More than nervous: The emerging roles of plexins
Abstract
Plexins are the receptors for semaphorins, a large family of axon guidance cues. Accordingly, the role of plexins in the development of the nervous system was the first to be acknowledged. However, the expression of plexins is not restricted to neuronal cells, and recent research has been increasingly focused on the roles of plexin-semaphorin signalling outside of the nervous system. During embryogenesis, plexins regulate the development of many organs, including the cardiovascular system, skeleton and kidney. They have also been shown to be involved in immune system functions and tumour progression. Analyses of the plexin signalling in different tissues and cell types have provided new insight to the versatility of plexin interactions with semaphorins and other cell-surface receptors. In this review we try to summarise the current understanding of the roles of plexins in non-neural development and immunity.
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The CR1 susceptibility allele explains 0.39% of variance in β-amyloid load in our data.
“For example, the CR1 susceptibility allele explains 0.39% of variance in β-amyloid load in our data34.”
From A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease (2018) · cites this paper as [34]
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Self-citation
Flagged first, then by citations
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Mostafavi, S., Gaiteri, C., Sullivan, S. E., White, C. C., Tasaki, S., Xu, J., Taga, M., Klein, H.-U., Patrick, E., Komashko, V., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0154-9 · Cited by 509 · see citing works
- Authors
- Perälä, N., Sariola, H., & Immonen, T.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Immonen, Tiina
- Venue
- Differentiation
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 83
- Issue
- 1
- Pages
- 77-91
- ISSN
- 0301-4681 (ISSN-L)
- OpenAlex
- W2319601890
- Cited by
- 66
- References
- 152
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 7 · 2012: 6
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- plexins, semaphorins, embryonic development, cardiovascular development, skeletal development, kidney development, immune system, tumor progression, cell surface receptors
- MeSH terms
- Bone and Bones, Cardiovascular System, Cell Transformation, Neoplastic, Humans, Immune System, Kidney, Neovascularization, Pathologic, Nerve Tissue Proteins, Signal Transduction, Cell Adhesion Molecules, Gene Expression Regulation, Developmental, Semaphorins
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