The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Biology, detection, and clinical implications of circulating tumor cells
Open accessAbstract
Cancer metastasis is the main cause of cancer‐related death, and dissemination of tumor cells through the blood circulation is an important intermediate step that also exemplifies the switch from localized to systemic disease. Early detection and characterization of circulating tumor cells ( CTC s) is therefore important as a general strategy to monitor and prevent the development of overt metastatic disease. Furthermore, sequential analysis of CTC s can provide clinically relevant information on the effectiveness and progression of systemic therapies (e.g., chemo‐, hormonal, or targeted therapies with antibodies or small inhibitors). Although many advances have been made regarding the detection and molecular characterization of CTC s, several challenges still exist that limit the current use of this important diagnostic approach. In this review, we discuss the biology of tumor cell dissemination, technical advances, as well as the challenges and potential clinical implications of CTC detection and characterization.
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Cites
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“Through this approach, CTC counts have been associated with an independent prognostic power on progression-free survival (PFS) and overall survival (OS) in primary and metastatic disease (Cristofanilli et al , 2004; de Bono et al , 2008; Cohen et al , 2009; Bidard et al , 2014; Rack et al , 2014).”
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D’Hulst, G., Soro-Arnaiz, I., Masschelein, E., Veys, K., Fitzgerald, G., Smeuninx, B., Kim, S., Deldicque, L., Blaauw, B., Carmeliet, P., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13889-6 · Cited by 2,310
Cancer stem cells as key drivers of tumour progression
Ayob, A. Z., & Ramasamy, T. S. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0426-4 · Cited by 910
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Interrogating open issues in cancer precision medicine with patient-derived xenografts
Byrne, A. T., Alférez, D. G., Amant, F., Annibali, D., Arribas, J., Biankin, A. V., Bruna, A., Budinská, E., Caldas, C., Chang, D. K., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.140 · Cited by 657
Metadata
- Authors
- Joosse, S. A., Gorges, T. M., & Pantel, K.
- Venue
- EMBO Molecular Medicine
- Published
- 2014-11-14
- Volume
- 7
- Issue
- 1
- Pages
- 1-11
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- OpenAlex
- W2149255571
- Cited by
- 528
- References
- 10
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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