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The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Brandt, C., Hillmann, P., Noack, A., Römermann, K., Öhler, L. A., Rageot, D., Beaufils, F., Melone, A., Sele, A., Wymann, M. P., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.002 · Cited by 83 · see citing works

Wnt/β-catenin signaling as a potential target for novel epilepsy therapies

Hodges, S. L., & Lugo, J. N. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.07.002 · Cited by 75 · see citing works

Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy

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Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy

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Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes

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Microglial mTOR is Neuronal Protective and Antiepileptogenic in the Pilocarpine Model of Temporal Lobe Epilepsy

Zhao, X., Liao, Y., Alam, M. M., Mathur, R., Feustel, P. J., Mazurkiewicz, J. E., Adamo, M. A., Zhu, X. C., & Huang, Y. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2754-19.2020 · Cited by 58 · see citing works

Aberrant Complement System Activation in Neurological Disorders

Ziąbska, K., Ziemka‐Nałęcz, M., Pawelec, P., Sypecka, J., & Zalewska, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094675 · Cited by 55 · see citing works

WONOEP appraisal: Biomarkers of epilepsy‐associated comorbidities

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Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy

Mazumder, A. G., Patial, V., & Singh, D. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.020 · Cited by 54 · see citing works

Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury

Song, Y. N., Pimentel, C., Walters, K., Boller, L., Ghiasvand, S., Liu, J., Staley, K. J., & Berdichevsky, Y. (2016) · Scientific Reports · doi:10.1038/srep32095 · Cited by 53 · see citing works

TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury

Gibb, S. L., Zhao, Y., Potter, D. R., Hylin, M. J., Bruhn, R. L., Baimukanova, G., Zhao, J., Xue, H., Abdel‐Mohsen, M., Pillai, S. K., et al. (2015) · Stem Cells · doi:10.1002/stem.2189 · Cited by 52 · see citing works

Role of mTOR inhibitors in epilepsy treatment

Sadowski, K., Kotulska, K., & Jóźwiak, S. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.017 · Cited by 51 · see citing works

Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus

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Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism

Musto, A., Rosencrans, R. F., Walker, C. P., Bhattacharjee, S., Raulji, C. M., Belayev, L., Fang, Z., Gordon, W., & Bazan, N. (2016) · Scientific Reports · doi:10.1038/srep30298 · Cited by 48 · see citing works

Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors

Tavares, M. T., Kozikowski, A. P., & Shen, S. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112887 · Cited by 52 · see citing works

The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease

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Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation

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Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis

Sosanya, N. M., Brager, D. H., Wolfe, S., Niere, F., & Raab-Graham, K. F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.09.011 · Cited by 49 · see citing works

Emerging Roles for Microglial Phagocytic Signaling in Epilepsy

Wyatt‐Johnson, S. K., & Brewster, A. L. (2019) · Epiliepsy currents/Epilepsy currents · doi:10.1177/1535759719890336 · Cited by 47 · see citing works

Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis

Zimmer, T. S., Broekaart, D. W. M., Gruber, V.-E., van Vliet, E. A., Mühlebner, A., & Aronica, E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.01028 · Cited by 48 · see citing works

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala‐Tecuapetla, C., Cuéllar‐Herrera, M., & Luna‐Munguía, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228573 · Cited by 48 · see citing works

Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain

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Signaling Pathways and Cellular Mechanisms Regulating Mossy Fiber Sprouting in the Development of Epilepsy

Godale, C. M., & Danzer, S. C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00298 · Cited by 46 · see citing works

How is homeostatic plasticity important in epilepsy?

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PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure

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Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus

Mohammad, H., Sekar, S., Wei, Z., Moien‐Afshari, F., & Taghibiglou, C. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1230-6 · Cited by 40 · see citing works

mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy

Nguyen, L. H., & Anderson, A. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-21656-8 · Cited by 39 · see citing works

Analysis of proteins that rapidly change upon mechanistic/mammalian target of rapamycin complex 1 (mTORC1) repression identifies parkinson protein 7 (PARK7) as a novel protein aberrantly expressed in tuberous sclerosis complex (TSC)

Niere, F., Namjoshi, S., Song, E., Dilly, G. A., Schoenhard, G., Zemelman, B. V., Mechref, Y., & Raab-Graham, K. F. (2016) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.m115.055079 · Cited by 38 · see citing works

Interictal network dysfunction and cognitive impairment in epilepsy

Gelinas, J. N., & Khodagholy, D. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00924-3 · Cited by 37 · see citing works

Role of mTOR‐regulated autophagy in spine pruning defects and memory impairments induced by binge‐like ethanol treatment in adolescent mice

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The role of dendritic spines in epileptogenesis

Jean, G., Carton, J., Haq, K., & Musto, A. E. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1173694 · Cited by 33 · see citing works

Neuroinflammation as a Therapeutic Target for Mitigating the Long-Term Consequences of Acute Organophosphate Intoxication

Andrew, P. M., & Lein, P. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.674325 · Cited by 33 · see citing works

Effect of Chronic Administration of Low Dose Rapamycin on Development and Immunity in Young Rats

Lu, Z., Liu, F., Chen, L., Zhang, H., Ding, Y., Liu, J., Wong, M., & Zeng, L.-H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135256 · Cited by 31 · see citing works

Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation

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Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy

Ramandi, D., Salmani, M. E., Moghimi, A., Lashkarbolouki, T., & Fereidoni, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246068 · Cited by 32 · see citing works

FDA-Approved Kinase Inhibitors in Preclinical and Clinical Trials for Neurological Disorders

Lui, A., Vanleuven, J., Perekopskiy, D., Liu, D., Xu, D., Alzayat, O., Elgokhy, T., Do, T., Gann, M., Martin, R. M., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15121546 · Cited by 35 · see citing works

Everolimus improves memory and learning while worsening depressive- and anxiety-like behavior in an animal model of depression.

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Functional protection of learning and memory abilities in rats with vascular dementia

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Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

Theilmann, W., Gericke, B., Schidlitzki, A., Anjum, S. M. M., Borsdorf, S., Harries, T., Roberds, S. L., Aguiar, D. J., Brunner, D., Leiser, S. C., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108297 · Cited by 30 · see citing works

Mechanistic target of rapamycin (mTOR) signaling in status epilepticus

Crino, P. B. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106550 · Cited by 29 · see citing works

Wortmannin Attenuates Seizure-Induced Hyperactive PI3K/Akt/mTOR Signaling, Impaired Memory, and Spine Dysmorphology in Rats

Carter, A. N., Born, H. A., Levine, A. T., Dao, A. T., Zhao, A. J., Lee, W. L., & Anderson, A. E. (2017) · eNeuro · doi:10.1523/eneuro.0354-16.2017 · Cited by 29 · see citing works

Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome

Born, H. A., Martinez, L. A., Levine, A. T., Harris, S. E., Mehra, S., Lee, W. L., Dindot, S. V., Nash, K. R., Silverman, J. L., Segal, D. J., et al. (2021) · eNeuro · doi:10.1523/eneuro.0345-20.2020 · Cited by 28 · see citing works

Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy

Aroor, A., Nguyen, P., Li, Y., Das, R. R., Lugo, J. N., & Brewster, A. L. (2023) · Epilepsia Open · doi:10.1002/epi4.12744 · Cited by 26 · see citing works

mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways

Niere, F., & Raab‐Graham, K. F. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00152 · Cited by 27 · see citing works

Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat

Wyatt‐Johnson, S. K., Sommer, A. L., Shim, K., & Brewster, A. L. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.651096 · Cited by 26 · see citing works

Virulence factor activity relationships (VFARs): a bioinformatics perspective

Waseem, H., Williams, M. R., Stedtfeld, T. M., Chai, B., Stedtfeld, R. D., Cole, J. R., Tiedje, J. M., & Hashsham, S. A. (2017) · Environmental Science Processes & Impacts · doi:10.1039/c6em00689b · Cited by 25 · see citing works

Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats

Fanoudi, S., Hosseini, M., Alavi, M. S., Boroushaki, M. T., Hosseini, A., & Sadeghnia, H. R. (2018) · EXCLI journal · doi:10.17179/excli2018-1626 · Cited by 24 · see citing works

Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia

Leitner, D., Kanshin, E., Askenazi, M., Siu, Y., Friedman, D. J., Devore, S., Jones, D. R., Ueberheide, B. M., Wısnıewskı, T., & Devinsky, O. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268597 · Cited by 23 · see citing works

Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy

Brewster, A. L., Marzec, K., Hairston, A., Ho, M., Anderson, A. E., & Lai, Y. (2016) · Epilepsia · doi:10.1111/epi.13516 · Cited by 23 · see citing works

Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures

Alam, M. M., Zhao, X., Liao, Y., Mathur, R., McCallum, S. E., Mazurkiewicz, J. E., Adamo, M. A., Feustel, P. J., Belin, S., Poitelon, Y., et al. (2021) · eNeuro · doi:10.1523/eneuro.0183-20.2021 · Cited by 21 · see citing works

Early treatment with C1 esterase inhibitor improves weight but not memory deficits in a rat model of status epilepticus

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A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Increases Dendritic Spine Density via RasGRF1/ERK Pathway

Song, J. M., Sung, Y. M., Nam, J. H., Yoon, H., Chung, A., Moffat, E., Jung, M., Pak, D. T. S., Kim, J., & Hoe, H.-S. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150717 · Cited by 18 · see citing works

Mice deficient in complement C3 are protected against recognition memory deficits and astrogliosis induced by status epilepticus

Schartz, N. D., Aroor, A., Li, Y., Pinzón-Hoyos, N., & Brewster, A. L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1265944 · Cited by 17 · see citing works

Effects of Chronic Akt/mTOR Inhibition by Rapamycin on Mechanical Overload–Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle

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The effect of early life status epilepticus on ultrasonic vocalizations in mice

Reynolds, C. D., Smith, G., Jefferson, T. S., & Lugo, J. N. (2016) · Epilepsia · doi:10.1111/epi.13450 · Cited by 16 · see citing works

Phosphorylation of PRAS40 contributes to the activation of the PI3K/AKT/mTOR signaling pathway and the inhibition of autophagy following status epilepticus in rats

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Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol

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Importance of EEG in validating the chronic effects of drugs: Suggestions from animal models of epilepsy treated with rapamycin

Cambiaghi, M., Magri, L., & Cursi, M. (2015) · Seizure · doi:10.1016/j.seizure.2015.02.015 · Cited by 14 · see citing works

Dual Targeting by Inhibition of Phosphoinositide-3-Kinase and Mammalian Target of Rapamycin Attenuates the Neuroinflammatory Responses in Murine Hippocampal Cells and Seizures in C57BL/6 Mice

Vyas, P., Tulsawani, R., & Vohora, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.739452 · Cited by 13 · see citing works

mTOR referees memory and disease through mRNA repression and competition

Raab‐Graham, K. F., & Niere, F. (2017) · FEBS Letters · doi:10.1002/1873-3468.12675 · Cited by 13 · see citing works

Importance of neonatal immunoglobulin transfer for hippocampal development and behaviour in the newborn pig

Pierzynowska, K. G., Lozinska, L. M., Sureda, E. A., Woliński, J., Weström, B. R., & Pierzynowski, S. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180002 · Cited by 13 · see citing works

Exploring Dendritic and Spine Structural Profiles in Epilepsy: Insights From Human Studies and Experimental Animal Models

Kumari, S., & Brewster, A. L. (2023) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597231218603 · Cited by 12 · see citing works

Neural Progenitor Cells Rptor Ablation Impairs Development but Benefits to Seizure‐Induced Behavioral Abnormalities

Chen, L., Wu, M., Zhu, F., Kai, J., Dong, J., Wu, X., & Zeng, L. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12607 · Cited by 11 · see citing works

Rapamycin prevents acute dendritic injury following seizures

Guo, D., Zeng, L., Zou, J., Chen, L., Rensing, N. R., & Wong, M. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.284 · Cited by 10 · see citing works

Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury

Reynolds, J. R., Jimenez-Mateos, E. M., Cao, L., Bian, F., Alves, M., Miller-Delaney, S. F. C., Zhou, A., & Henshall, D. C. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2260-6 · Cited by 10 · see citing works

Cognitive comorbidities in the rat pilocarpine model of epilepsy

Guarino, A., Pignata, P., Lovisari, F., Asth, L., Simonato, M., & Soukupovà, M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1392977 · Cited by 10 · see citing works

Rapamycin, but not minocycline, significantly alters ultrasonic vocalization behavior in C57BL/6J pups in a flurothyl seizure model

Hodges, S. L., Womble, P. D., Kwok, E. M., Darner, A. M., Senger, S., Binder, M. S., Faust, A. M., Condon, S. M., Nolan, S. O., Quintero, S. I., et al. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113317 · Cited by 9 · see citing works

Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus

Levine, A. T., Born, H. A., Landstrom, A. P., Larson, S. R., Lee, W. L., Dao, A. T., Wehrens, X. H. T., Lai, Y., & Anderson, A. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-60324-8 · Cited by 7 · see citing works

Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats

Aghaie, F., Shemshaki, A., Rajabi, M., Khatami, P., & Hosseini, A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06504-9 · Cited by 7 · see citing works

Acute depletion of complement C3 with cobra venom factor attenuates memory deficits induced by status epilepticus

Schartz, N. D., Li, Y., Sommer, A. L., & Brewster, A. L. (2024) · Epilepsia Open · doi:10.1002/epi4.13030 · Cited by 6 · see citing works

Screening the Molecular Framework Underlying Local Dendritic mRNA Translation

Namjoshi, S. V., & Raab‐Graham, K. F. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00045 · Cited by 6 · see citing works

Experimental and clinical tests of FDA-approved kinase inhibitors for the treatment of neurological disorders (update 2024)

Aliashrafzadeh, H., Liu, D., Alba, S. D., Akbar, I., Lui, A., Vanleuven, J., Martin, R. M., Wang, Z., & Liu, D. (2025) · Exploration of Drug Science · doi:10.37349/eds.2025.1008116 · Cited by 5 · see citing works

The Effects of Rapamycin and 3-Methyladenine on Nitric Oxide Synthase Enzymes in Cisplatin-Induced Neurotoxicity

Kaymak, E., Karabulut, D., Öztürk, E., Akın, A. T., & Yakan, B. (2021) · International Journal of Morphology · doi:10.4067/s0717-95022021000200659 · Cited by 4 · see citing works

mTOR in Acquired and Genetic Models of Epilepsy

Wong, M., Bordey, A., & Danzer, S. C. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0004 · Cited by 4 · see citing works

NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density

Narvaiz, D. A., Blandin, K. J., Sullens, D. G., Womble, P. D., Pilcher, J. B., O’Neill, G., Wiley, T. A., Kwok, E. M., Chilukuri, S. V., & Lugo, J. N. (2024) · Epilepsy Research · doi:10.1016/j.eplepsyres.2024.107440 · Cited by 4 · see citing works

EEG-Findings during long-term treatment with everolimus in TSC-associated and therapy-resistant epilepsies in children

Wiegand, G., Japaridze, N., Gröning, K., Stephani, U., & Kadish, N. E. (2022) · Seizure · doi:10.1016/j.seizure.2022.10.022 · Cited by 4 · see citing works

Cognitive dysfunction associated with activation of the mTOR signaling pathway after TSH suppression therapy in rats

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Rapamisinin Sıçanlarda Penisilinle Oluşturulmuş Epileptiform Aktivite Üzerine Etkisi: Bir Elektrofizyolojik Çalışma

Ankaralı, S., Beyazçiçek, E., Ankaralı, H. Ç., & Demír, Ş. (2016) · Anadolu Kliniği Tıp Bilimleri Dergisi · doi:10.21673/anadoluklin.254223 · Cited by 4 · see citing works

Effectiveness of low dose of rapamycin in preventing seizure-induced anxiety-like behaviour, cognitive impairment, and defects in neurogenesis in developing rats

Liu, F., Wu, M., Kai, J., Dong, J., Zhang, B., Liu, L., Zhu, F., & Zeng, L.-H. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1486827 · Cited by 4 · see citing works

Pericytes and Microglia

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Glibenclamide ameliorates the expression of neurotrophic factors in sevoflurane anaesthesia-induced oxidative stress and cognitive impairment in hippocampal neurons of old rats

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