The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
CLPP coordinates mitoribosomal assembly through the regulation of ERAL 1 levels
Open accessAbstract
Despite being one of the most studied proteases in bacteria, very little is known about the role of Clp XP in mitochondria. We now present evidence that mammalian CLPP has an essential role in determining the rate of mitochondrial protein synthesis by regulating the level of mitoribosome assembly. Through a proteomic approach and the use of a catalytically inactive CLPP , we produced the first comprehensive list of possible mammalian Clp XP substrates involved in the regulation of mitochondrial translation, oxidative phosphorylation, and a number of metabolic pathways. We further show that the defect in mitoribosomal assembly is a consequence of the accumulation of ERAL 1, a putative 12S rRNA chaperone, and novel Clp XP substrate. The presented data suggest that the timely removal of ERAL 1 from the small ribosomal subunit is essential for the efficient maturation of the mitoribosome and a normal rate of mitochondrial translation.
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GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
Eden, E., Navon, R., Steinfeld, I., Lipson, D., & Yakhini, Z. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-48 · Cited by 3,356
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis
Hance, N., Ekstrand, M. I., & Trifunovic, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi184 · Cited by 272
Yagi, M., Uchiumi, T., Takazaki, S., Okuno, B., Nomura, M., Yoshida, S.-I., Kanki, T., & Kang, D. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks774 · Cited by 169
Cited by
Genetic diagnosis of Mendelian disorders via RNA sequencing
Kremer, L. S., Bader, D. M., Mertes, C., Kopajtich, R., Pichler, G., Iuso, A., Haack, T. B., Graf, E., Schwarzmayr, T., Terrile, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15824 · Cited by 590
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
Peralta, S., Goffart, S., Williams, S. L., Diaz, F., Garcia, S., Nissanka, N., Area-Gomez, E., Pohjoismäki, J., & Moraes, C. T. (2018) · Journal of Cell Science · doi:10.1242/jcs.217075 · Cited by 110
The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
Yi, H.-S., Chang, J. Y., & Shong, M. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0005 · Cited by 99
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis
Becker, C., Kukat, A., Szczepanowska, K., Hermans, S., Senft, K., Brandscheid, C. P., Maiti, P., & Trifunovic, A. (2018) · The EMBO Reports · doi:10.15252/embr.201745126 · Cited by 60
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Metadata
- Authors
- Szczepanowska, K., Maiti, P., Kukat, A., Hofsetz, E., Nolte, H., Senft, K., Becker, C., Ruzzenente, B., Hornig‐Do, H., Wibom, R., Wiesner, R. J., Krüger, M., & Trifunovic, A.
- Venue
- The EMBO Journal
- Published
- 2016-10-20
- Volume
- 35
- Issue
- 23
- Pages
- 2566-2583
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2533060164
- Cited by
- 161
- References
- 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Szczepanowska, K., Maiti, P., Kukat, A., Hofsetz, E., Nolte, H., Senft, K., Becker, C., Ruzzenente, B., Hornig‐Do, H., Wibom, R., Wiesner, R. J., Krüger, M., & Trifunovic, A. (2016). CLPP coordinates mitoribosomal assembly through the regulation of ERAL 1 levels. The EMBO Journal. https://doi.org/10.15252/embj.201694253
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