Synapse specificity of long-term potentiation breaks down at short distances
Abstract
Long-term potentiation (LTP), the long-lasting increase in synaptic transmission, has been proposed to be a cellular mechanism essential for learning and memory, neuronal development, and circuit reorganization. In the original theoretical and experimental work it was assumed that only synapses that had experienced concurrent pre- and postsynaptic activity are subject to synaptic modification. It has since been shown, however, that LTP is also expressed in synapses on neighbouring neurons that have not undergone the induction procedure. Yet, it is still believed that this spread of LTP is limited to adjacent postsynaptic cells, and does not occur for synapses on neighbouring input fibres. However, for technical reasons, tests for 'input specificity' were always done for synapses relatively far apart. Here we have used a new local superfusion technique, which allowed us to assess the synaptic specificity of LTP with a spatial resolution of approximately 30 microm. Our results indicate that there is no input specificity at a distance of less than 70 microm. Synapses in close proximity to a site of potentiation are also potentiated regardless of their own history of activation, whereas synapses far away show no potentiation.
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LTP can be induced at a single synapse without causing postsynaptic potentiation or depression of neighboring synapses.
“Experiments using this approach to induce NMDAR-dependent LTP have shown that LTP can be induced at a single synapse without causing postsynaptic potentiation or depression of neighboring synapses (Matsuzaki et al. 2004;Harvey and Svoboda 2007; but see Engert and Bonhoeffer 1997).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Engert and Bonhoeffer 1997
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- Authors
- Engert, F., & Bonhoeffer, T.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Bonhoeffer, Tobias
- Venue
- Nature
- Published
- 1997-07-17
- Volume
- 388
- Issue
- 6639
- Pages
- 279-284
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1598503391
- Cited by
- 252
- References
- 27
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 13 · 2013: 6 · 2012: 6
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, synaptic specificity, input specificity, synaptic plasticity, learning and memory, postsynaptic neurons
- MeSH terms
- Animals, Cell Communication, Culture Media, Evoked Potentials, Hippocampus, Models, Neurological, Perfusion, Synapses, Long-Term Potentiation, Pyramidal Cells, Rats, In Vitro Techniques
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