Cited by 228Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingAutophagy in Disease and Therapy

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RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

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Malagelada, Cristina, Jin, Zong Hao, Greene, Lloyd A.·2008·The Journal of Neuroscience

DOI 10.1523/jneurosci.3928-08.2008PMC PMC3865436

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Abstract

Previously, we reported that RTP801, a stress regulated protein, is induced in multiple cellular models of Parkinson's disease (PD), in an animal model of PD and in dopaminergic neurons of PD patients. In cellular PD models, RTP801 is both sufficient and necessary for death. We further showed that RTP801 and PD mimetics such as 6-OHDA trigger neuron death by suppressing activation of the key kinase mammalian target of rapamycin (mTOR). Here, we report that as a consequence of mTOR signaling blockade, 6-OHDA suppresses the phosphorylation and activation of Akt, a major supporter of neuron survival. This effect is mediated by RTP801 and appears to underlie neuron death induced by 6-OHDA. Examination of postmortem dopaminergic neurons reveals a consistent depletion of phospho-Akt, but not of total Akt in PD patients. These observations support a sequential mechanism in which PD-associated stresses induce RTP801, suppress mTOR signaling, deplete phosphorylated/activated Akt and permit neuron degeneration and death.

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Authors: Malagelada, C., Jin, Z. H., & Greene, L. A.
Affiliations: Columbia University (US)
ORCID: Malagelada, Cristina
Greene, Lloyd A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2008-12-31
Volume: 28
Issue: 53
Pages: 14363-14371
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.3928-08.2008
PMC: PMC3865436
OpenAlex: W2084140068
Cited by: 228
References: 50
Citations by year: 2026: 8 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 15 · 2021: 20 · 2020: 13 · 2019: 17 · 2018: 10 · 2017: 9 · 2016: 19 · 2015: 11 · 2014: 15 · 2013: 13 · 2012: 19
FWCI: 6.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Parkinson's Disease Foundation
National Institutes of Health
National Institute of Neurological Disorders and Stroke (P50NS038370)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: RTP801, Parkinson's disease, dopaminergic neuron death, Akt phosphorylation, mTOR signaling, 6-hydroxydopamine, neurodegeneration, stress response, Akt/mTOR signaling
MeSH terms: Analysis of Variance, Animals, Animals, Newborn, Cells, Cultured, Gene Expression Regulation, Humans, Melanins, Neurons, Parkinson Disease, Phosphorylation, Serine, Substantia Nigra, Sympatholytics, Threonine, Time Factors, Transcription Factors, Transfection, Oxidopamine, Cell Death, Superior Cervical Ganglion, Green Fluorescent Proteins, Oncogene Protein v-akt, Rats

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RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

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