MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859

Emotion circuits in the brain

LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y. (2008) · Science · doi:10.1126/science.1153252 · Cited by 1,823

The amygdala.

Davis, M., & Shi, C. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00345-6 · Cited by 1,756

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Guy, J., Hendrich, B., Holmes, M., Martin, J. E., & Bird, A. (2001) · Nature Genetics · doi:10.1038/85899 · Cited by 1,558

Neurobiology of Pavlovian fear conditioning

Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,543

A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: Report of 35 cases

Hagberg, B. A., Aicardi, J. F., Dias, K., & Ramos, O. (1983) · Annals of Neurology · doi:10.1002/ana.410140412 · Cited by 1,515

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390

Interneuron dysfunction in psychiatric disorders

Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797

Epigenetic regulation of gene expression in physiological and pathological brain processes

Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373

Epigenetic influences on brain development and plasticity

Fagiolini, M., Jensen, C. L., & Champagne, F. A. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.009 · Cited by 362

Rett syndrome: a complex disorder with simple roots

Lyst, M. J., & Bird, A. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3897 · Cited by 353

The Role of Histone Acetylation in Memory Formation and Cognitive Impairments

Peixoto, L., & Abel, T. G. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.86 · Cited by 353

Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury

Elovitz, M. A., Brown, A. G., Breen, K. E., Anton, L., Maubert, M. E., & Burd, I. D. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.02.011 · Cited by 254

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

Kim, M.-S., Akhtar, M. W., Adachi, M., Mahgoub, M., Bassel-Duby, R., Kavalali, E. T., Olson, E. N., & Monteggia, L. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2089-12.2012 · Cited by 235

Epigenetic Mechanisms in Learned Fear: Implications for PTSD

Zovkic, I. B., & Sweatt, J. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.79 · Cited by 192

The Impact of MeCP2 Loss- or Gain-of-Function on Synaptic Plasticity

Na, E. S., Nelson, E. D., Kavalali, E. T., & Monteggia, L. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.116 · Cited by 183

BDNF deregulation in Rett syndrome

Li, W., & Pozzo‐Miller, L. D. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.024 · Cited by 181

Wired for behaviors: from development to function of innate limbic system circuitry

Sokolowski, K., & Corbin, J. G. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00055 · Cited by 181

Rett Syndrome and MeCP2

Liyanage, V. R. B., & Rastegar, M. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8295-9 · Cited by 182

Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: Unraveling the genome to understand the mind

Hsieh, J., & Eisch, A. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.01.008 · Cited by 144

Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice

Balemans, M. C. M., Huibers, M. M. H., Eikelenboom, N., Kuipers, A. J., van Summeren, R. C. J., Pijpers, M. M. C. A., Tachibana, M., Shinkai, Y., van Bokhoven, H., & der Zee, C. E. E. M. V. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.008 · Cited by 142

Mammalian epigenetic mechanisms

Zhang, G., & Pradhan, S. (2014) · IUBMB Life · doi:10.1002/iub.1264 · Cited by 143

Experimental models of Rett syndrome based on Mecp2 dysfunction

Calfa, G. D., Percy, A. K., & Pozzo‐Miller, L. D. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010261 · Cited by 136

Epigenetic Treatments for Cognitive Impairments

Day, J. J., & Sweatt, J. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.85 · Cited by 132

Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements

Olson, C. O., Zachariah, R. M., Ezeonwuka, C. D., Liyanage, V. R. B., & Rastegar, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090645 · Cited by 118

Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

He, L.-J., Liu, N., Cheng, T.-L., Chen, X.-J., Li, Y.-D., Shu, Y.-S., Qiu, Z.-L., & Zhang, X.-H. (2014) · Nature Communications · doi:10.1038/ncomms6036 · Cited by 107

The dynamics of the stress neuromatrix

Sousa, N. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.196 · Cited by 111

A Synaptic Locus for TrkB Signaling Underlying Ketamine Rapid Antidepressant Action

Lin, P.-Y., Ma, Z. Z., Mahgoub, M., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109513 · Cited by 99

MeCP2 and Rett syndrome: reversibility and potential avenues for therapy

Gadalla, K. K. E., Bailey, M. E. S., & Cobb, S. (2011) · Biochemical Journal · doi:10.1042/bj20110648 · Cited by 101

X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal–lysosomal dysfunction

Strømme, P., Dobrenis, K., Sillitoe, R. V., Gulinello, M. E., Ali, N. F., Davidson, C. D., Micsenyi, M. C., Stephney, G. W., Ellevog, L., Klungland, A., et al. (2011) · Brain · doi:10.1093/brain/awr250 · Cited by 100

MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function

Karaca, K. G., Brito, D. V. C., & Oliveira, A. M. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184577 · Cited by 103

Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders

Gandhi, T., & Lee, C. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592710 · Cited by 97

An intra-amygdala circuit specifically regulates social fear learning

Twining, R. C., Vantrease, J. E., Love, S., Padival, M., & Rosenkranz, J. A. (2017) · Nature Neuroscience · doi:10.1038/nn.4481 · Cited by 93

p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear

Wei, W., Coelho, C. M., Li, X., Marek, R., Yan, S., Anderson, S., Meyers, D., Mukherjee, C., Sbardella, G., Castellano, S., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0178-12.2012 · Cited by 93

MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons

Kishi, N., & Macklis, J. D. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.12.007 · Cited by 93

Epigenetics of neurobiology and behavior during development and adulthood

Roth, T. L. (2012) · Developmental Psychobiology · doi:10.1002/dev.20550 · Cited by 93

Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons

Xiang, Y., Tanaka, Y., Patterson, B., Hwang, S., Hysolli, E., Çakır, B., Kim, K., Wang, W., Kang, Y., Clement, E. M., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.016 · Cited by 93

MeCP2 Is Critical within HoxB1-Derived Tissues of Mice for Normal Lifespan

Ward, C. S., Arvide, E. M., Huang, T.-W., Yoo, J. W., Noebels, J. L., & Neul, J. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0057-11.2011 · Cited by 88

Hippocampal deficits in neurodevelopmental disorders

Li, Y., Shen, M., Stockton, M. E., & Zhao, X. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.001 · Cited by 89

Selective role for DNMT3a in learning and memory

Morris, M. J., Adachi, M., Na, E. S., & Monteggia, L. M. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.06.005 · Cited by 82

Epigenetics in the mature mammalian brain: Effects on behavior and synaptic transmission

Nelson, E. D., & Monteggia, L. M. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.015 · Cited by 81

mGlu 7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Gogliotti, R. G., Senter, R. K., Fisher, N. M., Adams, J., Zamorano, R., Walker, A. G., Blobaum, A. L., Engers, D. W., Hopkins, C. R., Daniels, J. S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai7459 · Cited by 80

Amygdala NRG1–ErbB4 Is Critical for the Modulation of Anxiety-Like Behaviors

Bi, L.-L., Sun, X.-D., Zhang, J., Lu, Y.-S., Chen, Y.-H., Wang, J., Geng, F., Liu, F., Zhang, M., Liu, J.-H., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.274 · Cited by 76

MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome

Tai, D. J. C., Liu, Y., Hsu, W., Ma, Y., Cheng, S. J., Liu, S. Y., & Lee, E. H. Y. (2016) · Nature Communications · doi:10.1038/ncomms10552 · Cited by 73

Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes

Zachariah, R. M., Olson, C. O., Ezeonwuka, C. D., & Rastegar, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049763 · Cited by 74

Maternal high fat diet alters offspring epigenetic regulators, amygdala glutamatergic profile and anxiety

Glendining, K. A., Fisher, L. C., & Jasoni, C. L. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.06.015 · Cited by 73

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Kishi, N., MacDonald, J. L., Ye, J., Molyneaux, B. J., Azim, E., & Macklis, J. D. (2016) · Nature Communications · doi:10.1038/ncomms10520 · Cited by 69

Epigenetics of Autism Spectrum Disorder: Histone Deacetylases

Tseng, C.-E. J., McDougle, C. J., Hooker, J. M., & Zürcher, N. R. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.021 · Cited by 72

Are there depression and anxiety genetic markers and mutations? A systematic review

Lacerda-Pinheiro, S. D. F., Pinheiro, R. F. F., de Lima, M. A. P., da Silva, C. G. L., dos Santos, M. D. S. V., Júnior, A. G. T., de Oliveira, P. N. L., Ribeiro, K. D. B., Neto, M. L. R., & Bianco, B. A. V. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.016 · Cited by 69

Reversibility of functional deficits in experimental models of Rett syndrome

Cobb, S., Guy, J., & Bird, A. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380498 · Cited by 67

Abnormal emotional learning in a rat model of autism exposed to valproic acid in utero

Banerjee, A., Engineer, C. T., Sauls, B., Morales, A. A., Kilgard, M. P., & Ploski, J. E. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00387 · Cited by 66

Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation

Lang, M., Wither, R. G., Colic, S., Wu, C., Monnier, P. P., Bardakjian, B. L., Zhang, L., & Eubanks, J. H. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt421 · Cited by 63

Impact of DNMT1 and DNMT3a forebrain knockout on depressive- and anxiety like behavior in mice

Morris, M. J., Na, E. S., Autry, A. E., & Monteggia, L. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.012 · Cited by 64

Correlations between neurophysiological, behavioral, and cognitive function in Rett syndrome

Vignoli, A., Fabio, R. A., Briola, F. L., Giannatiempo, S., Antonietti, A., Maggiolini, S., & Canevini, M. P. (2010) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2010.01.024 · Cited by 62

Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex

Yu, B., Yuan, B., Dai, J.-K., Cheng, T.-L., Xia, S.-N., He, L.-J., Yuan, Y.-T., Zhang, Y.-F., Xu, H.-T., Xu, F.-Q., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00467-w · Cited by 58

Loss of MeCP2 function is associated with distinct gene expression changes in the striatum

Zhao, Y.-T., Goffin, D., Johnson, B. S., & Zhou, Z. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.08.001 · Cited by 59

Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex ofMecp2Null Mice

Sceniak, M. P., Lang, M., Enomoto, A. C., Howell, C., Hermes, D. J., & Katz, D. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv002 · Cited by 53

Postnatal Loss of Mef2c Results in Dissociation of Effects on Synapse Number and Learning and Memory

Adachi, M., Lin, P.-Y., Pranav, H., & Monteggia, L. M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.09.018 · Cited by 55

Anxiety-Related Mechanisms of Respiratory Dysfunction in a Mouse Model of Rett Syndrome

Ren, J. T., Ding, X., Funk, G. D., & Greer, J. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2951-12.2012 · Cited by 52

Epigenetic Mechanisms in Autism Spectrum Disorder

Zhubi, A., Cook, E. H., Guidotti, A., & Grayson, D. R. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801311-3.00006-8 · Cited by 56

Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome

Lavery, L. A., Ure, K., Wan, Y., Luo, C., Trostle, A. J., Wang, W., Jin, H., Lopez, J., Lucero, J. D., Durham, M. A., et al. (2020) · eLife · doi:10.7554/elife.52981 · Cited by 53

TrkB Signaling in Dorsal Raphe Nucleus is Essential for Antidepressant Efficacy and Normal Aggression Behavior

Adachi, M., Autry, A. E., Mahgoub, M., Suzuki, K., & Monteggia, L. M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.201 · Cited by 49

Rett syndrome treatment in mouse models: Searching for effective targets and strategies

Ricceri, L., Filippis, B. D., & Laviola, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.010 · Cited by 46

MeCP2 in the Rostral Striatum Maintains Local Dopamine Content Critical for Psychomotor Control

Su, S.-H., Kao, F.-C., Huang, Y.-B., & Liao, W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4624-14.2015 · Cited by 44

Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment

Banerjee, A., Luong, J. A., Ho, A., Saib, A., & Ploski, J. E. (2016) · Molecular Autism · doi:10.1186/s13229-016-0077-9 · Cited by 45

The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review

Persaud, N. S., & Cates, H. M. (2023) · eneuro · doi:10.1523/eneuro.0109-21.2021 · Cited by 41

MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors

Mahgoub, M., Adachi, M., Suzuki, K., Liu, X., Kavalali, E. T., Chahrour, M. H., & Monteggia, L. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4395 · Cited by 40

Epigenetic regulation of genes in learning and memory

Roth, T. L., Roth, E. D., & Sweatt, J. D. (2010) · Essays in Biochemistry · doi:10.1042/bse0480263 · Cited by 39

Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice

Robinson, L., Plano, A., Cobb, S., & Riedel, G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.041 · Cited by 38

Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation

Karaca, K. G., Brito, D. V. C., Zeuch, B., & Oliveira, A. M. M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.02.010 · Cited by 35

Beyond widespread Mecp2 deletions to model Rett syndrome: conditional spatio-temporal knockout, single-point mutations and transgenic rescue mice

Li, W. (2012) · Autism- Open Access · doi:10.4172/2165-7890.s1-005 · Cited by 35

Diminished prevalence but preserved synaptic distribution of N-methyl-d-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain

Maliszewska‐Cyna, E., Bawa, D., & Eubanks, J. H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.065 · Cited by 33

Physiological definition of upper airway obstructions in mouse model for Rett syndrome

Voituron, N., Menuet, C., Dutschmann, M., & Hilaire, G. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.07.006 · Cited by 31

Synaptic Maturation at Cortical Projections to the Lateral Amygdala in a Mouse Model of Rett Syndrome

Gambino, F., Khelfaoui, M., Poulain, B., Bienvenu, T., Chelly, J., & Humeau, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011399 · Cited by 31

Epigenetics of Fear, Anxiety and Stress – Focus on Histone Modifications

Ell, M. A., Schiele, M. A., Iovino, N., & Domschke, K. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230322154158 · Cited by 29

Wilm’s tumor 1 promotes memory flexibility

Mariottini, C., Munari, L., Gunzel, E., Seco, J., Tzavaras, N., Hansen, J., Stern, S. A., Gao, V., Aleyasin, H., Sharma, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11781-x · Cited by 30

Development of Histone Deacetylase Inhibitors as Therapeutics for Neurological Disease

Gottesfeld, J. M., & Pandolfo, M. (2009) · Future Neurology · doi:10.2217/fnl.09.55 · Cited by 29

Investigation of Rett syndrome using pluripotent stem cells

Dajani, R. B., Koo, S.-E., Sullivan, G. J., & Park, I. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24597 · Cited by 29

Decoding transcriptional repressor complexes in the adult central nervous system

Adachi, M., & Monteggia, L. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.024 · Cited by 27

Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys

Wu, S., Li, X., Qin, D., Zhang, L.-H., Cheng, T., Chen, Z., Nie, B., Ren, X., Wu, J., Wang, W., et al. (2020) · 中国科学通报：英文版 · doi:10.1016/j.scib.2020.12.017 · Cited by 27

Identifying Essential Cell Types and Circuits in Autism Spectrum Disorders

Maloney, S. E., Rieger, M. A., & Dougherty, J. D. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00003-4 · Cited by 26

Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes inMecp2Mutant Mice

Ribeiro, M. C., Moore, S. M., Kishi, N., Macklis, J. D., & MacDonald, J. L. (2020) · eNeuro · doi:10.1523/eneuro.0167-20.2020 · Cited by 25

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders

Garrido, D., Beretta, S., Grabrucker, S., Bauer, H. F., Bayer, D., Sala, C., Verpelli, C., Roselli, F., Bockmann, J., Proepper, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01756-8 · Cited by 26

MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

Zhang, Y., Zhu, Y., Cao, S.-X., Sun, P., Yang, J.-M., Xia, Y., Xie, S., Yu, X.-D., Fu, J., Shen, C.-J., et al. (2020) · eLife · doi:10.7554/elife.55342 · Cited by 21

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice

Zhou, H., Wu, W., Zhang, Y., He, H., Yuan, Z., Zhu, Z.-W., & Zhao, Z. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.023 · Cited by 20

Epigenetic (de)regulation of adult hippocampal neurogenesis: implications for depression

Mateus‐Pinheiro, A., Pinto, L., & Sousa, N. (2011) · Clinical Epigenetics · doi:10.1186/1868-7083-3-5 · Cited by 20

Multimodal Neuroimaging in Rett Syndrome With MECP2 Mutation

Kong, Y., Li, Q.-B., Zhao-hong, Y., Jiang, X., Zhang, G.-Q., Cheng, N., & Dang, N. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.838206 · Cited by 21

Lmo4 in the Basolateral Complex of the Amygdala Modulates Fear Learning

Maiya, R., Kharazia, V., Lasek, A. W., & Heberlein, U. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034559 · Cited by 18

Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration

Xu, S., Panikker, P., Iqbal, S., & Elefant, F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159623 · Cited by 18

Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling

Xu, F., Wang, X., Cai, X., Liu, J., Guo, J.-W., Yang, F., Chen, W., Schonewille, M., Zeeuw, C. I. D., Zhou, L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113559 · Cited by 15

Rett syndrome: A preliminary analysis of stereotypy, stress, and negative affect

Quest, K., Byiers, B. J., Payen, A., & Symons, F. J. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.01.011 · Cited by 15

The role of MeCP2 in learning and memoryPreprint

Robinson, H., & Pozzo‐Miller, L. D. (2019) · Learning & Memory · doi:10.1101/lm.048876.118 · Cited by 16

MeCP2 Expression in a Rat Model of Risky Decision Making

Deng, J. V., Orsini, C. A., Shimp, K. G., & Setlow, B. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.016 · Cited by 13

Patho-Epigenetics of Disease

Minárovits, J., & Niller, H. H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3345-3 · Cited by 13

Recent advances in the neurobiology of attachment behavior

Šešo-Šimić, Đ., Sedmak, G., Hof, P. R., & Šimić, G. (2010) · Translational Neuroscience · doi:10.2478/v10134-010-0020-0 · Cited by 12

Epigenetics, Brain and Behavior

Sassone‐Corsi, P., & Christen, Y. (2012) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-27913-3 · Cited by 11

Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model

Ribeiro, M. C., & MacDonald, J. L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105636 · Cited by 10

Alteration of epigenetic program to recover memory and alleviate neurodegeneration: prospects of multi-target molecules

Pandian, G. N., Taylor, R. D., Syed, J., Saha, A., Chandran, A., Vaijayanthi, T., & Sugiyama, H. (2014) · Biomaterials Science · doi:10.1039/c4bm00068d · Cited by 10

Risky decision-making following prefrontal D1 receptor manipulation

Beyer, D. K. E., Horn, L., Klinker, N., & Freund, N. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0187 · Cited by 10

Human MECP2 transgenic rats show increased anxiety, severe social deficits, and abnormal prefrontal neural oscillation stability

Li, X., Nie, Y., Qiu, Z., & Wang, S. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.01.057 · Cited by 9

Applying the ethoexperimental approach to neurodevelopmental syndrome research reveals exaggerated defensive behavior in Mecp2 mutant mice

Pearson, B. L., Defensor, E. B., Blanchard, D. C., & Blanchard, R. J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.035 · Cited by 11

Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning.

March, A., Borchelt, D., Golde, T. E., & Janus, C. (2014) · PubMed Central · Cited by 9

Neurobiology of Self-Injurious Behavior

Furniss, F., & Biswas, A. B. (2020) · Autism and child psychopathology series · doi:10.1007/978-3-030-36016-0_3 · Cited by 8

Exploration of group II metabotropic glutamate receptor modulation in mouse models of Rett syndrome and MECP2 Duplication syndrome

Vermudez, S. A. D., Buch, A. B., Weiss, K., Gogliotti, R. G., & Niswender, C. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109022 · Cited by 7

Analysis of MeCP2 Function in the CNS

Kavalali, E. T., & Monteggia, L. M. (2012) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-27913-3_11

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

McGill, B. E., Bundle, S. F., Yaylaoglu, M., Carson, J. P., Christina Thaller, B., & Zoghbi, H. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608702103 · Cited by 233

Postnatal Loss of Methyl-CpG Binding Protein 2 in the Forebrain is Sufficient to Mediate Behavioral Aspects of Rett Syndrome in Mice

Gemelli, T., Berton, O., Nelson, E. D., Perrotti, L. I., Jaenisch, R., & Monteggia, L. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.025 · Cited by 244

Mechanisms underlying anxiety in Rett Syndrome: Translational insights from preclinical findings

Impey, B., Newman, T. A., & Baldwin, D. S. (2022) · Neuroscience Applied · doi:10.1016/j.nsa.2022.100109

In Brief

(2002) · Nature Reviews Genetics · doi:10.1038/nrg901 · Cited by 2