The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency
Open accessAbstract
Transcription factor Stat3 directs self-renewal of pluripotent mouse embryonic stem (ES) cells downstream of the cytokine leukemia inhibitory factor (LIF). Stat3 upregulates pivotal transcription factors in the ES cell gene regulatory network to sustain naïve identity. Stat3 also contributes to the rapid proliferation of ES cells. Here, we show that Stat3 increases the expression of mitochondrial-encoded transcripts and enhances oxidative metabolism. Chromatin immunoprecipitation reveals that Stat3 binds to the mitochondrial genome, consistent with direct transcriptional regulation. An engineered form of Stat3 that localizes predominantly to mitochondria is sufficient to support enhanced proliferation of ES cells, but not to maintain their undifferentiated phenotype. Furthermore, during reprogramming from primed to naïve states of pluripotency, Stat3 similarly upregulates mitochondrial transcripts and facilitates metabolic resetting. These findings suggest that the potent stimulation of naïve pluripotency by LIF/Stat3 is attributable to parallel and synergistic induction of both mitochondrial respiration and nuclear transcription factors.
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Cites
The ground state of embryonic stem cell self-renewal
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Self-citationFunction of Mitochondrial Stat3 in Cellular Respiration
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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
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A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
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Supercomplex assembly determines electron flux in the mitochondrial electron transport chain
Lapuente-Brun, E., Moreno-Loshuertos, R., Acín-Pérez, R., Latorre-Pellicer, A., Colás, C., Balsa, E., Perales-Clemente, E., Quirós, P. M., Calvo, E., Rodríguez-Hernández, M. A., et al. (2013) · Science · doi:10.1126/science.1230381 · Cited by 830
Metabolic Regulation of Epigenetics
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Aerobic glycolysis tunes YAP/TAZ transcriptional activity
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Defining an essential transcription factor program for naïve pluripotency
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Cited by
Mechanisms and consequences of Jak–STAT signaling in the immune system
Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740
The JAK-STAT pathway at 30: Much learned, much more to do
Philips, R. L., Wang, Y., Cheon, H., Kanno, Y., Gadina, M., Sartorelli, V., Horvath, C. M., Darnell, J. E., Stark, G. R., & O’Shea, J. J. (2022) · Cell · doi:10.1016/j.cell.2022.09.023 · Cited by 720
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Bai, L., Zhou, H., Xu, R., Zhao, Y., Chinnaswamy, K., McEachern, D., Chen, J., Yang, C.-Y., Liu, Z., Wang, M., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.10.002 · Cited by 652
The potential and controversy of targeting STAT family members in cancer
Verhoeven, Y., Tilborghs, S., Jacobs, J., De Waele, J., Quatannens, D., Deben, C., Prenen, H., Pauwels, P., Trinh, X. B., Wouters, A., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.002 · Cited by 409
Metadata
- Authors
- Carbognin, E., Betto, R. M., Soriano, M. E., Smith, A. G., & Martello, G.
- Venue
- The EMBO Journal
- Published
- 2016-02-22
- Volume
- 35
- Issue
- 6
- Pages
- 618-634
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2284282032
- Cited by
- 188
- References
- 9
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Carbognin, E., Betto, R. M., Soriano, M. E., Smith, A. G., & Martello, G. (2016). Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency. The EMBO Journal. https://doi.org/10.15252/embj.201592629
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