D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase
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d-Serine is an endogenous ligand for NMDARs generated from l-serine by the enzyme serine racemase (Srr). Both neuronal and glial localizations have been reported for d-serine and Srr. 3-Phosphoglycerate dehydrogenase is an exclusively astrocytic enzyme that catalyzes the first committed step of l-serine biosynthesis. Using transgenic mice expressing enhanced green fluorescent protein under the Srr promoter and mice with targeted deletion of Srr or 3-Phosphoglycerate dehydrogenase, we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine. These findings clarify the cellular basis for the regulation of NMDAR neurotransmission by d-serine.
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Astrocytes and not neurons express the phosphoglycerate dehydrogenase involved in serine biosynthesis.
“For instance, astrocytes and not neurons express the phosphoglycerate dehydrogenase involved in serine biosynthesis (Ehmsen et al., 2013), which branches off of the main glycolytic pathway.”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Ehmsen et al., 2013
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Tonic NMDA Receptor Currents in the Brain: Regulation and Cognitive Functions
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A connectomics approach to understanding a retinal disease
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Nuclear Compartmentalization of Serine Racemase Regulates d-Serine Production
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ASC Transporters Mediate D-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain
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Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
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A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1
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Algorithmic reconstruction of glioblastoma network complexity
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Serine Racemase Expression Differentiates Aging from Alzheimer’s Brain
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Serine Racemase mediates subventricular zone neurogenesis via fatty acid metabolism
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Clinical histopathology and pathogenesis of macular telangiectasia type 2
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Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
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SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders
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Serine Racemase Expression by Striatal Neurons
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Serine Metabolic Networks in Plants
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d-Serine’s Journey Between Stars and Synapses
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Physiological Roles of d-Serine in the Central Nervous System
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Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell ResolutionPreprint
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- Authors
- Ehmsen, J. T., Ma, T. M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S. H., & Wolosker, H.
- Affiliations
- Johns Hopkins University (US)
- Technion – Israel Institute of Technology (IL)
- Kyushu University (JP)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-07-24
- Volume
- 33
- Issue
- 30
- Pages
- 12464-12469
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3721849
- OpenAlex
- W2055652253
- Cited by
- 118
- References
- 27
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 6 · 2014: 12 · 2013: 1
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Mental Health Research Organization
- Legacy Heritage Fund
- Israel Science Foundation
- National Institutes of Health (MH18501)
- Japan Society for the Promotion of Science (18300125, 22380078)
- National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
- National Institute of Neurological Disorders and Stroke (NS050275)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- D-serine, 3-phosphoglycerate dehydrogenase, serine racemase, NMDA receptor, L-serine biosynthesis, astrocytes, neurons, neuron-glia interactions, transgenic mice
- MeSH terms
- Serine Racemase, Animals, Astrocytes, Cerebral Cortex, Female, Glucose, Male, Mice, Transgenic, Synaptic Transmission, Neurons, Promoter Regions, Genetic, Serine, Racemases and Epimerases, Green Fluorescent Proteins, Phosphoglycerate Dehydrogenase, Mice, Primary Cell Culture
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