Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
Open accessAbstract
Objective This study sought to determine the effect of the recombinant human growth hormone (rhGH) treatment of Turner syndrome (TS) on height outcome. Methods We searched in MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews. A literature search identified 640 records. After screening and full-text assessment, 11 records were included in the systematic review. Methodological quality was assessed using the Cochrane Risk of Bias tool. RevMan 5.3 software was used for meta-analysis. We also assessed the quality of evidence with the GRADE system. Results Compared with controls, rhGH therapy led to increased final height (MD = 7.22 cm, 95% CI 5.27–9.18, P < 0.001, I 2 = 4%; P = 0.18), height standard deviation (HtSDS) (SMD = 1.22, 95% CI 0.88–1.56, P < 0.001, I 2 = 49%; P = 0.14) and height velocity (HV) (MD 2.68 cm/year; 95% CI 2.34, 3.02; P < 0.001, I 2 = 0%; P = 0.72). There was a small increase in bone age (SMD 0.32 years; 95% CI 0.1, 0.54; P = 0.004, I 2 = 73%; P = 0.02) after rhGH therapy for 12 months. What is more, the rhGH/oxandrolone combination therapy suggested greater final height (MD 2.46 cm; 95% CI 0.73, 4.18; P = 0.005, I 2 = 32%; P = 0.22), increase and faster HV (SMD 1.67 cm/year; 95% CI 1.03, 2.31; P < 0.03, I 2 = 80%; P < 0.001), with no significant increase in HtSDS and bone maturation compared with rhGH therapy alone. Conclusions For TS patients, rhGH alone or with concomitant use of oxandrolone treatment had advantages on final height.
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A meta-analysis reported mean adult height gain of 7.2 cm.
“A subsequent meta-analysis concluded a similar effect of GH therapy, reporting mean adult height gain of 7.2 cm,168 based on data from the two RCTs that followed non-GH-treated subjects to adult height.158,160”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [168]
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
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Turner syndrome through the lens of a gynaecologist
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- Authors
- Li, P., Cheng, F., & Xiu, L.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Li, Ping
- Venue
- Endocrine Connections
- Publisher
- Bioscientifica
- Published
- 2018-04
- Volume
- 7
- Issue
- 4
- Pages
- 573-583
- ISSN
- 2049-3614 (ISSN-L)
- PMC
- PMC5900457
- OpenAlex
- W2793290189
- Cited by
- 41
- References
- 41
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 6
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Endocrine Connections (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- Turner syndrome, recombinant human growth hormone, adult height, height velocity, bone age, oxandrolone, growth hormone therapy, short stature, skeletal maturation, height standard deviation score, combination therapy, risk of bias assessment, quality of evidence grading, GRADE, risk of bias in meta-analysis, risk of bias in individual studies
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