The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
TLR7 Negatively Regulates Dendrite Outgrowth through the Myd88-c-Fos-IL-6 Pathway
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Accordingly, the dual TLR7/8 agonist resiquimod was reported to inhibit neurite outgrowth [65, 66].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [65]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“in which dendritic outgrowth is regulated by both TLR7 and certain cytokines, such as IL-6 [65].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
O'Neill, L. A. J., & Bowie, A. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2079 · Cited by 2,667
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 2×
“TLR7 / (Lund et al., 2004), Myd88 / (Hou et al., 2008), IL-6 / (Kopf et al., 1994), TNF- / (Pasparakis et al., 1996), and TRIF mutant mice (Hoebe et al., 2003) in a C57BL/6 genetic background were imported from the Jackson Laboratory and were housed in the animal facility of the Institute of…”
MethodImmune involvement in schizophrenia and autism: Etiology, pathology and animal models
Patterson, P. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.016 · Cited by 766
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
Chevrier, N., Mertins, P., Artyomov, M. N., Shalek, A. K., Iannacone, M., Ciaccio, M. F., Gat-Viks, I., Tonti, E., DeGrace, M. M., Clauser, K. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.022 · Cited by 179
Expression of Toll-Like Receptors in the Developing Brain
Kaul, D., Habbel, P., Derkow, K., Krüger, C., Franzoni, E., Wulczyn, F. G., Bereswill, S., Nitsch, R., Schott, E., Veh, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037767 · Cited by 141
Research works printed but not linked: 50
- Akira S, Sato S (2003) Toll-like receptors and their signaling mechanisms. Scand J Infect Dis 35:555-562. CrossRef Medline · DOI
- Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732-738. CrossRef Medline · DOI · Paper page
- Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL (2005) Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 202:1131-1139. CrossRef Medline · DOI
- Bobrie A, Colombo M, Raposo G, The ´ry C (2011) Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12:1659 - 1668. CrossRef Medline · DOI
- Bowie AG, Haga IR (2005) The role of Toll-like receptors in the host re- sponse to viruses. Mol Immunol 42:859 -867. CrossRef Medline · DOI
- Brown AS, Schaefer CA, Wyatt RJ, Goetz R, Begg MD, Gorman JM, Susser ES (2000) Maternal exposure to respiratory infections and adult schizo- phrenia spectrum disorders: a prospective birth cohort study. Schizophr Bull 26:287-295. CrossRef Medline · DOI
- Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T (2007) Toll- like receptor 3 is a potent negative regulator of axonal growth in mam- mals. J Neurosci 27:13033-13041. CrossRef Medline · DOI
- Chao TY, Raines RT (2011) Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides. Biochemistry 50:8374 -8382. CrossRef Medline · DOI
- Chen CY, Lin CW, Chang CY, Jiang ST, Hsueh YP (2011) Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol 193:769 -784. CrossRef Medline · DOI
- Chung WC, Huang TN, Hsueh YP (2011) Targeted deletion of CASK- interacting nucleosome assembly protein causes higher locomotor and exploratory activities. Neurosignals 19:128 -141. CrossRef Medline · DOI
- Czirr E, Wyss-Coray T (2012) The immunology of neurodegeneration. J Clin Invest 122:1156 -1163. CrossRef Medline · DOI
- Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004) Innate antiviral responses by means of TLR7-mediated recognition of single- stranded RNA. Science 303:1529 -1531. CrossRef Medline · DOI · Paper page
- Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa C (2006) Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur J Immunol 36:3256 -3267. CrossRef Medline · DOI
- Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, Nana-Sinkam P, Perrotti D, Croce CM (2012) Mi- croRNAs bind to Toll-like receptors to induce prometastatic inflamma- tory response. Proc Natl Acad Sci U S A 109:E2110 -E2116. CrossRef Medline · DOI · Paper page
- Gauzzi MC, Del Corno `M, Gessani S (2010) Dissecting TLR3 signalling in dendritic cells. Immunobiology 215:713-723. CrossRef Medline · DOI
- Gilmore JH, Fredrik Jarskog L, Vadlamudi S, Lauder JM (2004) Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite development. Neuropsychopharmacology 29: 1221-1229. CrossRef Medline · DOI
- Gohlke JM, Griffith WC, Faustman EM (2004) The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse. Brain Res Dev Brain Res 151:43-54. CrossRef Medline · DOI
- Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lip- ford G, Wagner H, Bauer S (2004) Species-specific recognition of single- stranded RNA via toll-like receptor 7 and 8. Science 303:1526 -1529. CrossRef Medline · DOI · Paper page
- Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408:740 -745. CrossRef Medline · DOI · Paper page
- Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (2002) Small anti-viral compounds ac- tivate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3:196 -200. CrossRef Medline · DOI
- Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, Crozat K, Sovath S, Han J, Beutler B (2003) Identifi- cation of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424:743-748. CrossRef Medline · DOI
- Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Ue- matsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11:263-270. CrossRef Medline · DOI
- Hou B, Reizis B, DeFranco AL (2008) Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mech- anisms. Immunity 29:272-282. CrossRef Medline · DOI
- Huyton T, Rossjohn J, Wilce M (2007) Toll-like receptors: structural pieces of a curve-shaped puzzle. Immunol Cell Biol 85:406 -410. CrossRef Medline · DOI
- Jenkins KA, Mansell A (2010) TIR-containing adaptors in Toll-like receptor signalling. Cytokine 49:237-244. CrossRef Medline · DOI
- Kang JY, Lee JO (2011) Structural biology of the Toll-like receptor family. Annu Rev Biochem 80:917-941. CrossRef Medline · DOI
- Kawai T, Akira S (2006) TLR signaling. Cell Death Differ 13:816 -825. CrossRef Medline · DOI
- Kim SJ, Park GH, Kim D, Lee J, Min H, Wall E, Lee CJ, Simon MI, Lee SJ, Han SK (2011) Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. Proc Natl Acad Sci U S A 108:3371-3376. CrossRef Medline · DOI
- Kumar H, Kawai T, Akira S (2009) Toll-like receptors and innate immunity. Biochem Biophys Res Commun 388:621-625. CrossRef Medline · DOI
- Lathia JD, Okun E, Tang SC, Griffioen K, Cheng A, Mughal MR, Laryea G, Selvaraj PK, ffrench-Constant C, Magnus T, Arumugam TV, Mattson MP (2008) Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci 28:13978 -13984. CrossRef Medline · DOI
- Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Chris- tensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 202: 1171-1177. CrossRef Medline · DOI
- Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A (2007) Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315:1398 -1401. CrossRef Medline · DOI
- Lee J, Kim T, Hong J, Woo J, Min H, Hwang E, Lee SJ, Lee CJ (2012) Imi- quimod enhances excitability of dorsal root ganglion neurons by inhibit- ing background (K(2P)) and voltage-gated (K(v)1.1 and K(v)1.2) potassium channels. Mol Pain 8:2. CrossRef Medline · DOI
- Lehmann SM, Kru ¨ger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Ka ¨lin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, et al (2012a) An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci 15:827- 835. CrossRef Medline · DOI · Paper page
- Lehmann SM, Rosenberger K, Kru ¨ger C, Habbel P, Derkow K, Kaul D, Rybak A, Brandt C, Schott E, Wulczyn FG, Lehnardt S (2012b) Extracellularly delivered single-stranded viral RNA causes neurodegeneration depen- dent on TLR7. J Immunol 189:1448 -1458. CrossRef Medline · DOI · Paper page
- Lin YL, Lei YT, Hong CJ, Hsueh YP (2007) Syndecan-2 induces filopodia formation via the neurofibromin-PKA-Ena/VASP pathway. J Cell Biol 177:829 -841. CrossRef Medline · DOI
- Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA (2004) Recognition of single-stranded RNA viruses by Toll- like receptor 7. Proc Natl Acad Sci U S A 101:5598 -5603. CrossRef Medline · DOI
- Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lu ¨J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T (2006) Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol 175: 209 -215. CrossRef Medline · DOI · Paper page
- Maiorano NA, Mallamaci A (2009) Promotion of embryonic cortico- cerebral neuronogenesis by miR-124. Neural Dev 4:40. CrossRef Medline · DOI · Paper page
- Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31-40. CrossRef Medline · DOI
- Matsuda T, Cepko CL (2004) Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci U S A 101:16 -22. CrossRef Medline · DOI
- Nishiya T, DeFranco AL (2004) Ligand-regulated chimeric receptor ap- proach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem 279:19008 -19017. CrossRef Medline · DOI
- Pasparakis M, Alexopoulou L, Episkopou V, Kollias G (1996) Immune and inflammatory responses in TNF alpha-deficient mice: a critical require- ment for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184:1397-1411. CrossRef Medline · DOI
- Patterson PH (2002) Maternal infection: window on neuroimmune inter- actions in fetal brain development and mental illness. Curr Opin Neuro- biol 12:115-118. CrossRef Medline · DOI · Paper page
- Record M, Subra C, Silvente-Poirot S, Poirot M (2011) Exosomes as inter- cellular signalosomes and pharmacological effectors. Biochem Pharmacol 81:1171-1182. CrossRef Medline · DOI
- Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, Schwartz M (2007) Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 9:1081-1088. CrossRef Medline · DOI
- Tabata H, Nakajima K (2008) Labeling embryonic mouse central nervous system cells by in utero electroporation. Dev Growth Differ 50:507-511. CrossRef Medline · DOI
- Takeda K, Akira S (2004) TLR signaling pathways. Semin Immunol 16:3-9. CrossRef Medline · DOI
- Whelan JA, Russell NB, Whelan MA (2003) A method for the absolute quantification of cDNA using real-time PCR. J Immunol Methods 278: 261-269. CrossRef Medline · DOI
- Zhao CT, Li K, Li JT, Zheng W, Liang XJ, Geng AQ, Li N, Yuan XB (2009) PKCdelta regulates cortical radial migration by stabilizing the Cdk5 acti- vator p35. Proc Natl Acad Sci U S A 106:21353-21358. CrossRef Medline · DOI
Cited by
Sorted by citations
The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion
Ağaç, D., Estrada, L. D., Maples, R., Hooper, L. V., & Farrar, J. D. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.004 · Cited by 200
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality
Huang, T.-N., Chuang, H.-C., Chou, W.-H., Chen, C.-Y., Wang, H.-F., Chou, S.-J., & Hsueh, Y.-P. (2014) · Nature Neuroscience · doi:10.1038/nn.3626 · Cited by 180
Self-citationNeuroinflammation During RNA Viral Infections
Klein, R. S., Garber, C., Funk, K. E., Salimi, H., Soung, A., Kanmogne, M., Manivasagam, S., Agner, S., & Cain, M. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041417 · Cited by 160
Matsuda, T., Murao, N., Katano, Y., Juliandi, B., Kohyama, J., Akira, S., Kawai, T., & Nakashima, K. (2015) · Nature Communications · doi:10.1038/ncomms7514 · Cited by 145
Hung, Y.-F., Chen, C.-Y., Shih, Y.-C., Liu, H.-Y., Huang, C.-M., & Hsueh, Y.-P. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201712113 · Cited by 86
Self-citation
Metadata
- Authors
- Liu, H.-Y., Hong, Y.-F., Huang, C.-M., Chen, C.-Y., Huang, T.-N., & Hsueh, Y.-P.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-07-10
- Volume
- 33
- Issue
- 28
- Pages
- 11479-11493
- ISSN
- 0270-6474
- 1529-2401
- Cited by
- 71
- References
- 5
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
