Non-Hebbian Synaptic Plasticity Induced by Repetitive Postsynaptic Action Potentials
Open accessAbstract
Modern theories on memory storage have mainly focused on Hebbian long-term potentiation (LTP), which requires coincident activation of presynaptic and postsynaptic neurons for its induction. In addition to Hebbian LTP, the roles of non-Hebbian plasticity have also been predicted by some neuronal network models. However, still only a few pieces of evidence have been presented for the presence of such plasticity. In this study, we show in mouse hippocampal slices that LTP can be induced by postsynaptic repetitive depolarization alone in the absence of presynaptic inputs. The induction was dependent on voltage-dependent calcium channels instead of NMDA receptors (NMDARs), whereas the expression mechanism was shared with conventional NMDAR-dependent LTP. During the potentiation, the amplitude of spontaneous EPSCs was increased, suggesting a novel neuron-wide nature of this form of LTP. Furthermore, we also successfully induced LTP with trains of action potentials, which supported the possible existence of depolarizing pulse-induced LTP in vivo. Based on these findings, we suggest a model in which neuron-wide LTP works in concert with synapse-specific Hebbian plasticity to help information processing in memory formation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Voltage pulse potentiation (VPP) typically is transient, lasting no longer than 20 min.
“the potentiation typically is transient, lasting no longer than 20 min (Refs. 189–193, but see Refs. 194, 195).”
From Synaptic memory and CaMKII (2023) · cites this paper as [194]
In 'Induction of non-Hebbian LTP by postsynaptic depolarization' (page unavailable), the paper contrasts an earlier transient result with its own stable potentiation, observed for nearly an hour without a tendency to decay. The cited paper therefore provides an exception to the stated 20-minute limit, consistent with the citing sentence’s 'but see' qualification, rather than evidence for that limit. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116 · see citing works
Manabe, T., Renner, P., & Nicoll, R. A. (1992) · Nature · doi:10.1038/355050a0 · Cited by 366 · cited 7× · see citing works
“NMDARs, with their characteristics as a coincident detector, are widely accepted as the molecular basis of Hebbian LTP (Dingledine et al., 1999).”
BackgroundMethodResultInfluentialSelf-citationSynapse specificity of long-term potentiation breaks down at short distances
Engert, F., & Bonhoeffer, T. (1997) · Nature · doi:10.1038/40870 · Cited by 252 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Hebb DO (1949) The organization of behavior: a neuropsychological the- ory. New York: Wiley Interscience.
Cited by
Sorted by citations
Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits
Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2017.10.024 · Cited by 810 · see citing works
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Wu, D., Bacaj, T., Morishita, W., Goswami, D., Arendt, K. L., Xu, W., Chen, L., Malenka, R. C., & Südhof, T. C. (2017) · Nature · doi:10.1038/nature21720 · Cited by 195 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works
“194, 195).”
Perkins, E. M., Burr, K., Banerjee, P., Mehta, A. R., Dando, O., Selvaraj, B. T., Suminaite, D., Nanda, J., Henstridge, C. M., Gillingwater, T. H., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00433-8 · Cited by 54 · see citing works
- Authors
- Kato, H. K., Watabe, A. M., & Manabe, T.
- Affiliations
- Institute of Medical Science, The University of Tokyo (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Manabe, Toshiya
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-09-09
- Volume
- 29
- Issue
- 36
- Pages
- 11153-11160
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6665946
- OpenAlex
- W2056202524
- Cited by
- 41
- References
- 3
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 2 · 2015: 4 · 2013: 3 · 2012: 4
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novartis Foundation
- Uehara Memorial Foundation
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- NOVARTIS Foundation (Japan) for the Promotion of Science
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, voltage-gated calcium channels, NMDA receptor, spontaneous EPSCs, hippocampus, memory formation, Hebbian plasticity
- MeSH terms
- Animals, Guinea Pigs, Hippocampus, Male, Memory, Mice, Inbred C57BL, Neuronal Plasticity, Organ Culture Techniques, Synapses, Long-Term Potentiation, Mice, Synaptic Potentials
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
