Cited by 56Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsMyofascial pain diagnosis and treatment

Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities

Singh, Lovedeep, Kaur, Anudeep, Bhatti, Manpreet S., Bhatti, Rajbir·2019·Neurochemical Research

Abstract

Fibromyalgia is a chronic complex syndrome of non-articulate origin characterized by musculoskeletal pain, painful tender points, sleep problems and co-morbidities including depression, migraine. The etiopathogenesis of fibromyalgia is complex, variable and remains inconclusive. The etiological factors that have been defined include stress, genetic predisposition and environmental components. As per the reports of the American College of Rheumatology (ACR) the prevalence of fibromyalgia varies from 2 to 22% among the general population with poor diagnostic features primarily pain. Fibromyalgia encompasses a spectrum of co-morbid conditions with multifarious pathogenesis. The highly prevalent manifestations of fibromyalgia include heterogeneous pain and aches. Biochemical and neurobiological elements of fibromyalgia include neurotransmitters, hypothalamic pituitary adrenal axis (HPA axis), inflammatory cytokines, monoaminergic pathway, opioid peptides, sex hormones, nerve growth factor (NGF) and local free radical insult. An imbalance in the serotonergic system is the major underlying etiological factor that has been explored most widely. Owing to complex interplay of diverse pathophysiological pathways, overlapping co-morbidities such as depression have been clinically observed. Therapeutic management of fibromyalgia involves both non pharmacological and pharmacological measures. The current review presents various dysregulations and their association with symptoms of fibromyalgia along with their underlying neurobiological aspects.

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Crossref · 10.1007/s11064-019-02805-5

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Authors
Singh, L., Kaur, A., Bhatti, M. S., & Bhatti, R.
Affiliations
Guru Nanak Dev University (IN)
Corresponding author
  • Bhatti, Manpreet S.
  • Bhatti, Rajbir
Venue
Neurochemical Research
Published
2019-04-19
Volume
44
Issue
7
Pages
1517-1532
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
OpenAlex
W2935820385
Cited by
55
References
200
Citations by year
2026: 6 · 2025: 5 · 2024: 11 · 2023: 5 · 2022: 6 · 2021: 15 · 2020: 6 · 2019: 1
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
DST (EMR/2016/005878)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Myofascial pain diagnosis and treatment
Keywords
fibromyalgia, comorbidities, depression, migraine, serotonergic system, hypothalamic-pituitary-adrenal axis, inflammatory cytokines, monoaminergic pathways, opioid peptides, sex hormones, nerve growth factor, free radicals, neurotransmitters, pain, etiopathogenesis, fibromyalgia treatment
MeSH terms
Animals, Depression, Fibromyalgia, Humans, Hypothalamo-Hypophyseal System, Migraine Disorders, Neuropeptides, Pain, Pituitary-Adrenal System, Inflammatory Bowel Diseases, Comorbidity, Cytokines, Oxidative Stress, Hepatitis C, Chronic, Intercellular Signaling Peptides and Proteins

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