The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo
Open accessAbstract
Semaphorins and their receptors, plexins, have emerged as important cellular cues regulating key developmental processes. B-type plexins directly regulate the actin cytoskeleton in a variety of cell types. Recently, B-type plexins have been shown to be expressed in striking patterns in the nervous system over critical developmental windows. However, in contrast to the well characterized plexin-A family, the functional role of plexin-B proteins in neural development and organogenesis in vertebrates in vivo is not known. Here, we have elucidated the functional contribution of the two neuronally expressed plexin-B proteins, Plexin-B1 or Plexin-B2, toward the development of the peripheral nervous system and the CNS by generating and analyzing constitutive knock-out mice. The development of the nervous system was found to be normal in mice lacking Plexin-B1, whereas mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and a conspicuous disorganization of the embryonic brain. After analyzing mutant mice, which bypassed neural tube defects, we observed a key requirement for Plexin-B2 in proliferation and migration of granule cell precursors in the developing dentate gyrus, olfactory bulb, and cerebellum. Furthermore, we identified semaphorin 4C as a high-affinity ligand for Plexin-B2 in binding and functional assays. Semaphorin 4C stimulated activation of ErbB-2 and RhoA via Plexin-B2 and enhanced proliferation and migration of granule cell precursors. Semaphorin 4C-induced proliferation of ventricular zone neuroblasts was abrogated in mice lacking Plexin-B2. These genetic and functional analyses reveal a key requirement for Plexin-B2, but not Plexin-B1, in patterning of the vertebrate nervous system in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Plexin-B1 knockout (KO) mice are viable and fertile, with no overt neurodevelopmental defects21, 22.”
From Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease (2024) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · cited 1×
“Indeed, approaches interfering with RhoA activity, such as inhibition of RhoA-dependent kinase (ROCK) or RhoA knockdown, in neurulating embryos have been reported to result in neural tube defects (Cummings et al., 2001).”
BackgroundTamagnone, L., Artigiani, S., Chen, H., He, Z., Ming, G., Song, H., Chédotal, A., Winberg, M. L., Goodman, C. S., Poo, M.-M., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80063-x · Cited by 1,163
Self-citationEfficient in vivo manipulation of mouse genomic sequences at the zygote stage.
Lakso, M., Pichel, J. G., Gorman, J. R., Sauer, B., Okamoto, Y., Lee, E., Alt, F. W., & Westphal, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5860 · Cited by 1,125
The role of the Rho GTPases in neuronal developmentPreprint
Govek, E., Newey, S. E., & Aelst, L. V. (2005) · Genes & Development · doi:10.1101/gad.1256405 · Cited by 1,030
Sonic hedgehog regulates the growth and patterning of the cerebellum
Dahmane, N., & Altaba, A. R. I. (1999) · Development · doi:10.1242/dev.126.14.3089 · Cited by 908
Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors
Takahashi, T., Fournier, A. E., Nakamura, F., Wang, L.-H., Murakami, Y., Kalb, R. G., Fujisawa, H., & Strittmatter, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80062-8 · Cited by 817
Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins
Gu, C., Yoshida, Y., Livet, J., Reimert, D. V., Mann, F., Merte, J., Henderson, C. E., Jessell, T. M., Kolodkin, A. L., & Ginty, D. D. (2004) · Science · doi:10.1126/science.1105416 · Cited by 543
Semaphorins command cells to move
Kruger, R. P., Aurandt, J., & Guan, K. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1740 · Cited by 508
Semaphorins and their receptors in vertebrates and invertebrates
Raper, J. A. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00057-4 · Cited by 465
The Semaphorin 4D receptor controls invasive growth by coupling with Met
Giordano, S., Corso, S., Conrotto, P., Artigiani, S., Gilestro, G. F., Barberis, D., Tamagnone, L., & Comoglio, P. M. (2002) · Nature Cell Biology · doi:10.1038/ncb843 · Cited by 444
Self-citation
Cited by
Sorted by citations
Semaphorins and plexins as therapeutic targets
Worzfeld, T., & Offermanns, S. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4337 · Cited by 325
Self-citationGetting neural circuits into shape with semaphorins
Pasterkamp, R. J. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3302 · Cited by 281
Zhou, X., Wahane, S., Friedl, M.-S., Kluge, M., Friedel, C. C., Avrampou, K., Zachariou, V., Guo, L., Zhang, B., He, X., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0597-7 · Cited by 275
Immunological functions of the neuropilins and plexins as receptors for semaphorins
Kumanogoh, A., & Kikutani, H. (2013) · Nature reviews. Immunology · doi:10.1038/nri3545 · Cited by 221
Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance
Santavanond, J. P., Rutter, S. F., Atkin‐Smith, G. K., & Poon, I. K. H. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_4 · Cited by 211
The role of Rho GTPase proteins in CNS neuronal migration
Govek, E., Hatten, M. E., & Aelst, L. V. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20850 · Cited by 181
The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function
Witherden, D. A., Watanabe, M., Garijo, O., Rieder, S., Sarkisyan, G., Cronin, S. J. F., Verdino, P., Wilson, I. A., Kumanogoh, A., Kikutani, H., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.026 · Cited by 164
Hota, P. K., & Buck, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1019-0 · Cited by 170
Should I stay or should I go? Becoming a granule cell
Chédotal, A. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.004 · Cited by 145
The proteome of rat olfactory sensory cilia
Mayer, U., Küller, A., Daiber, P. C., Neudorf, I., Warnken, U. H., Schnölzer, M., Frings, S., & Möhrlen, F. (2008) · PROTEOMICS · doi:10.1002/pmic.200800149 · Cited by 122
Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin
Yu, W., Goncalves, K. A., Li, S., Kishikawa, H., Sun, G., Yang, H., Vanli, N., Wu, Y., Jiang, Y., Hu, M. G., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.005 · Cited by 121
Giacobini, P., Messina, A., Morello, F., Ferraris, N., Corso, S., Penachioni, J. Y., Giordano, S., Tamagnone, L., & Fasolo, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806160 · Cited by 108
Self-citationErbB-2 signals through Plexin-B1 to promote breast cancer metastasis
Worzfeld, T., Swiercz, J. M., Looso, M., Straub, B. K., Sivaraj, K. K., & Offermanns, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60568 · Cited by 94
Self-citationSemaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development
Maier, V., Jolicoeur, C., Rayburn, H., Takegahara, N., Kumanogoh, A., Kikutani, H., Tessier‐Lavigne, M., Wurst, W., & Friedel, R. H. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.005 · Cited by 91
Gurrapu, S., Pupo, E., Franzolin, G., Lanzetti, L., & Tamagnone, L. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0097-4 · Cited by 81
Self-citationSiu, M., Butcher, D. T., Turinsky, A. L., Cytrynbaum, C. S., Stavropoulos, D. J., Walker, S., Caluseriu, O., Carter, M., Lou, Y., Nicolson, R., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0684-3 · Cited by 82
Zhang, C., Xiao, C., Dang, E., Cao, J., Zhu, Z., Fu, M., Yao, X., Liu, Y., Jin, B., Wang, G., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.09.005 · Cited by 78
Buglo, E., Sarmiento, E., Martuscelli, N. B., Sant, D., Danzi, M. C., Abrams, A. J., Dallman, J. E., & Zuchner, S. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230566 · Cited by 74
Azzarelli, R., Pacary, E., Garg, R., Garcez, P. P., van den Berg, D. L. C., Riou, P., Ridley, A. J., Friedel, R. H., Parsons, M., & Guillemot, F. (2014) · Nature Communications · doi:10.1038/ncomms4405 · Cited by 75
Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?
Iragavarapu‐Charyulu, V., Wojcikiewicz, E. P., & Urdaneta, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00346 · Cited by 72
Semaphorins and Plexins in central nervous system patterning: the key to it all?
Limoni, G., & Niquille, M. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.014 · Cited by 61
Mechanochemical control of epidermal stem cell divisions by B-plexins
Chen, J., Javed, A., Kaiser, L., Nava, M. M., Xu, R. C., Brandt, D. T., Zhao, D., Mayer, B., Fernández-Baldovinos, J., Zhou, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21513-9 · Cited by 73
Self-citationXia, J., Swiercz, J. M., Bañón‐Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, C., Kumanogoh, A., Friedel, R. H., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.02.001 · Cited by 69
Self-citationIdentification of 22q13 genes most likely to contribute to Phelan McDermid syndrome
Mitz, A. R., Philyaw, T. J., Boccuto, L., Shcheglovitov, A., Sarasua, S. M., Kaufmann, W. E., & Thurm, A. E. (2018) · European Journal of Human Genetics · doi:10.1038/s41431-017-0042-x · Cited by 72
Plexin-B2 promotes invasive growth of malignant glioma
Le, A. P., Huang, Y., Pingle, S. C., Kesari, S., Wang, H., Yong, R. L. M., Zou, H., & Friedel, R. H. (2015) · Oncotarget · doi:10.18632/oncotarget.3421 · Cited by 68
More than nervous: The emerging roles of plexins
Perälä, N., Sariola, H., & Immonen, T. (2012) · Differentiation · doi:10.1016/j.diff.2011.08.001 · Cited by 66
In vivo interaction screening reveals liver-derived constraints to metastasis
Borrelli, C., Roberts, M., Eletto, D., Hussherr, M., Fazilaty, H., Valenta, T., Lafzi, A., Kretz, J. A., Vinzoni, E. G., Karakatsani, A., et al. (2024) · Nature · doi:10.1038/s41586-024-07715-3 · Cited by 67
Genetic dissection of plexin signaling in vivo
Worzfeld, T., Swiercz, J. M., Sentürk, A., Genz, B., Korostylev, A., Deng, S., Xia, J., Hoshino, M., Epstein, J. A., Chan, A. M.-L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308418111 · Cited by 62
Self-citationSaha, B., Ypsilanti, A. R., Boutin, C., Cremer, H., & Chédotal, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0344-12.2012 · Cited by 62
Alves, C. J., Dariolli, R., Haydak, J. C., Kang, S., Hannah, T. C., Wiener, R. J., DeFronzo, S., Tejero, R., Gusella, G. L., Ramakrishnan, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26296-7 · Cited by 55
Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly
Atkin‐Smith, G. K., Miles, M. A., Tixeira, R., Lay, F. T., Duan, M., Hawkins, C. J., Phan, T. K., Paone, S., Mathivanan, S., Hulett, M. D., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.014 · Cited by 55
Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center
Yan, H., Wu, L., Shih, C., Hou, S., Shi, J., Mao, T., Chen, W., Melvin, B., Rigby, R. J., Chen, Y., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.022 · Cited by 54
Ricciardello, A., Tomaiuolo, P., & Persico, A. M. (2021) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62222 · Cited by 48
Hirschberg, A., Deng, S., Korostylev, A., Páldy, E., Costa, M. R., Worzfeld, T., Vodrazka, P., Wizenmann, A., Götz, M., Offermanns, S., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01458-09 · Cited by 48
Self-citationCostes, V., Chaulot‐Talmon, A., Sellem, E., Perrier, J., Aubert-Frambourg, A., Jouneau, L., Pontlevoy, C., Hozé, C., Fritz, S., Boussaha, M., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01275-x · Cited by 52
Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury
Mehrotra, P., Jablonski, J., Toftegaard, J., Zhang, Y., Shahini, S., Wang, J., Hung, C. W., Ellis, R., Kayal, G., Rajabian, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53276-4 · Cited by 53
Semaphorin 4A, 4C, and 4D: Function comparison in the autoimmunity, allergy, and cancer
Rajabinejad, M., Asadi, G., Ranjbar, S., Hezarkhani, L. A., Salari, F., Karaji, A. G., & Rezaiemanesh, A. (2020) · Gene · doi:10.1016/j.gene.2020.144637 · Cited by 49
Plexin-B2 Negatively Regulates Macrophage Motility, Rac, and Cdc42 Activation
Roney, K. E., O’Connor, B. P., Wen, H., Holl, E. K., Guthrie, E. H., Davis, B. K., Jones, S. W., Jha, S., Sharek, L., García‐Mata, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024795 · Cited by 46
Sema4A induces cell morphological changes through B-type plexin-mediated signaling
Yukawa (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000334 · Cited by 46
Vodrazka, P., Korostylev, A., Hirschberg, A., Swiercz, J. M., Worzfeld, T., Deng, S., Fazzari, P., Tamagnone, L., Offermanns, S., & Kuner, R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06934.x · Cited by 46
Self-citationSemaphorin 4D Promotes Skeletal Metastasis in Breast Cancer
Yang, Y.-H., Buhamrah, A., Schneider, A., Lin, Y., Zhou, H., Bugshan, A., & Basile, J. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150151 · Cited by 45
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer
Yang, J., Zeng, Z., Qiao, L., Jiang, X., Ma, J., Wang, J., Ye, S., Ma, Q., Wei, J., Wu, M., et al. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0933 · Cited by 45
Korostylev, A., Worzfeld, T., Deng, S., Friedel, R. H., Swiercz, J. M., Vodrazka, P., Maier, V., Hirschberg, A., Ohoka, Y., Inagaki, S., et al. (2008) · Development · doi:10.1242/dev.019760 · Cited by 45
Self-citationA reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
Sun, T., Yang, L., Kaur, H., Pestel, J., Looso, M., Nolte, H., Krasel, C., Heil, D., Krishnan, R. K., Santoni, M.-J., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201602002 · Cited by 44
Self-citationAntagonistic interactions among Plexins regulate the timing of intersegmental vessel formation
Lamont, R. E., Lamont, E. J., & Childs, S. J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.04.037 · Cited by 44
McDermott, J. E., Goldblatt, D., & Paradis, S. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.06.008 · Cited by 42
Huang, Y., Wang, M., Ni, H., Zhang, J., Li, A., Hu, B., Junqueira Alves, C., Wahane, S., Rios de Anda, M., Ho, L., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01664-w · Cited by 42
“Plexin-B1 knockout (KO) mice are viable and fertile, with no overt neurodevelopmental defects 21,22 , but important functions of Plexin-B1 in immune system activation and bone homeostasis of adult animals have been reported 23–25 .”
Zielonka, M., Xia, J., Friedel, R. H., Offermanns, S., & Worzfeld, T. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.05.007 · Cited by 42
Self-citationSimonetti, M., Paldy, E., Njoo, C., Bali, K. K., Worzfeld, T., Pitzer, C., Kuner, T., Offermanns, S., Mauceri, D., & Kuner, R. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0491-4 · Cited by 41
Self-citationPáldy, E., Simonetti, M., Worzfeld, T., Bali, K. K., Vicuña, L., Offermanns, S., & Kuner, R. (2017) · Nature Communications · doi:10.1038/s41467-017-00341-w · Cited by 38
Self-citationSema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
Perälä, N. M., Jakobson, M., Ola, R., Fazzari, P., Penachioni, J. Y., Nymark, M., Tanninen, T. H., Immonen, T., Tamagnone, L., & Sariola, H. V. (2010) · Differentiation · doi:10.1016/j.diff.2010.10.001 · Cited by 38
Self-citationAn ENU-Mutagenesis Screen in the Mouse: Identification of Novel Developmental Gene Functions
Wansleeben, C., van Gurp, L., Feitsma, H., Kroon, C., Rieter, E., Verberne, M. E., Guryev, V., Cuppen, E. P. J. G., & Meijlink, F. C. P. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019357 · Cited by 37
Impaired cortical neurogenesis in plexin‐B 1 and ‐B 2 double deletion mutant
Daviaud, N., Chen, K., Huang, Y., Friedel, R. H., & Zou, H. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22364 · Cited by 35
Engineering strategies for apoptotic bodies
Hu, Z., Qian, S., Zhao, Q., Lu, B., Lu, Q., Wang, Y., Zhang, L., Mao, X., Wang, D., Cui, W., et al. (2024) · Smart Medicine · doi:10.1002/smmd.20240005 · Cited by 36
Swiercz, J. M., Worzfeld, T., & Offermanns, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00103-09 · Cited by 38
Self-citationOlig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury
Ueno, M., Nakamura, Y., Nakagawa, H., Niehaus, J. K., Maezawa, M., Gu, Z., Kumanogoh, A., Takebayashi, H., Lu, Q. R., Takada, M., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa142 · Cited by 28
Rnd3-induced cell rounding requires interaction with Plexin-B2
McColl, B., Garg, R., Riou, P., Riento, K., & Ridley, A. J. (2016) · Journal of Cell Science · doi:10.1242/jcs.192211 · Cited by 26
Mice lacking Plexin-B3 display normal CNS morphology and behaviour
Worzfeld, T., Rauch, P. J., Karram, K., Trotter, J., Kuner, R., & Offermanns, S. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.08.008 · Cited by 25
Self-citationPNPase knockout results in mtDNA loss and an altered metabolic gene expression program
Shimada, E., Ahsan, F., Nili, M., Huang, D., Atamdede, S., TeSlaa, T. A., Case, D., Yu, X., Gregory, B. D., Perrin, B., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200925 · Cited by 23
Liu, F., Cheng, X., Zhao, C., Zhang, X., Liu, C., Zhong, S., Lin, X., Lin, X., Qiu, W., & Zhang, X. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01109-7 · Cited by 24
Bulloj, A., Maminishkis, A., Mizui, M., & Finnemann, S. C. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0649-5 · Cited by 23
SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis
Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Bomberger, H. E., Shamsan, G. A., Peterson, J. J., Crosby, M. R., Draper, G. M., Becklin, K. L., Rahrmann, E. P., et al. (2019) · Oncogene · doi:10.1038/s41388-019-1041-x · Cited by 21
Grb2 mediates semaphorin-4D-dependent RhoA inactivation
Sun, T., Krishnan, R. K., & Swiercz, J. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.101063 · Cited by 21
Self-citationAge-related loss of axonal regeneration is reflected by the level of local translation
van Erp, S., van Berkel, A. A., Feenstra, E. M., Sahoo, P. K., Wagstaff, L. J., Twiss, J. L., Fawcett, J. W., Eva, R., & ffrench‐Constant, C. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113594 · Cited by 23
Wang, X., Shi, W., Zhao, S., Gong, D., Li, S., Hu, C., Chen, Z., Li, Y., & Yan, J. (2023) · Human Reproduction · doi:10.1093/humrep/dead039 · Cited by 20
Casden, N., Belzer, V., Khayari, A. E., Fatimy, R. E., & Behar, O. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400648121 · Cited by 19
Impact of semaphorin expression on prognostic characteristics in breast cancer
Butti, R., Kumar, T. V. S., Nimma, R., & Kundu, G. C. (2018) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s135753 · Cited by 19
The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases
Wang, N., Dhumale, P., Chiang, J., & Püschel, A. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-34092-5 · Cited by 18
Semaphorin 4D as a guidance molecule in the immune system
Куклина, Е. М. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1905807 · Cited by 18
Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells
Xue, D., Kaufman, G., Dembele, M., Béland, M., Massoud, A. H., Mindt, B. C., Fiter, R., Fixman, E. D., Martin, J. G., Friedel, R. H., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600831 · Cited by 18
Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons
van Battum, E. Y., Heitz‐Marchaland, C., Zagar, Y., Fouquet, S., Kuner, R., & Chédotal, A. (2021) · eLife · doi:10.7554/elife.60554 · Cited by 17
Self-citationMsheik, Z. S., Nassar, F. J., Chamandi, G., Itani, A. R., Gadaleta, E., Chalala, C., Alwan, N. H., & Nasr, R. (2022) · Diagnostics · doi:10.3390/diagnostics12030745 · Cited by 16
Murakami, T., Takahata, Y., Hata, K., Ebina, K., Hirose, K., Ruengsinpinya, L., Nakaminami, Y., Etani, Y., Kobayashi, S., Maruyama, T., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abl5304 · Cited by 15
Mitz, A. R., Boccuto, L., & Thurm, A. E. (2024) · Clinical Genetics · doi:10.1111/cge.14503 · Cited by 14
Chen, D., Wu, C., Wei, S., Guo, Y., Wu, M., Zhou, S., Fu, F., Tang, W., Xue, L., Zhang, J., et al. (2023) · Molecular Human Reproduction · doi:10.1093/molehr/gaad010 · Cited by 14
Schuster, E. J., Dashzeveg, N. K., Tong, F., Jia, Y., El-Shennawy, L., Zhang, T., Hoffman, A. D., Kitata, R. B., Kibria, G., Zhang, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62862-z · Cited by 13
Li, Z., Muller‐Greven, J., Kim, S., Tamagnone, L., & Buck, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03571-2 · Cited by 13
Self-citationB-plexins control microtubule dynamics and dendrite morphology of hippocampal neurons
Laht, P., Otsus, M., Remm, J., & Veske, A. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.06.005 · Cited by 14
Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Adel, S. S., Pranske, Z. J., Kowalski, T. F., Kanzler, N., Ray, R., Carmona, C., & Paradis, S. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103920 · Cited by 11
Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models
Shorning, B. Y., Trent, N., Griffiths, D. F. R., Worzfeld, T., Offermanns, S., Smalley, M. J., & Williamson, M. P. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0480 · Cited by 12
Self-citationPlexin-B2 in psoriasis; a clinical and immunohistochemical study
Hemida, A. S., Mareae, A. H., Elbasiony, A. S. A., & Shehata, W. A. (2020) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2020.1741385 · Cited by 10
Gerstmann, K., Kindbeiter, K., Telley, L., Bozon, M., Reynaud, F., Théoulle, E., Charoy, C., Jabaudon, D., Moret, F., & Castellani, V. (2022) · Science Advances · doi:10.1126/sciadv.abo4552 · Cited by 15
Muscone Can Improve Spinal Cord Injury by Activating the Angiogenin/Plexin-B2 Axis
Zhou, Y., Guo, S., Botchway, B. O. A., Zhang, Y., Jin, T., & Liu, X.-H. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02948-7 · Cited by 10
Vogler, M., Oleksy, A., Schulze, S., Fedorova, M., Kojonazarov, B. K., Nijjar, S., Patel, S. V., Jossi, S. E., Sawmynaden, K., Henry, M., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102265 · Cited by 9
Self-citationPlexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons
Laht, P., Tammaru, E., Otsus, M., Rohtla, J., Tiismus, L., & Veske, A. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.05.007 · Cited by 8
The RacGAP β-Chimaerin is essential for cerebellar granule cell migration
Estep, J. A., Wong, W., Wong, Y.-C. E., Loui, B. M., & Riccomagno, M. M. (2018) · Scientific Reports · doi:10.1038/s41598-017-19116-w · Cited by 8
Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis
Zu, C., Li, J., He, X., Ji, L., & Li, X. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221082929 · Cited by 8
Brundu, S., Napolitano, V., Franzolin, G., Cascio, E. L., Mastrantonio, R., Sardo, G., Cascardi, E., Verginelli, F., Sarnataro, S., Gambardella, G., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216104 · Cited by 8
Self-citationNi, H., Zhou, Z., Estill, M. S., Halawani, D., Alves, C. J., Shen, L., Xie, N., Friedel, R. H., & Zou, H. (2025) · Nature Communications · doi:10.1038/s41467-025-65095-2 · Cited by 8
Development and maturation of the spinal cord
Hawryluk, G. W. J., Ruff, C. A., & Fehlings, M. G. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52137-8.00001-2 · Cited by 7
Conservation, expression, and knockdown of zebrafish plxnb2a and plxnb2b
Perälä, N. M., Peitsaro, N., Sundvik, M., Koivula, H., Sainio, K., Sariola, H. V., Panula, P., & Immonen, T. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22397 · Cited by 7
Smith, C. E. L., Laugel-Haushalter, V., Hany, U., Best, S. K., Taylor, R. L., Poulter, J. A., Wortmann, S. B., Feichtinger, R. G., Mayr, J. A., Al‐Bahlani, S., et al. (2024) · Journal of Medical Genetics · doi:10.1136/jmg-2023-109728 · Cited by 7
PLXNB1 mutations in the etiology of idiopathic hypogonadotropic hypogonadism
Welch, B. A., Cho, H.-J., Uçaktürk, S. A., Farmer, S. M., Çetinkaya, S. Ç., Abacı, A., Akkuş, G., Şimşek, E., Kotan, L. D., Turan, İ., et al. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13103 · Cited by 7
Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins
Chapoval, S. P., Gao, H., Fanaroff, R. E., & Keegan, A. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1297354 · Cited by 5
Plexin B2 in physiology and pathophysiology of the central nervous system
Wang, Q., Zhang, Y., Ma, K., Lin, P., Wang, Y., Wang, R., Li, H., Li, Z., & Wang, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114627 · Cited by 5
Liu, Y., Qu, H., Chang, X., Mentch, F. D., Qiu, H., Nguyen, K., Wang, X., Saeidian, A. H., Watson, D. J., Glessner, J., et al. (2022) · Biomarker Research · doi:10.1186/s40364-022-00431-y · Cited by 5
Plexin-mediated neuronal development and neuroinflammatory responses in the nervous system.
Dai, L., Shen, K., & Zhang, C. (2023) · PubMed · doi:10.14670/hh-18-625 · Cited by 5
Darville, L. N. F., & Sokolowski, B. H. A. (2018) · Proteome Science · doi:10.1186/s12953-018-0144-6 · Cited by 5
Gerstmann, K., Kindbeiter, K., Telley, L., Bozon, M., Charoy, C., Jabaudon, D., Moret, F., & Castellani, V. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.20.106526 · Cited by 5
Schuster, E. J., Dashzeveg, N. K., Jia, Y., Golam, K., Zhang, T., Hoffman, A., Zhang, Y., Zheng, C., Ramos, E. K., Taftaf, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.10.536233 · Cited by 4
Metadata
- Authors
- Deng, S., Hirschberg, A., Worzfeld, T., Penachioni, J. Y., Korostylev, A., Swiercz, J. M., Vodrazka, P., Mauti, O., Stoeckli, E. T., Tamagnone, L., Offermanns, S., & Kuner, R.
- Affiliations
- Heidelberg University (DE)
- University of Turin (IT)
- University of Zurich (CH)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-06
- Volume
- 27
- Issue
- 23
- Pages
- 6333-6347
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672150
- OpenAlex
- W1977584759
- Cited by
- 121
- References
- 52
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 1 · 2012: 8
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 488)
- Universität Heidelberg
- Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN2005)
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Plexin-B2, Plexin-B1, semaphorin receptors, neural tube closure, neural tube defects, neuronal migration, granule cell precursors, dentate gyrus, olfactory bulb, cerebellum, ERBB2, RhoA, actin cytoskeleton, peripheral nervous system development, knockout mice
- MeSH terms
- Animals, Cell Movement, Chlorocebus aethiops, Cerebellum, Humans, Nerve Tissue Proteins, Nervous System, Receptors, Cell Surface, Prosencephalon, Mice, Knockout, Body Patterning, COS Cells, Organogenesis, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
