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Cited by 740Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

STAT3 signaling in immunity

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Hillmer, Emily J., Zhang, Huiyuan, Li, Haiyan S., Watowich, Stephanie S.·2016·Cytokine & Growth Factor Reviews
DOI 10.1016/j.cytogfr.2016.05.001PMC PMC5050093
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Abstract

The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer. Strikingly, however, either hyperactivation or inactivation of STAT3 results in human disease, indicating tightly regulated STAT3 function is central to health. Here, we attempt to summarize information on the numerous and distinct biological actions of STAT3, and highlight recent discoveries, with a specific focus on STAT3 function in the immune and hematopoietic systems. Our goal is to spur investigation on mechanisms by which aberrant STAT3 function drives human disease and novel approaches that might be used to modulate disease outcome.

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Cited by

Sorted by citations

Authors
Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Watowich, Stephanie S.
ORCID
Venue
Cytokine & Growth Factor Reviews
Publisher
Elsevier BV
Published
2016-10
Volume
31
Pages
1-15
ISSN
1359-6101 (ISSN-L)
DOI
10.1016/j.cytogfr.2016.05.001
PMC
PMC5050093
OpenAlex
W2345774905
Cited by
740
References
26
Citations by year
2026: 60 · 2025: 108 · 2024: 113 · 2023: 108 · 2022: 93 · 2021: 110 · 2020: 67 · 2019: 38 · 2018: 26 · 2017: 17
FWCI
2.72
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cytokine & Growth Factor Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH NIAID (RO1AI109294)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
STAT3, immune signaling, inflammation, hematopoietic system, immunodeficiency, autoimmunity, cancer, STAT3 mutations, transcriptional regulation, disease modulation
MeSH terms
Animals, Humans, Immunity, Innate, Immune System Diseases, Mutation, STAT3 Transcription Factor, Adaptive Immunity

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