Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome
Open accessAbstract
OBJECTIVE: Short stature is a prominent feature of Turner syndrome (TS), which is partially overcome by GH treatment. We have previously reported the results of a trial on the effect of oxandrolone (Ox) in girls with TS. Ox in a dose of 0.03 mg/kg per day (Ox 0.03) significantly increased adult height gain, whereas Ox mg/kg per day (0.06) did not, at the cost of deceleration of breast development and mild virilization. The aim of this follow-up study in adult participants of the pediatric trial was to investigate the long-term effects of previous Ox treatment. DESIGN AND METHODS: During the previous randomized controlled trial, 133 girls were treated with GH combined with placebo (Pl), Ox 0.03, or Ox 0.06 from 8 years of age and estrogen from 12 years. Sixty-eight women (Pl, n=23; Ox 0.03, n=27; and Ox 0.06, n=18) participated in the double-blind follow-up study (mean age, 24.0 years; mean time since stopping GH, 8.7 years; and mean time of Ox/Pl use, 4.9 years). We assessed height, body proportions, breast size, virilization, and body composition. RESULTS: Height gain (final minus predicted adult height) was maintained at follow-up (Ox 0.03 10.2±4.9 cm, Ox 0.06 9.7±4.4 cm vs Pl 8.0±4.6 cm). Breast size, Tanner breast stage, and body composition were not different between groups. Ox-treated women reported more subjective virilization and had a lower voice frequency. CONCLUSION: Ox 0.03 mg/kg per day has a beneficial effect on adult height gain in TS patients. Despite previously reported deceleration of breast development during Ox 0.03 treatment, adult breast size is not affected. Mild virilization persists in only a small minority of patients. The long-term evaluation indicates that Ox 0.03 treatment is effective and safe.
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Oxandrolone therapy was associated with lower HDL cholesterol.
“Oxandrolone therapy was associated with a lower HDL cholesterol,252”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [252]
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Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Durnin, J. V. G. A., & Womersley, J. (1974) · British Journal Of Nutrition · doi:10.1079/bjn19740060 · Cited by 6,343 · see citing works
Variations in pattern of pubertal changes in girls
Marshall, W. A., & Tanner, J. M. (1969) · Archives of Disease in Childhood · doi:10.1136/adc.44.235.291 · Cited by 5,963 · see citing works
New norms of upper limb fat and muscle areas for assessment of nutritional status
Frisancho, A. R. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.11.2540 · Cited by 1,916 · see citing works
Nielsen, J., & Wohlert, M. (1991) · Human Genetics · doi:10.1007/bf01213097 · Cited by 1,193 · see citing works
Birth Defects Original Article Series
Engel, A. G. (1970) · Neurology · doi:10.1212/wnl.20.5.523-a · Cited by 904 · see citing works
Growth curve for girls with Turner syndrome.
Lyon, A., Preece, M. A., & Grant, D. B. (1985) · Archives of Disease in Childhood · doi:10.1136/adc.60.10.932 · Cited by 409 · see citing works
Growth hormone therapy of Turner's syndrome: beneficial effect on adult height
Rosenfeld, R. G., Attie, K. M., Frane, J., Brasel, A., Burstein, S., Cara, J. F., Chernausek, S., Gotlin, R. W., Kuntze, J., Lippe, B. M., et al. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70452-4 · Cited by 265 · see citing works
(2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2187 · Cited by 256 · see citing works
Nielsen, J., & Wohlert, M. (1990) · PubMed · Cited by 247 · see citing works
van Pareren, Y. K., Keizer‐Schrama, S. M. P. F. D. M., Stijnen, T., Sas, T., Jansen, M., Otten, B. J., Hoorweg-Nijman, J. J. G., Vulsma, T., Stokvis‐Brantsma, W. H., Rouwé, C. W., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021171 · Cited by 244 · see citing works
Self-citationThe frequency range of the voice fundamental in the speech of male and female adults
Traunmüller, H., & Eriksson, A. (1993) · Cited by 211 · see citing works
Sas, T., Keizer‐Schrama, S. M. P. F. D. M., Stijnen, T., Jansen, M., Otten, B. J., Hoorweg-Nijman, J. J. G., Vulsma, T., Massa, G., Rouwé, C. W., Reeser, H. M., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.12.6241 · Cited by 158 · see citing works
Self-citationImproved final height in girls with Turner's syndrome treated with growth hormone and oxandrolone
NILSSON, K. O., Albertsson-Wikland, K. G., Alm, J., Aronson, S., Gustafsson, J.-Å., Hagenäs, L., Häger, A., Ivarsson, S. A., KARLBERG, J. P. E., Kriström, B., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636281 · Cited by 146 · see citing works
Reference values for height, height velocity and weight in Turner's Syndrome
Rongen‐Westerlaken, C., Corel, L. J. A., den Broeck, J. V., Massa, G., KARLBERG, J. P. E., Albertsson-Wikland, K. G., Næraa, R. W., & Wit, J. M. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb15174.x · Cited by 131 · see citing works
Self-citationSas, T. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.12.4607 · Cited by 111 · see citing works
Self-citationHoll, R. W., Kunze, D., Etzrodt, H., Teller, W. M., & Heinze, E. (1994) · European Journal of Pediatrics · doi:10.1007/bf02000780 · Cited by 99 · see citing works
Efficacy and safety of oxandrolone in growth hormone-treated girls with Turner syndrome
Menke, L. A., Sas, T. C. J., de Muinck Keizer-Schrama, S. M. P. F., Zandwijken, G. R. J., de Ridder, M. A. J., Odink, R. J., Jansen, M., Delemarre-van de Waal, H. A., Stokvis-Brantsma, W. H., Waelkens, J. J., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1821 · Cited by 94 · see citing works
Self-citationOstberg, J. E., Thomas, E. L., Hamilton, G., Hosseinzadeh‐Attar, M. J., Bell, J. D., & Conway, G. S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1939 · Cited by 83 · see citing works
Gravholt, C. H., Næraa, R. W., Fisker, S., & Christiansen, J. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4127 · Cited by 72 · see citing works
Gault, E. J., Perry, R. J., Cole, T. J., Casey, S., Paterson, W. F., Hindmarsh, P. C., Betts, P., Dunger, D. B., Donaldson, M. D. C., & on behalf of the British Society for Paediatric Endocrinology and Diabetes (2011) · BMJ · doi:10.1136/bmj.d1980 · Cited by 71 · see citing works
Androgen replacement therapy in Turner syndrome: a pilot study
Zuckerman-Levin, N., Frolova-Bishara, T., Militianu, D., Levin, M., Aharon-Peretz, J., & Hochberg, Z. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0514 · Cited by 69 · see citing works
Hamelin, C. E., Anglin, G., Quigley, C. A., & Deal, C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0490 · Cited by 62 · see citing works
Stahnke, N., Keller, E., Landy, H., & Serono Study Group (2002) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2002.15.2.129 · Cited by 59 · see citing works
Bardsley, M. Z., Shah, K. R., Kowal, K., Cutler, G. B., Kushner, H., & ROSS, J. L. (2010) · Hormone Research in Paediatrics · doi:10.1159/000317529 · Cited by 51 · see citing works
Sas, T., Gerver, W. M., de Bruin, R., Stijnen, T., Keizer‐Schrama, S. M. P. F. D. M., Cole, T. J., van Teunenbroek, A., & Drop, S. L. S. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.12.6225 · Cited by 51 · see citing works
Self-citationBinder, G., Trebar, B., Baur, F., Schweizer, R., & Ranke, M. B. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03090.x · Cited by 48 · see citing works
Haeusler, G., Schmitt, K., Blümel, P., Plöchl, E., Waldhör, T., & Frisch, H. (1996) · PubMed · Cited by 42 · see citing works
Long-Term Follow-Up of GH-Treated Girls with Turner Syndrome: BMI, Blood Pressure, Body Proportions
Bannink, E. M. N., van der Palen, R. L. F., Mulder, P. G. H., & Keizer‐Schrama, S. M. P. F. D. M. (2009) · Hormone Research in Paediatrics · doi:10.1159/000223418 · Cited by 41 · see citing works
Dehydroepiandrosterone, androgens and the mammary gland
Labrie, F. (2006) · Gynecological Endocrinology · doi:10.1080/09513590600624440 · Cited by 39 · see citing works
Sas, T. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.12.4622 · Cited by 39 · see citing works
Self-citationAre young women with Turner syndrome at greater risk of coronary artery disease?
Kozlowska-Wojciechowska, M., Jez, W., Zdrojewski, T., & Chwojnicki, K. (2006) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000216545.99807.fd · Cited by 33 · see citing works
Gravholt, C. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2570 · Cited by 31 · see citing works
Haeusler, G., Schmitt, K., Blümel, P., Plöchl, E., Waldhör, T., & Frisch, H. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636264 · Cited by 21 · see citing works
The Effect of Oxandrolone on Voice Frequency in Growth Hormone-Treated Girls With Turner Syndrome
Menke, L. A., Sas, T., van Koningsbrugge, S. H. L., de Ridder, M. A. J., Zandwijken, G. R. J., Boersma, B., Dejonckere, P. H. O., Keizer‐Schrama, S. M. P. F. D. M., Otten, B. J., & Wit, J. M. (2010) · Journal of Voice · doi:10.1016/j.jvoice.2010.06.002 · Cited by 17 · see citing works
Self-citationMenke, L. A., Sas, T., Zandwijken, G. R. J., de Ridder, M. A. J., Stijnen, T., Keizer‐Schrama, S. M. P. F. D. M., Otten, B. J., & Wit, J. M. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03789.x · Cited by 14 · see citing works
Self-citationChagin, A. S., Vannesjo, S. J., & Savendahl, L. S. (2009) · Hormone Research in Paediatrics · doi:10.1159/000201111 · Cited by 14 · see citing works
Growth Promoting Treatment Normalizes Speech Frequency in Turner Syndrome
Andersson‐Wallgren, G., Ohlsson, A., Albertsson-Wikland, K. G., & Barrenäs, M. (2008) · The Laryngoscope · doi:10.1097/mlg.0b013e31816927de · Cited by 13 · see citing works
[Anaphylactic reactions to chlorhexidine during urinary catheterisation].
van Zuuren, E. J., Boer, F., Ej, L. A. F., & Terreehorst, I. (2007) · PubMed · Cited by 7 · see citing works
[Androgens and the mammary gland].
Jm, S. I. (2004) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Gerver W. Paediatric Morphometrics. A Reference Manual (second extended edition). Universitaire Pers Maastricht, 2001.
Cited by
Sorted by citations
Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., Lin, A. E., Mauras, N., Quigley, C. A., Rubin, K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0430 · Cited by 1,101 · see citing works
Self-citationClinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224 · see citing works
Self-citationEstrogen replacement in Turner syndrome: literature review and practical considerations
Klein, K. O., Rosenfield, R. L., Santen, R. J., Gawlik, A. M., Backeljauw, P. F., Gravholt, C. H., Sas, T. C. J., & Mauras, N. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02183 · Cited by 151 · see citing works
Self-citationSas, T. C. J., Gault, E. J., Zeger Bardsley, M., Menke, L. A., Freriks, K., Perry, R. J., Otten, B. J., de Muinck Keizer-Schrama, S. M. P. F., Timmers, H., Wit, J. M., et al. (2014) · Hormone Research in Paediatrics · doi:10.1159/000358195 · Cited by 55 · see citing works
Self-citationLin, A. E., Prakash, S. K., Andersen, N. H., Viuff, M. H., Levitsky, L. L., Rivera‐Davila, M., Crenshaw, M. L., Hansen, L., Colvin, M. K., Hayes, F. J., et al. (2019) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61310 · Cited by 50 · see citing works
Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
Li, P., Cheng, F., & Xiu, L. (2018) · Endocrine Connections · doi:10.1530/ec-18-0115 · Cited by 41 · see citing works
Novel approaches to short stature therapy
Wit, J. M., & Oostdijk, W. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.01.003 · Cited by 41 · see citing works
Self-citationFreriks, K., Verhaak, C. M., Sas, T. C. J., Menke, L. A., Wit, J. M., Otten, B. J., de Muinck Keizer-Schrama, S. M. P. F., Smeets, D. F. C. M., Netea-Maier, R. T., Hermus, A. R. M. M., et al. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.12.008 · Cited by 20 · see citing works
Self-citationVerver, E. J. J., Freriks, K., Sas, T., Huygen, P. L. M., Pennings, R. J. E., Smeets, D., Hermus, A. R., Menke, L. A., Wit, J. M., Otten, B. J., et al. (2014) · Otology & Neurotology · doi:10.1097/mao.0000000000000406 · Cited by 18 · see citing works
Self-citationAn FT-Raman, FT-IR, and Quantum Chemical Investigation of Stanozolol and Oxandrolone
Lemma, T., Souza, F. D. B., Soto, C. A. T., & Martin, A. A. (2017) · Biosensors · doi:10.3390/bios8010002 · Cited by 18 · see citing works
Diagnostic and therapeutic considerations in Turner syndrome
Yang, S. (2017) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2017.22.4.226 · Cited by 16 · see citing works
Perry, R., Gault, E. J., Paterson, W. F., Dunger, D. B., & Donaldson, M. (2014) · Hormone Research in Paediatrics · doi:10.1159/000356924 · Cited by 17 · see citing works
Oxandrolone for growth hormone-treated girls aged up to 18 years with Turner syndrome
Mohamed, S., Alkofide, H., Adi, Y., Amer, Y. S., & AlFaleh, K. M. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010736.pub2 · Cited by 13 · see citing works
Testosterone exposure in childhood: discerning pathology from physiology
Cabrera, S. M., & Rogol, A. D. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.782000 · Cited by 13 · see citing works
Kriström, B., Ankarberg-Lindgren, C., Barrenäs, M.-L., Nilsson, K. O., & Albertsson-Wikland, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1197897 · Cited by 11 · see citing works
Voice dissatisfaction in individuals with a disorder of sex development
Nygren, U., Södersten, M., Thyen, U., Köhler, B., Nordenskjöld, A., & the dsd‐LIFE Group (2019) · Clinical Endocrinology · doi:10.1111/cen.14000 · Cited by 7 · see citing works
Backeljauw, P. F., Chernausek, S. D., Gravholt, C. H., & Kruszka, P. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00017-8 · Cited by 5 · see citing works
Emerging Developments in Pubertal Suppression for Gender Incongruent/Gender Dysphoric Youth
Marinković, M. D., Carswell, J. M., & Roberts, S. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-56963-7.00012-0 · Cited by 1 · see citing works
Turner syndrome in adulthood. A childhood disease grown up
Freriks, K. (2015) · Radboud Repository (Radboud University)
Self-citationThe effectiveness of the growth hormone treatment of children with Turner syndrome in Ukraine
Zelinska, N., Шевченко, І. Ю., Вікторівна, Г. Є., & Погадаєва, Н. Л. (2015) · Clinical endocrinology and endocrine surgery · doi:10.24026/1818-1384.3(51).2015.75060
Update in Pediatric Endocrinology
Marks, S. D., & Wicklow, B. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-58027-2_9
Estrogen Replacement in Turner Syndrome
Klein, K. O., Rosenfield, R. L., Santen, R. J., Gawlik, A., Backeljauw, P. F., Gravholt, C. H., Sas, T., & Mauras, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-34150-3_5
Self-citationQuigley, C. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-34150-3_3
Update in Pediatric Endocrinology
Marks, S. D., & Wicklow, B. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-41542-5_14
- Authors
- Freriks, K., Sas, T. C. J., Traas, M. A. F., Netea-Maier, R. T., den Heijer, M., Hermus, A. R. M. M., Wit, J. M., van Alfen-van der Velden, J. A. E. M., Otten, B. J., de Muinck Keizer-Schrama, S. M. P. F., Gotthardt, M., Dejonckere, P. H., Zandwijken, G. R. J., Menke, L. A., & Timmers, H. J. L. M.
- Affiliations
- Radboud University Medical Center (NL)
- Erasmus MC (NL)
- Gelre Hospitals (NL)
- Leiden University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Freriks, Kim
- ORCID
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01
- Volume
- 168
- Issue
- 1
- Pages
- 91-99
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2161179909
- Cited by
- 24
- References
- 40
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2015: 4 · 2014: 3 · 2013: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Funders
- Pfizer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- Turner syndrome, oxandrolone, growth hormone therapy, short stature, long-term follow-up, breast development, masculinization, body composition, body proportions, voice frequency, anabolic steroids
- MeSH terms
- Adult, Body Height, Breast, Child, Child, Preschool, Double-Blind Method, Female, Follow-Up Studies, Humans, Oxandrolone, Turner Syndrome, Virilism, Randomized Controlled Trials as Topic, Treatment Outcome, Human Growth Hormone
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