The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Theoretical Evaluation of Voltage Inducement on Internal Membranes of Biological Cells Exposed to Electric Fields
Open accessAbstract
Several reports have recently been published on effects of very short and intense electric pulses on cellular organelles; in a number of cases, the cell plasma membrane appeared to be affected less than certain organelle membranes, whereas with longer and less intense pulses the opposite is the case. The effects are the consequence of the voltages induced on the membranes, and in this article we investigate the conditions under which the induced voltage on an organelle membrane could exceed its counterpart on the cell membrane. This would provide a possible explanation of the observed effects of very short pulses. Frequency-domain analysis yields an insight into the dependence of the voltage inducement on the electric and geometric parameters characterizing the cell and its vicinity. We show that at sufficiently high field frequencies, for a range of parameter values the voltage induced on the organelle membrane can indeed exceed the voltage induced on the cell membrane. Particularly, this can occur if the organelle interior is electrically more conductive than the cytosol, or if the organelle membrane has a lower dielectric permittivity than the cell membrane, and we discuss the plausibility of these conditions. Time-domain analysis is then used to determine the courses of the voltage induced on the membranes by pulses with risetimes and durations in the nanosecond range. The particularly high resting voltage in mitochondria, to which the induced voltage superimposes, could contribute to the explanation why these organelles are the primary target of many observed effects.
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“as the frequency of the field increases, the high membrane field gain diminishes, allowing for higher field intensities to penetrate into the cell.”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [31]
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Biophysics and Clinical Applications of Pulsed-Field Ablation
Kawamura, I., Oates, C. P., & Koruth, J. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93110-6.00004-9
Ninagawa, Y., Sugiura, R., Kato, E., Yagi, I., Nagata, K., Yamaoka, H., Tachibana, K., Oda, A., & Uchida, S. (2024) · IEEJ Transactions on Fundamentals and Materials · doi:10.1541/ieejfms.144.407
Irreversible Electroporation for Partial Gland Ablation: Clinical Application and Outcomes
Fainberg, J. S., Coleman, J., Marra, G., Stricker, P. D., & Lawrentschuk, N. (2024) · Springer eBooks · doi:10.1007/978-3-031-66754-1_29
Modeling the interplay between myelin architecture and local electromagnetic fields
Han, J., Qin, P., Zhu, G., Wang, R., Bai, S., Wen, J., Italiano, M. L., Aplin, F. P., Lovell, N. H., Tsai, D., et al. (2025) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc58623.2025.11253436
“[11, 12] One end of the axon was assigned an electric potential to generate voltage, whereas both ends of the myelin were defined as electrically insulated surfaces, in accordance with its inherent insulating properties and the physiological condition wherein adjacent myelin segments exhibit…”
Kou, H., Wu, F., Kai, C., Wang, S., Liang, R., & Yao, C. (2026) · Applied Sciences · doi:10.3390/app16021086
Плевако, Д. С., Garanin, A., Vasileva, O. A., Yevtushenko, V., Якубович, Е. И., & Malek, A. V. (2025) · Nanobiotechnology Reports · doi:10.1134/s2635167625600518
68526 Pulsed electric field extraction: a sustainable approach
Rajendran, V., Gnanakani, S. P. E., Dave, H., & Basha, N. S. (2026) · De Gruyter eBooks · doi:10.1515/9783111628240-031
Liu, H., Ma, W., Xu, F., Xu, L., Zhang, C., Lou, W., Xie, L., & Jiang, T. (2026) · iRadiology · doi:10.1002/ird3.70068
“When a high‐voltage electric field is applied to a cell, it alters the resting membrane potential, and once the transmembrane potential exceeds a particular threshold, nanoscale pores, referred to as electropores, form in the cell membrane [15, 16].”
Pires, R. S., Santos, M. S., Miguel, F., da Silva, C. L., & Silva, J. C. (2026) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2026.109326
Yang, S., Fan, R., Li, L., Ji, L., & LIU, Y. (2026) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2026.109370
Neal, A., Graham, T., Samandari, M., Ghorbannia, A., Dobrian, A. D., Beebe, S. J., & Biancatelli, R. M. L. C. (2026) · Applied Sciences · doi:10.3390/app16157628
Measurement and Characterization of Exposure Systems for High-Frequency, Ultrashort Pulses
Lévêque, P., Orlacchio, R., O'Connor, R. P., & Arnaud‐Cormos, D. (2026) · Springer eBooks · doi:10.1007/978-3-319-26779-1_207-2
Analysis of the role of ECM in modulating electroporation efficiency in 3D HeLa cultures
Sieni, E., Giri, P., Zamuner, A., Dettin, M., Zaccara, S., Antognazza, C., Martinelli, N., Dall’Olmo, L., Saluto, S., Conconi, M. T., et al. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154711
Biophysical principles of pulsed field ablation
Apollonio, F., Camera, F., Liberti, M., Merla, C., Mir, L. M., Pisano, C., Poompavai, S., Srimathveeravalli, G., Casciola, M., & Neven, K. G. E. J. (2026) · EP Europace · doi:10.1093/europace/euag229
Metadata
- Authors
- Kotnik, T., & Miklavčič, D.
- Affiliations
- University of Ljubljana (SI)
- Corresponding author
- Kotnik, Tadej
- ORCID
- Kotnik, Tadej
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 90
- Issue
- 2
- Pages
- 480-491
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC1367054
- OpenAlex
- W2106955112
- Cited by
- 318
- References
- 68
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 15 · 2023: 22 · 2022: 12 · 2021: 12 · 2020: 17 · 2019: 20 · 2018: 19 · 2017: 26 · 2016: 19 · 2015: 12 · 2014: 19 · 2013: 17 · 2012: 17
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrical and Electromagnetic Research
- Keywords
- electric field effects on cells, organelle membranes, nanosecond pulses, frequency domain analysis, time-domain analysis, membrane conductivity
- MeSH terms
- Animals, Biological Transport, Active, Biophysics, Cell Membrane, Cell Membrane Permeability, Cytosol, Electric Conductivity, Electromagnetic Fields, Intracellular Membranes, Membrane Fluidity, Membrane Lipids, Membrane Potentials, Models, Theoretical, Time Factors
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