The DOI matches its Crossref record; 455 of the 457 references it cites were found in a registry or an index.
Sarcoma treatment in the era of molecular medicine
Open accessAbstract
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult‐to‐treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This seed and soil phenomenon is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration, and drug resistance 15,51,52,53 and contributes to their intrinsic heterogeneity 54,55 .”
From Osteosarcoma (2022) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Mu, J., Sun, P., Ma, Z., & Sun, P. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2170-4 · Cited by 36
RetractedThéry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Self-citation3D bioprinting of tissues and organs
Murphy, S. V., & Atala, A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2958 · Cited by 7,034
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
Galon, J., & Bruni, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0007-y · Cited by 3,520
DNA methylation-based classification of central nervous system tumours
Capper, D., Jones, D., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., Koelsche, C., Sahm, F., Chávez, L., Reuß, D., et al. (2018) · Nature · doi:10.1038/nature26000 · Cited by 3,114
Self-citationA view on drug resistance in cancer
Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma
Andtbacka, R. H. I., Kaufman, H. L., Collichio, F. A., AMATRUDA, T. T., Senzer, N. N., Chesney, J. A., Delman, K. A., S̄pitler, L. E., Puzanov, I. J., Agarwala, S. S., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.3377 · Cited by 2,728
The human tumor microbiome is composed of tumor type–specific intracellular bacteria
Nejman, D., Livyatan, I., Fuks, G., Gavert, N., Zwang, Y., Geller, L. T., Rotter-Maskowitz, A., Weiser, R., Mallel, G., Gigi, E., et al. (2020) · Science · doi:10.1126/science.aay9189 · Cited by 2,464
Self-citationPatient-derived organoids model treatment response of metastatic gastrointestinal cancers
Vlachogiannis, G., Hedayat, S., Vatsiou, A., Jamin, Y., Fernández-Mateos, J., Khan, K., Lampis, A., Eason, K., Huntingford, I., Burke, R., et al. (2018) · Science · doi:10.1126/science.aao2774 · Cited by 2,096
B cells are associated with survival and immunotherapy response in sarcoma
Petitprez, F., de Reyniès, A., Keung, E. Z., Chen, T. W.-W., Sun, C.-M., Calderaro, J., Jeng, Y.-M., Hsiao, L.-P., Lacroix, L., Bougoüin, A., et al. (2020) · Nature · doi:10.1038/s41586-019-1906-8 · Cited by 1,942
The Epidemiology of Osteosarcoma
Giulia Ottaviani, M., & Jaffe, N. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_1 · Cited by 1,844
Visvader, J. E. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,524
Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy
Ribas, A., Dummer, R., Puzanov, I., VanderWalde, A., Andtbacka, R. H. I., Michielin, O., Olszanski, A. J., Malvehy, J., Cebon, J., Fernandez, E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.027 · Cited by 1,520
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin
Snyder, M. W., Kircher, M., Hill, A. J., Daza, R. M., & Shendure, J. (2016) · Cell · doi:10.1016/j.cell.2015.11.050 · Cited by 1,492
Tumor Antigen Escape from CAR T-cell Therapy
Majzner, R. G., & Mackall, C. L. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0442 · Cited by 1,233
Judson, I. R., Verweij, J., Gelderblom, H. A. J., Hartmann, J. T., Schöffski, P., Blay, J., Kerst, J. M., Šufliarský, J., Whelan, J. S., Hohenberger, P., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70063-4 · Cited by 1,185
Liquid biopsy and minimal residual disease - latest advances and implications for cure
Pantel, K., & Alix-Panabières, C. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0187-3 · Cited by 1,110
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G.-H., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0349 · Cited by 1,092
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Abeshouse, A., Adebamowo, C., Adebamowo, S. N., Akbani, R., Akeredolu, T., Ally, A., Anderson, M. L., Anur, P., Appelbaum, E. L., Armenia, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.014 · Cited by 1,069
Ahmed, N., Brawley, V. S., Hegde, M., Robertson, C., Ghazi, A., Gerken, C., Liu, E., Dakhova, O., Ashoori, A., Corder, A., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.0225 · Cited by 1,004
Genetic and transcriptional evolution alters cancer cell line drug response
Ben-David, U., Siranosian, B., Ha, G., Tang, H., Oren, Y., Hinohara, K., Strathdee, C. A., Dempster, J., Lyons, N. J., Burns, R., et al. (2018) · Nature · doi:10.1038/s41586-018-0409-3 · Cited by 931
Helleday, T. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.07.001 · Cited by 895
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
Behjati, S., Tarpey, P. S., Presneau, N., Scheipl, S., Pillay, N., Van Loo, P., Wedge, D. C., Cooke, S. L., Gundem, G., Davies, H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2814 · Cited by 854
Corless, C. L., Schroeder, A., Griffith, D., Town, A., McGreevey, L. S., Harrell, P. M., Shiraga, S., Bainbridge, T., Morich, J. R., & Heinrich, M. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.14.068 · Cited by 847
Clark, J., Rocques, P. J., Crew, A. J., Gill, S., SHIPLEY, J. M., Chan, A. M.-L., Gusterson, B. A., & Cooper, C. S. (1994) · Nature Genetics · doi:10.1038/ng0894-502 · Cited by 773
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration
Gaspar, N., Hawkins, D. S., Dirksen, U., Lewis, I. J., Ferrari, S., Deley, M. L., Kovar, H., Grimer, R. J., Whelan, J., Claude, L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.5256 · Cited by 757
Shern, J. F., Chen, L., Chmielecki, J., Wei, J. S., Patidar, R., Rosenberg, M. W., Ambrogio, L., Auclair, D., Wang, J., Song, Y. K., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0639 · Cited by 753
Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis
Eyler, C. E., & Rich, J. N. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.1829 · Cited by 752
Casali, P. G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovée, J. V. M. G., Brodowicz, T., Broto, J. M., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy095 · Cited by 752
Descriptive epidemiology of sarcomas in Europe: Report from the RARECARE project
Stiller, C. A., Trama, A., Serraino, D., Rossi, S., Navarro, C., Chirlaque, M. D., & Casali, P. G. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.09.011 · Cited by 693
Majzner, R. G., Theruvath, J. L., Nellan, A., Heitzeneder, S., Cui, Y., Mount, C. W., Rietberg, S. P., Linde, M. H., Xu, P., Rota, C., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0432 · Cited by 681
Jayasingam, S. D., Citartan, M., Tang, T., Zin, A. A. M., Ang, K., & Ch’ng, E. S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01512 · Cited by 652
The hazards of biopsy in patients with malignant primary bone and soft-tissue tumors.
Mankin, H. J., Lange, T. A., & Spanier, S. S. (1982) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198264080-00002 · Cited by 650
PD-L1 expression and prognostic impact in glioblastoma
Nduom, E. K.-E., Wei, J., Yaghi, N. K., Huang, N., Kong, L.-Y., Gabrusiewicz, K. R., Ling, X., Zhou, S., Ivan, C., Chen, J. Q., et al. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov172 · Cited by 612
Tirode, F., Surdez, D., Ma, X., Parker, M. D., Deley, M. L., Bahrami, A., Zhang, Z., Lapouble, E., Grossetête, S., Rusch, M., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0622 · Cited by 594
Next-generation sequencing in liquid biopsy: cancer screening and early detection
Chen, M., & Zhao, H. (2019) · Human Genomics · doi:10.1186/s40246-019-0220-8 · Cited by 561
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Keller, L., & Pantel, K. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0180-2 · Cited by 560
Rougraff, B. T., Simon, M. A., Kneisl, J. S., Greenberg, D. B., & Mankin, H. J. (1994) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199405000-00004 · Cited by 534
Buddingh, E. P., Kuijjer, M. L., Duim, R. A. J., Bürger, H., Agelopoulos, K., Myklebost, O., Serra, M., Mertens, F., Hogendoorn, P. C. W., Lankester, A. C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2047 · Cited by 508
Genetically engineered mouse models in oncology research and cancer medicine
Kersten, K., de Visser, K. E., van Miltenburg, M. H., & Jonkers, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606857 · Cited by 502
Lysosomes as mediators of drug resistance in cancer
Zhitomirsky, B., & Assaraf, Y. G. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2015.11.004 · Cited by 488
Perry, J. A., Kiezun, A., Tonzi, P., Van Allen, E. M., Carter, S. L., Baca, S. C., Cowley, G. S., Bhatt, A. S., Rheinbay, E., Pedamallu, C. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419260111 · Cited by 481
Osteosarcoma, Chondrosarcoma, and Chordoma
Whelan, J., & Davis, L. E. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.75.1743 · Cited by 477
Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur.
Simon, M. A., Aschliman, M. A., Thomas, N., & Mankin, H. J. (1986) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198668090-00005 · Cited by 469
Riggi, N., Knoechel, B., Gillespie, S. M., Rheinbay, E., Boulay, G., Suvà, M. L., Rossetti, N. E., Boonseng, W. E., Oksuz, O., Cook, E., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.004 · Cited by 466
Descriptive epidemiology of Kaposi sarcoma in Europe. Report from the RARECARE project
Stiller, C. A., Trama, A., Brewster, D., Verne, J., Bouchardy, C., Navarro, C., Chirlaque, M. D., Marcos‐Gragera, R., Visser, O. J., Serraino, D., et al. (2014) · Cancer Epidemiology · doi:10.1016/j.canep.2014.09.009 · Cited by 463
Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications
Jeyaram, A., & Jay, S. M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0160-y · Cited by 461
Limb-Salvage Treatment Versus Amputation for Osteosarcoma of the Distal End of the Femur
Simon, M. A., Aschliman, M. A., Thomas, N. J., & Mankin, H. J. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.8712.cl · Cited by 452
Genome-Informed Targeted Therapy for Osteosarcoma
Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452
Advances in sarcoma genomics and new therapeutic targets
Taylor, B. S., Barretina, J., Maki, R. G., Antonescu, C. R., Singer, S., & Ladanyi, M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3087 · Cited by 444
Inferring expressed genes by whole-genome sequencing of plasma DNA
Ulz, P., Thallinger, G., Auer, M., Graf, R., Kashofer, K., Jahn, S. W., Abete, L., Pristauz, G., Petru, E., Geigl, J. B., et al. (2016) · Nature Genetics · doi:10.1038/ng.3648 · Cited by 438
Biological Laser Printing: A Novel Technique for Creating Heterogeneous 3-dimensional Cell Patterns
Barron, J. A., Wu, P., Ladouceur, H. D., & Ringeisen, B. R. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000031751.67267.9f · Cited by 437
D’Angelo, S. P., Melchiori, L., Merchant, M. S., Bernstein, D. B., Glod, J. W., Kaplan, R. N., Grupp, S. A., Tap, W. D., Chagin, K., Binder, G. K., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1417 · Cited by 436
Bioprinting for vascular and vascularized tissue biofabrication
Datta, P., Ayan, B., & Ozbolat, I. T. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.035 · Cited by 431
Michel, B. C., D’Avino, A. R., Cassel, S. H., Mashtalir, N., McKenzie, Z. M., McBride, M. J., Valencia, A. M., Zhou, Q., Bocker, M., Soares, L. M. M., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0221-1 · Cited by 429
Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts
Hoffman, R. M. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3972 · Cited by 424
A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype
Naumov, G. N., Bender, E., Zurakowski, D., Kang, S.-Y., Sampson, D., Flynn, E., Watnick, R. S., Straume, O., Akslen, L. A., Folkman, J., et al. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj068 · Cited by 423
Blay, J., Serrano, C., Heinrich, M. C., Zalcberg, J. R., Bauer, S., Gelderblom, H. A. J., Schöffski, P., Jones, R. L., Attia, S., D’Amato, G. Z., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30168-6 · Cited by 422
Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas
Toulmonde, M., Penel, N., Adam, J., Chevreau, C., Blay, J., Cesne, A. L., Bompas, E., Piperno-Neumann, S., Cousin, S., Grellety, T., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.1617 · Cited by 420
Ma, X., Liu, J., Zhu, W. Z., Tang, M., Lawrence, N., Yu, C., Gou, M., & Chen, S. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.011 · Cited by 417
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Lü, C., Jain, S. U., Hoelper, D., Béchet, D., Molden, R. C., Ran, L., Murphy, D. A., Venneti, S., Hameed, M., Pawel, B., et al. (2016) · Science · doi:10.1126/science.aac7272 · Cited by 406
Doebele, R. C., Davis, L. E., Vaishnavi, A., Le, A. T., Estrada‐Bernal, A., Keysar, S. B., Jimeno, A., Varella‐Garcia, M., Aisner, D. L., Li, Y., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0443 · Cited by 402
Dickson, M. A., Tap, W. D., Keohan, M. L., D'Angelo, S. P., Gounder, M. M., Antonescu, C. R., Landa, J., Qin, L.-X., Rathbone, D. D., Condy, M. M., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.5476 · Cited by 399
Expression of P-Glycoprotein in High-Grade Osteosarcomas in Relation to Clinical Outcome
Baldini, N., Scotlandi, K., Bròdano, G. B., Manara, M. C., Maurici, D., Bacci, G., Bertoni, F., Picci, P., Sottili, S., Campanacci, M., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332103 · Cited by 396
Self-citationOsteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
Lawson, M. A., McDonald, M. M., Kovačić, N., Khoo, W. H., Terry, R. L., Down, J. M., Kaplan, W. H., Paton‐Hough, J., Fellows, C., Pettitt, J. A., et al. (2015) · Nature Communications · doi:10.1038/ncomms9983 · Cited by 389
The expanding landscape of ‘oncohistone’ mutations in human cancers
Nacev, B. A., Feng, L., Bagert, J. D., Lemiesz, A. E., Gao, J., Soshnev, A. A., Kundra, R., Schultz, N., Muir, T. W., & Allis, C. D. (2019) · Nature · doi:10.1038/s41586-019-1038-1 · Cited by 384
Pathology image analysis using segmentation deep learning algorithms
Wang, S., Yang, D. M., Rong, R., Zhan, X., & Xiao, G. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.05.007 · Cited by 382
Improved survival using specialized multidisciplinary board in sarcoma patients
Blay, J., Soibinet, P., Penel, N., Bompas, E., Duffaud, F., Stoeckle, E., Mir, O., Adam, J., Chevreau, C., Bonvalot, S., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx484 · Cited by 370
Autophagy, cancer stem cells and drug resistance
Smith, A. G., & Macleod, K. F. (2018) · The Journal of Pathology · doi:10.1002/path.5222 · Cited by 369
Targeting Cancer Cell Dormancy
Recasens, A., & Munoz, L. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.12.004 · Cited by 356
Gene expression profiling of human sarcomas: insights into sarcoma biology.
Baird, K., Davis, S., Antonescu, C. R., Harper, U. L., Walker, R. L., Chen, Y., Glatfelter, A. A., Duray, P. H., & Meltzer, P. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1699 · Cited by 353
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
Kovac, M., Blattmann, C., Ribi, S., Smida, J., Mueller, N. S., Engert, F., Castro-Giner, F., Weischenfeldt, J., Kovacova, M., Krieg, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms9940 · Cited by 353
Self-citationOsteoblasts are target cells for transformation in c-fos transgenic mice
Grigoriadis, A. E., Schellander, K., Wang, Z., & Wagner, E. F. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.3.685 · Cited by 348
Self-citationMulti-omic measurements of heterogeneity in HeLa cells across laboratories
Liu, Y., Mi, Y., Mueller, T., Kreibich, S., Williams, E. G., Van Drogen, A., Borel, C., Frank, M., Germain, P.-L., Bludau, I., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0037-y · Cited by 338
Transcriptomic definition of molecular subgroups of small round cell sarcomas
Watson, S., Perrin, V., Guillemot, D., Reynaud, S., Coindre, J., Karanian, M., Guinebretière, J., Fréneaux, P., Loarer, F. L., Bouvet, M., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5053 · Cited by 335
Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid Tumors
Merchant, M. S., Wright, M., Baird, K., Wexler, L. H., Rodriguez-Galindo, C., Bernstein, D., Delbrook, C., Lodish, M., Bishop, R., Wolchok, J. D., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0491 · Cited by 331
Heinrich, M. C., Jones, R. L., von Mehren, M., Schöffski, P., Serrano, C., Kang, Y., Cassier, P. A., Mir, O., Eskens, F. A. L. M., Tap, W. D., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30269-2 · Cited by 325
Musa, J., Aynaud, M.-M., Mirabeau, O., Delattre, O., & Grünewald, T. G. P. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.244 · Cited by 321
Self-citationPAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability
Gryder, B. E., Yohe, M. E., Chou, H.-C., Zhang, X., Marques, J. G., Wachtel, M., Schaefer, B. W., Sen, N., Song, Y., Gualtieri, A., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1297 · Cited by 317
Integrative genomic and transcriptomic analysis of leiomyosarcoma
Chudasama, P., Mughal, S. S., Sanders, M. A., Hübschmann, D., Chung, I., Deeg, K. I., Wong, S.-H., Rabe, S., Hlevnjak, M., Zapatka, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02602-0 · Cited by 316
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma
Xiao, X., Wang, W., Li, Y., Yang, D., Li, X., Shen, C., Liu, Y., Ke, X., Guo, S., & Guo, Z. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0880-6 · Cited by 313
D’Angelo, S. P., Shoushtari, A. N., Agaram, N. P., Kuk, D., Qin, L., Carvajal, R. D., Dickson, M. A., Gounder, M. M., Keohan, M. L., Schwartz, G. K., et al. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.11.001 · Cited by 305
Keller, C., Arenkiel, B. R., Coffin, C. M., Bardeesy, N. M., DePinho, R. A., & Capecchi, M. R. (2004) · Genes & Development · doi:10.1101/gad.1244004 · Cited by 304
Cancer stem cells in osteosarcoma
Brown, H. K., Tellez-Gabriel, M., & Heymann, D. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.11.019 · Cited by 303
Self-citationFrom the archives of the AFIP. Extraskeletal osseous and cartilaginous tumors of the extremities.
Kransdorf, M. J., & Meis, J. M. (1993) · Radiographics · doi:10.1148/radiographics.13.4.8356273 · Cited by 292
Kim, J. R., Moon, Y. J., Kwon, K. S., Bae, J. S., Wagle, S., Kim, K. M., Park, H. S., Lee, H., Moon, W. S., Chung, M. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082870 · Cited by 290
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis
El-Naggar, A. M., Veinotte, C. J., Cheng, H., Grünewald, T. G. P., Negri, G. L., Somasekharan, S. P., Corkery, D., Tirode, F., Mathers, J. A., Khan, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.003 · Cited by 287
Self-citationOrthotopic patient-derived xenografts of paediatric solid tumours
Stewart, E., Federico, S. M., Chen, X., Shelat, A. A., Bradley, C., Gordon, B., Karlstrom, A., Twarog, N. R., Clay, M. R., Bahrami, A., et al. (2017) · Nature · doi:10.1038/nature23647 · Cited by 286
A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.
Suzuki, K., Fueyo-Margareto, J., Krasnykh, V. N., Reynolds, P. N., Curiel, D. T., & Alemany, R. (2001) · PubMed · Cited by 286
Causes, consequences, and therapy of tumors acidosis
Pillai, S., Damaghi, M., Marunaka, Y., Spugnini, E. P., Fais, S., & Gillies, R. J. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09792-7 · Cited by 286
The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
Fang, D., Gan, H., Lee, J., Han, J., Wang, Z., Riester, S. M., Jin, L. G., Chen, J., Zhou, H., Wang, J., et al. (2016) · Science · doi:10.1126/science.aae0065 · Cited by 285
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors
Vaira, V., Fedele, G., Pyne, S., Fasoli, E., Zadra, G., Bailey, D., Snyder, E. L., Faversani, A., Coggi, G., Flavin, R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907676107 · Cited by 282
Riggi, N., Suvà, M.-L., Vito, C. D., Provero, P., Stehle, J., Baumer, K., Cironi, L., Janiszewska, M., Petricevic, T., Suvà, D., et al. (2010) · Genes & Development · doi:10.1101/gad.1899710 · Cited by 281
Pollack, S. M., He, Q., Yearley, J. H., Emerson, R., Vignali, M., Zhang, Y., Redman, M. W., Baker, K. K., Cooper, S., Donahue, B., et al. (2017) · Cancer · doi:10.1002/cncr.30726 · Cited by 272
Koirala, P., Roth, M. E., Gill, J., Piperdi, S., Chinai, J. M., Geller, D. S., Hoang, B. H., Park, A., Fremed, M. A., Zang, X., et al. (2016) · Scientific Reports · doi:10.1038/srep30093 · Cited by 267
Nemunaitis, J. J., Tong, A. W., Nemunaitis, M., Senzer, N. N., Phadke, A. P., Bedell, C., Adams, N., Zhang, Y.-A., Maples, P. B., Chen, S., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.262 · Cited by 266
Behjati, S., Tarpey, P. S., Haase, K., Ye, H., Young, M. D., Alexandrov, L. B., Farndon, S. J., Collord, G., Wedge, D. C., Martincorena, I., et al. (2017) · Nature Communications · doi:10.1038/ncomms15936 · Cited by 261
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
Sheffield, N. C., Pierron, G., Klughammer, J., Datlinger, P., Schönegger, A., Schuster, M. K., Hadler, J., Surdez, D., Guillemot, D., Lapouble, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4273 · Cited by 258
Self-citationSox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
Basu-Roy, U., Bayin, N. S., Rattanakorn, K., Han, E. J., Placantonakis, D. G., Mansukhani, A., & Basilico, C. (2015) · Nature Communications · doi:10.1038/ncomms7411 · Cited by 257
Tomazou, E. M., Sheffield, N. C., Schmidl, C., Schuster, M. K., Schönegger, A., Datlinger, P., Kubicek, S., Bock, C., & Kovar, H. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.042 · Cited by 256
Self-citationCao, Y., OʼReilly, M., Marshall, B., Flynn, E. A., Ji, R. W., & Folkman, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1558 · Cited by 252
Demetri, G. D., Chawla, S. P., Ray-Coquard, I., Le Cesne, A., Staddon, A. P., Milhem, M. M., Penel, N., Riedel, R. F., Bui-Nguyen, B., Cranmer, L. D., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.5766 · Cited by 245
Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., LaRue, R. S., Temiz, N. A., Molyneux, S. D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3293 · Cited by 244
Circulating Tumor Cells: A Review of Non–EpCAM-Based Approaches for Cell Enrichment and Isolation
Tellez-Gabriel, M., Calleja, L. R., Chalopin, A., Ory, B., & Heymann, D. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2015.249706 · Cited by 242
Self-citationSox2 maintains self renewal of tumor-initiating cells in osteosarcomas
Basu-Roy, U., Seo, E., Ramanathapuram, L. V., Rapp, T. B., Perry, J. A., Orkin, S. H., Mansukhani, A., & Basilico, C. (2011) · Oncogene · doi:10.1038/onc.2011.405 · Cited by 239
3D printing of biomimetic microstructures for cancer cell migration
Huang, T. Q., Qu, X., Liu, J., & Chen, S. (2013) · Biomedical Microdevices · doi:10.1007/s10544-013-9812-6 · Cited by 238
Gaude, E., Schmidt, C., Gammage, P. A., Dugourd, A. J. F., Blacker, T. S., Peak‐Chew, S., Sáez-Rodríguez, J., O'Neill, J. S., Szabadkai, G., Minczuk, M. A., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.034 · Cited by 235
Liquid Biopsy: Current Status and Future Perspectives
Mader, S., & Pantel, K. (2017) · Oncology Research and Treatment · doi:10.1159/000478018 · Cited by 234
Heymann, M.-F., Lézot, F., & Heymann, D. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2017.10.011 · Cited by 233
Self-citationLaser Printing of Single Cells: Statistical Analysis, Cell Viability, and Stress
Barron, J. A., Krizman, D. B., & Ringeisen, B. R. (2005) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-8971-x · Cited by 227
Bone microenvironment signals in osteosarcoma development
Alfranca, A., Martínez-Cruzado, L., Tornín, J., Abarrategi, A., Amaral, A. T., de Álava, E., Menéndez, P. R., Garcı́a-Castro, J., & Rodrı́guez, R. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1918-y · Cited by 224
Jaboin, J. J., Wild, J., Hamidi, H., Khanna, C., Kim, C. J., Robey, R. W., Bates, S. E., & Thiele, C. J. (2002) · PubMed · Cited by 224
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
Brien, G. L., Remillard, D., Shi, J., Hemming, M. L., Chabon, J., Wynne, K. J., Dillon, E., Cagney, G., van Mierlo, G., Baltissen, M. P. A., et al. (2018) · eLife · doi:10.7554/elife.41305 · Cited by 222
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al-Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.09.003 · Cited by 221
Musculoskeletal Tumors: How to Use Anatomic, Functional, and Metabolic MR Techniques
Fayad, L. M., Jacobs, M. A., Wang, X., Carrino, J. A., & Bluemke, D. A. (2012) · Radiology · doi:10.1148/radiol.12111740 · Cited by 217
Keung, E. Z., Burgess, M., Salazar, R., Parra, E. R., Rodrigues-Canales, J., Bolejack, V., Van Tine, B. A., Schuetze, S. M., Attia, S., Riedel, R. F., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1824 · Cited by 215
Osteosarcoma: Cells‐of‐Origin, Cancer Stem Cells, and Targeted Therapies
Abarrategi, A., Tornín, J., Martínez-Cruzado, L., Hamilton, A., Martínez‐Campos, E., Rodrigo, J. P., González, M. V., Baldini, N., Garcı́a-Castro, J., & Rodrı́guez, R. (2016) · Stem Cells International · doi:10.1155/2016/3631764 · Cited by 211
Self-citationSynovial Sarcoma Is a Stem Cell Malignancy
Naka, N., Takenaka, S., Araki, N., Miwa, T., Hashimoto, N., Yoshioka, K., Joyama, S., Hamada, K., Tsukamoto, Y., Tomita, Y., et al. (2010) · Stem Cells · doi:10.1002/stem.452 · Cited by 210
Volckmar, A., Sültmann, H., Riediger, A. L., Fioretos, T., Schirmacher, P., Endris, V., Stenzinger, A., & Dietz, S. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22517 · Cited by 209
Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance
Angelis, M. L. D., Francescangeli, F., Torre, F. L., & Zeuner, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00626 · Cited by 209
Ségaliny, A. I., Mohamadi, A., Dizier, B., Lokajczyk, A., Brion, R., Lanel, R., Amiaud, J., Charrier, C., Boisson‐Vidal, C., & Heymann, D. (2015) · International Journal of Cancer · doi:10.1002/ijc.29376 · Cited by 199
Self-citationBelluco, C., Nitti, D., Frantz, M., Toppan, P., Basso, D., Plebani, M., Lise, M., & Jessup, J. M. (2000) · Annals of Surgical Oncology · doi:10.1007/s10434-000-0133-7 · Cited by 196
Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer
Vallette, F. M., Olivier, C., Lézot, F., Oliver, L., Cochonneau, D., Lalier-Bretaudeau, L., Cartron, P., & Heymann, D. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.004 · Cited by 192
Self-citationExosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression
Casadei, L., Calore, F., Creighton, C. J., Guescini, M., Batte, K., Iwenofu, O. H., Zewdu, A., Braggio, D., Bill, K. L. J., Fadda, P., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2984 · Cited by 192
Italiano, A., Mauro, I. D., Rapp, J., Pierron, G., Auger, N., Alberti, L., Chibon, F., Escande, F., Voegeli, A., Ghnassia, J., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00583-5 · Cited by 191
(2003) · PubMed · Cited by 190
Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Baglio, S. R., Lagerweij, T., Pérez-Lanzón, M., Ho, X. D., Léveillé, N., Melo, S. A., Cleton-Jansen, A.-M., Jordanova, E. S., Roncuzzi, L., Greco, M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2726 · Cited by 187
Self-citationPreoperative serum vascular endothelial growth factor can predict stage in colorectal cancer.
Kumar, H., Heer, K., Lee, P. W. R., Duthie, G. S., MacDonald, A. W., Greenman, J., Kerin, M. J., & Monson, J. R. T. (1998) · PubMed · Cited by 187
Targeting the DNA Repair Pathway in Ewing Sarcoma
Stewart, E. A., Goshorn, D. R., Bradley, C. L., Griffiths, L. M., Benavente, C. A., Twarog, N. R., Miller, G. M., Caufield, W. V., Freeman, B. B., Bahrami, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.028 · Cited by 183
Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma
Dumars, C., Ngyuen, J.-M., Gaultier, A., Lanel, R., Corradini, N., Gouin, F., Heymann, D., & Heymann, M. (2016) · Oncotarget · doi:10.18632/oncotarget.13055 · Cited by 183
Self-citationEndo, H., & Inoue, M. (2018) · Cancer Science · doi:10.1111/cas.13917 · Cited by 183
Gomez‐Brouchet, A., Illac, C., Gilhodes, J., Bouvier, C., Aubert, S., Guinebretière, J., Marie, B., Larousserie, F., Entz‐Werlé, N., Pinieux, G. D. B. D., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1331193 · Cited by 180
Longo, D. L., Sun, P. Z., Consolino, L., MICHELOTTI, F. C., Uggeri, F., & Aime, S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5059313 · Cited by 176
Self-citationTreatment pathway of bone sarcoma in children, adolescents, and young adults
Reed, D. R., Hayashi, M., Wagner, L. M., Binitie, O. T., Steppan, D. A., Brohl, A. S., Shinohara, E. T., Bridge, J. A., Loeb, D. M., Borinstein, S. C., et al. (2017) · Cancer · doi:10.1002/cncr.30589 · Cited by 174
Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells
Satelli, A., Mitra, A., Cutrera, J. J., Devarie, M., Xia, X., Ingram, D. R., Dibra, D., Somaiah, N., Torres, K. E., Ravi, V., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1739 · Cited by 173
Advances in immune checkpoint inhibitors for bone sarcoma therapy
Thanindratarn, P., Dean, D. C., Nelson, S. D., Hornicek, F. J., & Duan, Z. (2019) · Journal of bone oncology · doi:10.1016/j.jbo.2019.100221 · Cited by 173
Mesenchymal stroma: Role in osteosarcoma progression
Cortini, M., Avnet, S., & Baldini, N. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.07.024 · Cited by 171
Self-citationRole of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance
Kilic, M., Kasperczyk, H., Fulda, S., & Debatin, K. (2006) · Oncogene · doi:10.1038/sj.onc.1210008 · Cited by 170
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
Gryder, B. E., Pomella, S., Sayers, C. M., Wu, X., Song, Y., Chiarella, A. M., Bagchi, S., Chou, H.-C., Sinniah, R., Walton, A., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0534-4 · Cited by 164
Biology of Bone Sarcomas and New Therapeutic Developments
Brown, H. K., Schiavone, K., Gouin, F., Heymann, M.-F., & Heymann, D. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0372-2 · Cited by 163
Self-citationImaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH
Anemone, A., Consolino, L., Arena, F., Capozza, M., & Longo, D. L. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09782-9 · Cited by 162
Self-citationCripe, T. P., Ngo, M. C., Geller, J. I., Louis, C. U., Currier, M. A., Racadio, J. M., Towbin, A. J., Rooney, C. M., Pelusio, A., Moon, A., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.243 · Cited by 160
Local Recurrence of Disease after Unplanned Excisions of High-grade Soft Tissue Sarcomas
Potter, B. K., Adams, S. C., Pitcher, D. J., & Temple, T. H. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0529-4 · Cited by 160
The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma
Banito, A., Li, X., Laporte, A. N., Roe, J., Sánchez-Vega, F., Huang, C., Dancsok, A. R., Hatzi, K., Chen, C.-C., Tschaharganeh, D. F., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.018 · Cited by 158
Self-citationPatient‐derived xenografts for individualized care in advanced sarcoma
Stebbing, J., Paz, K., Schwartz, G. K., Wexler, L. H., Maki, R. G., Pollock, R. E., Morris, R., Cohen, R., Shankar, A., Blackman, G., et al. (2014) · Cancer · doi:10.1002/cncr.28696 · Cited by 157
Dudeck, O., Zeile, M., Pink, D., Pech, M., Tunn, P., Reichardt, P., Ludwig, W., & Hamm, B. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21358 · Cited by 157
In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging
Longo, D. L., Bartoli, A., Consolino, L., Bardini, P., Arena, F., Schwaiger, M., & Aime, S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0825 · Cited by 157
Self-citationHan, Q., Shi, H., & Liu, F. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.01.023 · Cited by 153
Lamoureux, F., Baud’huin, M., Calleja, L. R., Jacques, C., Berreur, M., Rédiní, F., Lecanda, F., Bradner, J. E., Heymann, D., & Ory, B. (2014) · Nature Communications · doi:10.1038/ncomms4511 · Cited by 150
Self-citationShulman, D. S., Klega, K., Imamovic-Tuco, A., Clapp, A., Nag, A., Thorner, A. R., Van Allen, E., Ha, G., Lessnick, S. L., Gorlick, R., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0212-9 · Cited by 149
Sannino, G., Marchetto, A., Kirchner, T., & Grünewald, T. G. P. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0032 · Cited by 145
Self-citationStreby, K. A., Geller, J. I., Currier, M. A., Warren, P. S., Racadio, J. M., Towbin, A. J., Vaughan, M. R., Triplet, M., Ott-Napier, K., Dishman, D. J., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2900 · Cited by 144
Honoki (2010) · Oncology Reports · doi:10.3892/or_00000885 · Cited by 143
Killander, D., Dohlwitz, A., Engstedt, L., Franzén, S., Gahrton, G., GULLBRING, B., Holm, G., Holmgren, A., Höglund, S., KILLANDER, A., et al. (1976) · Cancer · doi:10.1002/1097-0142(197601)37:1 · Cited by 143
Kovatcheva, M., Liu, D. D., Dickson, M. A., Klein, M. E., O’Connor, R., Wilder, F. O., Socci, N. D., Tap, W. D., Schwartz, G. K., Singer, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3364 · Cited by 142
Koelsche, C., Mynarek, M., Schrimpf, D., Bertero, L., Serrano, J., Sahm, F., Reuß, D., Hou, Y., Baumhoer, D., Vokuhl, C., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1871-6 · Cited by 142
Self-citationModeling sarcomagenesis using multipotent mesenchymal stem cells
Rodrı́guez, R., Rubio, R., & Menéndez, P. R. (2011) · Cell Research · doi:10.1038/cr.2011.157 · Cited by 141
Cain, D. M., Wacnik, P. W., Turner, M., Wendelschafer‐Crabb, G., Kennedy, W. R., Wilcox, G. L., & Simone, D. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09367.2001 · Cited by 141
Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
Bonuccelli, G., Avnet, S., Grisendi, G., Salerno, M., Granchi, D., Dominici, M., Kusuzaki, K., & Baldini, N. (2014) · Oncotarget · doi:10.18632/oncotarget.2243 · Cited by 140
Self-citationFritzsching, B., Fellenberg, J., Moskovszky, L. E., Sápi, Z., Krenács, T., Machado, I., Poeschl, J., Lehner, B., Szendrői, M., Bosch, A. L., et al. (2015) · OncoImmunology · doi:10.4161/2162402x.2014.990800 · Cited by 140
Avnet, S., Pompo, G. D., Chano, T., Errani, C., Ibrahim‐Hashim, A., Gillies, R. J., Donati, D. M., & Baldini, N. (2016) · International Journal of Cancer · doi:10.1002/ijc.30540 · Cited by 137
Self-citationTarnowski, M., Grymula, K., Liu, R., Tarnowska, J., Drukala, J., Ratajczak, J., Mitchell, R. A., Ratajczak, M. Z., & Kucia, M. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0288 · Cited by 136
Genomic landscape of liposarcoma
Kanojia, D., Nagata, Y., Garg, M., Lee, D. H., Sato, A., Yoshida, K., Sato, Y., Sanada, M., Mayakonda, A., Bartenhagen, C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6464 · Cited by 136
East Siberian Arctic inland waters emit mostly contemporary carbon
Dean, J. F., Meisel, O. H., Rosco, M. M., Marchesini, L. B., Garnett, M. H., Lenderink, H., van Logtestijn, R. S. P., Borges, A. V., Bouillon, S., Lambert, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15511-6 · Cited by 135
Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways
Steele, C. D., Tarabichi, M., Oukrif, D., Webster, A. P., Ye, H., Fittall, M. W., Lombard, P., Martincorena, I., Tarpey, P. S., Collord, G., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.02.002 · Cited by 131
A Mouse Model of Rhabdomyosarcoma Originating from the Adipocyte Lineage
Hatley, M. E., Tang, W., Garcia, M. R., Finkelstein, D., Millay, D. P., Liu, N., Graff, J. M., Galindo, R. L., & Olson, E. N. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.004 · Cited by 131
Zebrafish xenograft models of cancer and metastasis for drug discovery
Brown, H. K., Schiavone, K., Tazzyman, S. J., Heymann, D., & Chico, T. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1297416 · Cited by 130
Self-citationCats, Cancer and Comparative Oncology
Cannon, C. M. (2015) · Veterinary Sciences · doi:10.3390/vetsci2030111 · Cited by 128
Roberts, R. D., Lizardo, M. M., Reed, D. R., Hingorani, P., Glover, J., Allen‐Rhoades, W., Fan, T., Khanna, C., Sweet‐Cordero, E. A., Cash, T., et al. (2019) · Cancer · doi:10.1002/cncr.32351 · Cited by 127
Self-citationVaupel, P. W., Okunieff, P., Kallinowski, F., & Neuringer, L. J. (1989) · Radiation Research · doi:10.2307/3577798 · Cited by 126
Unplanned Excision of Soft-Tissue Sarcomas
Pretell-Mazzini, J. A., Barton, M. D., Conway, S. A., & Temple, H. T. (2015) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.n.00649 · Cited by 123
Ghilardi, J. R., Freeman, K. T., Jiménez‐Andrade, J. M., Mantyh, W. G., Bloom, A. P., Kuskowski, M. A., & Mantyh, P. W. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-87 · Cited by 121
Rodríguez-García, A., Giménez-Alejandre, M., Rojas, J. J., Moreno, R., Bazán‐Peregrino, M., Cascalló, M., & Alemany, R. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2213 · Cited by 119
Rutkowski, P. L., Kaminska, J. A., Kowalska, M. M., Ruka, W., & Steffen, J. A. (2003) · Journal of Surgical Oncology · doi:10.1002/jso.10305 · Cited by 117
Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment
Indraccolo, S., Stievano, L., Minuzzo, S. A., Tosello, V., Esposito, G., Piovan, E., Zamarchi, R., Chieco‐Bianchi, L., & Amadori, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506200103 · Cited by 115
Overexpression of Smad7 Blocks Primary Tumor Growth and Lung Metastasis Development in Osteosarcoma
Lamora, A., Talbot, J., Bougras-Cartron, G., Amiaud, J., Leduc, M., Chesneau, J., Taurelle, J., Stresing, V., Deley, M. L., Heymann, M., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3191 · Cited by 114
Self-citationChemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling
Martins‐Neves, S. R., Paiva‐Oliveira, D. I., Wijers‐Koster, P. M., Abrunhosa, A., Ribeiro, C., Bovée, J. V. M. G., Cleton-Jansen, A., & Gomes, C. M. F. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.11.013 · Cited by 113
Zhang, H., Wu, H., Zheng, J., Yu, P., Xu, L., Jiang, P., Gao, J., Wang, H., & Zhang, Y. (2012) · Stem Cells · doi:10.1002/stem.1298 · Cited by 112
Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis
Almog, N., Henke, V. G., Flores, L. M., Hlatky, L., Kung, A. L., Wright, R. D., Berger, R., Hutchinson, L., Naumov, G. N., Bender, E. R., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-3946fje · Cited by 112
Riethmüller, G., & Klein, C. A. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0386 · Cited by 112
Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity
Tellez-Gabriel, M., Heymann, M., & Heymann, D. (2019) · Theranostics · doi:10.7150/thno.34337 · Cited by 112
Self-citationVakkila, J., Jaffe, R., Michelow, M., & Lotze, M. T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1824 · Cited by 111
Sundara, Y. T., Kostine, M., Cleven, A. H. G., Bovée, J. V. M. G., Schilham, M. W., & Cleton-Jansen, A.-M. (2017) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-016-1925-3 · Cited by 111
Koelsche, C., Hartmann, W., Schrimpf, D., Stichel, D., Jabar, S., Ranft, A., Reuß, D., Sahm, F., Jones, D., Bewerunge‐Hudler, M., et al. (2018) · Modern Pathology · doi:10.1038/s41379-018-0045-3 · Cited by 111
Self-citationThe Role of 18 F-FDG-PET/CT in Pediatric Sarcoma
Harrison, D. J., Parisi, M. T., & Shulkin, B. L. (2017) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.12.004 · Cited by 109
Rugo, H. S., Jacobs, I. A., Sharma, S., Scappaticci, F. A., Paul, T. A., Jensen-Pergakes, K., & Malouf, G. G. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01379-x · Cited by 109
Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma
Santoro, M., Lamhamedi-Cherradi, S.-E., Menegaz, B. A., Ludwig, J. A., & Mikos, A. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506684112 · Cited by 107
Expression of lymphocyte immunoregulatory biomarkers in bone and soft-tissue sarcomas
Dancsok, A. R., Setsu, N., Gao, D., Blay, J., Thomas, D. M., Maki, R. G., Nielsen, T. O., & Demicco, E. G. (2019) · Modern Pathology · doi:10.1038/s41379-019-0312-y · Cited by 107
CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma
Shiraishi, D., Fujiwara, Y., Horlad, H., Saito, Y., Iriki, T., Tsuboki, J., Pan, C., Nakagata, N., Mizuta, H., Bekki, H., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2011 · Cited by 107
Traub, F., Griffin, A. M., Wunder, J. S., & Ferguson, P. C. (2018) · Cancer · doi:10.1002/cncr.31648 · Cited by 106
Advances in limb salvage treatment of osteosarcoma
Yang, Y., Han, L., He, Z., Li, X., Yang, S., Yang, J., Zhang, Y., Li, D., Yang, Y., & Yang, Z. (2017) · Journal of bone oncology · doi:10.1016/j.jbo.2017.11.005 · Cited by 105
Mesenchymal stem cell transformation and sarcoma genesis
Xiao, W., Mohseny, A. B., Hogendoorn, P. C. W., & Cleton-Jansen, A. (2013) · Clinical Sarcoma Research · doi:10.1186/2045-3329-3-10 · Cited by 104
Wei, S., Henderson‐Jackson, E., Qian, X., & Bui, M. M. (2017) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2016-0417-ra · Cited by 103
Cortini, M., Massa, A., Avnet, S., Bonuccelli, G., & Baldini, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166500 · Cited by 102
Self-citationTargetable Alterations in Adult Patients With Soft-Tissue Sarcomas
Lucchesi, C., Khalifa, E., Laizet, Y., Soubeyran, I., Mathoulin‐Pélissier, S., Chomienne, C., & Italiano, A. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.0723 · Cited by 102
Therapeutic implications of tumor interstitial acidification
Kolosenko, I., Avnet, S., Baldini, N., Viklund, J., & Milito, A. D. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.01.008 · Cited by 101
Self-citationGenomic EWSR1 Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma
Krumbholz, M., Hellberg, J., Steif, B., Bäuerle, T., Gillmann, C., Fritscher, T., Agaimy, A., Frey, B., Juengert, J., Wardelmann, E., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3028 · Cited by 100
Self-citationQue, Y., Xiao, W. L., Guan, Y., Liang, Y., Yan, S., Chen, H.-Y., Li, Q.-Q., Xu, B.-S., Zhou, Z., & Zhang, X. (2017) · Journal of Cancer · doi:10.7150/jca.18683 · Cited by 100
Endo, Y., Beauchamp, E. M., Woods, D. M., Taylor, W. G., Toretsky, J. A., Üren, A., & Rubin, J. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01780-07 · Cited by 99
Flagged first, then by citations
2 of the 457 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Heymann D (2014) Bone Cancer. Academic Press, San Diego, California, USA
Cited by
Sorted by citations
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660
Self-citationCruz, A. S., Mendes‐Frias, A., Oliveira, A. I., Dias, L., Matos, A. R., Carvalho, A., Capela, C., Pedrosa, J., Castro, A. G., & Silvestre, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613422 · Cited by 364
Naringenin: A potential flavonoid phytochemical for cancer therapy
Motallebi, M., Bhia, M., Rajani, H. F., Bhia, I., Tabarraei, H., Mohammadkhani, N., Pereira‐Silva, M., Kasaii, M. S., Nouri-Majd, S., Mueller, A., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120752 · Cited by 336
Self-citationEwing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
Zöllner, S. K., Amatruda, J. F., Bauer, S., Collaud, S., de Álava, E., DuBois, S. G., Hardes, J., Hartmann, W., Kovar, H., Metzler, M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081685 · Cited by 292
Self-citationAccelerating antibiotic discovery through artificial intelligence
Melo, M. C. R., Maasch, J. R. M. A., & de la Fuente-Nunez, C. (2021) · Communications Biology · doi:10.1038/s42003-021-02586-0 · Cited by 234
Metadata
- Authors
- Grünewald, T. G., Alonso, M., Avnet, S., Banito, A., Burdach, S., Cidre‐Aranaz, F., Di Pompo, G., Distel, M., Dorado‐Garcia, H., Garcia‐Castro, J., González‐González, L., Grigoriadis, A. E., Kasan, M., Koelsche, C., Krumbholz, M., Lecanda, F., Lemma, S., Longo, D. L., Madrigal‐Esquivel, C., Morales‐Molina, Á., Musa, J., Ohmura, S., Ory, B., Pereira‐Silva, M., Perut, F., Rodriguez, R., Seeling, C., Al Shaaili, N., Shaabani, S., Shiavone, K., Sinha, S., Tomazou, E. M., Trautmann, M., Vela, M., Versleijen‐Jonkers, Y. M., Visgauss, J., Zalacain, M., Schober, S. J., Lissat, A., English, W. R., Baldini, N., & Heymann, D.
- Affiliations
- German Cancer Research Center (DE)
- Universidad de Navarra (ES)
- Istituto Ortopedico Rizzoli (IT)
- Technical University of Munich (DE)
- Pathologisches Institut (DE)
- Instituto de Salud Carlos III (ES)
- King's College London (GB)
- University Hospital Heidelberg (DE)
- Universitätsklinikum Erlangen (DE)
- Centro de Investigación Médica Aplicada (ES)
- Institute of Biostructure and Bioimaging (IT)
- University of Sheffield (GB)
- Heidelberg University (DE)
- Inserm (FR)
- University of Coimbra (PT)
- Universität Ulm (DE)
- University of Groningen (NL)
- University of Helsinki (FI)
- University of Münster (DE)
- Radboud University Medical Center (NL)
- Duke University (US)
- University Children's Hospital Zurich (CH)
- Institut de Cancérologie de l'Ouest (FR)
- Corresponding author
- Grünewald, Thomas GP
- Baldini, Nicola
- Heymann, Dominique
- ORCID
- Grünewald, Thomas GP
- Alonso, Marta
- Avnet, Sofia
- Banito, Ana
- Burdach, Stefan
- Cidre‐Aranaz, Florencia
- Distel, Martin
- González‐González, Laura
- Grigoriadis, Agamemnon E
- Kasan, Merve
- Koelsche, Christian
- Krumbholz, Manuela
- Lecanda, Fernando
- Lemma, Silvia
- Longo, Dario L
- Morales‐Molina, Álvaro
- Musa, Julian
- Ohmura, Shunya
- Ory, Benjamin
- Pereira‐Silva, Miguel
- Perut, Francesca
- Rodriguez, Rene
- Seeling, Carolin
- Shaabani, Shabnam
- Sinha, Snehadri
- Tomazou, Eleni M
- Trautmann, Marcel
- Versleijen‐Jonkers, Yvonne MH
- Visgauss, Julia
- Schober, Sebastian J
- Lissat, Andrej
- English, William R
- Baldini, Nicola
- Heymann, Dominique
- Venue
- EMBO Molecular Medicine
- Published
- 2020-10-13
- Volume
- 12
- Issue
- 11
- Pages
- e11131-e11131
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC7645378
- OpenAlex
- W3092176105
- Cited by
- 319
- References
- 457
- Citations by year
- 2026: 40 · 2025: 50 · 2024: 55 · 2023: 66 · 2022: 50 · 2021: 53 · 2020: 5
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche (ANR-16-IDEX-0007)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- sarcoma, soft tissue sarcoma, bone sarcoma, sarcoma subtypes, multimodal therapy, combination chemotherapy, hyperthermia, immunotherapy, targeted therapy, prognostic factors, predictive biomarkers, pediatric sarcoma, secondary malignancies, therapeutic target
- MeSH terms
- Adolescent, Bone Neoplasms, Child, Humans, Sarcoma, Osteosarcoma, Soft Tissue Neoplasms, Molecular Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review