Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

Capone, Carmen; Faraco, Giuseppe; Peterson, Jeffrey R.; Coleman, Christal; Anrather, Josef; Milner, Teresa A.; Pickel, Virginia M.; Davisson, Robin L.; Iadecola, Costantino

doi:10.1523/jneurosci.6262-11.2012

Cited by 107Renin-Angiotensin System StudiesNitric Oxide and Endothelin EffectsNeurological Disease Mechanisms and Treatments

Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

Open access

Capone, Carmen, Faraco, Giuseppe, Peterson, Jeffrey R., Coleman, Christal, Anrather, Josef, Milner, Teresa A., Pickel, Virginia M., Davisson, Robin L. +1 more·2012·The Journal of Neuroscience

DOI 10.1523/jneurosci.6262-11.2012PMC PMC3328774

Open this paper in CoChat — free account Open PDF

Abstract

Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels. In particular, hypertension alters vital cerebrovascular control mechanisms linking neural activity to cerebral perfusion. In experimental models of slow-developing hypertension, free radical signaling in the subfornical organ (SFO), one of the forebrain circumventricular organs, is critical for the hormonal release and sympathetic activation driving the elevation in arterial pressure. However, the contribution of this central mechanism to the cerebrovascular alterations induced by hypertension remains uncertain. We tested the hypothesis that free radical production in the SFO is involved in the alterations in cerebrovascular regulation produced by hypertension. In a mouse model of gradual hypertension induced by chronic administration of subpressor doses of angiotensin II (AngII), suppression of free radicals in the SFO by overexpression of CuZn-superoxide dismutase (CuZnSOD) prevented the alteration in neurovascular coupling and endothelium-dependent responses in somatosensory cortex induced by hypertension. The SFO mediates the dysfunction via two signaling pathways. One involves SFO-dependent activation of the paraventricular hypothalamic nucleus, elevations in plasma vasopressin, upregulation of endothelin-1 in cerebral resistance arterioles and activation of endothelin type A receptors. The other pathway depends on activation of cerebrovascular AngII type 1 (AT1) receptors by AngII. Both pathways mediate vasomotor dysfunction by inducing vascular oxidative stress. The findings implicate for the first time the SFO and its efferent hypothalamic pathways in the cerebrovascular alterations induced by AngII, and identify vasopressin and endothelin-1 as potential therapeutic targets to counteract the devastating effects of hypertension on the brain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.6262-11.2012

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In humans and animal models, hypertension disrupts the major mechanisms that regulate cerebral circulation, including neurovascular coupling and endothelial vasomotor function.
“Thus, in humans as in animal models, hypertension disrupts all the major factors regulating the cerebral circulation, including neurovascular coupling and endothelial vasomotor function (10,11).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [10]
The cerebrovascular dysfunction caused by slow-pressor ANGII is mediated by AT1 receptor activation and by vascular oxidative stress from a NOX2-containing NADPH oxidase.
“The cerebrovascular dysfunction is mediated by activation of ANGII type 1 receptors (AT1Rs) and vascular oxidative stress produced by a NOX2-containing NADPH oxidase (10,15).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [10]
Low-dose ANGII given for two weeks produces a slow-developing rise in blood pressure and profound changes in neurovascular coupling and endothelium-dependent vasodilation.
“Administration of low doses of ANGII for 2 weeks, which results in a slow-developing rise in BP (“slow pressor” hypertension) (14), induces profound alterations in neurovascular coupling and endothelium-dependent vasodilation (10,15).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [10]
ANGII increases the ROS signal in PVMs.
“As illustrated in Figure 7B, ANGII induces an increase in ROS signal, assessed by hydroethidine microfluorography (10,35) in PVMs.”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [10]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works
The Science of Stroke: Mechanisms in Search of Treatments
Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930 · see citing works
Self-citation
Gender differences in the regulation of blood pressure
Reckelhoff, J. F. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1199 · Cited by 1,268 · see citing works
Silent Brain Infarcts and White Matter Lesions Increase Stroke Risk in the General Population
Vermeer, S. E., Hollander, M., van Dijk, E. J., Albert Hofman, D., Koudstaal, P. J., & Breteler, M. M. B. (2003) · Stroke · doi:10.1161/01.str.0000068408.82115.d2 · Cited by 883 · see citing works
White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury
Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587 · see citing works
Hypertension and Cerebrovascular Dysfunction
Iadecola, C., & Davisson, R. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.010 · Cited by 557 · see citing works
Self-citation
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
Iadecola, C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0718-6 · Cited by 557 · see citing works
Self-citation
Oxidative Stress and Hypertension
Harrison, D. G., & Góngora, M. C. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.015 · Cited by 451 · see citing works
Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding
Chan, J., Aoki, C. J., & Pickel, V. M. (1990) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(90)90015-8 · Cited by 447 · see citing works
Self-citation
Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System
Zimmerman, M. C., Lazartigues, E. D., Sharma, R. V., & Davisson, R. L. (2004) · Circulation Research · doi:10.1161/01.res.0000135483.12297.e4 · Cited by 440 · see citing works
Self-citation
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
Iadecola, C., Zhang, F., Niwa, K., Eckman, C., Turner, S. K., Fischer, E., Younkin, S., Borchelt, D. R., Hsiao, K. K., & Carlson, G. A. (1999) · Nature Neuroscience · doi:10.1038/5715 · Cited by 399 · see citing works
Self-citation
The Association Between Blood Pressure, Hypertension, and Cerebral White Matter Lesions: Cardiovascular Determinants of Dementia Study
van Dijk, E. J., Breteler, M. M. B., Schmidt, R., Berger, K., Nilsson, L.-G., Oudkerk, M., Pajak, A., Sans, S., de Ridder, M., Dufouil, C., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000145857.98904.20 · Cited by 345 · see citing works
Endothelin-1 Increases Vascular Superoxide via Endothelin A –NADPH Oxidase Pathway in Low-Renin Hypertension
Li, L., Fink, G. D., Watts, S. W., Northcott, C. A., Galligan, J. J., Pagano, P. J., & Chen, A. F. (2003) · Circulation · doi:10.1161/01.cir.0000051459.74466.46 · Cited by 317 · see citing works
Endothelin: 20 years from discovery to therapyThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.
Barton, M., & Yanagisawa, M. (2008) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-059 · Cited by 307 · see citing works
The Sensory Circumventricular Organs of the Mammalian Brain
McKinley, M. J., McAllen, R. M., Davern, P. J., Giles, M., Penschow, J., Sunn, N., Uschakov, A., & Oldfield, B. J. (2003) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-55532-9 · Cited by 291 · see citing works
Cholinergic dilation of cerebral blood vessels is abolished in M 5 muscarinic acetylcholine receptor knockout mice
Yamada, M., Lamping, K. G., Duttaroy, A., Zhang, W., Cui, Y., Bymaster, F. P., McKinzie, D. L., Felder, C. C., Deng, C., Faraci, F. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251542998 · Cited by 275 · see citing works
Angiotensin II Impairs Neurovascular Coupling in Neocortex Through NADPH Oxidase–Derived Radicals
Kazama, K., Anrather, J., Zhou, P., Girouard, H., Frys, K., Milner, T. A., & Iadecola, C. (2004) · Circulation Research · doi:10.1161/01.res.0000148637.85595.c5 · Cited by 253 · see citing works
Self-citation
WHITE MATTER CHANGES IN DEMENTIA OF ALZHEIMER'S TYPE: BIOCHEMICAL AND NEUROPATHOLOGICAL CORRELATES
ENGLUND, E., BRUN, A., & ALLING, C. (1988) · Brain · doi:10.1093/brain/111.6.1425 · Cited by 228 · see citing works
Cyclooxygenase-1 Participates in Selected Vasodilator Responses of the Cerebral Circulation
Niwa, K., Haensel, C., Ross, M. E., & Iadecola, C. (2001) · Circulation Research · doi:10.1161/01.res.88.6.600 · Cited by 212 · see citing works
Self-citation
Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI
Markus, H. S. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.1.48 · Cited by 202 · see citing works
Cerebrovascular Function in Pregnancy and Eclampsia
Cipolla, M. J. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.079442 · Cited by 201 · see citing works
Reduced cerebral blood flow response and compensation among patients with untreated hypertension
Jennings, J. R., Muldoon, M. F., Ryan, C., Price, J. C., Greer, P., Sutton-Tyrrell, K., van der Veen, F. M., & Meltzer, C. C. (2005) · Neurology · doi:10.1212/01.wnl.0000158283.28251.3c · Cited by 198 · cited 1× · see citing works
“In particular, hypertension disrupts vital neurovascular mechanisms coupling the local delivery of blood flow with the energetic needs of active brain regions (Kazama et al., 2004; Jennings et al., 2005; Iadecola and Davisson, 2008).”
Background
Protecting against vascular disease in brain
Faraci, F. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01310.2010 · Cited by 196 · see citing works
A Mouse Model of Angiotensin II Slow Pressor Response: Role of Oxidative Stress
Kawada, N., Imai, E., Karber, A., Welch, W. J., & Wilcox, C. S. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000035087.11758.ed · Cited by 195 · see citing works
Angiotensins in Alzheimer's disease - friend or foe?
Kehoe, P., Miners, S., & Love, S. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.006 · Cited by 180 · see citing works
Intravenous angiotensin II induces Fos-immunoreactivity in circumventricular organs of the lamina terminalis
McKinley, M. J., Badoer, E., & Oldfield, B. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91138-5 · Cited by 165 · see citing works
Circulating angiotensin II and dietary salt: Converging signals for neurogenic hypertension
Osborn, J. W., Fink, G. D., Sved, A. F., Toney, G. M., & Raizada, M. K. (2007) · Current Hypertension Reports · doi:10.1007/s11906-007-0041-3 · Cited by 164 · see citing works
Adenosine in the control of the cerebral circulation.
Phillis, J. W. (1989) · PubMed · Cited by 163 · see citing works
Periventricular white matter lucency and cerebral blood flow autoregulation in hypertensive patients
Matsushita, K., Kuriyama, Y., Nagatsuka, K., Nakamura, M., Sawada, T., & Omae, T. (1994) · Hypertension · doi:10.1161/01.hyp.23.5.565 · Cited by 157 · see citing works
Cerebrovascular Nitrosative Stress Mediates Neurovascular and Endothelial Dysfunction Induced by Angiotensin II
Girouard, H., Park, L., Anrather, J., Zhou, P., & Iadecola, C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000253885.41509.25 · Cited by 156 · see citing works
Self-citation
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β
Park, L., Wang, G., Zhou, P., Zhou, J., Pitstick, R., Previti, M. L., Younkin, L., Younkin, S. G., Van Nostrand, W. E., Cho, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015413108 · Cited by 156 · see citing works
Self-citation
Vascular risk factors and cognitive impairment in a stroke-free cohort
Unverzagt, F. W., McClure, L. A., Wadley, V. G., Jenny, N. S., Go, R. C., Cushman, M., Kissela, B. M., Kelley, B. J., Kennedy, R., Moy, C. S., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318236ef23 · Cited by 152 · see citing works
Angiotensin II Attenuates Endothelium-Dependent Responses in the Cerebral Microcirculation Through Nox-2–Derived Radicals
Girouard, H., Park, L., Anrather, J., Zhou, P., & Iadecola, C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000205849.22807.6e · Cited by 151 · see citing works
Self-citation
Endothelin Mediates Superoxide Production and Vasoconstriction through Activation of NADPH Oxidase and Uncoupled Nitric-Oxide Synthase in the Rat Aorta
Loomis, E. D., Sullivan, J. C., Osmond, D. A., Pollock, D. M., & Pollock, J. S. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.091728 · Cited by 147 · see citing works
Superoxide Mediates Angiotensin II–Induced Influx of Extracellular Calcium in Neural Cells
Zimmerman, M. C., Sharma, R. V., & Davisson, R. L. (2005) · Hypertension · doi:10.1161/01.hyp.0000153463.22621.5e · Cited by 144 · see citing works
Self-citation
Reactive oxygen species in the neuropathogenesis of hypertension
Peterson, J. R., Sharma, R. V., & Davisson, R. L. (2006) · Current Hypertension Reports · doi:10.1007/s11906-006-0056-1 · Cited by 139 · see citing works
Self-citation
Superoxide Is Involved in the Central Nervous System Activation and Sympathoexcitation of Myocardial Infarction–Induced Heart Failure
Lindley, T. E., Doobay, M. F., Sharma, R. V., & Davisson, R. L. (2003) · Circulation Research · doi:10.1161/01.res.0000112964.40701.93 · Cited by 137 · see citing works
Self-citation
A SLOWLY DEVELOPING PRESSOR RESPONSE TO SMALL CONCENTRATIONS OF ANGIOTENSIN ITS BEARING ON THE PATHOGENESIS OF CHRONIC RENAL HYPERTENSION
Dickinson, C. J., & Lawrence, J. R. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91929-9 · Cited by 136 · see citing works
The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension
Capone, C., Faraco, G., Park, L., Cao, X., Davisson, R. L., & Iadecola, C. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00679.2010 · Cited by 136 · see citing works
Self-citation
Improved Endothelium-Dependent Vasodilation After Blockade of Endothelin Receptors in Patients With Essential Hypertension
Cardillo, C., Campia, U., Kilcoyne, C. M., Bryant, M. B., & Panza, J. A. (2002) · Circulation · doi:10.1161/hc0402.102989 · Cited by 123 · see citing works
Role for the subfornical organ in vasopressin release
Mangiapane, M. L., Thrasher, T. N., KEIL, L. C., Simpson, J. B., & Ganong, W. F. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90006-6 · Cited by 122 · see citing works
Biophysical properties of normal and diseased renal glomeruli
Wyss, H. M., Henderson, J., Byfield, F. J., Bruggeman, L. A., Ding, Y., Huang, C., Suh, J. H., Franke, T., Mele, E., Pollak, M. R., et al. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00438.2010 · Cited by 122 · see citing works
Nuclear Factor-κB Activation and Postischemic Inflammation Are Suppressed in CD36-Null Mice after Middle Cerebral Artery Occlusion
Kunz, A. B., Abe, T., Hochrainer, K., Shimamura, M., Anrather, J., Racchumi, G., Zhou, P., & Iadecola, C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5205-07.2008 · Cited by 116 · see citing works
Self-citation
Systemic angiotensin acts at subfornical organ to facilitate activity of neurohypophysial neurons
Ferguson, A. V., & Renaud, L. P. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.251.4.r712 · Cited by 114 · see citing works
Vasopressin release to central and peripheral angiotensin II in rats with lesions of the subfornical organ
Iovino, M., & Steardo, L. (1984) · Brain Research · doi:10.1016/0006-8993(84)90135-5 · Cited by 113 · see citing works
Effect of antiepileptic medication on bone mineral measures
Petty, S., Paton, L. M., O'Brien, T. J., Makovey, J., Erbas, B., Sambrook, P. N., Berkovic, S. F., & Wark, J. D. (2005) · Neurology · doi:10.1212/01.wnl.0000180910.72487.18 · Cited by 108 · see citing works
Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex
Kazama, K., Wang, G., Frys, K. A., Anrather, J., & Iadecola, C. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00464.2003 · Cited by 105 · see citing works
Self-citation
Hypertension, Angiotensin, and Stroke: Beyond Blood Pressure
Iadecola, C., & Gorelick, P. B. (2004) · Stroke · doi:10.1161/01.str.0000115162.16321.aa · Cited by 101 · see citing works
Self-citation
Genetic Silencing of Nox2 and Nox4 Reveals Differential Roles of These NADPH Oxidase Homologues in the Vasopressor and Dipsogenic Effects of Brain Angiotensin II
Peterson, J. R., Burmeister, M. A., Tian, X., Zhou, Y., Guruju, M. R., Stupinski, J. A., Sharma, R. V., & Davisson, R. L. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.140087 · Cited by 98 · see citing works
Self-citation
Chapter 14 Molecular pharmacology and modeling of vasopressin receptors
Thibonnier, M., Coles, P., Thibonnier, A., & Shoham, M. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39016-2 · Cited by 96 · see citing works
Electrical stimulation in subfornical organ increases plasma vasopressin concentrations in the conscious rat
Ferguson, A. V., & Kasting, N. W. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.251.2.r425 · Cited by 96 · see citing works
Key role of tissue plasminogen activator in neurovascular coupling
Park, L., Gallo, E. F., Anrather, J., Wang, G., Norris, E. H., Paul, J., Strickland, S., & Iadecola, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708823105 · Cited by 96 · see citing works
Self-citation
Endothelin, Angiotensin, and Oxidative Stress in Hypertension
Pollock, D. M. (2005) · Hypertension · doi:10.1161/01.hyp.0000158262.11935.d0 · Cited by 84 · see citing works
Vascular Endothelin-1 Gene Expression and Synthesis and Effect on Renal Type I Collagen Synthesis and Nephroangiosclerosis During Nitric Oxide Synthase Inhibition in Rats
Tharaux, P., Chatziantoniou, C., Casellas, D., Fouassier, L., Ardaillou, R., & Dussaule, J. (1999) · Circulation · doi:10.1161/01.cir.99.16.2185 · Cited by 83 · see citing works
Distribution of estrogen receptor beta containing cells in the brains of bacterial artificial chromosome transgenic mice
Milner, T. A., Thompson, L. I., Wang, G., Kievits, J. A., Martin, E. M., Zhou, P., McEwen, B. S., Pfaff, D. W., & Waters, E. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.038 · Cited by 82 · see citing works
Self-citation
Subfornical organ neurons projecting to paraventricular nucleus: whole-cell properties
Anderson, J. W., Smith, P., & Ferguson, A. V. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03093-1 · Cited by 76 · see citing works
Muscarinic Acetylcholine Receptor Knockout Mice
Wess, J., Zhang, W., Duttaroy, A., Miyakawa, T., Gomeza, J., Cui, Y., Basile, A. S., Bymaster, F. P., McKinzie, D. L., Felder, C. C., et al. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18934-0_3 · Cited by 73 · see citing works
Effects of arginine vasopressin on cerebral microvascular pressure
Faraci, F. M., Mayhan, W. G., Schmid, P. G., & Heistad, D. D. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.255.1.h70 · Cited by 63 · see citing works
Cyclooxygenase 1–Derived Prostaglandin E 2 and EP1 Receptors Are Required for the Cerebrovascular Dysfunction Induced by Angiotensin II
Capone, C., Faraco, G., Anrather, J., Zhou, P., & Iadecola, C. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.145813 · Cited by 61 · see citing works
Self-citation
Endothelin mediates superoxide production in angiotensin II-induced hypertension in rats
Laplante, M., Wu, R., Moreau, P. R., & de Champlain, J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.026 · Cited by 55 · see citing works
Angiotensin-Converting Enzyme–Derived Angiotensin II Formation During Angiotensin II–Induced Hypertension
González-Villalobos, R. A., Satou, R., Seth, D. M., Semprun‐Prieto, L., Katsurada, A., Kobori, H., & Navar, L. G. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.124511 · Cited by 55 · see citing works
Estrous Cycle–Dependent Neurovascular Dysfunction Induced by Angiotensin II in the Mouse Neocortex
Capone, C., Anrather, J., Milner, T. A., & Iadecola, C. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133249 · Cited by 45 · see citing works
Self-citation
Cerebral vasoconstriction produced by vasopressin in conscious goats: role of vasopressin V1 and V2 receptors and nitric oxide
Fernández, N., Martínez, M. A., Garcı́a-Villalón, Á. L., Monge, L., & Diéguez, G. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704034 · Cited by 38 · see citing works
Vasopressin Induces Vascular Superoxide Via Endothelin-1 in Mineralocorticoid Hypertension
Li, L., Galligan, J. J., Fink, G. D., & Chen, A. F. (2003) · Hypertension · doi:10.1161/01.hyp.0000047875.43777.79 · Cited by 32 · see citing works
Effect of endogenous vasopressin on blood flow to choroid plexus during hypoxia and intracranial hypertension
Faraci, F. M., Kinzenbaw, D. A., & Heistad, D. D. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.2.h393 · Cited by 25 · see citing works
Principles and Methods for Measurement of Cerebral Blood Flow
Iadecola, C. (1997) · Primer on Cerebrovascular Diseases · doi:10.1016/b978-012743170-3.50010-8 · Cited by 13 · see citing works
Self-citation
Hypertension and late-life dementia
Knopman, D. S. (2009) · Neurology · doi:10.1212/01.wnl.0000345882.69564.f7 · Cited by 7 · see citing works

Flagged first, then by citations

Sorted by citations

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243 · see citing works
Neurovascular and Cognitive Dysfunction in Hypertension
Iadecola, C., & Gottesman, R. F. (2019) · Circulation Research · doi:10.1161/circresaha.118.313260 · Cited by 518 · see citing works
Self-citation
Defining the relationship between hypertension, cognitive decline, and dementia: a review
Walker, K. A., Power, M. C., & Gottesman, R. F. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0724-3 · Cited by 394 · see citing works
Hypertension: A Harbinger of Stroke and Dementia
Faraco, G., & Iadecola, C. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01063 · Cited by 367 · see citing works
Self-citation
Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension
Faraco, G., Sugiyama, Y., Lane, D., Garcia-Bonilla, L., Chang, H., Santisteban, M. M., Racchumi, G., Murphy, M., Van Rooijen, N., Anrather, J., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86950 · Cited by 350 · see citing works
Self-citation
Animal Models of Hypertension: A Scientific Statement From the American Heart Association
Lerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J. L., Eirin, A., et al. (2019) · Hypertension · doi:10.1161/hyp.0000000000000090 · Cited by 332 · see citing works
Self-citation
Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research
Montezano, A. C. I., & Touyz, R. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5302 · Cited by 275 · see citing works
Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly
Daulatzai, M. A. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23634 · Cited by 215 · see citing works
Hypertension enhances A <i>β</i> -induced neurovascular dysfunction, promotes <i>β</i> -secretase activity, and leads to amyloidogenic processing of APP
Faraco, G., Park, L., Zhou, P., Luo, W., Paul, S. M., Anrather, J., & Iadecola, C. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.79 · Cited by 158 · see citing works
Self-citation
Hypertension, Neurodegeneration, and Cognitive Decline
Pacholko, A. G., & Iadecola, C. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.21356 · Cited by 150 · see citing works
Self-citation
The interplay between Angiotensin II, TLR4 and hypertension
Biancardi, V. C., Bomfim, G. F., Reis, W. L., Al-Gassimi, S., & Nunes, K. P. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.03.017 · Cited by 126 · see citing works
TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-κB pathway and ROS production
Wang, Y., Hu, H., Yin, J., Shi, Y., Tan, J., Zheng, L., Wang, C., Li, X., Xue, M., Liu, J., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101186 · Cited by 120 · see citing works
Compromised blood–brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension
Biancardi, V. C., & Stern, J. E. (2015) · The Journal of Physiology · doi:10.1113/jp271584 · Cited by 116 · see citing works
Cross talk between AT1receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus
Biancardi, V. C., Stranahan, A. M., Krause, E. G., de Kloet, A. D., & Stern, J. E. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00247.2015 · Cited by 116 · see citing works
Neurovascular Regulation in the Ischemic Brain
Jackman, K. A., & Iadecola, C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5669 · Cited by 114 · see citing works
Self-citation
Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome
Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9379-2 · Cited by 111 · see citing works
Hypertension, dietary salt and cognitive impairment
Santisteban, M. M., & Iadecola, C. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18803374 · Cited by 106 · see citing works
Self-citation
Rostral Ventrolateral Medulla and Hypertension
Guyenet, P. G., Stornetta, R. L., Holloway, B. B., Souza, G. M. P. R., & Abbott, S. B. G. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10921 · Cited by 97 · see citing works
Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease
Csiszar, A., Tarantini, S., Fülöp, G. A., Kiss, T., Valcarcel-Ares, M. N., Galvan, V., Ungvari, Z., & Yabluchanskiy, A. (2017) · GeroScience · doi:10.1007/s11357-017-9991-9 · Cited by 93 · see citing works
Reducing T imp3 or vitronectin ameliorates disease manifestations in CADASIL mice
Capone, C., Cognat, E., Ghezali, L., Baron‐Menguy, C., Aubin, D., Mesnard, L., Stöhr, H., Domenga, V., Nelson, M. T., & Joutel, A. (2015) · Annals of Neurology · doi:10.1002/ana.24573 · Cited by 90 · see citing works
Self-citation
Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K + channel function
Longden, T. A., Dabertrand, F., Hill‐Eubanks, D. C., Hammack, S. E., & Nelson, M. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401811111 · Cited by 87 · see citing works
Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension
Presa, J., Saravia, F., Bagi, Z. A., & Filosa, J. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.584135 · Cited by 89 · see citing works
Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment
Tucsek, Z., Valcarcel‐Ares, M. N., Tarantini, S., Yabluchanskiy, A., Fülöp, G., Gautam, T., Orock, A. M., Csiszár, A., Deák, F., & Ungvari, Z. I. (2017) · GeroScience · doi:10.1007/s11357-017-9981-y · Cited by 89 · see citing works
Rodent models of hypertension
Jama, H. A., Muralitharan, R. R., Xu, C., O’Donnell, J. A., Bertagnolli, M., Broughton, B. R. S., Head, G. A., & Marques, F. Z. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15650 · Cited by 81 · see citing works
Prevalence of mild cognitive impairment in patients with hypertension: a systematic review and meta-analysis
Qin, J., He, Z., Wu, L., Wang, W. “., Lin, Q., Lin, Y., & Zheng, L. (2021) · Hypertension Research · doi:10.1038/s41440-021-00704-3 · Cited by 81 · see citing works
Angiotensin type 2 receptors: blood pressure regulation and end organ damage
Sumners, C., de Kloet, A. D., Krause, E. G., Unger, T., & Steckelings, U. M. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.01.004 · Cited by 79 · see citing works
Effects of angiotensin II on the cerebral circulation: role of oxidative stress
Silva, T. M. D., & Faraci, F. M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2012.00484 · Cited by 75 · see citing works
A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction
Hay, M., Polt, R. L., Heien, M. L., Vanderah, T. W., Largent‐Milnes, T. M., Rodgers, K. E., Falk, T., Bartlett, M. J., Doyle, K. P., & Konhilas, J. P. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254854 · Cited by 71 · see citing works
Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease
Csiszár, A., Tucsek, Z., Tóth, P., Sosnowska, D., Gautam, T., Koller, Á., Deák, F., Sonntag, W. E., & Ungvari, Z. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00288.2013 · Cited by 72 · see citing works
Water Deprivation Induces Neurovascular and Cognitive Dysfunction through Vasopressin-Induced Oxidative Stress
Faraco, G., Wijasa, T. S., Park, L., Moore, J. M. R., Anrather, J., & Iadecola, C. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.24 · Cited by 68 · see citing works
Self-citation
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics
Capone, C., Dabertrand, F., Baron‐Menguy, C., Chalaris, A., Ghezali, L., Domenga, V., Schmidt, S., Huneau, C., Rose‐John, S., Nelson, M. T., et al. (2016) · eLife · doi:10.7554/elife.17536 · Cited by 68 · see citing works
Self-citation
Chronic perfusion of angiotensin II causes cognitive dysfunctions and anxiety in mice
Duchemin, S., Bélanger, É., Wu, R., Ferland, G., & Girouard, H. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.10.005 · Cited by 66 · see citing works
The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes
Hariharan, A., Weir, N., Robertson, C., He, L., Betsholtz, C., & Longden, T. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.601324 · Cited by 63 · see citing works
Neurovascular signaling in the brain and the pathological consequences of hypertension
Dunn, K. M. J., & Nelson, M. T. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00364.2013 · Cited by 61 · see citing works
Circulating Endothelin-1 Alters Critical Mechanisms Regulating Cerebral Microcirculation
Faraco, G., Moraga, A., Moore, J. M. R., Anrather, J., Pickel, V. M., & Iadecola, C. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01761 · Cited by 61 · see citing works
Self-citation
Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension
Calcinaghi, N., Wyss, M. T., Jolivet, R., Singh, A., Keller, A. L., Winnik, S. H., Fritschy, J., Buck, A., Matter, C. M., & Weber, B. (2013) · Stroke · doi:10.1161/strokeaha.111.000185 · Cited by 60 · see citing works
Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons
Wang, G., Coleman, C. G., Chan, J., Faraco, G., Marques-Lopes, J., Milner, T. A., Guruju, M. R., Anrather, J., Davisson, R. L., Iadecola, C., et al. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2012 · Cited by 58 · see citing works
Self-citation
Vascular Contributions to Cognitive Impairment and Dementia
Madigan, J. B., Wilcock, D. M., & Hainsworth, A. H. (2016) · Stroke · doi:10.1161/strokeaha.116.012066 · Cited by 56 · see citing works
Brain and Circulating Levels of Aβ1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain
Park, L., Zhou, P., Koizumi, K., Jamal, S. E., Previti, M. L., Nostrand, W. E. V., Carlson, G. A., & Iadecola, C. (2012) · Stroke · doi:10.1161/strokeaha.112.670976 · Cited by 55 · see citing works
Self-citation
Brain Vasculature and Cognition
Fouda, A. Y., Fagan, S. C., & Ergul, A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311906 · Cited by 51 · see citing works
Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer’s disease
Nyúl‐Tóth, Á., Tarantini, S., Kiss, T., Tóth, P., Galván, V., Tarantini, A., Yabluchanskiy, A., Csiszár, A., & Ungvari, Z. I. (2020) · GeroScience · doi:10.1007/s11357-020-00256-3 · Cited by 52 · see citing works
The renin-angiotensin system and the retinal neurovascular unit: A role in vascular regulation and disease
Phipps, J. A., Dixon, M. A., Jobling, A. I., Wang, A. Y., Greferath, U., Vessey, K. A., & Fletcher, E. L. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107753 · Cited by 48 · see citing works
NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II
Glass, M. J., Wang, G., Coleman, C. G., Chan, J., Ogorodnik, E., Kempen, T. A. V., Milner, T. A., Butler, S. D., Young, C. N., Davisson, R. L., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2301-14.2015 · Cited by 45 · see citing works
Self-citation
Membrane Trafficking of NADPH Oxidase p47phoxin Paraventricular Hypothalamic Neurons Parallels Local Free Radical Production in Angiotensin II Slow-Pressor Hypertension
Coleman, C. G., Wang, G., Faraco, G., Marques-Lopes, J., Waters, E. M., Milner, T. A., Iadecola, C., & Pickel, V. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3061-12.2013 · Cited by 43 · see citing works
Self-citation
Functional Neural–Bone Marrow Pathways
Zubcevic, J. A., Santisteban, M. M., Pitts, T. E., Baekey, D. M., Pérez, P. D., Bolser, D. C., Febo, M., & Raizada, M. K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.02440 · Cited by 42 · see citing works
Accelerated Ovarian Failure as a Unique Model to Study Peri-Menopause Influence on Alzheimer’s Disease
Marongiu, R. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00242 · Cited by 44 · see citing works
Angiotensin and Neurovascular Coupling: Beyond Hypertension
Bloch, S., Obari, D., & Girouard, H. (2015) · Microcirculation · doi:10.1111/micc.12193 · Cited by 36 · see citing works
Potential Clinical Application of Recently Discovered Brain Mechanisms Involved in Hypertension
Hirooka, Y., Kishi, T., Ito, K., & Sunagawa, K. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00801 · Cited by 36 · see citing works
Vasopressin Hypersecretion-Associated Brain Edema Formation in Ischemic Stroke: Underlying Mechanisms
Jia, S., Liu, X., Wang, S. C., & Wang, Y. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.02.002 · Cited by 36 · see citing works
High salt induced hypertension leads to cognitive defect
Guo, C., Wei, Z. C., Huang, F., Qin, M., Li, X., Wang, Y.-M., Wang, Q., Wang, J., Liu, R., Zhang, B., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21326 · Cited by 34 · see citing works
Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension
Woods, C., Marques-Lopes, J., Contoreggi, N. H., Milner, T. A., Pickel, V. M., Wang, G., & Glass, M. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2360-19.2020 · Cited by 33 · see citing works
Self-citation
Melatonin receptor and KATP channel modulation in experimental vascular dementia
Singh, P. K., Gupta, S., & Sharma, B. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.009 · Cited by 33 · see citing works
Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction
Letra, L., & Sena, C. M. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_7 · Cited by 33 · see citing works
Perivascular macrophages in the CNS : From health to neurovascular diseases
Li, Z., Guo, Y., Zhai, X., Zhang, Y., Chen, W., Zhu, Z., Xuan, W., & Li, P. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13954 · Cited by 34 · see citing works
Long-Term Blood Pressure Variability Across the Clinical and Biomarker Spectrum of Alzheimer’s Disease
Sible, I. J., Initiative, A. D. N., & Nation, D. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200221 · Cited by 31 · see citing works
Mineralocorticoid and AT1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarct
Huang, B. S., Chen, A., Ahmad, M., Wang, H., & Leenen, F. H. H. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.276584 · Cited by 28 · see citing works
Endothelin and Diabetic Complications: a Brain-Centric View
LI, W., Abdul, Y., Ward, R., & Ergul, A. (2018) · Physiological Research · doi:10.33549/physiolres.933833 · Cited by 23 · see citing works
Improving Cerebrovascular Function to Increase Neuronal Recovery in Neurodegeneration Associated to Cardiovascular Disease
Vanherle, L., Matušková, H., Don‐Doncow, N., Uhl, F. E., & Meißner, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00053 · Cited by 23 · see citing works
Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension
Kempen, T. A. V., Dodos, M., Woods, C., Marques-Lopes, J., Justice, N. J., Iadecola, C., Pickel, V. M., Glass, M. J., & Milner, T. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.029 · Cited by 22 · see citing works
Self-citation
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
Chen, K., Sun, D., Qu, S., Chen, Y., Wang, J., Zhou, L., José, P. A., Yang, Y., & Zeng, C. (2019) · Clinical Science · doi:10.1042/cs20190254 · Cited by 21 · see citing works
Pathobiological Interactions of Local Bone Marrow Renin-Angiotensin System and Central Nervous System in Systemic Arterial Hypertension
Ciftciler, R., & Haznedaroglu, I. C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00425 · Cited by 20 · see citing works
Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats
Rodríguez‐Ortiz, C. J., Thorwald, M. A., Rodríguez, R., Mejias‐Ortega, M., Kieu, Z., Maitra, N., Hawkins, C., Valenzuela, J., Peng, M., Nishiyama, A., et al. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13738 · Cited by 13 · see citing works
Alterations in the subcellular distribution of NADPH oxidase p47phoxin hypothalamic paraventricular neurons following slow‐pressor angiotensin II hypertension in female mice with accelerated ovarian failure
Kempen, T. A. V., Narayan, A., Waters, E. M., Marques-Lopes, J., Iadecola, C., Glass, M. J., Pickel, V. M., & Milner, T. A. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23944 · Cited by 13 · see citing works
Self-citation
Endothelial Cells and the Cerebral Circulation
Lansdell, T. A., Chambers, L. C., & Dorrance, A. M. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210015 · Cited by 20 · see citing works
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
Schaeffer, S. M., Pacholko, A. G., Santisteban, M. M., Ahn, S. J., Racchumi, G., Wang, G., Park, L., Faraco, G., Anrather, J., & Iadecola, C. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.018 · Cited by 14 · see citing works
Self-citation
Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo
Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Chothani, S. P., Rackham, O. J. L., Meijles, D. N., Dash, P. R., Kerkelä, R., Ruparelia, N., Sugden, P. H., et al. (2024) · Clinical Science · doi:10.1042/cs20240496 · Cited by 11 · see citing works
Endothelial Cells and the Cerebral Circulation
Lansdell, T. A., Chambers, L. C., & Dorrance, A. M. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00220.x · Cited by 11 · see citing works
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice
Alharbi, H. O., Hardyman, M. A., Cull, J. J., Markou, T., Cooper, S. T. E., Glennon, P. E., Fuller, S. J., Sugden, P. H., & Clerk, A. (2022) · Clinical Science · doi:10.1042/cs20220607 · Cited by 11 · see citing works
Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus
Szczepanska‐Sadowska, E. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021310 · Cited by 10 · see citing works
Current updates on latest basic research of scientific relevance in hypertensive dementia
Mogi, M., Takami, Y., Ihara, M., Yamashita, T., Takeda, S., Shibata, S., Node, K., Kario, K., Prevention of Cognitive Impairment by Hypertension Management (PCIHM) Working Group of the Japanese Society of Hypertension, Mogi, M., et al. (2025) · Hypertension Research · doi:10.1038/s41440-025-02417-3 · Cited by 11 · see citing works
Rodent Models of Ovarian Failure
Marques-Lopes, J., Kempen, T. A. V., & Milner, T. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00060-9 · Cited by 9 · see citing works
Self-citation
Olmesartan combined with renal denervation reduces blood pressure in association with sympatho-inhibitory and aldosterone-reducing effects in hypertensive mice with chronic kidney disease
Nishihara, M., Takesue, K., & Hirooka, Y. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2018.1465075 · Cited by 9 · see citing works
Endothelium, the Blood–Brain Barrier, and Hypertension
Silva, T. M. D., Silva, R. A. P., & Faraci, F. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-25616-0_8 · Cited by 9 · see citing works
Border-associated macrophages: From physiology to therapeutic targets in Alzheimer's disease
Zheng, F., Dong, T., Chen, Y., Wang, L., & Peng, G. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115021 · Cited by 8 · see citing works
Angiotensin II Infusion Results in Both Hypertension and Increased AMPA GluA1 Signaling in Hypothalamic Paraventricular Nucleus of Male but not Female Mice
Wang, G., Woods, C., Johnson, M. A., Milner, T. A., & Glass, M. J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2021.12.041 · Cited by 7 · see citing works
Self-citation
A Review on Garlic as a Supplement for Alzheimer’s Disease: A Mechanistic Insight into its Direct and Indirect Effects
Ghazimoradi, M. M., Pour, M. G., Ghoushi, E., Ahmadabadi, H. K., & Rafieian‐Kopaei, M. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230222093016 · Cited by 7 · see citing works
Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model
Hancock, A. M., & Frostig, R. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206291 · Cited by 6 · see citing works
Experimental Evidences Supporting Training-Induced Benefits in Spontaneously Hypertensive Rats
Masson, G. S., & Michelini, L. C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4307-9_16 · Cited by 5 · see citing works
Angiotensin-(1-7) Receptor Mas in Hemodynamic and Thermoregulatory Dysfunction After High-Level Spinal Cord Injury in Mice: A Pilot Study
Järve, A., Todiraş, M., Kny, M., Fischer, F. I., Kraemer, J. F., Wessel, N., Plehm, R., Fielitz, J., Alenina, N. V., & Bäder, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01930 · Cited by 5 · see citing works
The relationship between dehydration and etiologic subtypes of major neurocognitive disorder in older patients
Kirazoğlu, D. A., Heybeli, C., Atcıyurt, K., Yigitalp, V., Smith, L., Veronese, N., Rahmati, M., & Soysal, P. (2024) · European Geriatric Medicine · doi:10.1007/s41999-024-00986-z · Cited by 5 · see citing works
Fourth European stroke science workshop
Debette, S., Strbian, D., Wardlaw, J. M., van der Worp, H. B., Rinkel, G. J. E., Caso, V., Dichgans, M., Co-convenors, O. B. O. T. E. S. S. W. P. A., & Universitätsmedizin Berlin, B. (2018) · European Stroke Journal · doi:10.1177/2396987318774443 · Cited by 5 · see citing works
Central Nucleus of Amygdala Mediate Pressor Response Elicited by Microinjection of Angiotensin II into the Parvocellular Paraventricular Nucleus in Rats.
Rostami, B., & Hatam, M. (2022) · PubMed Central · doi:10.30476/ijms.2021.90015.2080 · Cited by 4 · see citing works
The Correlation between High-Sensitivity C-Reactive Protein, Matrix Metallopeptidase 9, and Traditional Chinese Medicine Syndrome in Patients with Hypertension
Wu, A., Zhang, D., Gao, Y., Lou, L., Zhu, H., Chai, L., Lv, X., Sun, Y., Zhu, L., & Wang, S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/780937 · Cited by 4 · see citing works
Circulating mitochondria carrying cGAS promote endothelial Secreted group IIA phospholipase A2-mediated neuroinflammation through activating astroglial/microglial Integrin-alphavbeta3 in subfornical organ to augment central sympathetic overdrive in heart failure rats
Zhang, S., Huang, Y., Han, C., Chen, M., Yang, Z., & Wang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113649 · Cited by 4 · see citing works
Microvascular changes that stagger the mind
Faraci, F. M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci153202 · Cited by 3 · see citing works
Cellular Profile of Subfornical Organ Insulin Receptors in Mice
Kim, H. R., Jeong, J. K., & Young, C. N. (2024) · Biomolecules · doi:10.3390/biom14101256 · Cited by 3 · see citing works
Interrelationships of Depression with Cognitive Function and Their Association with Quality of Life in Older Adults with Hypertension: National Survey Findings from a Network Perspective
Fan, H., Sun, H., Feng, Y., Zhang, Q., Su, Z., Cheung, T. C. C., Jackson, T., Ungvari, G. S., Xiang, Y., & Wang, G. (2025) · Kidney & Blood Pressure Research · doi:10.1159/000548325 · Cited by 2 · see citing works
Structure and function of neurovascular unit in arterial hypertension
Koźniewska, E., & Aleksandrowicz, M. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1714892 · Cited by 2 · see citing works
Introduction of a pharmacological neurovascular uncoupling model in rats based on results of mice
Varga, B. T., Gáspár, A., Ernyey, A. J., Hutka, B., Tajti, B. T., Zádori, Z., & Gyertyán, I. (2022) · Physiology International · doi:10.1556/2060.2022.00226 · Cited by 2 · see citing works
Estrogen receptor beta activity contributes to both tumor necrosis factor alpha expression in the hypothalamic paraventricular nucleus and the resistance to hypertension following angiotensin II in female mice
Woods, C., Contoreggi, N. H., Johnson, M. A., Milner, T. A., Wang, G., & Glass, M. J. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105420 · Cited by 2 · see citing works
Self-citation
Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey
Fan, H., Sun, H., Feng, Y., Zhang, Q., Xing, H.-Q., Huang, Q.-H., Su, Z., Cheung, T. C. C., Ng, C. H., Xiang, Y., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1579560 · Cited by 2 · see citing works
Blood pressure variability compromises vascular function in middle-aged micePreprint
Mendiola, P. J., O’Herron, P. J., Xie, K., Brands, M. W., Bush, W., Patterson, R., Stefano, V. D., & Filosa, J. A. (2025) · eLife · doi:10.7554/elife.104082 · Cited by 2 · see citing works
Mechanisms of neurovascular regulation in health and disease: Insights from experimental animal models
Casey, N., & Faraco, G. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261448670 · Cited by 1 · see citing works
Self-citation
Perioperative hypertension associated neurohumoral stress response in craniotomy patients: Effects of β-blocker and angiotensin converting enzyme inhibitor
Velayutham, P. K., Adhikary, S. D., Job, V., Babu, K. S., Rajshekhar, V., Chacko, A. G., & Mets, B. (2019) · Interdisciplinary Neurosurgery · doi:10.1016/j.inat.2019.100539 · Cited by 1 · see citing works
Insulin resistance and stroke
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00005-5 · Cited by 1 · see citing works
Blood pressure variability compromises vascular function in middle-aged mice
Mendiola, P. J., O’Herron, P. J., Xie, K., Brands, M. W., Bush, W., Patterson, R., Stefano, V. D., & Filosa, J. A. (2025) · eLife · doi:10.7554/elife.104082.3 · Cited by 1 · see citing works
Ankle brachial index and cognitive function among elderly hypertensive patients with different age stratification: a 2-year longitudinal studyPreprint
Chen, H., Li, M., Liu, L., Shi, A., Yin, Z., & Tian, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1396097/v1 · Cited by 1 · see citing works
Blood pressure variability compromises vascular function in middle-aged micePreprint
Mendiola, P. J., O’Herron, P. J., Xie, K., Brands, M. W., Bush, W., Patterson, R., Stefano, V. D., & Filosa, J. A. (2025) · eLife · doi:10.7554/elife.104082.1 · Cited by 1 · see citing works
Speckle-tracking echocardiography in preclinical mouse models: Implications for cancer therapy-related cardiac dysfunction from inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascadePreprint
Duvenage, E., Cooper, S. T. E., Gattari, D., Cull, J. J., Dash, P. R., Chan, D., Llamedo, M., Rossi, M., Nasuto, S. J., Holderbaum, W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.16.654397 · Cited by 1 · see citing works
Treinamento aeróbio x disfunção autonômica na hipertensão espontânea: uma abordagem molecular em núcleos centrais de regulação.
Masson, G. S. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2014.tde-19112014-133201

The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension
Capone, C., Faraco, G., Park, L., Cao, X., Davisson, R. L., & Iadecola, C. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00679.2010 · Cited by 136 · see citing works
Self-citation
Free radical signaling in the subfornical organ (SFO) is required for the neurometabolic flow coupling dysfunction induced by angiotensin‐II (AngII) hypertension (HTN)
Iadecola, C., Capone, C., Faraco, G., Cao, X., Davisson, R. L., & Wang, G. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.1023.19
Self-citation
Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System
Zimmerman, M. C., Lazartigues, E. D., Sharma, R. V., & Davisson, R. L. (2004) · Circulation Research · doi:10.1161/01.res.0000135483.12297.e4 · Cited by 440 · see citing works
Self-citation
Overexpression of copper/zinc superoxide dismutase (SOD1) in the median preoptic nucleus attenuates chronic angiotensin II hypertension in the rat (686.16)
Collister, J. P., Bellrichard, M., Nahey, D. B., Tian, J., & Zimmerman, M. C. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.686.16
Angiotensin II‐Induced Hypertension Is Attenuated by Overexpressing Copper/Zinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis
Collister, J. P., Taylor‐Smith, H., Drebes, D., Nahey, D. B., Tian, J., & Zimmerman, M. C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3959087 · Cited by 14 · see citing works

Authors: Capone, C., Faraco, G., Peterson, J. R., Coleman, C., Anrather, J., Milner, T. A., Pickel, V. M., Davisson, R. L., & Iadecola, C.
Affiliations: Weill Cornell Medicine (US)
Rockefeller University (US)
Cornell University (US)
ORCID: Faraco, Giuseppe
Anrather, Josef
Milner, Teresa A.
Pickel, Virginia M.
Iadecola, Costantino
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2012-04-04
Volume: 32
Issue: 14
Pages: 4878-4886
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.6262-11.2012
PMC: PMC3328774
OpenAlex: W2132051579
Cited by: 106
References: 67
Citations by year: 2026: 4 · 2025: 9 · 2024: 7 · 2023: 2 · 2022: 10 · 2021: 4 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 11 · 2014: 5 · 2013: 13 · 2012: 2
FWCI: 6.38
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-96571, R01HL063887, HL98351, P01HL096571, R01HL098351)
National Institute of Neurological Disorders and Stroke (R01NS073666)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: subfornical organ, neurovascular coupling, cerebrovascular dysfunction, oxidative stress, Cu/Zn superoxide dismutase, paraventricular nucleus, vasopressin, endothelin-1, ETA receptor, angiotensin II type 1 receptor, somatosensory cortex, circumventricular organs, stroke risk
MeSH terms: Angiotensin II, Animals, Cerebrovascular Circulation, Endothelium, Vascular, Hypertension, Male, Mice, Inbred C57BL, Subfornical Organ, Reactive Oxygen Species, Gene Transfer Techniques, Receptor, Angiotensin, Type 1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks