Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works

Osteoclast differentiation and activation

Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · see citing works

Combinatorial microRNA target predictions

Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603 · see citing works

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766 · see citing works

Causes and consequences of microRNA dysregulation in cancer

Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,003 · see citing works

A multigenic program mediating breast cancer metastasis to bone

Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,562 · see citing works

Leukocyte-endothelial adhesion molecules

Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.bloodjournal8472068 · Cited by 2,500 · see citing works

Leukocyte-endothelial adhesion molecules

Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.2068 · Cited by 1,957 · see citing works

Genetic regulation of osteoclast development and function

Teitelbaum, S. L., & Ross, F. (2003) · Nature reviews genetics · doi:10.1038/nrg1122 · Cited by 1,733 · see citing works

The Diverse Functions of MicroRNAs in Animal Development and Disease

Kloosterman, W. P., & Plasterk, R. H. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.009 · Cited by 1,714 · see citing works

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298 · see citing works

Cancer to bone: a fatal attraction

Weilbaecher, K. N., Guise, T. A., & McCauley, L. K. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3055 · Cited by 1,283 · see citing works

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,253 · see citing works

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

Hodgkinson, C. A., Moore, K. J., Nakayama, A., Steingrı́msson, E., Copeland, N. G., Jenkins, N. A., & Arnheiter, H. (1993) · Cell · doi:10.1016/0092-8674(93)90429-t · Cited by 1,092 · see citing works

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

Sethi, N. S., Dai, X., Winter, C. G., & Kang, Y. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.022 · Cited by 573 · see citing works

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

Lü, X., Mu, E. W., Wei, Y., Riethdorf, S., Yang, Q., Yuan, M., Yan, J., Hua, Y., Tiede, B., Lu, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.002 · Cited by 494 · see citing works

A novel orthotopic model of breast cancer metastasis to bone

Lelekakis, M., Moseley, J. M., Martin, T. J., Hards, D. K., Williams, E. D., Ho, P. W. M., Lowen, D., Javni, J. A., Miller, F. R., Slavin, J., et al. (1999) · Clinical & Experimental Metastasis · doi:10.1023/a:1006689719505 · Cited by 428 · see citing works

A microRNA expression signature of osteoclastogenesis

Sugatani, T., Vacher, J., & Hruska, K. A. (2011) · Blood · doi:10.1182/blood-2010-10-311415 · Cited by 275 · see citing works

Impaired Micro-RNA Pathways Diminish Osteoclast Differentiation and Function

Sugatani, T., & Hruska, K. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805777200 · Cited by 233 · see citing works

Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis

Korpal, M., Yan, J., Lü, X., Xu, S., Lerit, D. A., & Kang, Y. (2009) · Nature Medicine · doi:10.1038/nm.1943 · Cited by 217 · see citing works

MicroRNA‐223 is a key factor in osteoclast differentiation

Sugatani, T., & Hruska, K. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21335 · Cited by 194 · see citing works

MITF and PU.1 Recruit p38 MAPK and NFATc1 to Target Genes during Osteoclast Differentiation

Sharma, S. M., Bronisz, A., Hu, R., Patel, K., Mansky, K. C., Sif, S., & Ostrowski, M. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609723200 · Cited by 174 · see citing works

Linkage of M-CSF Signaling to Mitf, TFE3, and the Osteoclast Defect in Mitfmi/mi Mice

Weilbaecher, K. N., Motyckova, G., Huber, W. E., Takemoto, C. M., Hemesath, T. J., Xu, Y., Hershey, C. L., Dowland, N., Wells, A. G., & Fisher, D. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00360-4 · Cited by 168 · see citing works

Osteoclast‐specific Dicer gene deficiency suppresses osteoclastic bone resorption

Mizoguchi, F., Izu, Y., Hayata, T., Hemmi, H., Nakashima, K., Nakamura, T., Kato, S., Miyasaka, N., Ezura, Y., & Noda, M. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22228 · Cited by 167 · see citing works

Free DNA and Carcinoembryonic Antigen Serum Levels: An Important Combination for Diagnosis of Colorectal Cancer

Flamini, E., Mercatali, L., Nanni, O., Calistri, D., Nunziatini, R., Zoli, W., Rosetti, P., Gardini, N., Lattuneddu, A., Verdecchia, G. M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1931 · Cited by 132 · see citing works

Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function

Hershey, C. L., & Fisher, D. E. (2003) · Bone · doi:10.1016/j.bone.2003.08.014 · Cited by 126 · see citing works

MT1-MMP Is Required for Myeloid Cell Fusion via Regulation of Rac1 Signaling

Gonzalo, P., Guadamillas, M. C., Hernández-Riquer, M. V., Pollán, Á., Grande-García, A., Bartolomé, R. A., Vasanji, A., Ambrogio, C., Chiarle, R., Teixidó, J., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.11.012 · Cited by 125 · see citing works

Interferon‐β‐induced miR‐155 inhibits osteoclast differentiation by targeting SOCS1 and MITF

Zhang, J., Zhao, H., Chen, J., Xia, B., Jin, Y., Wei, W., Shen, J., & Huang, Y. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.06.047 · Cited by 120 · see citing works

SnapShot: Bone Metastasis

Ell, B. J., & Kang, Y. (2012) · Cell · doi:10.1016/j.cell.2012.10.005 · Cited by 115 · see citing works

RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II

Hemingway, F., Taylor, R., Knowles, H. J., & Athanasou, N. A. (2010) · Bone · doi:10.1016/j.bone.2010.12.023 · Cited by 112 · see citing works

miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate

Mann, M., Barad, O., Agami, R., Geiger, B., & Hornstein, E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915022107 · Cited by 108 · see citing works

Therapeutic targets for bone metastases in breast cancer

Clézardin, P. (2011) · Breast Cancer Research · doi:10.1186/bcr2835 · Cited by 108 · see citing works

Global secretome analysis identifies novel mediators of bone metastasis

Blanco, M. A., LeRoy, G., Khan, Z., Alečković, M., Zee, B. M., Garcia, B. A., & Kang, Y. (2012) · Cell Research · doi:10.1038/cr.2012.89 · Cited by 96 · see citing works

The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade

Le, X., Merchant, O., Bast, R. C., & Calin, G. A. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0037-4 · Cited by 93 · see citing works

Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia in Mice

Davey, R. A., Turner, A. G., McManus, J. F., Chiu, W. M., Tjahyono, F., Moore, A. J., Atkins, G. J., Anderson, P. H., Ma, C., Glatt, V., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080310 · Cited by 87 · see citing works

Integrins and Cytokines Activate Nuclear Transcription Factor-κB in Human Neutrophils

Kettritz, R., Choi, M., Rolle, S., Wellner, M., & Luft, F. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309778200 · Cited by 77 · see citing works

Involvement of adhesion molecules LFA-1 and ICAM-1 in osteoclast development

Kurachi, T., Morita, I., & Murota, S. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90202-z · Cited by 70 · see citing works

Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts

Nakano, K., Okada, Y., Saito, K., & Tanaka, Y. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20367 · Cited by 69 · see citing works

Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder

Chaffer, C. L., Dopheide, B., McCulloch, D. R., Lee, A. B., Moseley, J. M., Thompson, E. W., & Williams, E. D. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-005-5141-3 · Cited by 55 · see citing works

Involvement of Lymphocyte Function-Associated Antigen-1 and Intercellular Adhesion Molecule-1 in Osteoclastogenesis: A Possible Role in Direct Interaction between Osteoclast Precursors

Harada, H., Kukita, T., Kukita, A., Iwamoto, Y., & Iijima, T. (1998) · Endocrinology · doi:10.1210/endo.139.9.6171 · Cited by 47 · see citing works

Aggregation of β2 integrins activates human neutrophils through the IκB/NF-κB pathway

Kim, C. H., Lee, K., Lee, C., Kim, Y. W., Han, S. K., Shim, Y.-S., & Yoo, C. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103038 · Cited by 33 · see citing works

Differential effect of zoledronic acid on normal trabecular and cortical bone density in oncologic patients with bone metastases

Quattrocchi, C. C., Dell’Aia, P., Errante, Y., Occhicone, F., Longo, D., Virzì, V., Tonini, G., Napoli, N., Santini, D., & Zobel, B. B. (2012) · Journal of bone oncology · doi:10.1016/j.jbo.2012.02.001 · Cited by 5 · see citing works

Metastatic colonization by circulating tumour cells

Massagué, J., & Obenauf, A. C. (2016) · Nature · doi:10.1038/nature17038 · Cited by 2,062 · see citing works

Characteristics and Significance of the Pre-metastatic Niche

Liu, Y., & Cao, X. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.011 · Cited by 1,287 · see citing works

Clinical relevance of circulating cell-free microRNAs in cancer

Schwarzenbach, H., Nishida, N., Călin, G. A., & Pantel, K. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.5 · Cited by 1,091 · see citing works

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

Zeng, Z., Li, Y., Pan, Y., Lan, X.-L., Song, F., Sun, J., Zhou, K., Liu, X., Ren, X., Wang, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07810-w · Cited by 995 · see citing works

Tumor metastasis: moving new biological insights into the clinic

Wan, L., Pantel, K., & Kang, Y. (2013) · Nature Medicine · doi:10.1038/nm.3391 · Cited by 746 · see citing works

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

Óskarsson, T., Batlle, E., & Massagué, J. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.002 · Cited by 702 · see citing works

Bone metastases

Coleman, R. E., Croucher, P. I., Padhani, A. R., Clézardin, P., Chow, E., Fallon, M., Guise, T. A., Colangeli, S., Capanna, R., & Costa, L. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00216-3 · Cited by 610 · see citing works

Surviving at a Distance: Organ-Specific Metastasis

Obenauf, A. C., & Massagué, J. (2015) · Trends in cancer · doi:10.1016/j.trecan.2015.07.009 · Cited by 569 · see citing works

Biology, detection, and clinical implications of circulating tumor cells

Joosse, S. A., Gorges, T. M., & Pantel, K. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201303698 · Cited by 531 · see citing works

Understanding the Bone in Cancer Metastasis

Fornetti, J., Welm, A. L., & Stewart, S. A. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3618 · Cited by 528 · see citing works

Data Normalization Strategies for MicroRNA Quantification

Schwarzenbach, H., da Silva, A. M., Calin, G., & Pantel, K. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2015.239459 · Cited by 426 · see citing works

Bone metastasis: mechanisms, therapies, and biomarkers

Clézardin, P., Coleman, R., Puppo, M., Ottewell, P. D., Bonnelye, E., Paycha, F., Confavreux, C. B., & Holen, I. (2020) · Physiological Reviews · doi:10.1152/physrev.00012.2019 · Cited by 427 · see citing works

Cancer stem cells: The root of tumor recurrence and metastases

Peitzsch, C., Tyutyunnykova, A., Pantel, K., & Dubrovska, A. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.02.011 · Cited by 371 · see citing works

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

Sun, W., Zhao, C., Li, Y., Wang, L., Nie, G., Peng, J., Wang, A., Zhang, P., Tian, W., Li, Q., et al. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.15 · Cited by 308 · see citing works

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

Esposito, M., Mondal, N., Greco, T. M., Wei, Y., Spadazzi, C., Lin, S.-C., Zheng, H., Cheung, C., Magnani, J. L., Lin, S.-H., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0309-2 · Cited by 250 · see citing works

MicroRNAs and metastasis: small RNAs play big roles

Kim, J., Yao, F., Xiao, Z., Sun, Y., & Ma, L. (2017) · Cancer and Metastasis Reviews · doi:10.1007/s10555-017-9712-y · Cited by 236 · see citing works

MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis

Deng, R., Zhang, H., Huang, J.-H., Cai, R., Wang, Y., Chen, Y., Hu, B., Ye, Z.-P., Li, Z., Mai, J., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1850609 · Cited by 234 · see citing works

Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake

Zhao, X., Wu, D. L., Ma, X., Wang, J., Hou, W., & Zhang, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110237 · Cited by 220 · see citing works

MicroRNA regulons in tumor microenvironment

Suzuki, H. I., Katsura, A., Matsuyama, H., & Miyazono, K. (2014) · Oncogene · doi:10.1038/onc.2014.254 · Cited by 208 · see citing works

Novel approaches to target the microenvironment of bone metastasis

Hofbauer, L. C., Bözec, A., Rauner, M., Jakob, F. J., Perner, S., & Pantel, K. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00499-9 · Cited by 213 · see citing works

Deep Sequencing of RNA from Three Different Extracellular Vesicle (EV) Subtypes Released from the Human LIM1863 Colon Cancer Cell Line Uncovers Distinct Mirna-Enrichment Signatures

Ji, H., Chen, M.-S., Greening, D., He, W., Rai, A., Zhang, W.-W., & Simpson, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110314 · Cited by 199 · see citing works

miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13

Zhang, P., Wang, L., Rodriguez‐Aguayo, C., Yuan, Y., Debeb, B. G., Chen, D., Sun, Y., You, M. J., Liu, Y., Dean, D. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6671 · Cited by 188 · see citing works

miRNA-30 Family Members Inhibit Breast Cancer Invasion, Osteomimicry, and Bone Destruction by Directly Targeting Multiple Bone Metastasis–Associated Genes

Croset, M., Pantano, F., Kan, C. W. S., Bonnelye, E., Descôtes, F., Alix‐Panabières, C., Lecellier, C., Bachelier, R., Allioli, N., Hong, S. S., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3058 · Cited by 188 · see citing works

Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease

Taipaleenmäki, H., Browne, G., Akech, J., Zustin, J., van Wijnen, A. J., Stein, J. L., Hesse, E., Stein, G. S., & Lian, J. B. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1026 · Cited by 180 · see citing works

Exosomal micro RNA s as tumor markers in epithelial ovarian cancer

Pan, C., Stevic, I., Müller, V., Ni, Q., Oliveira‐Ferrer, L., Pantel, K., & Schwarzenbach, H. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12371 · Cited by 176 · see citing works

Bone metastasis and the metastatic niche

Ren, G., Esposito, M., & Kang, Y. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1329-4 · Cited by 161 · see citing works

Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy

Zheng, H., Bae, Y., Kasimir‐Bauer, S., Tang, R. B., Chen, J., Ren, G., Yuan, M., Esposito, M., Li, W., Wei, Y., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.002 · Cited by 161 · see citing works

Clinical and molecular complexity of breast cancer metastases

Kimbung, S., Loman, N., & Hedenfalk, I. A. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.08.009 · Cited by 149 · see citing works

The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology

Krist, B., Florczyk, U., Pietraszek‐Gremplewicz, K., Józkowicz, A., & Dulak, J. (2015) · International Journal of Endocrinology · doi:10.1155/2015/281756 · Cited by 146 · see citing works

Hypoxia‐Inducible Exosomes Facilitate Liver‐Tropic Premetastatic Niche in Colorectal Cancer

Sun, H., Meng, Q., Shi, C., Yang, H., Li, X., Wu, S., Familiari, G., Relucenti, M., Aschner, M., Wang, X., et al. (2021) · Hepatology · doi:10.1002/hep.32009 · Cited by 143 · see citing works

Green and cost-effective synthesis of carbon dots from date kernel and their application as a novel switchable fluorescence probe for sensitive assay of Zoledronic acid drug in human serum and cellular imaging

Amin, N., Afkhami, A., Hosseinzadeh, L., & Madrakian, T. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.05.014 · Cited by 136 · see citing works

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2

Colden, M., Dar, A. A., Saini, S., Dahiya, P. V., Shahryari, V., Yamamura, S., Tanaka, Y., Stein, G. S., Dahiya, R., & Majid, S. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.15 · Cited by 134 · see citing works

The role of MicroRNAs in Osteoclasts and Osteoporosis

Tang, P., Xiong, Q., Ge, W., & Zhang, L. (2014) · RNA Biology · doi:10.1080/15476286.2014.996462 · Cited by 133 · see citing works

Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both?

Azevedo, A. S., Follain, G., Patthabhiraman, S., Harlepp, S., & Goetz, J. G. (2015) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1059563 · Cited by 126 · see citing works

Targeting bone metastases in prostate cancer: improving clinical outcome

Body, J., Casimiro, S., & Costa, L. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.90 · Cited by 123 · see citing works

Cancer Cell Colonisation in the Bone Microenvironment

Kan, C. W. S., Vargas, G., Pape, F. L., & Clézardin, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101674 · Cited by 116 · see citing works

Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer

Ma, Z., Wei, K., Yang, F., Guo, Z., Pan, C., He, Y., Wang, J., Li, Z., Chen, L., Chen, Y., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04037-4 · Cited by 112 · see citing works

Overexpression and knockout of miR-126 both promote leukemogenesis

Li, Z., Chen, P., Su, R. J., Li, Y., Hu, C., Wang, Y., Arnovitz, S., He, M., Gurbuxani, S. K., Zuo, Z., et al. (2015) · Blood · doi:10.1182/blood-2015-04-639062 · Cited by 111 · see citing works

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works

Considering Exosomal miR-21 as a Biomarker for Cancer

Shi, J. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5040042 · Cited by 109 · see citing works

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade

Wu, X., Zhang, W., Font-Burgada, J., Palmer, T. D., Hamil, A. S., Biswas, S. K., Poidinger, M., Borcherding, N. C., Xie, Q. M., Ellies, L. G., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414358111 · Cited by 105 · see citing works

Cavin‐1/PTRF alters prostate cancer cell‐derived extracellular vesicle content and internalization to attenuate extracellular vesicle‐mediated osteoclastogenesis and osteoblast proliferation

Inder, K. L., Ruelcke, J. E., Petelin, L., Moon, H., Choi, E. A., Rae, J., Blumenthal, A., Hutmacher, D. W., Saunders, N. A., Stow, J. L., et al. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.23784 · Cited by 101 · see citing works

Non-coding RNAs: Epigenetic regulators of bone development and homeostasis

Hassan, M. Q., Tye, C. E., Stein, G. S., & Lian, J. B. (2015) · Bone · doi:10.1016/j.bone.2015.05.026 · Cited by 102 · see citing works

Aberrant plasma levels of circulatingmiR-16, miR-107, miR-130aandmiR-146aare associated with lymph node metastasis and receptor status of breast cancer patients

Stückrath, I., Rack, B. K., Janni, W., Jäger, B., Pantel, K., & Schwarzenbach, H. (2015) · Oncotarget · doi:10.18632/oncotarget.3874 · Cited by 101 · see citing works

Osteoclast Signal Transduction During Bone Metastasis Formation

Győri, D., & Mócsai, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00507 · Cited by 104 · see citing works

Breast Cancer Metastasis

Kim, M. Y. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9620-6_9 · Cited by 101 · see citing works

Development of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model

Mercatali, L., Manna, F. L., Groenewoud, A., Casadei, R., Recine, F., Miserocchi, G., Pieri, F., Liverani, C., Bongiovanni, A., Spadazzi, C., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081375 · Cited by 101 · see citing works

Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness

Waning, D. L., & Guise, T. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1590 · Cited by 100 · see citing works

MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation

Dou, C., Zhang, C., Kang, F., Yang, X., Jiang, H., Bai, Y., Xiang, J., Xu, J., & Dong, S. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.08.002 · Cited by 100 · see citing works

Regulation of cancer metastasis by cell-free miRNAs

Alečković, M., & Kang, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.10.005 · Cited by 100 · see citing works

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban, J., Fock, V., Aryee, D. N. T., & Kovar, H. (2021) · Cells · doi:10.3390/cells10112944 · Cited by 103 · see citing works

Bone marrow as a reservoir for disseminated tumor cells: a special source for liquid biopsy in cancer patients

Pantel, K., & Alix‐Panabières, C. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2014.79 · Cited by 96 · see citing works

microRNA-210 is involved in the regulation of postmenopausal osteoporosis through promotion of VEGF expression and osteoblast differentiation

Liu, X., Cai, F., Liu, L., Zhang, Y., & Yang, A. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0268 · Cited by 92 · see citing works

miRNA-15a/16: As Tumor Suppressors and More

Huang, E., Liu, R., & Chu, Y. (2015) · Future Oncology · doi:10.2217/fon.15.101 · Cited by 90 · see citing works

miR-16-5p Is a Stably-Expressed Housekeeping MicroRNA in Breast Cancer Tissues from Primary Tumors and from Metastatic Sites

Rinnerthaler, G., Hackl, H., Gampenrieder, S. P., Hamacher, F., Hufnagl, C., Hauser‐Kronberger, C., Zehentmayr, F., Fastner, G., Sedlmayer, F., Mlineritsch, B., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020156 · Cited by 90 · see citing works

The role of osteoclasts in breast cancer bone metastasis

le Pape, F., Vargas, G., & Clézardin, P. (2016) · Journal of Bone Oncology · doi:10.1016/j.jbo.2016.02.008 · Cited by 84 · see citing works

MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5

Pan, Y., Wei, L., Wu, X., Huo, F., Mou, J., & Pei, D. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.561 · Cited by 89 · see citing works

Metastases in Prostate CancerPreprint

Manna, F. L., Karkampouna, S., Zoni, E., Menna, M. D., Hensel, J., Thalmann, G. N., & Julio, M. K. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a033688 · Cited by 92 · see citing works

MicroRNAs as regulators of bone homeostasis and bone metastasis

Ell, B. J., & Kang, Y. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2014.44 · Cited by 86 · see citing works

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

Taipaleenmäki, H., Farina, N. H., van Wijnen, A. J., Stein, J. L., Hesse, E., Stein, G. S., & Lian, J. B. (2016) · Oncotarget · doi:10.18632/oncotarget.12593 · Cited by 85 · see citing works

Mechanisms of osteolytic and osteoblastic skeletal lesions

Roodman, G. D., & Silbermann, R. W. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.122 · Cited by 84 · see citing works

Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer

Liu, J., Li, D., Dang, L., Liang, C., Guo, B., Lu, C. C., He, X., Cheung, H. Y.-S., He, B., Liu, B., et al. (2017) · Scientific Reports · doi:10.1038/srep40487 · Cited by 83 · see citing works

New therapeutic targets for cancer bone metastasis

Krzeszinski, J. Y., & Wan, Y. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.006 · Cited by 82 · see citing works

Plasma miRNAs Effectively Distinguish Patients With Pancreatic Cancer From Controls

Xu, J., Cao, Z., Liu, W., You, L., Zhou, L., Wang, C., Lou, W., Sun, B., Miao, Y., Liu, X., et al. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001345 · Cited by 82 · see citing works

Circulating microRNAs in cancer: Hope or hype?

Singh, R., Ramasubramanian, B., Kanji, S., Chakraborty, A., Haque, S. J., & Chakravarti, A. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.07.002 · Cited by 82 · see citing works

Mechanisms governing metastatic dormancy in breast cancer

Dittmer, J. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.006 · Cited by 82 · see citing works

Targeting initial tumour–osteoclast spatiotemporal interaction to prevent bone metastasis

Gu, C., Chen, P., Tian, H., Yang, Y., Huang, Z., Yan, H., Tang, C., Xiang, J., Shangguan, L., Pan, K., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01613-5 · Cited by 81 · see citing works

Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients

Ni, Q., Stevic, I., Pan, C., Müller, V., Oliveira‐Ferrer, L., Pantel, K., & Schwarzenbach, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-31108-y · Cited by 80 · see citing works

An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis

Pekarek, L., Torres‐Carranza, D., Fraile‐Μartinez, O., Montero, C. G., Pekarek, T., Sáez, M. A., Rueda-Correa, F., Pimentel-Martinez, C., Guijarro, L. G., Dı́az, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087268 · Cited by 76 · see citing works

Bone marrow niches in the regulation of bone metastasis

Chen, F., Han, Y., & Kang, Y. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01329-6 · Cited by 75 · see citing works

Molecular insights into tumour metastasis: tracing the dominant events

Jin, K., Li, T., van Dam, H., Zhou, F.-F., & Zhang, L. (2017) · Journal of Pathology · doi:10.1002/path.4871 · Cited by 59 · see citing works

Bisphosphonate-Based Conjugates and Derivatives as Potential Therapeutic Agents in Osteoporosis, Bone Cancer and Metastatic Bone Cancer

Mbese, Z., & Aderibigbe, B. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136869 · Cited by 71 · see citing works

Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: A comprehensive review

Ismail, A., El‐Mahdy, H. A., Abulsoud, A. I., Sallam, A.-A. M., Eldeib, M. G., Elsakka, E. G. E., Zaki, M. B., & Doghish, A. S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.241 · Cited by 67 · see citing works

MicroRNAs: master regulators of drug resistance, stemness, and metastasis

Raza, U., Zhang, J. D., & Şahin, Ö. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1129-2 · Cited by 65 · see citing works

The Role of Bone-Derived Exosomes in Regulating Skeletal Metabolism and Extraosseous Diseases

Lyu, H., Xiao, Y., Guo, Q., Huang, Y., & Luo, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00089 · Cited by 65 · see citing works

Osteocytes and Bone Metastasis

Riquelme, M. A., Cardenas, E. R., & Jiang, J. X. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.567844 · Cited by 65 · see citing works

MicroRNAs in the control of metastatic bone disease

Browne, G., Taipaleenmäki, H., Stein, G. S., Stein, J. L., & Lian, J. B. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.03.014 · Cited by 65 · see citing works

Molecular Regulation of Bone Marrow Metastasis in Prostate and Breast Cancer

Rahim, F., Hajizamani, S., Mortaz, E., Ahmadzadeh, A., Shahjahani, M., Shahrabi, S., & Saki, N. (2014) · Bone Marrow Research · doi:10.1155/2014/405920 · Cited by 64 · see citing works

Deregulated miRNAs in osteoporosis: effects in bone metastasis

Bellavia, D., Salamanna, F., Raimondi, L., Luca, A. D., Carina, V., Costa, V., Alessandro, R., Fini, M., & Giavaresi, G. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03162-w · Cited by 63 · see citing works

Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics

Payandeh, Z., Tangruksa, B., Synnergren, J., Heydarkhan‐Hagvall, S., Nordin, J. Z., Andaloussi, S. E., Borén, J., Wiseman, J., Bohlooly‐Y, M., Lindfors, L., et al. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101302 · Cited by 65 · see citing works

The roles of microRNAs in the regulation of tumor metastasis

Zhou, L., Liu, F., Wang, X., & Ouyang, G. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0028-8 · Cited by 62 · see citing works

MicroRNAs and post-transcriptional regulation of skeletal development

Gámez, B., Rodríguez-Carballo, E., & Ventura, F. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0294 · Cited by 63 · see citing works

Predicting and Overcoming Chemotherapeutic Resistance in Breast Cancer

Chun, K., Park, J. H., & Fan, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6020-5_4 · Cited by 59 · see citing works

Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis

Hegewald, A. B., Breitwieser, K., Ottinger, S. M., Mobarrez, F., Korotkova, M., Réthi, B., Jakobsson, P., Catrina, A. I., Wähämaa, H., & Saul, M. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585282 · Cited by 62 · see citing works

miR-181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM

Liu, X., Liao, W., Peng, H., Luo, X., Luo, Z., Jiang, H., & Xu, L. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-015-1995-1 · Cited by 61 · see citing works

Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox1

Chen, Y., Sun, J., Dou, C., Li, N., Kang, F., Wang, Y., Cao, Z., Yang, X., & Dong, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091516 · Cited by 61 · see citing works

Role of Runx2 in breast cancer-mediated bone metastasis

Mohanakrishnan, V., Swetha, R., Thejaswini, G., Balasubramanian, A., & Selvamurugan, N. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.03.021 · Cited by 62 · see citing works

Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways

Reis, P. P., Drigo, S. A., Carvalho, R. F., Lapa, R. M. L., Felix, T. F., Patel, D., Cheng, D., Pintilie, M., Liu, G., & Tsao, M. (2020) · Cancers · doi:10.3390/cancers12082071 · Cited by 60 · see citing works

Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin

Velletri, T., Huang, Y., Wang, Y., Li, Q., Hu, M., Xie, N., Yang, Q., Chen, Q., Chen, Q., Shou, P., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0590-4 · Cited by 58 · see citing works

MicroRNA-378 Suppressed Osteogenesis of MSCs and Impaired Bone Formation via Inactivating Wnt/β-Catenin Signaling

Lu, F., Zhang, J., Shi, L., Yang, Z., Wu, T., Wang, H., Lin, W., Lu, Y., Lo, J. H. T., Zhu, D., et al. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.07.018 · Cited by 58 · see citing works

Toward biosensors for the detection of circulating microRNA as a cancer biomarker: an overview of the challenges and successes

Tavallaie, R., Almeida, S. R. M. D., & Gooding, J. J. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1324 · Cited by 56 · see citing works

Osteoblast-derived WISP-1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126

Tai, H., Chang, A., Yu, H., Huang, C., Tsai, Y., Lai, Y., Sun, H., Tang, C., & Wang, S. (2014) · Oncotarget · doi:10.18632/oncotarget.2280 · Cited by 55 · see citing works

High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6

Chen, G., Luo, Y., Eriksson, D., Meng, X., Cheng, Q., Bäuerle, T., Chen, X., Schett, G. A., & Bözec, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8474 · Cited by 55 · see citing works

Bone turnover markers and novel biomarkers in lung cancer bone metastases

Lang, J., Zhao, Q., He, Y., & Yu, X. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1463566 · Cited by 54 · see citing works

Tumor-derived miR-378a-3p-containing extracellular vesicles promote osteolysis by activating the Dyrk1a/Nfatc1/Angptl2 axis for bone metastasis

Wang, J., Du, X., Wang, X., Xiao, H., Jing, N., Xue, W., Dong, B., Gao, W., & Fang, Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.11.017 · Cited by 54 · see citing works

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

Zhao, Y., Wu, L., Yue, X., Zhang, C., Wang, J., Li, J., Sun, X., Zhu, Y., Feng, Z., & Hu, W. (2018) · eLife · doi:10.7554/elife.34701 · Cited by 53 · see citing works

miR-590-3p is a novel microRNA which suppresses osteosarcoma progression by targeting SOX9

Wang, W., Qi, Q., Zhao, P., Li, C.-Y., Yin, X.-Y., & Yan, R. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.124 · Cited by 53 · see citing works

Reference miRNAs for colorectal cancer: analysis and verification of current data

Danese, E., Minicozzi, A. M., Benati, M., Paviati, E., Lima-Oliveira, G., Gusella, M., Pasini, F., Salvagno, G. L., Montagnana, M., & Lippi, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-08784-3 · Cited by 52 · see citing works

Runx2 Suppression by miR-342 and miR-363 Inhibits Multiple Myeloma Progression

Gowda, P. S., Wildman, B. J., Trotter, T. N., Xu, X., Hao, X., Hassan, M. Q., & Yang, Y. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0606 · Cited by 53 · see citing works

MicroRNAs and Osteolytic Bone Metastasis: The Roles of MicroRNAs in Tumor-Induced Osteoclast Differentiation

Kagiya, T. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091741 · Cited by 39 · see citing works

Cancer-Associated Osteoclast Differentiation Takes a Good Look in the miR(NA)ror

Waning, D. L., Mohammad, K. S., & Guise, T. A. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.001 · Cited by 15 · see citing works

miRNAs within osteoclasts regulate osteolytic bone metastasis and could be important biomarkers

(2014) · IBMS BoneKEy · doi:10.1038/bonekey.2014.26

Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis

Kitayama, K., Kawamoto, T., Kawakami, Y., Hara, H., Takemori, T., Fujiwara, S., Yahiro, S., Miyamoto, T., Mifune, Y., Hoshino, Y. Y., et al. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5277 · Cited by 13 · see citing works

Deregulated miRNAs in osteoporosis: effects in bone metastasis

Bellavia, D., Salamanna, F., Raimondi, L., Luca, A. D., Carina, V., Costa, V., Alessandro, R., Fini, M., & Giavaresi, G. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03162-w · Cited by 63 · see citing works