The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Abstract Representations of Location and Facing Direction in the Human Brain
Open accessAbstract
Humans, like other mobile organisms, rely on spatial representations to guide navigation from place to place. Although previous work has identified neural systems involved in wayfinding, the specific spatial codes supported by these systems are not well understood. We use functional magnetic resonance imaging to identify regions within the human medial temporal and medial parietal lobes that encode two fundamental spatial quantities—location and facing direction—in a manner that abstracts away from sensory inputs. University students were scanned while viewing photographs taken at several familiar campus locations. Multivoxel pattern analyses indicated that the left presubiculum, retrosplenial complex, and parietal-occipital sulcus coded location identity even across non-overlapping views, whereas the right presubiculum coded facing direction even across noncontiguous locations. The location and direction codes supported by these regions may be critical to our ability to navigate within the extended environment and to understand its large-scale spatial structure.
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“recent work has observed similar spatial codes in these regions in humans4–8”
From Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe (2014) · cites this paper as [4]
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“and we previously reported that multivoxel patterns elicited in RSC when viewing familiar scenes contain information about location and direction that is independent of the specific view4.”
From Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe (2014) · cites this paper as [4]
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Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151
Microstructure of a spatial map in the entorhinal cortex
Hafting, T., Fyhn, M., Molden, S., Moser, M.-B., & Moser, E. I. (2005) · Nature · doi:10.1038/nature03721 · Cited by 4,068
Distributed and overlapping representations of faces and objects in ventral temporal cortex
Haxby, J. V., Gobbini, M. I., Furey, M. L., Ishai, A., Schouten, J. L., & Pietrini, P. (2001) · Science · doi:10.1126/science.1063736 · Cited by 3,940
Large-scale automated synthesis of human functional neuroimaging data.
Yarkoni, T., Poldrack, R. A., Nichols, T. E., Van Essen, D. C., & Wager, T. D. (2011) · Nature Methods · doi:10.1038/nmeth.1635 · Cited by 3,686
Gallistel, C. R. (1990) · Cited by 2,571
Repetition and the brain: neural models of stimulus-specific effects
Grill-Spector, K., Henson, R., & Martin, A. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.11.006 · Cited by 2,256
Information-based functional brain mapping
Kriegeskorte, N., Goebel, R., & Bandettini, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600244103 · Cited by 2,113
Taube, J., Muller, R., & Ranck, J. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00420.1990 · Cited by 1,809
Cellular networks underlying human spatial navigation
Ekstrom, A. D., Kahana, M. J., Caplan, J. B., Fields, T. A., Isham, E. A., Newman, E. L., & Fried, I. (2003) · Nature · doi:10.1038/nature01964 · Cited by 1,425
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Li, A., Chen, H., & Naya, Y. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102670 · Cited by 2
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Cetron, J. S., Connolly, A. C., Diamond, S. G., May, V. V., Haxby, J. V., & Kraemer, D. J. M. (2018) · doi:10.31234/osf.io/6ac7f · Cited by 2
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Chrastil, E. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00016-4 · Cited by 2
Han, L. T., & Epstein, R. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634774 · Cited by 2
Self-citationBeatty, E. L., Muller-Gass, A., Wojtarowicz, D., Jobidon, M.-E., Smith, I., Lam, Q., & Vartanian, O. A. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001006 · Cited by 1
Han, L. T., & Epstein, R. A. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0187-25.2025 · Cited by 5
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Han, D., Qin, T., Yang, T., Liao, H., Hei, Q., Yu, F., Si, B., & Dong, W. (2025) · Geo-spatial Information Science · doi:10.1080/10095020.2025.2541878 · Cited by 2
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Epstein, R. A., & Vass, L. K. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0001 · Cited by 1
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Kessler, F., Frankenstein, J., & Rothkopf, C. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00091-7 · Cited by 1
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Watson, D. M. (2016)
Zhou, R. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3cz32g3m
Meissner, T. W., Genç, E., Mädler, B., & Weigelt, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/662809
Murray, E. A., Wise, S. P., Baldwin, M. K. L., & Graham, K. S. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780198828051.003.0004
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Sun, L., Tse, P. U., Li, C., & Zhang, X. (2020) · IEEE International Conference on Mechatronics and Automation (ICMA) · doi:10.1109/icma49215.2020.9233612
Navigational systems in the human brain dynamically code for past, present, and future trajectoriesPreprint
Cheng, Y., Ling, S., Stern, C. E., & Chrastil, E. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.22.554387
Satish, A., Keller, V. G., Raza, S., Fitzpatrick, S., & Horner, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.18.562859
Obstacle coding in scene-selective cortices
Kham, D., Lee, Y., & Park, S. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116137 · Cited by 1
Büchel, P. K., & Kunz, L. (2026) · Springer eBooks · doi:10.1007/978-3-032-20563-6_6
Bleau, M., Donbrowe, M., Kupers, R. C., Dricot, L., Axmacher, N., Chebat, D., & Ptito, M. (2026) · Research Square · doi:10.21203/rs.3.rs-10060586/v1
Metadata
- Authors
- Vass, L. K., & Epstein, R. A.
- Affiliations
- University of Pennsylvania (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-04-03
- Volume
- 33
- Issue
- 14
- Pages
- 6133-6142
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3656495
- OpenAlex
- W2046415503
- Cited by
- 131
- References
- 53
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 8 · 2018: 16 · 2017: 8 · 2016: 25 · 2015: 13 · 2014: 9 · 2013: 2
- Type
- conference abstract
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Science Foundation (0541957)
- National Institutes of Health (R01-EY016464)
- National Eye Institute (R01EY016464)
- National Institute of Neurological Disorders and Stroke (F31NS074729)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- spatial representation, location encoding, wayfinding, presubiculum, retrosplenial complex, medial temporal lobe, navigation, multi-voxel pattern analysis
- MeSH terms
- Analysis of Variance, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Orientation, Oxygen, Photic Stimulation, Reaction Time, Space Perception, Young Adult
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