Information-based functional brain mapping
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The development of high-resolution neuroimaging and multielectrode electrophysiological recording provides neuroscientists with huge amounts of multivariate data. The complexity of the data creates a need for statistical summary, but the local averaging standardly applied to this end may obscure the effects of greatest neuroscientific interest. In neuroimaging, for example, brain mapping analysis has focused on the discovery of activation, i.e., of extended brain regions whose average activity changes across experimental conditions. Here we propose to ask a more general question of the data: Where in the brain does the activity pattern contain information about the experimental condition? To address this question, we propose scanning the imaged volume with a “searchlight,” whose contents are analyzed multivariately at each location in the brain.
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MVPA is more likely to reflect population codes across neurons and has greater sensitivity and specificity to particular types of mental events.
“MVPA is more likely to reflect population codes across neurons43,45,48, as they have demonstrably greater sensitivity and specificity to particular types of mental events17,31,32.”
From Separate neural representations for physical pain and social rejection (2014) · cites this paper as [45]
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Qin, S., Young, C. B., Supekar, K., Uddin, L. Q., & Menon, V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120408109 · Cited by 130 · see citing works
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Distributed neural representations of phonological features during speech perception
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Distinct representations of basic taste qualities in human gustatory cortex
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Self-citationEmotion unfolded by motion: a role for parietal lobe in decoding dynamic facial expressions
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Self-citationInsula response and connectivity during social and non-social attention in children with autism
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Decoding the Content of Delayed Intentions
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“A searchlight approach was used (Kriegeskorte et al., 2006), investigating decoding accuracy from a sphere of voxels centered on each voxel in the brain in turn (radius, three voxels).”
MethodComplementary roles of human hippocampal subregions during retrieval of spatiotemporal context
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Reliable individual differences in fine-grained cortical functional architecture
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The social brain automatically predicts others’ future mental states
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Unveiling functions of the visual cortex using task-specific deep neural networks
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The Hippocampus Generalizes across Memories that Share Item and Context Information
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Model-based feature construction for multivariate decoding
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Self-citationBrain network dynamics during spontaneous strategy shifts and incremental task optimization
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Time-dependent consolidation mechanisms of durable memory in spaced learning
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- Authors
- Kriegeskorte, N., Goebel, R., & Bandettini, P.
- Affiliations
- National Institutes of Health (US)
- Maastricht University (NL)
- National Institute of Mental Health (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-02-28
- Volume
- 103
- Issue
- 10
- Pages
- 3863-3868
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1383651
- OpenAlex
- W2048631316
- Cited by
- 2,113
- References
- 29
- Citations by year
- 2026: 64 · 2025: 125 · 2024: 108 · 2023: 84 · 2022: 106 · 2021: 144 · 2020: 135 · 2019: 151 · 2018: 145 · 2017: 141 · 2016: 172 · 2015: 118 · 2014: 130 · 2013: 123 · 2012: 100
- FWCI
- 15.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (acceptedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Universiteit Maastricht
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- functional brain mapping, searchlight analysis, multivariate pattern analysis, brain activation, neuroimaging, local averaging
- MeSH terms
- Adolescent, Adult, Brain Mapping, Computer Simulation, Data Interpretation, Statistical, Female, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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