The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo
Open accessAbstract
Macroscopic changes in cerebral blood flow, such as those captured by functional imaging of the brain, require highly organized, large-scale dynamics of astrocytes, glial cells that interact with both neuronal and cerebrovascular networks. However, astrocyte activity has been studied mainly at the level of individual cells, and information regarding their collective behavior is lacking. In this work, we monitored calcium activity simultaneously from hundreds of mouse hippocampal astrocytes in vivo and found that almost all astrocytes participated en masse in regenerative waves that propagated from cell to cell (referred to here as “glissandi”). Glissandi emerged depending on the neuronal activity and accompanied a reduction in infraslow fluctuations of local field potentials and a decrease in the flow of red blood cells. This novel phenomenon was heretofore overlooked, probably because of the high vulnerability of astrocytes to light damage; glissandi occurred only when observed at much lower laser intensities than previously used.
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Cites
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
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Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
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Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
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On the relationship between slow cortical potentials and BOLD signal changes in humans
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Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244
“…increase of neurotransmitters in the synaptic cleft, such as glutamate, GABA and ATP, has the high relationship with the pathogenesis of MDD. 41,496 The interaction between neurons and glial cells can induce the oxidative stress, pro-in fl ammatory cytokines released, the reduction of…”
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Development of a Method for the Purification and Culture of Rodent Astrocytes
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Astrocytes Mediate In Vivo Cholinergic-Induced Synaptic Plasticity
Navarrete, M., Perea, G., de Sevilla, D. F., Gómez-Gonzalo, M., Núñez, A., Martín, E. D., & Araque, A. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001259 · Cited by 387
Metadata
- Authors
- Kuga, N., Sasaki, T., Takahara, Y., Matsuki, N., & Ikegaya, Y.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-02-16
- Volume
- 31
- Issue
- 7
- Pages
- 2607-2614
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2065349788
- Cited by
- 261
- References
- 8
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kuga, N., Sasaki, T., Takahara, Y., Matsuki, N., & Ikegaya, Y. (2011). Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.5319-10.2011
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