Cited by 66Axon Guidance and Neuronal SignalingDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

More than nervous: The emerging roles of plexins

Perälä, Nina, Sariola, Hannu, Immonen, Tiina·2012·Differentiation

Abstract

Plexins are the receptors for semaphorins, a large family of axon guidance cues. Accordingly, the role of plexins in the development of the nervous system was the first to be acknowledged. However, the expression of plexins is not restricted to neuronal cells, and recent research has been increasingly focused on the roles of plexin-semaphorin signalling outside of the nervous system. During embryogenesis, plexins regulate the development of many organs, including the cardiovascular system, skeleton and kidney. They have also been shown to be involved in immune system functions and tumour progression. Analyses of the plexin signalling in different tissues and cell types have provided new insight to the versatility of plexin interactions with semaphorins and other cell-surface receptors. In this review we try to summarise the current understanding of the roles of plexins in non-neural development and immunity.

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Crossref · 10.1016/j.diff.2011.08.001

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Authors
Perälä, N., Sariola, H., & Immonen, T.
Affiliations
University of Helsinki (FI)
Corresponding author
Immonen, Tiina
Venue
Differentiation
Publisher
Elsevier BV
Published
2012-01
Volume
83
Issue
1
Pages
77-91
ISSN
0301-4681 (ISSN-L)
OpenAlex
W2319601890
Cited by
66
References
152
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 7 · 2012: 6
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Locations
  • Differentiation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
plexins, semaphorins, embryonic development, cardiovascular development, skeletal development, kidney development, immune system, tumor progression, cell surface receptors
MeSH terms
Bone and Bones, Cardiovascular System, Cell Transformation, Neoplastic, Humans, Immune System, Kidney, Neovascularization, Pathologic, Nerve Tissue Proteins, Signal Transduction, Cell Adhesion Molecules, Gene Expression Regulation, Developmental, Semaphorins

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