Cited by 341Bipolar Disorder and TreatmentNeuroscience and Neuropharmacology ResearchTreatment of Major Depression

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Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania

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Prickaerts, Jos, Moechars, Dieder, Cryns, Kim, Lenaerts, Ilse, van Craenendonck, Hansfried, Goris, Ilse, Daneels, Guy, Bouwknecht, J. Adriaan, Steckler, Thomas·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.5216-05.2006PMC PMC6675350

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Abstract

Lithium is used as treatment for bipolar disorder with particular efficacy in the treatment of mania. Lithium inhibits glycogen synthase kinase 3beta (GSK-3beta) directly or indirectly via stimulation of the kinase Akt-1. We therefore investigated the possibility that transgenic mice overexpressing GSK-3beta could be of relevance to model bipolar disorder. Transgenic mice showed hypophagia, an increased general locomotor activity, and decreased habituation as assessed in an open field, an increased acoustic startle response, and again decreased habituation. The forced swim test revealed a reduced immobility in transgenic mice, but this is probably related to the hyperactivity of the animals. There were no differences in baseline and stress-induced increases of plasma adrenocorticotrophic hormone and corticosterone levels. Molecular analysis suggests compensatory mechanisms in the striatum of these transgenic mice for the overload of active GSK-3beta by dimming the endogenous GSK-3beta signaling pathway via upregulation of Akt-1 expression. Brain-derived neurotrophic factor protein levels were increased in the hippocampus of the transgenic mice. This suggests some kind of compensatory mechanism to the observed reduction in brain weight, which has been related previously to a reduced size of the somatodendritic compartment. Together, in mice overexpressing GSK-3beta, specific intracellular signaling pathways are affected, which is accompanied by altered plasticity processes and increased activity and reactivity, whereas habituation processes seem to be decreased. The behavioral observations led to the suggestion that the model at hand recapitulates hyperactivity as observed in the manic phase of bipolar disorder.

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
GSK-3: tricks of the trade for a multi-tasking kinase
Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
Grimes, C. A., & Jope, R. S. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00011-9 · Cited by 1,440
GSK3 takes centre stage more than 20 years after its discovery
FRAME, S., & COHEN, P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590001 · Cited by 1,433
The neurobiology of startle
Koch, M. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00098-7 · Cited by 1,287
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206
Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics
BRAFF, D. L., Stone, C., Callaway, E., Geyer, M. A., Glick, I. D., & Bali, L. (1978) · Psychophysiology · doi:10.1111/j.1469-8986.1978.tb01390.x · Cited by 1,171

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Kakefuda, K., Oyagi, A., Ishisaka, M., Tsuruma, K., Shimazawa, M., Yokota, K., Shirai, Y., Horie, K., Saito, N., Takeda, J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013447 · Cited by 83
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Sharma, A. N., Fries, G. R., Galvez, J. F., Valvassori, S. S., Soares, J. C., Carvalho, A. F., & Quevedo, J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.001 · Cited by 51
Rhythm and mood: Relationships between the circadian clock and mood-related behavior.
Schnell, A., Albrecht, U., & Sandrelli, F. (2014) · Behavioral Neuroscience · doi:10.1037/a0035883 · Cited by 51
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Alon, L. T., Pietrokovski, S., Barkan, S., Avrahami, L., Kaidanovich‐Beilin, O., Woodgett, J. R., Barnea, A., & Eldar-Finkelman, H. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.025 · Cited by 54
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Kim, J. K., Forger, D. B., Marconi, M., Wood, D., Doran, A. C., Wager, T. T., Chang, C., & Walton, K. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.34 · Cited by 49
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Shioya, A., Saito, Y., Arima, K., Kakuta, Y., Yuzuriha, T., Tanaka, N., Murayama, S., & Tamaoka, A. (2015) · Neuropathology · doi:10.1111/neup.12191 · Cited by 47
An emerging role for Wnt and GSK3 signaling pathways in schizophrenia
Singh, K. K. (2013) · Clinical Genetics · doi:10.1111/cge.12111 · Cited by 46
Region‐specific dysregulation of glycogen synthase kinase‐3β and β‐catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia
Pandey, G. N., Rizavi, H. S., Tripathi, M., & Ren, X. (2014) · Bipolar Disorders · doi:10.1111/bdi.12228 · Cited by 45
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Spiers, J. G., Chen, H. C., Bourgognon, J.-M., & Steinert, J. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.025 · Cited by 46
The emerging role of dopamine–glutamate interaction and of the postsynaptic density in bipolar disorder pathophysiology: Implications for treatment
de Bartolomeis, A., Buonaguro, E. F., Iasevoli, F., & Tomasetti, C. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114523864 · Cited by 44
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Crivelli, S. M., Luo, Q., Stevens, J., Giovagnoni, C., van Kruining, D., Bode, G. H., den Hoedt, S., Hobo, B., Scheithauer, A.-L., Walter, J., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00780-0 · Cited by 41
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Li, M., Mo, Y., Luo, X., Xiao, X., Shi, L., Peng, Y., Qi, X., Liu, X., Yin, L.-D., Diao, H.-B., et al. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.09.013 · Cited by 43
Sleep and circadian disruption in bipolar disorders: From psychopathology to digital phenotyping in clinical practice
Tonon, A. C., Nexha, A., da Silva, M. M., Gomes, F. A., Hidalgo, M. P. L., & Frey, B. N. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13729 · Cited by 51
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Maurin, H., Lechat, B., Dewachter, I., Ris, L., Louis, J. V., Borghgraef, P., Devijver, H., Jaworski, T., & LEUVEN, F. V. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-27 · Cited by 39
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Avrahami, L., Licht-Murava, A., Eisenstein, M., & Eldar-Finkelman, H. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.01.016 · Cited by 41
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Rexhepaj, R., Dërmaku‐Sopjani, M., Gehring, E., Sopjani, M., Kempe, D. S., Föller, M., & Lang, F. J. W. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000322331 · Cited by 39
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Perrine, S. A., Miller, J. S., & Unterwald, E. M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05632.x · Cited by 38
Deficiency of diacylglycerol kinase η induces lithium‐sensitive mania‐like behavior
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GSK-3/Shaggy regulates olfactory habituation in Drosophila
Wolf, F. W., Eddison, M., Lee, S., Cho, W., & Heberlein, U. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700493104 · Cited by 36
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Kara, N., & Einat, H. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1594-x · Cited by 35
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Garza, J. C., Qi, X., Gjeluci, K., Leussis, M. P., Basu, H., Reis, S. A., Zhao, W. N., Piguel, N. H., Penzes, P., Haggarty, S. J., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0182-y · Cited by 37
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Sarnyai, Z., Alsaif, M., Bahn, S., Ernst, A., Guest, P. C., Hradetzky, E., Kluge, W. F., Stelzhammer, V., & Wesseling, H. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00008-0 · Cited by 35
Lithium preferentially inhibits adenylyl cyclase V and VII isoforms
Mann, L., Heldman, E., Shaltiel, G., Belmaker, R. H., & Agam, G. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008395 · Cited by 35
Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling
Qu, Z., Sun, D., & Young, W. (2011) · Cell & Bioscience · doi:10.1186/2045-3701-1-18 · Cited by 35
Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice.
Lee, F. H., Kaidanovich-Beilin, O., Roder, J., Woodgett, J., & Wong, A. H. C. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.03.032 · Cited by 31
Computer assisted video analysis of swimming performance in a forced swim test: Simultaneous assessment of duration of immobility and swimming style in mice selected for high and low swim-stress induced analgesia
Juszczak, G. R., Lisowski, P., Śliwa, A. T., & Swiergiel, A. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.07.003 · Cited by 33
Annual Research Review: Transgenic mouse models of childhood‐onset psychiatric disorders
Robertson, H. R., & Feng, G. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02380.x · Cited by 33
Paternal nicotine exposure induces hyperactivity in next-generation via down-regulating the expression of DAT
Zhang, M., Zhang, D., Dai, J., Cao, Y., Xu, W., He, G., Wang, Z., Wang, L., Li, R., & Qiao, Z. (2020) · Toxicology · doi:10.1016/j.tox.2020.152367 · Cited by 33
Lithium orotate: A superior option for lithium therapy?
Pacholko, A. G., & Bekar, L. K. (2021) · Brain and Behavior · doi:10.1002/brb3.2262 · Cited by 34
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Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
Geoffroy, P. A., Étain, B., Sportiche, S., & Bellivier, F. (2014) · International Journal of Bipolar Disorders · doi:10.1186/2194-7511-2-5 · Cited by 32
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Medina, M., & Ávila, J. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/ern.13.39 · Cited by 33
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Higher BDNF concentrations in the hippocampus and cortex of an aggressive mouse strain
Lang, U. E., Günther, L., SCHEUCH, K., KLEIN, J., Eckhart, S. G., Hellweg, R., Danker‐Hopfe, H., & Oehler, J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.025 · Cited by 31
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression
Zhou, R., Lu, Y., Han, Y., Li, X., Lou, H., Zhu, L., Zhen, X., & Duan, S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.007 · Cited by 30
GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions
Li, Q., Michaud, M., Canosa, S., Kuo, A., & Madri, J. A. (2011) · Angiogenesis · doi:10.1007/s10456-011-9201-9 · Cited by 30
β-Catenin Promoter ChIP-Chip Reveals Potential Schizophrenia and Bipolar Disorder Gene Network
Pedrosa, E., Shah, A., Tenore, C., Capogna, M., Villa, C., Guo, X., Zheng, D., & Lachman, H. M. (2010) · Journal of Neurogenetics · doi:10.3109/01677063.2010.495182 · Cited by 31
Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment
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Authors: Prickaerts, J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J. A., & Steckler, T.
Affiliations: Janssen Research & Development (United States) (US)
Corresponding author: Steckler, Thomas
ORCID: Prickaerts, Jos
Lenaerts, Ilse
Steckler, Thomas
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-08-30
Volume: 26
Issue: 35
Pages: 9022-9029
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5216-05.2006
PMC: PMC6675350
OpenAlex: W1963600261
Cited by: 341
References: 59
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 13 · 2021: 14 · 2020: 17 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 22 · 2015: 20 · 2014: 27 · 2013: 27 · 2012: 21
FWCI: 11.04
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, cc-by-nc-sa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders: European Commission
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: glycogen synthase kinase-3β, transgenic mice, hyperactivity, mania, bipolar disorder, lithium, AKT1, brain-derived neurotrophic factor, striatum, hippocampus, locomotor activity, acoustic startle response, habituation, ACTH, compensatory signaling, neuroplasticity
MeSH terms: Glycogen Synthase Kinase 3 beta, Adrenocorticotropic Hormone, Animals, Bipolar Disorder, Corticosterone, Disease Models, Animal, DNA, Drinking, Eating, Female, Hippocampus, Hyperkinesis, Male, Mice, Transgenic, Motor Activity, Reflex, Startle, Swimming, Signal Transduction, Photoperiod, Brain-Derived Neurotrophic Factor, Glycogen Synthase Kinase 3, Mice

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Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania

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