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Sarcoma treatment in the era of molecular medicine
Open accessAbstract
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult‐to‐treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.
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“This seed and soil phenomenon is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration, and drug resistance 15,51,52,53 and contributes to their intrinsic heterogeneity 54,55 .”
From Osteosarcoma (2022) · cites this paper as [53]
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Metadata
- Authors
- Grünewald, T. G., Alonso, M., Avnet, S., Banito, A., Burdach, S., Cidre‐Aranaz, F., Di Pompo, G., Distel, M., Dorado‐Garcia, H., Garcia‐Castro, J., González‐González, L., Grigoriadis, A. E., Kasan, M., Koelsche, C., Krumbholz, M., Lecanda, F., Lemma, S., Longo, D. L., Madrigal‐Esquivel, C., Morales‐Molina, Á., Musa, J., Ohmura, S., Ory, B., Pereira‐Silva, M., Perut, F., Rodriguez, R., Seeling, C., Al Shaaili, N., Shaabani, S., Shiavone, K., Sinha, S., Tomazou, E. M., Trautmann, M., Vela, M., Versleijen‐Jonkers, Y. M., Visgauss, J., Zalacain, M., Schober, S. J., Lissat, A., English, W. R., Baldini, N., & Heymann, D.
- Affiliations
- German Cancer Research Center (DE)
- Universidad de Navarra (ES)
- Istituto Ortopedico Rizzoli (IT)
- Technical University of Munich (DE)
- Pathologisches Institut (DE)
- Instituto de Salud Carlos III (ES)
- King's College London (GB)
- University Hospital Heidelberg (DE)
- Universitätsklinikum Erlangen (DE)
- Centro de Investigación Médica Aplicada (ES)
- Institute of Biostructure and Bioimaging (IT)
- University of Sheffield (GB)
- Heidelberg University (DE)
- Inserm (FR)
- University of Coimbra (PT)
- Universität Ulm (DE)
- University of Groningen (NL)
- University of Helsinki (FI)
- University of Münster (DE)
- Radboud University Medical Center (NL)
- Duke University (US)
- University Children's Hospital Zurich (CH)
- Institut de Cancérologie de l'Ouest (FR)
- Corresponding author
- Grünewald, Thomas GP
- Baldini, Nicola
- Heymann, Dominique
- ORCID
- Grünewald, Thomas GP
- Alonso, Marta
- Avnet, Sofia
- Banito, Ana
- Burdach, Stefan
- Cidre‐Aranaz, Florencia
- Distel, Martin
- González‐González, Laura
- Grigoriadis, Agamemnon E
- Kasan, Merve
- Koelsche, Christian
- Krumbholz, Manuela
- Lecanda, Fernando
- Lemma, Silvia
- Longo, Dario L
- Morales‐Molina, Álvaro
- Musa, Julian
- Ohmura, Shunya
- Ory, Benjamin
- Pereira‐Silva, Miguel
- Perut, Francesca
- Rodriguez, Rene
- Seeling, Carolin
- Shaabani, Shabnam
- Sinha, Snehadri
- Tomazou, Eleni M
- Trautmann, Marcel
- Versleijen‐Jonkers, Yvonne MH
- Visgauss, Julia
- Schober, Sebastian J
- Lissat, Andrej
- English, William R
- Baldini, Nicola
- Heymann, Dominique
- Venue
- EMBO Molecular Medicine
- Published
- 2020-10-13
- Volume
- 12
- Issue
- 11
- Pages
- e11131-e11131
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC7645378
- OpenAlex
- W3092176105
- Cited by
- 319
- References
- 457
- Citations by year
- 2026: 40 · 2025: 50 · 2024: 55 · 2023: 66 · 2022: 50 · 2021: 53 · 2020: 5
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche (ANR-16-IDEX-0007)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- sarcoma, soft tissue sarcoma, bone sarcoma, sarcoma subtypes, multimodal therapy, combination chemotherapy, hyperthermia, immunotherapy, targeted therapy, prognostic factors, predictive biomarkers, pediatric sarcoma, secondary malignancies, therapeutic target
- MeSH terms
- Adolescent, Bone Neoplasms, Child, Humans, Sarcoma, Osteosarcoma, Soft Tissue Neoplasms, Molecular Medicine
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