MicroRNAs and neurodegeneration: role and impact
Open accessAbstract
Neurodegenerative diseases are typically late-onset, progressive disorders that affect neural function and integrity. Although most attention has been focused on the genetic underpinnings of familial disease, mechanisms are likely to be shared with more predominant sporadic forms, which can be influenced by age, environment, and genetic inputs. Previous work has largely addressed the roles of select protein-coding genes; however, disease pathogenesis is complicated and can be modulated through not just protein-coding genes, but also regulatory mechanisms mediated by the exploding world of small non-coding RNAs. Here, we focus on emerging roles of miRNAs in age-associated events impacting long-term brain integrity and neurodegenerative disease.
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Alterations in miRNA levels have been observed in AD and other neurodegenerative disorders.
“Alterations in miRNA levels have been observed in AD and other neurodegenerative disorders [613].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [613]
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Role of MicroRNAs in the Trabecular Meshwork
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Oligonucleotide-based therapy for neurodegenerative diseases
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Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases
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Tau Abnormalities and the Potential Therapy in Alzheimer’s Disease
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Current progress on microRNAs ‐based therapeutics in neurodegenerative diseases
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Genetics and Pharmacology of Longevity
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- Authors
- Abe, M., & Bonini, N. M.
- Affiliations
- University of Pennsylvania (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bonini, Nancy M.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 23
- Issue
- 1
- Pages
- 30-36
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC3540990
- OpenAlex
- W2090196938
- Cited by
- 190
- References
- 105
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 16 · 2019: 12 · 2018: 18 · 2017: 23 · 2016: 12 · 2015: 20 · 2014: 34 · 2013: 11
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Ellison Medical Foundation
- National Institutes of Health (4r01ns078283-05)
- National Institute of Neurological Disorders and Stroke (R01-NS078283)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microRNA, neurodegenerative diseases, small RNA, pathogenesis, regulatory mechanisms
- MeSH terms
- Aging, Brain, Humans, Neurodegenerative Diseases, MicroRNAs, Metabolic Networks and Pathways
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