Cited by 150Action Observation and SynchronizationPsychosomatic Disorders and Their TreatmentsPain Mechanisms and Treatments

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Functional Dissociation of the Frontoinsular and Anterior Cingulate Cortices in Empathy for Pain

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Gu, Xiaosi, Liu, Xun, Guise, Kevin G., Naidich, Thomas P., Hof, Patrick R., Fan, Jin·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.4844-09.2010PMC PMC2845539

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Abstract

The frontoinsular cortex (FI) and the anterior cingulate cortex (ACC) are thought to be involved in empathy for others' pain. However, the functional roles of FI and ACC in empathetic responses have not yet been clearly dissociated in previous studies. In this study, participants viewed color photographs depicting human body parts in painful or nonpainful situations and performed either pain judgment (painful/nonpainful) or laterality judgment (left/right) of the body parts. We found that activation of FI, rather than ACC, showed significant increase for painful compared with nonpainful images, regardless of the task requirement. Our data suggest a clear functional dissociation between FI and ACC in which FI is more domain-specific than ACC when processing empathy for pain.

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Authors: Gu, X., Liu, X., Guise, K. G., Naidich, T. P., Hof, P. R., & Fan, J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Fan, Jin
ORCID: Gu, Xiaosi
Liu, Xun
Naidich, Thomas P.
Hof, Patrick R.
Fan, Jin
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-03-10
Volume: 30
Issue: 10
Pages: 3739-3744
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4844-09.2010
PMC: PMC2845539
OpenAlex: W2109880731
Cited by: 150
References: 38
Citations by year: 2026: 4 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 15 · 2014: 15 · 2013: 20 · 2012: 18
FWCI: 23.61
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: James S. McDonnell Foundation (22002078)
National Institutes of Health
National Institute of Mental Health (MH083164, R21MH083164)
National Center for Research Resources (MO1RR00071, M01RR000071)
Topics: Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: empathy for pain, frontoinsular cortex, anterior cingulate cortex, functional dissociation, pain perception, domain specificity, mirror neuron system
MeSH terms: Adult, Brain Mapping, Cerebral Cortex, Empathy, Female, Frontal Lobe, Gyrus Cinguli, Humans, Male, Pain, Pain Measurement, Photic Stimulation, Pilot Projects, Young Adult

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Functional Dissociation of the Frontoinsular and Anterior Cingulate Cortices in Empathy for Pain

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