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Nutrient sensing and TOR signaling in yeast and mammals
Open accessAbstract
Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR ) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR ‐related diseases.
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Citations
Cites
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Self-citationAMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797
Self-citationCancer cell metabolism: the essential role of the nonessential amino acid, glutamine
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Metadata
- Authors
- González, A., & Hall, M. N.
- Venue
- The EMBO Journal
- Published
- 2017-01-17
- Volume
- 36
- Issue
- 4
- Pages
- 397-408
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2576890255
- Cited by
- 732
- References
- 37
- FWCI
- 27.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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