The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Nuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward
Open accessAbstract
Although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (NAc) neurons have been correlated with behavioral sensitization, the molecular pathways governing these structural changes, and their resulting behavioral effects, are poorly understood. The transcription factor, nuclear factor κ B (NFκB), is rapidly activated by diverse stimuli and regulates expression of many genes known to maintain cell structure. Therefore, we evaluated the role of NFκB in regulating cocaine-induced dendritic spine changes on medium spiny neurons of the NAc and the rewarding effects of cocaine. We show that chronic cocaine induces NFκB-dependent transcription in the NAc of NFκB-Lac transgenic mice. This induction of NFκB activity is accompanied by increased expression of several NFκB genes, the promoters of which show chromatin modifications after chronic cocaine exposure consistent with their transcriptional activation. To study the functional significance of this induction, we used viral-mediated gene transfer to express either a constitutively active or dominant-negative mutant of Inhibitor of κ B kinase (IKKca or IKKdn), which normally activates NFκB signaling, in the NAc. We found that activation of NFκB by IKKca increases the number of dendritic spines on NAc neurons, whereas inhibition of NFκB by IKKdn decreases basal dendritic spine number and blocks the increase in dendritic spines after chronic cocaine. Moreover, inhibition of NFκB blocks the rewarding effects of cocaine and the ability of previous cocaine exposure to increase an animal's preference for cocaine. Together, these studies establish a direct role for NFκB pathways in the NAc to regulate structural and behavioral plasticity to cocaine.
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Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 2×
“Thirty-three gauge syringe needles (Hamilton) were used to bilaterally infuse 0.5 l of virus into the NAc at a rate of 0.1 ml/min (Graham et al., 2007; Krishnan et al., 2007).”
MethodInfluentialSelf-citationA cytokine-mediated link between innate immunity, inflammation, and cancer
Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31537 · Cited by 1,940 · cited 2×
“Nuclear factor B (NF B), a transcription factor best studied for its involvement in inflammation and immune responses (Chen and Greene, 2004; Lin and Karin, 2007), has more recently been shown to regulate synaptic plasticity and memory in the adult brain (O’Neill and Kaltschmidt, 1997; Meffert et al.”
BackgroundNF-kB: a crucial transcription factor for glial and neuronal cell function
O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 1,013
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815
Robinson, T. E., & Kolb, B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08491.1997 · Cited by 704
Ferrario, C. R., Gorny, G., Crombag, H. S., Li, Y., Kolb, B., & Robinson, T. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.046 · Cited by 283
Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity
Pulipparacharuvil, S., Renthal, W., Hale, C. F., Taniguchi, M., Xiao, G., Kumar, A., Russo, S. J., Sikder, D., Dewey, C. M., Davis, M. M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.020 · Cited by 281
Self-citationDietrich, J.-B., Mangeol, A., Revel, M.-O., Burgun, C., Aunis, D., & Zwiller, J. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.018 · Cited by 168 · cited 2×
“In contrast to methamphetamine, cocaine, at least at the dosing schedules used here, does not induce cell death or frank injury in the CNS (Dietrich et al., 2005), although it has been shown to alter cell morphology in the NAc and certain other reward-related brain structures (Li et al., 2004;…”
BackgroundSynaptic plasticity in the mesolimbic dopamine system
Thomas, M. J., & Malenka, R. C. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1236 · Cited by 137 · cited 2×
“Also, electrophysiological evidence has associated the induction of behavioral sensitization with long-term potentiation (LTP) (Yao et al., 2004) or long-term depression (LTD) at excitatory glutamatergic synapses in the NAc (Ungless et al., 2001; Thomas and Malenka, 2003).”
Background
Cited by
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Self-citationTranscriptional and epigenetic mechanisms of addiction
Robison, A. J., & Nestler, E. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3111 · Cited by 993
Self-citationEssential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., et al. (2010) · Science · doi:10.1126/science.1179438 · Cited by 665
Self-citationThe addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.002 · Cited by 654
Self-citationDnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612
Self-citation
Metadata
- Authors
- Russo, S. J., Wilkinson, M. B., Mazei-Robison, M. S., Dietz, D. M., Maze, I., Krishnan, V., Renthal, W., Graham, A., Birnbaum, S. G., Green, T. A., Robison, B., Lesselyong, A., Perrotti, L. I., Bolaños, C. A., Kumar, A., Clark, M. S., Neumaier, J. F., Neve, R. L., Bhakar, A. L., Barker, P. A., & Nestler, E. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-03-18
- Volume
- 29
- Issue
- 11
- Pages
- 3529-3537
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1966207206
- Cited by
- 250
- References
- 9
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Russo, S. J., Wilkinson, M. B., Mazei-Robison, M. S., Dietz, D. M., Maze, I., Krishnan, V., Renthal, W., Graham, A., Birnbaum, S. G., Green, T. A., Robison, B., Lesselyong, A., Perrotti, L. I., Bolaños, C. A., Kumar, A., Clark, M. S., Neumaier, J. F., Neve, R. L., Bhakar, A. L., . . . Nestler, E. J. (2009). Nuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.6173-08.2009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
