Determining minimal important change for the thyroid related quality of life questionnaire ThyPRO
Open accessAbstract
OBJECTIVE: ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. METHODS: A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0-100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. RESULTS: ROC analyses provided group-MIC estimates of 6.3-14.3 (score range 0-100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0-21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. CONCLUSIONS: Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3-14.3 for groups and 8.0-21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice.
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A change of nine points in the ThyPRO Composite score has been identified as a valid minimal important change (MIC).
“A change of nine points in the ThyPRO Composite score has been identified as a valid MIC (36).”
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- Authors
- Nordqvist, S. F., Boesen, V. B., Rasmussen, Å. K., Feldt-Rasmussen, U., Hegedüs, L., Bonnema, S. J., Cramon, P. K., Watt, T., Groenvold, M., & Bjorner, J. B.
- Affiliations
- Copenhagen University Hospital (DK)
- 1Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
- 3Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
- Odense University Hospital (DK)
- Frederiksberg Hospital (DK)
- University of Copenhagen (DK)
- 6Department of Public Health, University of Copenhagen, Copenhagen, Denmark
- Corresponding author
- Watt, Torquil
- Venue
- Endocrine Connections
- Publisher
- Bioscientifica
- Published
- 2021-03
- Volume
- 10
- Issue
- 3
- Pages
- 316-324
- ISSN
- 2049-3614 (ISSN-L)
- PMC
- PMC8052573
- OpenAlex
- W3132683215
- Cited by
- 31
- References
- 34
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 3
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Endocrine Connections (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- minimal important change, patient-reported outcomes, benign thyroid disease, reliable change index, receiver operating characteristic, global rating of change, responder identification
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