The DOI matches its Crossref record; 65 of the 68 references it cites were found in a registry or an index.
Dopamine, Time, and Impulsivity in Humans
Open accessAbstract
Disordered dopamine neurotransmission is implicated in mediating impulsiveness across a range of behaviors and disorders including addiction, compulsive gambling, attention-deficit/hyperactivity disorder, and dopamine dysregulation syndrome. Whereas existing theories of dopamine function highlight mechanisms based on aberrant reward learning or behavioral disinhibition, they do not offer an adequate account of the pathological hypersensitivity to temporal delay that forms a crucial behavioral phenotype seen in these disorders. Here we provide evidence that a role for dopamine in controlling the relationship between the timing of future rewards and their subjective value can bridge this explanatory gap. Using an intertemporal choice task, we demonstrate that pharmacologically enhancing dopamine activity increases impulsivity by enhancing the diminutive influence of increasing delay on reward value (temporal discounting) and its corresponding neural representation in the striatum. This leads to a state of excessive discounting of temporally distant, relative to sooner, rewards. Thus our findings reveal a novel mechanism by which dopamine influences human decision-making that can account for behavioral aberrations associated with a hyperfunctioning dopamine system.
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“Interestingly, delay discounting seems to depend on the function of the ventral striatum (104) and of the PFC, including OFC (105) and its connections to the NAc (106), and is sensitive to DA manipulations (107).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [107]
In the citing paper
“Delay discounting seems to depend on the function of ventral striatum (Gregorios-Pippas et al 2009) and of the PFC, including OFC (Bjork et al 2009), and is sensitive to DA manipulations (Pine et al 2010).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Pine et al 2010
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Citations
Cites
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“In agreement with the framework, an increase of DA via levodopa led to increased temporal discounting rates compared to placebo (Pine et al., 2010).”
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“…missing data, the remaining N was comparable to sample sizes from previous investigations into the impact of dopaminergic pharmacological intervention on decision-making, that employed comparable blinding tests (Leow et al., 2023; Pine et al., 2010; Vo et al., 2016, 2018; Wunderlich et al., 2012).”
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Metadata
- Authors
- Pine, A., Shiner, T., Seymour, B., & Dolan, R. J.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-06-30
- Volume
- 30
- Issue
- 26
- Pages
- 8888-8896
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3059485
- OpenAlex
- W2046808635
- Cited by
- 300
- References
- 68
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 15 · 2020: 18 · 2019: 16 · 2018: 14 · 2017: 17 · 2016: 22 · 2015: 18 · 2014: 19 · 2013: 27 · 2012: 30
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- Cambridge University Engineering Department Publications Database (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (078865)
- Medical Research Council
- Economic and Social Research Council (RES-538-28-1001)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- dopamine, impulsivity, delay discounting, intertemporal choice, reward value, striatum, decision-making, dopamine dysregulation syndrome, addiction, gambling addiction, attention deficit hyperactivity disorder, behavioral disinhibition, reward learning
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Corpus Striatum, Decision Making, Dopamine, Female, Haloperidol, Humans, Impulsive Behavior, Levodopa, Magnetic Resonance Imaging, Male, Reinforcement Schedule, Reward, Time Factors, Dopamine Agents, Dopamine Antagonists, Young Adult
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