Supercomplex assembly determines electron flux in the mitochondrial electron transport chain

Supercomplexes in the respiratory chains of yeast and mammalian mitochondria

Schägger, H., & Pfeiffer, K. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1777 · Cited by 1,356 · see citing works

The Staden Package, 1998

Staden, R., Beal, K. F., & Bonfield, J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:115 · Cited by 1,097 · see citing works

Respiratory active mitochondrial supercomplexes

Acín-Pérez, R., Fernández-Silva, P., Peleato, M. L., Pérez-Martos, A., & Enriquez, J. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.021 · Cited by 817 · see citing works

Respiratory Complex III Is Required to Maintain Complex I in Mammalian Mitochondria

Acín‐Pérez, R., Bayona‐Bafaluy, M. P., Fernández‐Silva, P., Moreno‐Loshuertos, R., Martos, A. P., Bruno, C., Moraes, C. T., & Enrı́quez, J. A. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00124-8 · Cited by 475 · see citing works

The random collision model and a critical assessment of diffusion and collision in mitochondrial electron transport

Hackenbrock, C. R., Chazotte, B., & Gupte, S. S. (1986) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00743010 · Cited by 384 · see citing works

Structure of a mitochondrial supercomplex formed by respiratory-chain complexes I and III

Dudkina, N. V., Eubel, H., Keegstra, W., Boekema, E. J., & Braun, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408870102 · Cited by 336 · see citing works

Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1

Althoff, T., Mills, D. J., Popot, J., & Kühlbrandt, W. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.324 · Cited by 334 · see citing works

Regulation of the pyruvate dehydrogenase complex

Korotchkina, L. G., & Patel, M. S. (2006) · Biochemical Society Transactions · doi:10.1042/bst20060217 · Cited by 330 · see citing works

Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants

Moreno‐Loshuertos, R., Acín‐Pérez, R., Fernández‐Silva, P., Movilla, N., Martos, A. P., de Córdoba, S. R., Gallardo, M. E., & Enrı́quez, J. A. (2006) · Nature Genetics · doi:10.1038/ng1897 · Cited by 325 · see citing works

Architecture of Active Mammalian Respiratory Chain Supercomplexes

Schäfer, E., Seelert, H., Reifschneider, N. H., Krause, F., Dencher, N. A., & Vonck, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513525200 · Cited by 289 · see citing works

Cytochrome c Oxidase Is Required for the Assembly/Stability of Respiratory Complex I in Mouse Fibroblasts

Díaz, F., Fukui, H., García, S., & Moraes, C. T. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01767-05 · Cited by 236 · see citing works

Identification of a Protein Mediating Respiratory Supercomplex Stability

Chen, Y.-C., Taylor, E. B., Dephoure, N., Heo, J.-M., Tonhato, A., Papandreou, I., Nath, N., Denko, N. C., Gygi, S. P., & Rutter, J. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.006 · Cited by 205 · see citing works

Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex

Vukotic, M., Oeljeklaus, S., Wiese, S., Vögtle, F. ‐., Meisinger, C., Meyer, H. E., Zieseniß, A., Katschinski, D. M., Jans, D. C., Jakobs, S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.016 · Cited by 199 · see citing works

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography

Dudkina, N. V., Kudryashev, M., Stahlberg, H., & Boekema, E. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107819108 · Cited by 190 · see citing works

Rcf1 and Rcf2, Members of the Hypoxia-Induced Gene 1 Protein Family, Are Critical Components of the Mitochondrial Cytochrome bc1-Cytochrome c Oxidase Supercomplex

Strogolova, V., Furness, A. I., Robb-McGrath, M., Garlich, J., & Stuart, R. A. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06369-11 · Cited by 185 · see citing works

Identification and Characterization of Respirasomes in Potato Mitochondria

Eubel, H., Heinemeyer, J., & Braun, H. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.038018 · Cited by 168 · see citing works

Isolation of biogenetically competent mitochondria from mammalian tissues and cultured cells

Fernández‐Vizarra, E. (2002) · Methods · doi:10.1016/s1046-2023(02)00034-8 · Cited by 161 · see citing works

Kinetics of integrated electron transfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling

Lenaz, G., & Genova, M. L. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00263.2006 · Cited by 155 · see citing works

Three-Dimensional Structure of the Respiratory Chain Supercomplex I1III2IV1 from Bovine Heart Mitochondria,

Schäfer, E., Dencher, N. A., Vonck, J., & Parcej, D. N. (2007) · Biochemistry · doi:10.1021/bi700983h · Cited by 153 · see citing works

Revisiting the mouse mitochondrial DNA sequence

Bayona‐Bafaluy, M. P. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg739 · Cited by 128 · see citing works

Assay of Mitochondrial ATP Synthesis in Animal Cells and Tissues

Vives-Bauzá, C., Yang, L., & Manfredi, G. (2007) · Methods in cell biology · doi:10.1016/s0091-679x(06)80007-5 · Cited by 111 · see citing works

An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA

Acín‐Pérez, R. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg021 · Cited by 78 · see citing works

Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines

Brea‐Calvo, G., Hernández, M., Fernández‐Ayala, D. J. M., Navas, P., & Sánchez-Alcázar, J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.014 · Cited by 75 · see citing works

Five Entry Points of the Mitochondrially Encoded Subunits in Mammalian Complex I Assembly

Perales‐Clemente, E., Fernández‐Vizarra, E., Acín‐Pérez, R., Movilla, N., Bayona‐Bafaluy, M. P., Moreno‐Loshuertos, R., Martos, A. P., Fernández‐Silva, P., & Enrı́quez, J. A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00025-10 · Cited by 73 · see citing works

Lack of Cytochrome c in Mouse Fibroblasts Disrupts Assembly/Stability of Respiratory Complexes I and IV

Vempati, U. D., Han, X., & Moraes, C. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805972200 · Cited by 66 · see citing works

m.6267G>A: a recurrent mutation in the human mitochondrial DNA that reduces cytochrome c oxidase activity and is associated with tumors

Gallardo, M. E., Moreno‐Loshuertos, R., López‐Menéndez, C., Casqueiro, M., Silva, J., Bonilla, F., de Córdoba, S. R., & Enrı́quez, J. A. (2006) · Human Mutation · doi:10.1002/humu.20338 · Cited by 60 · see citing works

Functional Genetic Analysis of the Mammalian Mitochondrial DNA Encoded Peptides

Bayona‐Bafaluy, M. P., Movilla, N., Martos, A. P., et al. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-261-8_28 · Cited by 12 · see citing works

Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency

Cogliati, S., Frezza, C., Soriano, M. E., Varanita, T., Quintana-Cabrera, R., Corrado, M., Cipolat, S., Costa, V., Casarin, A., Gomes, L. C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.032 · Cited by 1,265 · see citing works

Mitochondrial Cristae: Where Beauty Meets Functionality

Cogliati, S., Enriquez, J. A., & Scorrano, L. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.01.001 · Cited by 816 · see citing works

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA

Tan, A. S., Baty, J. W., Dong, L.-F., Bezawork-Geleta, A., Endaya, B., Goodwin, J., Bajzikova, M., Kovarova, J., Peterka, M., Yan, B., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.003 · Cited by 785 · see citing works

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Nicolás-Ávila, J. A., Lechuga-Vieco, A. V., Esteban-Martínez, L., Sánchez-Díaz, M., Díaz-García, E., Santiago, D. J., Rubio-Ponce, A., Li, J. L., Balachander, A., Quintana, J. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.031 · Cited by 762 · see citing works

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

Eisner, V., Picard, M., & Hajnóczky, G. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0133-0 · Cited by 622 · see citing works

Role of mitochondrial reverse electron transport in ros signaling: Potential roles in health and disease

Scialò, F., Fernández-Ayala, D. J., & Sanz, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00428 · Cited by 517 · see citing works

Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347 · see citing works

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

Garaude, J., Acín-Pérez, R., Martínez-Cano, S., Enamorado, M., Ugolini, M., Nistal-Villán, E., Hervás-Stubbs, S., Pelegrín, P., Sander, L. E., Enríquez, J. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3509 · Cited by 313 · see citing works

Functional role of mitochondrial respiratory supercomplexes

Genova, M. L., & Lenaz, G. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.11.002 · Cited by 306 · see citing works

Systems proteomics of liver mitochondria function

Williams, E. G., Wu, Y., Jha, P., Dubuis, S., Blattmann, P., Argmann, C. A., Houten, S. M., Amariuta, T., Wolski, W., Zamboni, N., et al. (2016) · Science · doi:10.1126/science.aad0189 · Cited by 289 · see citing works

How mitochondrial dynamism orchestrates mitophagy

Shirihai, O. S., Song, M., & Dorn, G. W. (2015) · Circulation Research · doi:10.1161/circresaha.116.306374 · Cited by 311 · see citing works

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

Greggio, C., Jha, P., Kulkarni, S. S., Lagarrigue, S., Broskey, N. T., Boutant, M., Wang, X., Conde Alonso, S., Ofori, E., Auwerx, J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.004 · Cited by 286 · see citing works

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

Brown, E. E., DeWeerd, A. J., Ildefonso, C. J., Lewin, A. S., & Ash, J. D. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101201 · Cited by 259 · see citing works

Understanding Ubiquinone

Wang, Y., & Hekimi, S. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.12.007 · Cited by 256 · see citing works

Reconsidering the Role of Mitochondria in Aging

Gonzalez-Freire, M., de Cabo, R., Bernier, M., Sollott, S. J., Fabbri, E., Navas, P., & Ferrucci, L. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv070 · Cited by 244 · see citing works

Na(+) controls hypoxic signalling by the mitochondrial respiratory chain

Hernansanz-Agustín, P., Choya-Foces, C., Carregal-Romero, S., Ramos, E., Oliva, T., Villa-Piña, T., Moreno, L., Izquierdo-Álvarez, A., Cabrera-García, J. D., Cortés, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2551-y · Cited by 238 · see citing works

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

Quirós, P. M., Español, Y., Acín-Pérez, R., Rodríguez, F., Bárcena, C., Watanabe, K., Calvo, E., Loureiro, M., Fernández-García, M. S., Fueyo, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.018 · Cited by 233 · see citing works

Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia

Mandò, C., De Palma, C., Stampalija, T., Anelli, G. M., Figus, M., Novielli, C., Parisi, F., Clementi, E., Ferrazzi, E., & Cetin, I. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00426.2013 · Cited by 196 · see citing works

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

Antoun, G., McMurray, F., Thrush, A. B., Patten, D. A., Peixoto, A. C., Slack, R. S., McPherson, R., Dent, R., & Harper, M.-E. (2015) · Diabetologia · doi:10.1007/s00125-015-3772-8 · Cited by 112 · see citing works

Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia–Reperfusion

Jang, S., Lewis, T. S., Powers, C., Khuchua, Z., Baines, C. P., Wipf, P., & Javadov, S. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6635 · Cited by 103 · see citing works

ATP Citrate Lyase Improves Mitochondrial Function in Skeletal Muscle

Das, S., Morvan, F., Jourde, B., Meier, V., Kahle, P., Brebbia, P., Toussaint, G., Glass, D. J., & Fornaro, M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.006 · Cited by 91 · see citing works

High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content

Granata, C., Caruana, N. J., Botella, J., Jamnick, N. A., Huynh, K., Kuang, J., Janssen, H. A., Reljic, B., Mellett, N. A., Laskowski, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27153-3 · Cited by 93 · see citing works

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

Acín-Pérez, R., Iborra, S., Martí-Mateos, Y., Cook, E. C. L., Conde-Garrosa, R., Petcherski, A., Muñoz, M. D. M., Martínez de Mena, R., Krishnan, K. C., Jiménez, C., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00273-8 · Cited by 83 · see citing works

Secondary Coenzyme Q 10 Deficiencies in Oxidative Phosphorylation (OXPHOS) and Non-OXPHOS Disorders

Yubero, D., Montero, R., Martín, M. A., Montoya, J., Ribes, A., Grazina, M., Trevisson, E., Rodriguez-Aguilera, J. C., Hargreaves, I. P., Salviati, L., et al. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.06.007 · Cited by 72 · see citing works

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes

Milenkovic, D., Misic, J., Hevler, J. F., Molinié, T., Chung, I., Atanassov, I., Li, X., Filograna, R., Mesaros, A., Mourier, A., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.015 · Cited by 68 · see citing works

Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies

Tepp, K., Timohhina, N., Puurand, M., Klepinin, A., Chekulayev, V., Shevchuk, I., & Kaambre, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.001 · Cited by 21 · see citing works

Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency

Rustin, P., Münnich, A., & Rötig, A. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)82005-6 · Cited by 23 · see citing works

Total and reduced/oxidized forms of coenzyme Q10 in fibroblasts of patients with mitochondrial disease

Watanabe, C., Osaka, H., Watanabe, M., Miyauchi, A., Jimbo, E. F., Tokuyama, T., Uosaki, H., Kishita, Y., Okazaki, Y., Onuki, T., et al. (2023) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2022.100951 · Cited by 11 · see citing works

Mitochondrial DNA damage in aging and in apoptosis

Viña, J., Pallardó, F. V., & Sastre, J. (1998) · Pathophysiology · doi:10.1016/s0928-4680(98)80623-8

Oxidative phosphorylation and its reversal

Ernster, L. (1963) · Springer eBooks · doi:10.1007/978-3-642-86784-2_8 · Cited by 3 · see citing works

Erratum to “Ascorbate reduces superoxide production and improves mitochondrial respiratory chain function in human fibroblasts with electron transport chain deficiencies” [Mitochondrian (2001) 191–198]

Sharma, P., & Mongan, P. D. (2001) · Mitochondrion · doi:10.1016/s1567-7249(01)00032-0 · Cited by 1 · see citing works