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Cited by 328

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Faecal microbiota transplantation protects against radiation‐induced toxicity

Open access
Cui, Ming, Xiao, Huiwen, Li, Yuan, Zhou, Lixin, Zhao, Shuyi, Luo, Dan, Zheng, Qisheng, Dong, Jiali, Zhao, Yu, Zhang, Xin, Zhang, Junling, Lu, Lu, Wang, Haichao, Fan, Saijun·2017·EMBO Molecular Medicine

Abstract

Abstract Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation‐induced toxicity. High‐throughput sequencing showed that gastrointestinal bacterial community composition differed between male and female mice and was associated with susceptibility to radiation toxicity. Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice. FMT preserved the intestinal bacterial composition and retained mRNA and long non‐coding RNA expression profiles of host small intestines in a sex‐specific fashion. Despite promoting angiogenesis, sex‐matched FMT did not accelerate the proliferation of cancer cells in vivo . FMT might serve as a therapeutic to mitigate radiation‐induced toxicity and improve the prognosis of tumour patients after radiotherapy.

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Metadata

Authors
Cui, M., Xiao, H., Li, Y., Zhou, L., Zhao, S., Luo, D., Zheng, Q., Dong, J., Zhao, Y., Zhang, X., Zhang, J., Lu, L., Wang, H., & Fan, S.
Venue
EMBO Molecular Medicine
Published
2017-02-27
Volume
9
Issue
4
Pages
448-461
ISSN
  • 1757-4676 (ISSN-L)
  • 1757-4684
OpenAlex
W2594663793
Cited by
328
References
50
FWCI
15.34
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Faecal microbiota transplantation protects against radiation‐induced toxicity. https://app.cochat.ai/papers/10.15252/emmm.201606932
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Cui, M., Xiao, H., Li, Y., Zhou, L., Zhao, S., Luo, D., Zheng, Q., Dong, J., Zhao, Y., Zhang, X., Zhang, J., Lu, L., Wang, H., & Fan, S. (2017). Faecal microbiota transplantation protects against radiation‐induced toxicity. EMBO Molecular Medicine. https://doi.org/10.15252/emmm.201606932

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