Cited by 2,113Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsNeural dynamics and brain function

Information-based functional brain mapping

Open access
Kriegeskorte, Nikolaus, Goebel, Rainer, Bandettini, Peter·2006·Proceedings of the National Academy of Sciences

Abstract

The development of high-resolution neuroimaging and multielectrode electrophysiological recording provides neuroscientists with huge amounts of multivariate data. The complexity of the data creates a need for statistical summary, but the local averaging standardly applied to this end may obscure the effects of greatest neuroscientific interest. In neuroimaging, for example, brain mapping analysis has focused on the discovery of activation, i.e., of extended brain regions whose average activity changes across experimental conditions. Here we propose to ask a more general question of the data: Where in the brain does the activity pattern contain information about the experimental condition? To address this question, we propose scanning the imaged volume with a “searchlight,” whose contents are analyzed multivariately at each location in the brain.

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  • MVPA is more likely to reflect population codes across neurons and has greater sensitivity and specificity to particular types of mental events.

    “MVPA is more likely to reflect population codes across neurons43,45,48, as they have demonstrably greater sensitivity and specificity to particular types of mental events17,31,32.”

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  1. Ishai, A., Ungerleider, L. G., Martin, A., Schouten, J. L. & Haxby, J. V. (1999) Proc. Natl. Acad. Sci. USA 96, 9379-9384.
  2. Van Essen, D. C., Drury, H. A., Joshi, S. & Miller, M. I. (1998) Proc. Natl. Acad. Sci. USA 95, 788-795.

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Authors
Kriegeskorte, N., Goebel, R., & Bandettini, P.
Affiliations
  • National Institutes of Health (US)
  • Maastricht University (NL)
  • National Institute of Mental Health (US)
Venue
Proceedings of the National Academy of Sciences
Published
2006-02-28
Volume
103
Issue
10
Pages
3863-3868
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2048631316
Cited by
2,113
References
29
Citations by year
2026: 64 · 2025: 125 · 2024: 108 · 2023: 84 · 2022: 106 · 2021: 144 · 2020: 135 · 2019: 151 · 2018: 145 · 2017: 141 · 2016: 172 · 2015: 118 · 2014: 130 · 2013: 123 · 2012: 100
FWCI
15.45
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (acceptedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion)
Funders
  • Universiteit Maastricht
  • National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
functional brain mapping, searchlight analysis, multivariate pattern analysis, brain activation, neuroimaging, local averaging
MeSH terms
Adolescent, Adult, Brain Mapping, Computer Simulation, Data Interpretation, Statistical, Female, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Multivariate Analysis

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