Mitochondrial filaments and clusters as intracellular power-transmitting cables
Abstract
Mitochondria exist in two interconverting forms; as small isolated particles, and as extended filaments, networks or clusters connected with intermitochondrial junctions. Extended mitochondria can represent electrically united systems, which can facilitate energy delivery from the cell periphery to the cell core and organize antioxidant defence of the cell interior when O2 is consumed by mitochondrial clusters near the the outer cell membrane, and protonic potential is transmitted to the cell core mitochondria to form ATP. As to small mitochondria, they might represent a transportable form of these organelles.
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This operation is unique to myotubes; previous reports on cardiac myocytes or fibroblasts suggest there are several independent clusters of electrically connected mitochondria per cell.
“This operation is unique to myotubes, and previous reports on cardiac myocytes or on fibroblasts suggest there are several independent clusters of electrically connected mitochondria per cell (3”
From Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism (2003) · cites this paper as [4]
Mitochondrial fusion enables redistribution of energy in the form of mitochondrial potential, metabolites, proteins, and mtDNA, improving calcium handling and ATP synthesis.
“This process enables the redistribution of energy in the form of mitochondrial potential, metabolites, proteins, and mtDNA, improving calcium handling, and ATP synthesis [24, 54–57].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [56]
In healthy cells, mitochondrial fusion provides a synchronized internal cable for translocating metabolites and intramitochondrial mixing during biogenesis, whereas mitochondrial division facilitates the equal distribution of mitochondria into daughter cells during mitosis and allows the selective degradation of damaged mitochondria through autophagy.
“In healthy cells, mitochondrial fusion provides a synchronized internal cable for translocating metabolites and intramitochondrial mixing during biogenesis, whereas mitochondrial division facilitates the equal distribution of mitochondria into daughter cells during mitosis and allows the selective degradation of damaged mitochondria through autophagy (Chen and Chan, 2009; Skulachev, 2001).”
From New insights into the role of mitochondria in aging: mitochondrial dynamics and more (2010) · cites this paper as Skulachev, 2001
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- Authors
- Skulachev, V. P.
- Affiliations
- Lomonosov Moscow State University (RU)
- Corresponding author
- Skulachev, Vladimir P.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 26
- Issue
- 1
- Pages
- 23-29
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2041061895
- Cited by
- 477
- References
- 40
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 10 · 2023: 12 · 2022: 17 · 2021: 28 · 2020: 19 · 2019: 23 · 2018: 16 · 2017: 13 · 2016: 20 · 2015: 19 · 2014: 18 · 2013: 11 · 2012: 30
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial network, antioxidant defense, proton potential, ATP production, mitochondrial transport, mitochondrial morphology
- MeSH terms
- Adenosine Triphosphate, Animals, Electrophysiology, Humans, Mitochondria, Neurons, Afferent
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