Small-Conductance Ca2+-Activated K+Channel Type 2 (SK2) Modulates Hippocampal Learning, Memory, and Synaptic Plasticity

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UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis

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Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

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Regulation of Surface Localization of the Small Conductance Ca2+-activated Potassium Channel, Sk2, through Direct Phosphorylation by cAMP-dependent Protein Kinase

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Sustaining Sleep Spindles through Enhanced SK2-Channel Activity Consolidates Sleep and Elevates Arousal Threshold

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Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes

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Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity

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SK2 Channels Are Neuroprotective for Ischemia-Induced Neuronal Cell Death

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Neurotransmitter Modulation of Small-Conductance Ca2+-Activated K+ Channels by Regulation of Ca2+ Gating

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A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia

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Small Conductance Calcium-Activated Potassium Type 2 Channels Regulate Alcohol-Associated Plasticity of Glutamatergic Synapses

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Intrinsic Excitability Increase in Cerebellar Purkinje Cells after Delay Eye-Blink Conditioning in Mice

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An Amino Acid Outside the Pore Region Influences Apamin Sensitivity in Small Conductance Ca2+-activated K+ Channels

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Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels

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SK channel blockade reverses cognitive and motor deficits induced by nigrostriatal dopamine lesions in rats

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Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memoryPreprint

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In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant

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Sizing up Ethanol‐Induced Plasticity: The Role of Small and Large Conductance Calcium‐Activated Potassium Channels

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The SK2-long isoform directs synaptic localization and function of SK2-containing channels

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Bee Venom for the Treatment of Parkinson Disease – A Randomized Controlled Clinical Trial

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Amnestic Concentrations of Sevoflurane Inhibit Synaptic Plasticity of Hippocampal CA1 Neurons through γ-Aminobutyric Acid–mediated Mechanisms

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Calcium Microdomains Near R-Type Calcium Channels Control the Induction of Presynaptic Long-Term Potentiation at Parallel Fiber to Purkinje Cell Synapses

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Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels

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KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction

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In vivo pharmacological manipulation of small conductance Ca2+-activated K+ channels influences motor behavior, object memory and fear conditioning

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The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

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Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders

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Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

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Small-conductance, Ca2+-activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder

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Intellectual Disability and Potassium Channelopathies: A Systematic Review

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Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration

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Increasing SK2 channel activity impairs associative learning

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SK2 channel regulation of neuronal excitability, synaptic transmission, and brain rhythmic activity in health and diseases

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Disruption of the Ether-à-go-go K+Channel Gene BEC1/KCNH3 Enhances Cognitive Function

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Developmental profile of SK2 channel expression and function in CA1 neurons

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Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy

Diness, J. G., Bentzen, B. H., Sørensen, U. S., & Grunnet, M. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000249 · Cited by 42

Trafficking of Intermediate (KCa3.1) and Small (KCa2.x) Conductance, Ca2+‐Activated K+ Channels: a Novel Target for Medicinal Chemistry Efforts?

Balut, C., Hamilton, K. L., & Devor, D. C. (2012) · ChemMedChem · doi:10.1002/cmdc.201200226 · Cited by 41

The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.

Pousinha, P., Mouska, X., Bianchi, D., Temido-Ferreira, M., Rajão-Saraiva, J., Gomes, R., Fernandez, S., Salgueiro-Pereira, A. R., Gandin, C., Raymond, E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.103 · Cited by 29

Increased Small Conductance Calcium-Activated Potassium Type 2 Channel-Mediated Negative Feedback on N-methyl-D-aspartate Receptors Impairs Synaptic Plasticity Following Context-Dependent Sensitization to Morphine

Fakira, A. K., Portugal, G. S., Carusillo, B., Melyan, Z., & Morón, J. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.026 · Cited by 41

KCa2 and KCa3 Channels in Learning and Memory Processes, and Neurodegeneration

Kuiper, E. F. E., Nelemans, A., Luiten, P. G. M., Nijholt, I. M., Dolga, A. M., & Eisel, U. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00107 · Cited by 39

Dopamine and Aging: Intersecting Facets

Rollo, C. D. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9858-7 · Cited by 37

Increasing small conductance Ca2+‐activated potassium channel activity reverses ischemia‐induced impairment of long‐term potentiation

Orfila, J. E., Shimizu, K., Garske, A. K., Deng, G., Maylie, J., Traystman, R. J., Quillinan, N., Adelman, J. P., & Herson, P. S. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12683 · Cited by 36

METAPLASTICITY: NEW INSIGHTS THROUGH ELECTROPHYSIOLOGICAL INVESTIGATIONS

Mockett, B. G., & Hulme, S. R. (2008) · Journal of Integrative Neuroscience · doi:10.1142/s0219635208001782 · Cited by 37

Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior

Cannady, R., McGonigal, J. T., Newsom, R. J., Woodward, J. J., Mulholland, P. J., & Gass, J. T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2873-16.2017 · Cited by 34

Neonatal exposure to sevoflurane caused cognitive deficits by dysregulating SK2 channels and GluA2-lacking AMPA receptors in juvenile rat hippocampus

Yu, X., Zhang, F., & Shi, J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.014 · Cited by 34

Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex

Criado‐Marrero, M., Santini, E., & Porter, J. T. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00096 · Cited by 34

CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate1

Herrik, K. F., Redrobe, J. P., Holst, D., Hougaard, C. Ø., Sandager‐Nielsen, K., Nielsen, A. N., Ji, H., Holst, N. M., Rasmussen, H. B., Nielsen, E. Ø., et al. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00011 · Cited by 33

SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments

Martin, S., Lazzarini, M., Dullin, C., Balakrishnan, S., Gomes, F. V., Ninković, M., Hady, A. E., Pardo, L. A., Stühmer, W., & Bel, E. A. D. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9680-6 · Cited by 32

Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes

Zhao, Y., Chen, Z., Cao, Z., Li, W., & Wu, Y. (2019) · Molecules · doi:10.3390/molecules24112045 · Cited by 31

Genetics of autosomal recessive non‐syndromic mental retardation: recent advances

Basel‐Vanagaite, L. (2007) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00881.x · Cited by 31

Ataxias and cerebellar dysfunction: involvement of synaptic plasticity deficits?

Rinaldo, L., & Hansel, C. (2010) · PubMed · Cited by 30

Overexpression of SK2 Channels Enhances Efferent Suppression of Cochlear Responses Without Enhancing Noise Resistance

Maison, S. F., Parker, L. L., Young, L., Adelman, J. P., Zuo, J., & Liberman, M. C. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01183.2006 · Cited by 29

Infection‐induced endothelial amyloids impair memory

Balczon, R., Pittet, J., Wagener, B. M., Moser, S. A., Voth, S. B., Vorhees, C. V., Williams, M. T., Bridges, J. P., Alvarez, D. F., Koloteva, A., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900322r · Cited by 28

A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens

Jayanthi, S., Torres, O. V., Ladenheim, B., & Cadet, J. L. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01830-3 · Cited by 29

Two Conserved Arginine Residues from the SK3 Potassium Channel Outer Vestibule Control Selectivity of Recognition by Scorpion Toxins

Feng, J. Q., Hu, Y., Yi, H., Yin, S., Han, S. H., Hu, J., Chen, Z., Yang, W., Cao, Z., WAARD, M. M. D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.433888 · Cited by 28

Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

Jacobsen, J. P. R., Redrobe, J. P., Hansen, H. H., Petersen, S., Bond, C. T., Adelman, J. P., Mikkelsen, J. D., & Mirza, N. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.062 · Cited by 27

Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer's disease mouse model

Spoleti, E., Krashia, P., Barbera, L. L., Nobili, A., Lupaşcu, C. A., Giacalone, E., Keller, F., Migliore, M., Renzi, M., & D’Amelio, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113969 · Cited by 29

Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels

Nam, Y., Downey, M., Rahman, M. A., Cui, M., & Zhang, M. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00935-1 · Cited by 28

Small Conductance Ca2+-Activated K+Channels Modulate Synaptic Plasticity and Memory Encoding

Stackman, R. W., Hammond, R., Linardatos, E., Gerlach, A. C., Maylie, J., Adelman, J. P., & Tzounopoulos, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10163.2002 · Cited by 279

Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficitPreprint

Stackman, R. W., Bond, C. T., & Adelman, J. P. (2008) · Learning & Memory · doi:10.1101/lm.906808 · Cited by 20

The small conductance Ca2+-activated K+ channel activator GW542573X impairs hippocampal memory in C57BL/6J mice

Rice, C. A., & Stackman, R. W. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109960 · Cited by 4

Small Conductance Ca2+-Activated K+ Channels as Targets of CNS Drug Development

Blank, T., Nijholt, I. M., Kye, M. J., & Spiess, J. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337472 · Cited by 78

Cellular/Molecular Small Conductance Ca 2 �-Activated K � Channel Knock-Out Mice Reveal the Identity of Calcium-Dependent Afterhyperpolarization Currents

Bond, C. T., Herson, P. S., Strassmaier, T., Hammond, R., Stackman, R. W., Maylie, J., & Adelman, J. P. (2013)