The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
State-Dependent Dendritic Computation in Hippocampal CA1 Pyramidal Neurons
Open accessAbstract
Depending on the behavioral state, hippocampal CA1 pyramidal neurons receive very distinct patterns of synaptic input and likewise produce very different output patterns. We have used simultaneous dendritic and somatic recordings and multisite glutamate uncaging to investigate the relationship between synaptic input pattern, the form of dendritic integration, and action potential output in CA1 neurons. We found that when synaptic input arrives asynchronously or highly distributed in space, the dendritic arbor performs a linear integration that allows the action potential rate and timing to vary as a function of the quantity of the input. In contrast, when synaptic input arrives synchronously and spatially clustered, the dendritic compartment receiving the clustered input produces a highly nonlinear integration that leads to an action potential output that is extraordinarily precise and invariant. We also present evidence that both of these forms of information processing may be independently engaged during the two distinct behavioral states of the hippocampus such that individual CA1 pyramidal neurons could perform two different state-dependent computations: input strength encoding during theta states and feature detection during sharp waves.
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Cites
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Replay and Time Compression of Recurring Spike Sequences in the Hippocampus
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“…areas for consolidation as a tightly compressed replay (now over only tens of milliseconds) of essentially the same neuronal firing sequences activated during previous theta states (Qin et al., 1997; Siapas and Wilson, 1998; Kudrimoti et al., 1999; Nadasdy et al., 1999; Lee and Wilson, 2002).”
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Cited by
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688
Principles of two-photon excitation microscopy and its applications to neuroscience
Svoboda, K., & Yasuda, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.019 · Cited by 1,027
Intracellular dynamics of hippocampal place cells during virtual navigation
Harvey, C. D., Collman, F., Dombeck, D. A., & Tank, D. W. (2009) · Nature · doi:10.1038/nature08499 · Cited by 873
Integrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons
Losonczy, A., & Magee, J. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.016 · Cited by 649
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Metadata
- Authors
- Gasparini, S., & Magee, J. C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-02-15
- Volume
- 26
- Issue
- 7
- Pages
- 2088-2100
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2028626656
- Cited by
- 293
- References
- 15
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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