The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Connectivity Changes Underlying Spectral EEG Changes during Propofol-Induced Loss of Consciousness
Open accessAbstract
The mechanisms underlying anesthesia-induced loss of consciousness remain a matter of debate. Recent electrophysiological reports suggest that while initial propofol infusion provokes an increase in fast rhythms (from beta to gamma range), slow activity (from delta to alpha range) rises selectively during loss of consciousness. Dynamic causal modeling was used to investigate the neural mechanisms mediating these changes in spectral power in humans. We analyzed source-reconstructed data from frontal and parietal cortices during normal wakefulness, propofol-induced mild sedation, and loss of consciousness. Bayesian model selection revealed that the best model for explaining spectral changes across the three states involved changes in corticothalamic interactions. Compared with wakefulness, mild sedation was accounted for by an increase in thalamic excitability, which did not further increase during loss of consciousness. In contrast, loss of consciousness per se was accompanied by a decrease in backward corticocortical connectivity from frontal to parietal cortices, while thalamocortical connectivity remained unchanged. These results emphasize the importance of recurrent corticocortical communication in the maintenance of consciousness and suggest a direct effect of propofol on cortical dynamics.
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Self-citationPHARMACOKINETIC MODEL DRIVEN INFUSION OF PROPOFOL IN CHILDREN
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Self-citationREBUS and the anarchic brain: Toward a unified model of the brain action of psychedelics
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Self-citationElectroencephalogram signatures of loss and recovery of consciousness from propofol
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Metadata
- Authors
- Boly, M., Moran, R., Murphy, M., Boveroux, P., Bruno, M.-A., Noirhomme, Q., Ledoux, D., Bonhomme, V., Brichant, J.-F., Tononi, G., Laureys, S., & Friston, K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-05-16
- Volume
- 32
- Issue
- 20
- Pages
- 7082-7090
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1983192672
- Cited by
- 307
- References
- 74
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Boly, M., Moran, R., Murphy, M., Boveroux, P., Bruno, M.-A., Noirhomme, Q., Ledoux, D., Bonhomme, V., Brichant, J.-F., Tononi, G., Laureys, S., & Friston, K. (2012). Connectivity Changes Underlying Spectral EEG Changes during Propofol-Induced Loss of Consciousness. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3769-11.2012
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