The Cells and Circuitry for Itch Responses in Mice

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Specific C-Receptors for Itch in Human Skin

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Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

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A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

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Putative Mammalian Taste Receptors

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Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

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A subpopulation of nociceptors specifically linked to itch

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Cellular Basis of Itch Sensation

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TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A 2 and 12-Lipoxygenase

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TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

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TRPV1‐lineage neurons are required for thermal sensation

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Separate Peripheral Pathways for Pruritus in Man

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The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

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A Role for Polymodal C-Fiber Afferents in Nonhistaminergic Itch

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Phospholipase Cβ 3 Mediates the Scratching Response Activated by the Histamine H1 Receptor on C-Fiber Nociceptive Neurons

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Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate

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The Majority of Dorsal Spinal Cord Gastrin Releasing Peptide is Synthesized Locally Whereas Neuromedin B is Highly Expressed in Pain- and Itch-Sensing Somatosensory Neurons

Fleming, M. S., Ramos, D., Han, S. B., et al. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-52 · Cited by 104 · see citing works

Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase

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An Itch To Be Scratched

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Peripheral mechanisms of itch

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Targeted toxins in pain

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Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening

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Inhibitory effects of gastrin releasing peptide on gastric emptying in rats

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Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

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Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

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Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Kardon, A. P., Polgár, E., Hachisuka, J., Snyder, L. M., Cameron, D., Savage, S., Cai, X., Karnup, S., Fan, C. R., Hemenway, G. M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.046 · Cited by 369 · see citing works

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

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UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

Moore, C., Cevikbas, F., Pasolli, H. A., Chen, Y., Kong, W., Kempkes, C., Parekh, P., Lee, S. H., Kontchou, N.-A., Yeh, I., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312933110 · Cited by 259 · see citing works

Circuit dissection of the role of somatostatin in itch and pain

Huang, J., Polgár, E., Solinski, H. J., Mishra, S. K., Tseng, P.-Y., Iwagaki, N., Boyle, K. A., Dickie, A. C., Kriegbaum, M. C., Wildner, H., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0119-z · Cited by 257 · see citing works

The Itch–Scratch Cycle: A Neuroimmune Perspective

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A harmonized atlas of mouse spinal cord cell types and their spatial organization

Russ, D. E., Cross, R. B. P., Li, L., Koch, S. C., Matson, K. J. E., Yadav, A., Alkaslasi, M. R., Lee, D. I., Le Pichon, C. E., Menon, V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25125-1 · Cited by 255 · see citing works

Pruritus in cholestasis: facts and fiction

Beuers, U., Kremer, A. E., Bolier, R., & Elferink, R. P. J. O. (2014) · Hepatology · doi:10.1002/hep.26909 · Cited by 225 · see citing works

Normal and abnormal coding of somatosensory stimuli causing pain

Prescott, S. A., Ma, Q., & De Koninck, Y. (2014) · Nature Neuroscience · doi:10.1038/nn.3629 · Cited by 210 · see citing works

Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch

Pan, H., Fatima, M., Li, A., Lee, H., Cai, W., Horwitz, L., Hor, C. C., Zaher, N., Cin, M., Slade, H., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.016 · Cited by 140 · see citing works

Pruritus in allergy and immunology

Yang, T.-L. B., & Kim, B. S. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.06.016 · Cited by 112 · see citing works

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch

Acton, D., Ren, X., Di Costanzo, S., Dalet, A., Bourane, S., Bertocchi, I., Eva, C., & Goulding, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.033 · Cited by 108 · see citing works

A spinoparabrachial circuit defined by Tacr1 expression drives pain

Barik, A., Sathyamurthy, A., Thompson, J., Seltzer, M., Levine, A., & Chesler, A. (2021) · eLife · doi:10.7554/elife.61135 · Cited by 93 · see citing works

A Functional Topographic Map for Spinal Sensorimotor Reflexes

Gatto, G., Bourane, S., Ren, X., Di Costanzo, S., Fenton, P. K., Halder, P., Seal, R. P., & Goulding, M. D. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.003 · Cited by 92 · see citing works

A quantitative study of neurochemically defined excitatory interneuron populations in laminae I–III of the mouse spinal cord

Gutierrez-Mecinas, M., Furuta, T., Watanabe, M., & Todd, A. J. (2016) · Molecular Pain · doi:10.1177/1744806916629065 · Cited by 81 · see citing works

Neuronal diversity in the somatosensory system: bridging the gap between cell type and function

Gatto, G., Smith, K. M., Ross, S. E., & Goulding, M. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.03.002 · Cited by 74 · see citing works

Spinal somatostatin-positive interneurons transmit chemical itch

Fatima, M., Ren, X., Pan, H., Slade, H. F. E., Asmar, A. J., Xiong, C. M., Shi, A., Xiong, A. E., Wang, L., & Duan, B. (2019) · Pain · doi:10.1097/j.pain.0000000000001499 · Cited by 41 · see citing works

Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse

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Decoding cell type diversity within the spinal cord

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