The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent
Open accessAbstract
Abstract The mitochondrial membrane potential (ΔΨ m ) is the main driver of oxidative phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of cristae and inner boundary membranes (IBM), is considered to carry a uniform ΔΨ m . However, sequestration of OXPHOS components in cristae membranes necessitates a re‐examination of the equipotential representation of the IMM. We developed an approach to monitor ΔΨ m at the resolution of individual cristae. We found that the IMM was divided into segments with distinct ΔΨ m , corresponding to cristae and IBM. ΔΨ m was higher at cristae compared to IBM. Treatment with oligomycin increased, whereas FCCP decreased, ΔΨ m heterogeneity along the IMM. Impairment of cristae structure through deletion of MICOS‐complex components or Opa1 diminished this intramitochondrial heterogeneity of ΔΨ m . Lastly, we determined that different cristae within the individual mitochondrion can have disparate membrane potentials and that interventions causing acute depolarization may affect some cristae while sparing others. Altogether, our data support a new model in which cristae within the same mitochondrion behave as independent bioenergetic units, preventing the failure of specific cristae from spreading dysfunction to the rest.
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Cites
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · cited 1×
“…at different subcellular compartments can be used to extrapolate the differences in concentrations of the probe, which are needed to calculate the difference in D Ψ m between compartments (Ehrenberg et al , 1988; Farkas et al , 1989; Loew et al , 1993; Wikstrom et al , 2007; Twig et al , 2008).”
Self-citationOPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.025 · Cited by 1,673
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
Ishihara, N., Fujita, Y., Oka, T., & Mihara, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601184 · Cited by 899
OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes
Amati-Bonneau, P., Valentino, M. L., Reynier, P., Gallardo, M. E., Bornstein, B., Boissiere, A., Campos, Y., Rivera, H., de la Aleja, J. G., Carroccia, R., et al. (2008) · Brain · doi:10.1093/brain/awm298 · Cited by 520
Mitochondrial filaments and clusters as intracellular power-transmitting cables
Skulachev, V. P. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01735-7 · Cited by 477
Mitochondrial reticulum for cellular energy distribution in muscle
Glancy, B., Hartnell, L. M., Malide, D., Yu, Z.-X., Combs, C. A., Connelly, P. S., Subramaniam, S., & Balaban, R. S. (2015) · Nature · doi:10.1038/nature14614 · Cited by 450
Amchenkova, A. A., Bakeeva, L. E., Chentsov, Y. S., Skulachev, V. P., & Zorov, D. B. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.2.481 · Cited by 284
Cited by
The cell biology of mitochondrial membrane dynamics
Giacomello, M., Pyakurel, A., Glytsou, C., & Scorrano, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0210-7 · Cited by 1,550
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Kleele, T., Rey, T., Winter, J., Zaganelli, S., Mahecic, D., Perreten Lambert, H., Ruberto, F. P., Nemir, M., Wai, T., Pedrazzini, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03510-6 · Cited by 794
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
Mitochondrial calcium exchange in physiology and disease
Garbincius, J. F., & Elrod, J. W. (2022) · Physiological Reviews · doi:10.1152/physrev.00041.2020 · Cited by 412
Imaging Approaches for the Study of Metabolism in Real Time Using Genetically Encoded Reporters
Chandris, P., Giannouli, C. C., & Panayotou, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725114 · Cited by 19
Metadata
- Authors
- Wolf, D. M., Segawa, M., Kondadi, A. K., Anand, R., Bailey, S. T., Reichert, A. S., van der Bliek, A. M., Shackelford, D. B., Liesa, M., & Shirihai, O. S.
- Venue
- The EMBO Journal
- Published
- 2019-10-14
- Volume
- 38
- Issue
- 22
- Pages
- e101056-e101056
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2980251061
- Cited by
- 330
- References
- 7
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wolf, D. M., Segawa, M., Kondadi, A. K., Anand, R., Bailey, S. T., Reichert, A. S., van der Bliek, A. M., Shackelford, D. B., Liesa, M., & Shirihai, O. S. (2019). Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. The EMBO Journal. https://doi.org/10.15252/embj.2018101056
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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