The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Nutrient sensing and TOR signaling in yeast and mammals
Open accessAbstract
Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR ) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR ‐related diseases.
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Citations
Cites
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
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“In yeast, the EGO (Ego1 – Ego2 – Ego3) ternary complex, the ortholog of RAGULATOR, tethers Gtr1/2 to the vacuole (the yeast equivalent of the lysosome) (Kogan et al , 2010; Zhang et al , 2012; Levine et al , 2013; Powis et al , 2015).”
InfluentialRheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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Self-citationZoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science · doi:10.1126/science.1207056 · Cited by 1,673
Regulation of TORC1 by Rag GTPases in nutrient response
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p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
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“…proposed to repress mTORC1 through at least three different mechanisms: (i) by activating AMPK (AMP-activated protein kinase) and the TSC complex (Budanov & Karin, 2008), (ii) by acting as a GDI (guanosine dissociation inhibitor) to prevent GDP dissociation from RAGA/B (Peng et al , 2014), and…”
Cited by
Mechanism and medical implications of mammalian autophagy
Dikic, I., & Elazar, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0003-4 · Cited by 2,771
mTOR signalling and cellular metabolism are mutual determinants in cancer
Mossmann, D., Park, S., & Hall, M. N. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0074-8 · Cited by 1,088
Self-citationAMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797
Self-citationCancer cell metabolism: the essential role of the nonessential amino acid, glutamine
Zhang, J., Pavlova, N. N., & Thompson, C. B. (2017) · The EMBO Journal · doi:10.15252/embj.201696151 · Cited by 651
Regulation of proteasome assembly and activity in health and disease
Rousseau, A., & Bertolotti, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0040-z · Cited by 510
Metadata
- Authors
- González, A., & Hall, M. N.
- Venue
- The EMBO Journal
- Published
- 2017-01-17
- Volume
- 36
- Issue
- 4
- Pages
- 397-408
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2576890255
- Cited by
- 732
- References
- 37
- FWCI
- 27.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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