cited by 34 · see citing works

NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin

Pacharinsak, C., Khasabov, S. G., Beitz, A. J., & Simone, D. A. (2008) · Pain · doi:10.1016/j.pain.2008.02.032 · Cited by 34 · see citing works

Further observations on the behavioral and neural effects of bone marrow stromal cells in rodent pain models

Guo, W., Chu, Y.-X., Imai, S., Yang, J.-L., Zou, S., Mohammad, Z., Wei, F., Dubner, R. A., & Ren, K. (2016) · Molecular Pain · doi:10.1177/1744806916658043 · Cited by 33 · see citing works

Exercise training and BDNF injections alter amyloid precursor protein (APP) processing enzymes and improve cognition

Baranowski, B. J., Mohammad, A., Finch, M. S., Brown, A. D. H., Dhaliwal, R., Marko, D. M., LeBlanc, P. J., McCormick, C. M., Fajardo, V. A., & MacPherson, R. E. K. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00114.2023 · Cited by 33 · see citing works

In Vivo Evidence that Truncated Trkb.T1 Participates in Nociception

Renn, C. L., Leitch, C. C., & Dorsey, S. G. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-61 · Cited by 33 · see citing works

Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions

Chou, D. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108068 · Cited by 29 · see citing works

Neonatal Maternal Separation Increases Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Expression in the Descending Pain Modulatory System

Chung, E. K. Y., Bian, Z., Xu, H., & Sung, J. J. �. (2009) · Neurosignals · doi:10.1159/000224631 · Cited by 32 · see citing works

Pain Management in Horses

Guedes, A. G. P. (2017) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2016.11.006 · Cited by 32 · see citing works

Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors

Aira, Z., Buesa, I., del Caño, G. G., Salgueiro, M., Mendiable, N., Mingo, J., Aguilera, L., Bilbao, J., & Azkue, J. J. (2012) · Pain · doi:10.1016/j.pain.2012.03.017 · Cited by 30 · see citing works

The BDNF/TrkB Signaling Pathway Is Involved in Heat Hyperalgesia Mediated by Cdk5 in Rats

Zhang, H., Zhang, X., Xue, Q., YanLuo, Huang, J., Zhang, S., Shao, H., Han, L., Wang, W., & Yu, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085536 · Cited by 29 · see citing works

Cellular basis for opioid potentiation in the rostral ventromedial medulla of rats with persistent inflammatory nociception

Zhang, L. N., & Hammond, D. L. (2010) · Pain · doi:10.1016/j.pain.2010.01.017 · Cited by 27 · see citing works

Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla

Khasabov, S. G., Malecha, P. W., Noack, J., Tabakov, J., Giesler, G. J., & Simone, D. A. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00478.2017 · Cited by 27 · see citing works

Paradoxical Sleep Deprivation Aggravates and Prolongs Incision-Induced Pain Hypersensitivity via BDNF Signaling-Mediated Descending Facilitation in Rats

Xue, J., Li, H., Xu, Z., Ma, D., Guo, R., Yang, K., & Wang, Y. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2660-2 · Cited by 27 · see citing works

Changes in response properties of rostral ventromedial medulla neurons during prolonged inflammation: Modulation by neurokinin-1 receptors

Khasabov, S. G., Brink, T. S., Schupp, M., Noack, J., & Simone, D. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.029 · Cited by 26 · see citing works

Medullary control of nociceptive transmission: Reciprocal dual communication with the spinal cord

Almeida, A., Leite‐Almeida, H., & Tavares, I. (2006) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2006.09.001 · Cited by 26 · see citing works

BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and Implications

Shamsnia, H. S., Peyrovinasab, A., Amirlou, D., Sirouskabiri, S., Rostamian, F., Basiri, N., Shalmani, L. M., Hashemi, M., Hushmandi, K., & Abdolghaffari, A. H. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04381-4 · Cited by 25 · see citing works

Brain-Derived Neurotrophic Factor Modulates Nociceptive Sensory Inputs and NMDA-Evoked Responses in the Rat Spinal Cord

Kerr, B. J., Bradbury, E. J., Bennett, D., Trivedi, P. M., Dassan, P., French, J., Shelton, D., McMahon, S. B., & Thompson, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05138.1999 · Cited by 442 · see citing works

Open Access

(2013)

Full-length tropomyosin-related kinase B expression in the brainstem in response to persistent inflammatory pain

Renn, C. L., Lin, L., Thomas, S., & Dorsey, S. G. (2006) · Neuroreport · doi:10.1097/01.wnr.0000215771.61355.e1 · Cited by 9 · see citing works

Pain Facilitation and Activity-Dependent Plasticity in Pain Modulatory Circuitry: Role of BDNF-TrkB Signaling and NMDA Receptors

Ren, K., & Dubner, R. A. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0028-8 · Cited by 119 · see citing works

BDNF in sensory neurons and chronic pain

Obata, K., & Noguchi, K. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.01.005 · Cited by 241 · see citing works