The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cortical and Subcortical Connectivity Changes during Decreasing Levels of Consciousness in Humans: A Functional Magnetic Resonance Imaging Study using Propofol
Open accessAbstract
While ubiquitous, pharmacological manipulation of consciousness remains poorly defined and incompletely understood (Prys-Roberts, 1987). This retards anesthetic drug development, confounds interpretation of animal studies conducted under anesthesia, and limits the sensitivity of clinical monitors of cerebral function to intact perception. Animal and human studies propose a functional "switch" at the level of the thalamus, with inhibition of thalamo-cortical transmission characterizing loss of consciousness (Alkire et al., 2000; Mashour, 2006). We investigated the effects of propofol, widely used for anesthesia and sedation, on spontaneous and evoked cerebral activity using functional magnetic resonance imaging (fMRI). A series of auditory and noxious stimuli was presented to eight healthy volunteers at three behavioral states: awake, "sedated" and "unresponsive." Performance in a verbal task and the absence of a response to verbal stimulation, rather than propofol concentrations, were used to define these states clinically. Analysis of stimulus-related blood oxygenation level-dependent signal changes identified reductions in cortical and subcortical responses to auditory and noxious stimuli in sedated and unresponsive states. A specific reduction in activity within the putamen was noted and further investigated with functional connectivity analysis. Progressive failure to perceive or respond to auditory or noxious stimuli was associated with a reduction in the functional connectivity between the putamen and other brain regions, while thalamo-cortical connectivity was relatively preserved. This result has not been previously described and suggests that disruption of subcortical thalamo-regulatory systems may occur before, or even precipitate, failure of thalamo-cortical transmission with the induction of unconsciousness.
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Cites
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Cited by
General Anesthesia, Sleep, and Coma
Brown, E. N., Lydic, R., & Schiff, N. D. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0808281 · Cited by 1,350
Structure and function of complex brain networks
Sporns, O. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.3/osporns · Cited by 932
On the stability of BOLD fMRI correlations
Laumann, T. O., Snyder, A. Z., Mitra, A., Gordon, E. M., Gratton, C., Adeyemo, B., Gilmore, A. W., Nelson, S. M., Berg, J. J., Greene, D. J., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw265 · Cited by 516
Unresponsiveness ≠ unconsciousness
Sanders, R. D., Tononi, G., Laureys, S., Sleigh, J. W., & Warner, D. S. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318249d0a7 · Cited by 474
Consciousness and Complexity during Unresponsiveness Induced by Propofol, Xenon, and Ketamine
Sarasso, S., Boly, M., Napolitani, M., Gosseries, O., Charland-Verville, V., Casarotto, S., Rosanova, M., Casali, A. G., Brichant, J.-F., Boveroux, P., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.10.014 · Cited by 399
Metadata
- Authors
- Mhuircheartaigh, R. N., Rosenorn-Lanng, D., Wise, R., Jbabdi, S., Rogers, R., & Tracey, I.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-07-07
- Volume
- 30
- Issue
- 27
- Pages
- 9095-9102
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2097792392
- Cited by
- 208
- References
- 10
- FWCI
- 20.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mhuircheartaigh, R. N., Rosenorn-Lanng, D., Wise, R., Jbabdi, S., Rogers, R., & Tracey, I. (2010). Cortical and Subcortical Connectivity Changes during Decreasing Levels of Consciousness in Humans: A Functional Magnetic Resonance Imaging Study using Propofol. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.5516-09.2010
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